R Fukuzawa

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. pmc Imprinting, expression, and localisation of DLK1 in Wilms tumours
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    J Clin Pathol 58:145-50. 2005
  2. pmc A necropsy case of Denys-Drash syndrome with a WT1 mutation in exon 7
    R Fukuzawa
    Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Med Genet 39:e48. 2002
  3. ncbi request reprint Embryonal hyperplasia of Bowman's capsular epithelium in patients with WT1 mutations
    Ryuji Fukuzawa
    Department of Pathology, Keio University School of Medicine, Tokyo, Japan
    Pediatr Nephrol 18:9-13. 2003
  4. ncbi request reprint Beckwith-Wiedemann syndrome-associated hepatoblastoma: wnt signal activation occurs later in tumorigenesis in patients with 11p15.5 uniparental disomy
    Ryuji Fukuzawa
    Department of Pathology, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Pediatr Dev Pathol 6:299-306. 2003
  5. doi request reprint Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pathol 215:377-87. 2008
  6. ncbi request reprint Autopsy case of microcephalic osteodysplastic primordial "dwarfism" type II
    Ryuji Fukuzawa
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Am J Med Genet 113:93-6. 2002
  7. pmc Sequential WT1 and CTNNB1 mutations and alterations of beta-catenin localisation in intralobar nephrogenic rests and associated Wilms tumours: two case studies
    Ryuji Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    J Clin Pathol 60:1013-6. 2007
  8. doi request reprint Canonical WNT signalling determines lineage specificity in Wilms tumour
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Oncogene 28:1063-75. 2009
  9. ncbi request reprint A novel WT1 gene mutation associated with wilms' tumor and congenital male genitourinary malformation
    J Sakamoto
    Department of Pediatric Surgery, University of Tokyo Faculty of Medicine, Tokyo, Japan
    Pediatr Res 50:337-44. 2001
  10. pmc Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer
    A Anjomshoaa
    Department of Biochemistry and Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
    Br J Cancer 99:966-73. 2008

Collaborators

Detail Information

Publications27

  1. pmc Imprinting, expression, and localisation of DLK1 in Wilms tumours
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    J Clin Pathol 58:145-50. 2005
    ..The GTL2/DLK1 domain is also imprinted and is structurally similar to H19/IGF2. The question arises as to whether DLK1 also undergoes LOI in Wilms tumour, or whether the LOI mechanism is restricted to the H19/IGF2 domain...
  2. pmc A necropsy case of Denys-Drash syndrome with a WT1 mutation in exon 7
    R Fukuzawa
    Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Med Genet 39:e48. 2002
  3. ncbi request reprint Embryonal hyperplasia of Bowman's capsular epithelium in patients with WT1 mutations
    Ryuji Fukuzawa
    Department of Pathology, Keio University School of Medicine, Tokyo, Japan
    Pediatr Nephrol 18:9-13. 2003
    ..Abnormal expression of WT1 and PAX2 in the EHBCE was observed in both patients, supporting our hypothesis. The nephropathy associated with constitutional WT1 mutations might therefore be associated with EHBCE...
  4. ncbi request reprint Beckwith-Wiedemann syndrome-associated hepatoblastoma: wnt signal activation occurs later in tumorigenesis in patients with 11p15.5 uniparental disomy
    Ryuji Fukuzawa
    Department of Pathology, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Pediatr Dev Pathol 6:299-306. 2003
    ..These data indicate that Wnt signal activation can be involved as a later event in BWS-associated hepatoblastoma involving 11p15.5 UPD...
  5. doi request reprint Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pathol 215:377-87. 2008
    ....
  6. ncbi request reprint Autopsy case of microcephalic osteodysplastic primordial "dwarfism" type II
    Ryuji Fukuzawa
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Am J Med Genet 113:93-6. 2002
    ..These findings suggest that impairment of chondrocytic formation and differentiation is the major pathogenesis of MOPD type II...
  7. pmc Sequential WT1 and CTNNB1 mutations and alterations of beta-catenin localisation in intralobar nephrogenic rests and associated Wilms tumours: two case studies
    Ryuji Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    J Clin Pathol 60:1013-6. 2007
    ..ILNR-associated Wilms tumours have a co-clustering of WT1 and beta-catenin (CTNNB1) mutations and unique histological features characterised by a stromal-predominant histology...
  8. doi request reprint Canonical WNT signalling determines lineage specificity in Wilms tumour
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Oncogene 28:1063-75. 2009
    ....
  9. ncbi request reprint A novel WT1 gene mutation associated with wilms' tumor and congenital male genitourinary malformation
    J Sakamoto
    Department of Pediatric Surgery, University of Tokyo Faculty of Medicine, Tokyo, Japan
    Pediatr Res 50:337-44. 2001
    ..These results, together with the data from previous reports, suggest that WT1 may function in gonadogenesis, nephrogenesis, and Wilms' tumor tumorigenesis...
  10. pmc Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer
    A Anjomshoaa
    Department of Biochemistry and Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
    Br J Cancer 99:966-73. 2008
    ..This contrasts with many other carcinomas such as breast cancer. Investigating the reasons underlying this unusual observation may provide important insight into the biology of colon cancer progression and putative novel therapy options...
  11. ncbi request reprint Nesidioblastosis and mixed hamartoma of the liver in Beckwith-Wiedemann syndrome: case study including analysis of H19 methylation and insulin-like growth factor 2 genotyping and imprinting
    R Fukuzawa
    Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
    Pediatr Dev Pathol 4:381-90. 2001
    ..Thus, somatic mosaicism may result in unbalanced tissue growth, which may contribute to the formation of MHL in BWS...
  12. pmc Do intronic mutations affecting splicing of WT1 exon 9 cause Frasier syndrome?
    H Kikuchi
    Department of Pathology, Keio University School of Medicine, Tokyo, Japan
    J Med Genet 35:45-8. 1998
    ..Our results indicate that WT1 isoforms, including/excluding KTS, have different functions in tumorigenesis and organogenesis of the kidneys and gonads...
  13. ncbi request reprint A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors
    Z Xin
    Department of Biochemistry, Saga Medical School, Nabeshima, Saga, Saga 849 8501, Japan
    J Biochem 128:847-53. 2000
    ..These results suggest that KCNQ1DN existing far from the H19/IGF2 region may play some role in Wilms' tumorigenesis along with IGF2...
  14. ncbi request reprint Genome wide expression profiling identifies genes associated with colorectal liver metastasis
    H M Lin
    Cancer Genetics Laboratory, Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Oncol Rep 17:1541-9. 2007
    ..However, downregulation of genes associated with proliferation suggests that proliferation in metastases was reduced relative to primary tumours...
  15. ncbi request reprint Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer
    Bostjan Humar
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Cancer Res 67:2480-9. 2007
    ....
  16. pmc Increased levels of active c-Src distinguish invasive from in situ lobular lesions
    Donghui Zou
    Cancer Genetics Laboratory, Biochemistry Department, University of Otago, 710 Cumberland St, Dunedin 9054, Aotearoa New Zealand
    Breast Cancer Res 11:R45. 2009
    ..Here, we investigated whether c-Src kinase, an established inducer of invasive states, contributes to the progression from ALH/LCIS to ILC...
  17. ncbi request reprint Digynic triploid infant surviving for 46 days
    T Hasegawa
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Am J Med Genet 87:306-10. 1999
    ..These findings support the notion that type II triploids are digynic in parental origin and that they survive longer than type I, diandric triploids...
  18. ncbi request reprint Myogenesis in Wilms' tumors is associated with mutations of the WT1 gene and activation of Bcl-2 and the Wnt signaling pathway
    Ryuji Fukuzawa
    Department of Biochemistry, Cancer Genetics Laboratory, University of Otago, P O Box 56, Dunedin, New Zealand
    Pediatr Dev Pathol 7:125-37. 2004
    ....
  19. ncbi request reprint Epigenetic differences between Wilms' tumours in white and east-Asian children
    Ryuji Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Lancet 363:446-51. 2004
    ..We investigated whether the difference in incidence of Wilms' tumour between children of east-Asian descent and white children is due to variations in proportion of tumours with loss of IGF2 imprinting (IGF2 LOI)...
  20. ncbi request reprint Molecular pathology and epidemiology of nephrogenic rests and Wilms tumors
    Ryuji Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pediatr Hematol Oncol 29:589-94. 2007
    ....
  21. ncbi request reprint Pulmonary epithelial cell maturation in hyperplastic lungs associated with fetal tracheal agenesis
    K Mori
    Division of Neonatology, Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    J Pediatr Surg 36:1845-8. 2001
    ..CONCLUSION: The differentiation of pulmonary epithelial cells appeared to be more advanced for the gestational age in pulmonary hyperplasia with congenital tracheal agenesis. J Pediatr Surg 36:1845-1848...
  22. ncbi request reprint Expression of mitogen-activated protein kinases in human renal dysplasia
    Sayu Omori
    Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Kidney Int 61:899-906. 2002
    ..Dysregulation of MAPKs may lead to kidney malformation. Thus, we investigated the expression of MAPKs in human renal dysplasia, one of the most common kidney malformations...
  23. pmc Beckwith-Wiedemann syndrome, pancreatoblastoma, and the wnt signaling pathway
    Natalie J Kerr
    Am J Pathol 160:1541-2; author reply 1542. 2002
  24. ncbi request reprint Insulin-like growth factor-II imprinting in cancer
    Anthony E Reeve
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Lancet 359:2050-1. 2002
  25. ncbi request reprint Correct usage of "loss of imprinting"
    Ryuji Fukuzawa
    Am J Med Genet A 138:412; author reply 413-4. 2005
  26. doi request reprint Mcl-1, an anti-apoptotic Bcl-2 family member, essentially overlaps with insulin-producing cells in neonatal nesidioblastosis
    Makoto Sano
    Virchows Arch 452:469-70. 2008
  27. ncbi request reprint Acinic cell carcinoma in an African pygmy hedgehog (Atelerix albiventris)
    Ryuji Fukuzawa
    Department ofPathology, Keio University School of Medicine, Tokyo, Japan
    Vet Clin Pathol 33:39-42. 2004
    ..The histopathologic, immunohistochemical, and ultrastructural findings were those of acinic cell carcinoma, the origin of which was unknown. This is the first known case of acinic cell carcinoma in an African hedgehog...