J Keelan

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi request reprint Interleukin (IL)-6 and IL-8 production by human amnion: regulation by cytokines, growth factors, glucocorticoids, phorbol esters, and bacterial lipopolysaccharide
    J A Keelan
    Department of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, New Zealand
    Biol Reprod 57:1438-44. 1997
  2. ncbi request reprint Placental cytokines and preeclampsia
    Jeffrey A Keelan
    The Liggins Institute University of Auckland, New Zealand
    Front Biosci 12:2706-27. 2007
  3. ncbi request reprint Epithelial cell-derived neutrophil-activating peptide-78 is present in fetal membranes and amniotic fluid at increased concentrations with intra-amniotic infection and preterm delivery
    J A Keelan
    Liggins Institute and Department of Pharmacology and Clinical Pharmacology, University of Auckland Faculty of Medical and Health Sciences, Auckland, New Zealand
    Biol Reprod 70:253-9. 2004
  4. ncbi request reprint Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes
    Jeffrey A Keelan
    Liggins Institute, Department of Pharmacology, University of Aukland Faculty of Medical and Health Sciences, Aukland, New Zealand
    Mol Hum Reprod 9:535-40. 2003
  5. ncbi request reprint Cytokines, prostaglandins and parturition--a review
    J A Keelan
    Liggins Institute, University of Auckland, 2 6 Park Ave, Grafton, New Zealand
    Placenta 24:S33-46. 2003
  6. ncbi request reprint Serum activin A, inhibin A, and follistatin concentrations in preeclampsia or small for gestational age pregnancies
    Jeffrey A Keelan
    Liggins Institute and Division of Pharmacology and Clinical Pharmacology, University of Auckland, Faculty of Medical and Health Sciences, New Zealand
    Obstet Gynecol 99:267-74. 2002
  7. ncbi request reprint 15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells
    J Keelan
    Liggins Institute and Divisions of Pharmacology, University of Auckland Faculty of Medical and Health Sciences, New Zealand
    Prostaglandins Other Lipid Mediat 66:265-82. 2001
  8. ncbi request reprint Prostanoid stimulation of cytokine production in an amnion-derived cell line: evidence of a feed-forward mechanism with implications for term and preterm labor
    J A Keelan
    Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, New Zealand
    J Soc Gynecol Investig 7:37-44. 2000
  9. ncbi request reprint Regulation of activin-A production by human amnion, decidua and placenta in vitro by pro-inflammatory cytokines
    J A Keelan
    Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, New Zealand
    Placenta 19:429-34. 1998
  10. ncbi request reprint Interleukin-4 differentially regulates prostaglandin production in amnion-derived WISH cells stimulated with pro-inflammatory cytokines and epidermal growth factor
    J A Keelan
    University of Auckland School of Medicine, Department of Pharmacology and Clinical Pharmacology, New Zealand
    Prostaglandins Leukot Essent Fatty Acids 60:255-62. 1999

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Interleukin (IL)-6 and IL-8 production by human amnion: regulation by cytokines, growth factors, glucocorticoids, phorbol esters, and bacterial lipopolysaccharide
    J A Keelan
    Department of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, New Zealand
    Biol Reprod 57:1438-44. 1997
    ..We speculate that amnion-derived cytokines might have functions during normal human parturition that are distinct from their conventional roles as inflammatory mediators...
  2. ncbi request reprint Placental cytokines and preeclampsia
    Jeffrey A Keelan
    The Liggins Institute University of Auckland, New Zealand
    Front Biosci 12:2706-27. 2007
    ..Nevertheless, convincing evidence is now accruing that autocrine/paracrine interactions between placental cytokines/growth factors and the maternal endothelium play a central role in the pathogenesis of preeclampsia...
  3. ncbi request reprint Epithelial cell-derived neutrophil-activating peptide-78 is present in fetal membranes and amniotic fluid at increased concentrations with intra-amniotic infection and preterm delivery
    J A Keelan
    Liggins Institute and Department of Pharmacology and Clinical Pharmacology, University of Auckland Faculty of Medical and Health Sciences, Auckland, New Zealand
    Biol Reprod 70:253-9. 2004
    ....
  4. ncbi request reprint Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes
    Jeffrey A Keelan
    Liggins Institute, Department of Pharmacology, University of Aukland Faculty of Medical and Health Sciences, Aukland, New Zealand
    Mol Hum Reprod 9:535-40. 2003
    ..We conclude that AF MIC-1 is derived from the fetal membranes and decidua, but that MIC-1 is unlikely to be involved in the pathophysiology of preterm birth or PROM...
  5. ncbi request reprint Cytokines, prostaglandins and parturition--a review
    J A Keelan
    Liggins Institute, University of Auckland, 2 6 Park Ave, Grafton, New Zealand
    Placenta 24:S33-46. 2003
    ..A more complete understanding of these aspects of cytokine-prostaglandin interactions in pregnancy and parturition will, no doubt, unfold as current studies come to fruition...
  6. ncbi request reprint Serum activin A, inhibin A, and follistatin concentrations in preeclampsia or small for gestational age pregnancies
    Jeffrey A Keelan
    Liggins Institute and Division of Pharmacology and Clinical Pharmacology, University of Auckland, Faculty of Medical and Health Sciences, New Zealand
    Obstet Gynecol 99:267-74. 2002
    ..To determine whether maternal serum activin A, inhibin A, and follistatin concentrations in idiopathic small for gestational age (SGA) pregnancies are similar to those in normal pregnancies or elevated as in preeclampsia...
  7. ncbi request reprint 15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells
    J Keelan
    Liggins Institute and Divisions of Pharmacology, University of Auckland Faculty of Medical and Health Sciences, New Zealand
    Prostaglandins Other Lipid Mediat 66:265-82. 2001
    ..The mechanism of induction of apoptosis by 15d-PGJ2 and delta12PGJ2, which may be independent of PPAR-gamma activation, requires further elucidation...
  8. ncbi request reprint Prostanoid stimulation of cytokine production in an amnion-derived cell line: evidence of a feed-forward mechanism with implications for term and preterm labor
    J A Keelan
    Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, New Zealand
    J Soc Gynecol Investig 7:37-44. 2000
    ..To test the hypothesis that amnion cytokine production might be regulated by prostanoids...
  9. ncbi request reprint Regulation of activin-A production by human amnion, decidua and placenta in vitro by pro-inflammatory cytokines
    J A Keelan
    Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, New Zealand
    Placenta 19:429-34. 1998
    ..This may provide an explanation for the elevated concentrations of activin-A measured in the sera of some women in preterm labour...
  10. ncbi request reprint Interleukin-4 differentially regulates prostaglandin production in amnion-derived WISH cells stimulated with pro-inflammatory cytokines and epidermal growth factor
    J A Keelan
    University of Auckland School of Medicine, Department of Pharmacology and Clinical Pharmacology, New Zealand
    Prostaglandins Leukot Essent Fatty Acids 60:255-62. 1999
    ....
  11. ncbi request reprint 15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells
    J A Keelan
    Faculty of Medicine and Health Science, University of Auckland School of Medicine, Auckland, New Zealand
    Biochem Biophys Res Commun 262:579-85. 1999
    ..JEG3 cells expressed PPAR-gamma mRNA by Northern analysis. These novel findings imply a role for PPAR-gamma ligands in various processes associated with pregnancy and parturition...
  12. ncbi request reprint Concentrations of activin A, inhibin A and follistatin in human amnion, choriodecidual and placental tissues at term and preterm
    J A Keelan
    Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, Private Bag 92019, Auckland, New Zealand
    J Endocrinol 163:99-106. 1999
    ..The data, however, do not support an association between increased intrauterine activin biosynthesis and preterm delivery...
  13. ncbi request reprint Regulation of prostaglandin production in an immortalized human myometrial cell line by cytokines and non-steroidal anti-inflammatory drugs
    Timothy A Sato
    The Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Eur J Obstet Gynecol Reprod Biol 100:158-62. 2002
    ..To test the effect of selective and non-selective inhibitors of prostaglandin H synthase-2 (PGHS-II) on basal and cytokine-stimulated prostaglandin (PG) production by the immortalized human myometrial cell line, UTLRp16...
  14. ncbi request reprint Paradoxical proinflammatory actions of interleukin-10 in human amnion: potential roles in term and preterm labour
    Murray D Mitchell
    Liggins Institute, Department of Pharmacology, University of Auckland, Faculty of Medical and Health Sciences, Private Bag 92019, Auckland, New Zealand
    J Clin Endocrinol Metab 89:4149-52. 2004
    ....
  15. ncbi request reprint Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B
    Elicia B E Berry
    Liggins Institute, University of Auckland, Faculty of Medical and Health Sciences, Auckland, New Zealand
    Mol Pharmacol 68:169-78. 2005
    ....
  16. ncbi request reprint Cytokines, hypoxia, and preeclampsia
    Jeffrey A Keelan
    J Soc Gynecol Investig 12:385-7. 2005
  17. ncbi request reprint Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived antiinflammatory prostaglandins in human placenta
    Rachel J A Helliwell
    The Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Clin Endocrinol Metab 91:597-606. 2006
    ..However, the complexity of these pathways and the mechanism(s) of their coordinated regulation in physiological and pathological conditions are only now being appreciated...
  18. ncbi request reprint ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast
    Denis A Evseenko
    Liggins Institute, Univ of Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 290:R1357-65. 2006
    ..With respect to their ABC protein expression profile, Jar cells are more similar to nondifferentiated cytotrophoblast, whereas BeWo appear to more closely reflect differentiated syncytiotrophoblast...
  19. ncbi request reprint Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors
    Denis A Evseenko
    Liggins Institute and Department of Pharmacology and Clinical Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Drug Metab Dispos 35:595-601. 2007
    ..Such changes could alter placental drug disposition, increase fetal susceptibility to toxic xenobiotics, and impact on placental viability and function...
  20. ncbi request reprint Insulin resistance is not due to persistently elevated serum tumor necrosis-alpha levels in small for gestational age, premature, or twin children
    Craig A Jefferies
    Department of Paediatrics and Liggins Institute, University of Auckland, Auckland, New Zealand
    Pediatr Diabetes 5:20-5. 2004
    ..We hypothesized that an adverse fetal or early neonatal environment for SGA, twin, and premature children leads to persistently elevated TNF-alpha levels that induce insulin resistance in each of these groups...
  21. ncbi request reprint Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue- and CB1-receptor-specific mechanism
    Murray D Mitchell
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Am J Physiol Endocrinol Metab 294:E352-6. 2008
    ....
  22. ncbi request reprint UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term
    Abby C Collier
    Department of Pharmacology and Clinical Pharmacology, University of Auckland Medical School, Private Bag 92019 Auckland, New Zealand
    Biochem Pharmacol 63:409-19. 2002
    ....
  23. ncbi request reprint Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor
    Marion Blumenstein
    Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Clin Endocrinol Metab 87:1094-7. 2002
    ..Reduced expression of SOCS proteins in gestational tissues may provide a mechanism by which inflammatory cytokines enter into a positive feedback loop of inflammatory changes leading to delivery...
  24. ncbi request reprint Expression of angiogenic and neurotrophic factors in the human amnion and choriodecidua
    Keith W Marvin
    Liggins Institute and the Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
    Am J Obstet Gynecol 187:728-34. 2002
    ..Our objective was to identify the novel or differential expression of growth or development associated genes in the human gestational membranes that might play roles in pregnancy or in term or preterm parturition...
  25. ncbi request reprint Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption
    Abby C Collier
    Department of Pharmacology Clinical Pharmacology and The Liggins Institute, University of Auckland, Private Bag 92019, New Zealand
    Hum Reprod 17:2564-72. 2002
    ....
  26. ncbi request reprint Critical paracrine interactions between TNF-alpha and IL-10 regulate lipopolysaccharide-stimulated human choriodecidual cytokine and prostaglandin E2 production
    Timothy A Sato
    Liggins Institute and Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Immunol 170:158-66. 2003
    ..In the setting of an infection of the intrauterine, TNF-alpha may be a potential target for treatment intervention; IL-10 could be one such therapeutic...
  27. ncbi request reprint Maternal serum activin A is not elevated before preeclampsia in women who are at high risk
    Catherine A Blackburn
    Department of Obstetrics and Gynaecology, University of Auckland Faculty of Medical and Health Sciences, New Zealand
    Am J Obstet Gynecol 188:807-11. 2003
    ....
  28. ncbi request reprint Altered placental lactogen and leptin expression in placentomes from bovine nuclear transfer pregnancies
    Susan R Ravelich
    Liggins Institute, Auckland, New Zealand
    Biol Reprod 71:1862-9. 2004
    ....
  29. ncbi request reprint 3'-azido-3'-deoxythymidine (AZT) induces apoptosis and alters metabolic enzyme activity in human placenta
    Abby C Collier
    Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand
    Toxicol Appl Pharmacol 192:164-73. 2003
    ..These findings have implications for the safe administration of AZT in pregnancy with respect to the maintenance of integrity of the maternal-fetal barrier...
  30. ncbi request reprint Human placental glucuronidation and transport of 3'azido-3'-deoxythymidine and uridine diphosphate glucuronic acid
    Abby C Collier
    Department of Pharmacology and Clinical Pharmacology, The Liggins Institute, The University of Auckland, Auckland, New Zealand
    Drug Metab Dispos 32:813-20. 2004
    ..Finally, the activity of the UGT enzymes in the placenta is not rate-limited by the supply of UDPGA cofactor, whereas the preferential transport of UDPGA toward the fetus observed here may indicate a role in fetal development...
  31. ncbi request reprint Drug transfer and metabolism by the human placenta
    Michael R Syme
    Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Clin Pharmacokinet 43:487-514. 2004
    ..Improved knowledge regarding transplacental drug transfer and metabolism will result in further expansion of pharmacological treatment of fetal conditions...
  32. ncbi request reprint Insulin-like growth factor-I and binding proteins 1, 2, and 3 in bovine nuclear transfer pregnancies
    Susan R Ravelich
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Biol Reprod 70:430-8. 2004
    ..Furthermore, increased cell numbers in NT placentomes likely have significant implications for fetomaternal communication and may contribute to the placental overgrowth observed in the NT placentomes...