Elizabeth C Ledgerwood

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. doi request reprint The role of peroxiredoxin 1 in redox sensing and transducing
    Elizabeth C Ledgerwood
    Department of Biochemistry, School of Biomedical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand Electronic address
    Arch Biochem Biophys . 2016
  2. doi request reprint Targeting the apoptosome for cancer therapy
    Elizabeth C Ledgerwood
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Clin Cancer Res 15:420-4. 2009
  3. pmc Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination
    Tracy M Josephs
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin, 9054, New Zealand
    J Biol Inorg Chem 18:289-97. 2013
  4. doi request reprint Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release
    Tracy M Josephs
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Biochem J 458:259-65. 2014
  5. doi request reprint The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax
    Dana Westphal
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Apoptosis 14:1317-30. 2009
  6. pmc Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c
    Tracy M Josephs
    Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    PLoS ONE 10:e0130292. 2015
  7. doi request reprint Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes
    Carolyn M Porteous
    Department of Chemistry, University of Otago, Dunedin 9054, New Zealand
    Biochim Biophys Acta 1800:1009-17. 2010
  8. doi request reprint Megakaryocytes from CYCS mutation-associated thrombocytopenia release platelets by both proplatelet-dependent and -independent processes
    Lily Ong
    Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Br J Haematol 176:268-279. 2017
  9. doi request reprint Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells
    Reagan M Jarvis
    Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
    Free Radic Biol Med 53:1522-30. 2012
  10. pmc A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus
    Dana Westphal
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    J Virol 81:7178-88. 2007

Collaborators

  • Michael P Murphy
  • Merilyn H Hibma
  • Joel D A Tyndall
  • Norihito Ueda
  • Mark B Hampton
  • Robert J Weeks
  • Robin A J Smith
  • Tracy M Josephs
  • Ian M Morison
  • Lily Ong
  • Reagan M Jarvis
  • Dana Westphal
  • Sigurd M Wilbanks
  • Gillian Hughes
  • Alexandra Lo
  • Carolyn M Porteous
  • Andrew G Cox
  • Andrew A Mercer
  • Stephen B Fleming
  • Moira E Hibbs
  • Catherine L Day
  • Kara L Bren
  • Matthew D Liptak
  • Stephanie M Hughes
  • David K Menon
  • Franklin Aigbirhio
  • Cameron Evans
  • Angela Logan
  • Melanie S A Coker
  • Andrew J Holyoake
  • Juliet M Pullar
  • Emma J Cheesman
  • Robert D Fagerlund
  • Serge Fichelson
  • Diana A Pippig
  • Elisabeth M Cramer Bordé
  • Stefan M K Davies
  • Mathew W Ludgate
  • Mark P Smith
  • Claude Capron
  • Nicholas A Bockett
  • Fernanda M da Silva Tatley
  • Pak Leng Cheong
  • Jana Göttert
  • Ellena M Whelan

Detail Information

Publications13

  1. doi request reprint The role of peroxiredoxin 1 in redox sensing and transducing
    Elizabeth C Ledgerwood
    Department of Biochemistry, School of Biomedical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand Electronic address
    Arch Biochem Biophys . 2016
    ..The evidence for each mechanism is discussed and areas for future work are identified...
  2. doi request reprint Targeting the apoptosome for cancer therapy
    Elizabeth C Ledgerwood
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Clin Cancer Res 15:420-4. 2009
    ....
  3. pmc Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination
    Tracy M Josephs
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin, 9054, New Zealand
    J Biol Inorg Chem 18:289-97. 2013
    ..These results suggest the impact of residue 41 on the conformation of cytochrome c influences its ability to act in both of its physiological roles, electron transport and caspase activation...
  4. doi request reprint Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release
    Tracy M Josephs
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Biochem J 458:259-65. 2014
    ..These changes enhance access of hydrogen peroxide and substrate to the haem...
  5. doi request reprint The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax
    Dana Westphal
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Apoptosis 14:1317-30. 2009
    ..Furthermore, we demonstrate that the binding profile of ORFV125 is distinct to that of other poxviral Bcl-2-like proteins...
  6. pmc Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c
    Tracy M Josephs
    Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    PLoS ONE 10:e0130292. 2015
    ..These results have important implications for studies of the effects of cytochrome c mutations on the intrinsic apoptosis pathway. ..
  7. doi request reprint Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes
    Carolyn M Porteous
    Department of Chemistry, University of Otago, Dunedin 9054, New Zealand
    Biochim Biophys Acta 1800:1009-17. 2010
    ..One approach to this is to deliver antioxidants, probes and pharmacophores to mitochondria by conjugation to the lipophilic triphenylphosphonium (TPP) cation that is taken up selectively by mitochondria driven by the membrane potential...
  8. doi request reprint Megakaryocytes from CYCS mutation-associated thrombocytopenia release platelets by both proplatelet-dependent and -independent processes
    Lily Ong
    Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Br J Haematol 176:268-279. 2017
    ..The failure to recapitulate this mechanism in vitro implies that the phenotype is not simply an intrinsic property of CYCS mutation-carrying megakaryocytes, but is dependent on the interaction between these cells and their environment...
  9. doi request reprint Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells
    Reagan M Jarvis
    Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
    Free Radic Biol Med 53:1522-30. 2012
    ..This model of active peroxide signal distribution via disulfide exchange is consistent with Prdx function in yeast and explains how peroxides may trigger specific disulfide bond formation in mammalian cells...
  10. pmc A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus
    Dana Westphal
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    J Virol 81:7178-88. 2007
    ..ORFV125 is the first parapoxvirus apoptosis inhibitor to be identified, and we propose that it is a new antiapoptotic member of the Bcl-2 family...
  11. doi request reprint A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia
    Ian M Morison
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Nat Genet 40:387-9. 2008
    ..Notably, the family has no other phenotypic indication of abnormal apoptosis, implying that cytochrome c activity is not a critical regulator of most physiological apoptosis...
  12. ncbi request reprint Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells
    Reagan M Jarvis
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Free Radic Res 41:1041-6. 2007
    ..Instead, these results suggest alternative mitochondrial functions, such as a respiration-dependent process, are critical for necrotic death...
  13. doi request reprint Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis
    Andrew G Cox
    Free Radical Research Group, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 44:1001-9. 2008
    ..We hypothesize that the selective oxidation of peroxiredoxin 3 leads to an increase in mitochondrial H2O2 and that this may influence the progression of apoptosis...