Graham M Donovan

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. doi request reprint Clustered ventilation defects and bilinear respiratory reactance in asthma
    Graham M Donovan
    Department of Mathematics, University of Auckland, Private Bag 92019, Auckland, New Zealand Electronic address
    J Theor Biol 406:166-75. 2016
  2. pmc Airway Bistability Is Modulated by Smooth Muscle Dynamics and Length-Tension Characteristics
    Graham M Donovan
    Department of Mathematics, University of Auckland, Auckland, New Zealand Electronic address
    Biophys J 111:2327-2335. 2016
  3. doi request reprint T cell and reticular network co-dependence in HIV infection
    Graham M Donovan
    Department of Mathematics, University of Auckland, Private Bag 92019, Auckland, New Zealand Electronic address
    J Theor Biol 395:211-20. 2016
  4. pmc Spatial pattern formation in the lung
    Graham M Donovan
    Department of Mathematics, University of Auckland, Auckland, New Zealand
    J Math Biol 70:1119-49. 2015
  5. pmc Modelling airway smooth muscle passive length adaptation via thick filament length distributions
    Graham M Donovan
    Department of Mathematics, University of Auckland, New Zealand
    J Theor Biol 333:102-8. 2013
  6. pmc The importance of synergy between deep inspirations and fluidization in reversing airway closure
    Graham M Donovan
    Department of Mathematics, University of Auckland, Auckland, New Zealand
    PLoS ONE 7:e48552. 2012
  7. doi request reprint T-cell movement on the reticular network
    Graham M Donovan
    Department of Mathematics, University of Auckland, Auckland, New Zealand
    J Theor Biol 295:59-67. 2012
  8. pmc A simplified model of airway narrowing due to bronchial mucosal folding
    Graham M Donovan
    Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    Respir Physiol Neurobiol 171:144-50. 2010
  9. pmc A continuous-binding cross-linker model for passive airway smooth muscle
    Graham M Donovan
    Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
    Biophys J 99:3164-71. 2010
  10. pmc Multiscale mathematical models of airway constriction and disease
    Graham M Donovan
    Auckland Bioengineering Institute, University of Auckland, New Zealand
    Pulm Pharmacol Ther 24:533-9. 2011

Detail Information

Publications13

  1. doi request reprint Clustered ventilation defects and bilinear respiratory reactance in asthma
    Graham M Donovan
    Department of Mathematics, University of Auckland, Private Bag 92019, Auckland, New Zealand Electronic address
    J Theor Biol 406:166-75. 2016
    ....
  2. pmc Airway Bistability Is Modulated by Smooth Muscle Dynamics and Length-Tension Characteristics
    Graham M Donovan
    Department of Mathematics, University of Auckland, Auckland, New Zealand Electronic address
    Biophys J 111:2327-2335. 2016
    ..We also explore the potential implications of this finding for airway closure in coupled airway models...
  3. doi request reprint T cell and reticular network co-dependence in HIV infection
    Graham M Donovan
    Department of Mathematics, University of Auckland, Private Bag 92019, Auckland, New Zealand Electronic address
    J Theor Biol 395:211-20. 2016
    ....
  4. pmc Spatial pattern formation in the lung
    Graham M Donovan
    Department of Mathematics, University of Auckland, Auckland, New Zealand
    J Math Biol 70:1119-49. 2015
    ..Extensions to hexagonal and cubic lattices are also studied. ..
  5. pmc Modelling airway smooth muscle passive length adaptation via thick filament length distributions
    Graham M Donovan
    Department of Mathematics, University of Auckland, New Zealand
    J Theor Biol 333:102-8. 2013
    ....
  6. pmc The importance of synergy between deep inspirations and fluidization in reversing airway closure
    Graham M Donovan
    Department of Mathematics, University of Auckland, Auckland, New Zealand
    PLoS ONE 7:e48552. 2012
    ..It also allows us to explore the types of subtle change which can cause this interaction to fail, and thus could provide the missing link to explain DI failure in asthmatics...
  7. doi request reprint T-cell movement on the reticular network
    Graham M Donovan
    Department of Mathematics, University of Auckland, Auckland, New Zealand
    J Theor Biol 295:59-67. 2012
    ..A non-random distribution of turning angles is one consequence of motion on a preformed network. Confining cell movement to a network does not, in itself, increase the frequency of cell-cell encounters...
  8. pmc A simplified model of airway narrowing due to bronchial mucosal folding
    Graham M Donovan
    Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    Respir Physiol Neurobiol 171:144-50. 2010
    ..We show that this model generates predictions in good agreement with existing models while being vastly simpler to solve...
  9. pmc A continuous-binding cross-linker model for passive airway smooth muscle
    Graham M Donovan
    Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
    Biophys J 99:3164-71. 2010
    ..Furthermore, experiments in noncontractile tissue show qualitatively similar behavior, suggesting support for the protein-filament theory as a biomechanical basis for the behavior...
  10. pmc Multiscale mathematical models of airway constriction and disease
    Graham M Donovan
    Auckland Bioengineering Institute, University of Auckland, New Zealand
    Pulm Pharmacol Ther 24:533-9. 2011
    ..This paper reviews several examples of multiscale models from the most important models in the literature, with a particular emphasis on those concerned with airway hyper-responsiveness and airway constriction...
  11. pmc A multiscale, spatially distributed model of asthmatic airway hyper-responsiveness
    Antonio Z Politi
    Department of Mathematics, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    J Theor Biol 266:614-24. 2010
    ..By incorporating and coupling the models at these scales, we obtain a detailed, computational multiscale model incorporating important physiological phenomena associated with asthma...
  12. pmc Quantifying parenchymal tethering in a finite element simulation of a human lung slice under bronchoconstriction
    Barbara J Breen
    Auckland Bioengineering Institute, University of Auckland, Private Bag 92019 Auckland Mail Centre, Auckland 1142, New Zealand
    Respir Physiol Neurobiol 183:85-90. 2012
    ..We show that the nonlinear law and Lai-Fook's relationship are consistent for small constrictions, but diverge when the constriction becomes large...
  13. pmc Phenotype, endotype and patient-specific computational modelling for optimal treatment design in asthma
    Graham M Donovan
    Department of Mathematics, University of Auckland, Auckland 1142, New Zealand
    Drug Discov Today Dis Models 15:23-27. 2015
    ..This would be not only an important improvement in its own right, but also an important step toward the ultimate goal of patient-specific modelling...