Q Chen

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi request reprint The localization of adrenomedullin in rat kidney tissue and its inhibitory effect on the growth of cultured rat mesangial cells
    Xueguang Liu
    Department of Pathology, School of Basic Medical Sciences, Medical Center, Fudan University, Shanghai 200032
    Chin Med Sci J 17:129-33. 2002
  2. doi request reprint Phagocytosis of apoptotic trophoblastic debris protects endothelial cells against activation
    Q Chen
    Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand
    Placenta 33:548-53. 2012
  3. doi request reprint Serum levels of GDF15 are reduced in preeclampsia and the reduction is more profound in late-onset than early-onset cases
    Qi Chen
    The Hospital of Obstetrics and Gynaecology, Fudan University, China Department of Obstetrics and Gynaecology, University of Auckland, New Zealand Electronic address
    Cytokine 83:226-30. 2016
  4. doi request reprint Increased expression of high mobility group box 1 (HMGB1) in the cytoplasm of placental syncytiotrophoblast from preeclamptic placentae
    Q Chen
    The Hospital of Obstetrics and Gynaecology, Fudan University, China Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand Electronic address
    Cytokine 85:30-6. 2016
  5. doi request reprint Calcium channel blockers prevent endothelial cell activation in response to necrotic trophoblast debris: possible relevance to pre-eclampsia
    Qi Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, 85 Park Road, Grafton 1011, New Zealand
    Cardiovasc Res 96:484-93. 2012
  6. doi request reprint Antiphospholipid antibodies prolong the activation of endothelial cells induced by necrotic trophoblastic debris: implications for the pathogenesis of preeclampsia
    Q Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Placenta 33:810-5. 2012
  7. doi request reprint A role for interleukin-6 in spreading endothelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia
    Q Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    J Pathol 217:122-30. 2009
  8. ncbi request reprint Antiphospholipid antibodies bind to activated but not resting endothelial cells: is an independent triggering event required to induce antiphospholipid antibody-mediated disease?
    Q Chen
    Department of Obstetrics and Gynecology, Faculty of Medical and Health Science, The University of Auckland Auckland, New Zealand
    Thromb Res 114:101-11. 2004
  9. doi request reprint Does oxygen concentration affect shedding of trophoblastic debris or production of inflammatory mediators from first trimester human placenta?
    Q Chen
    Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand
    Placenta 32:362-6. 2011
  10. doi request reprint Spreading endothelial cell dysfunction in response to necrotic trophoblasts. Soluble factors released from endothelial cells that have phagocytosed necrotic shed trophoblasts reduce the proliferation of additional endothelial cells
    Q Chen
    Department of Obstetrics and Gynaecology, The University of Auckland, 85 Park Rd, Grafton, Auckland 1001, New Zealand
    Placenta 31:976-81. 2010

Collaborators

Detail Information

Publications87

  1. ncbi request reprint The localization of adrenomedullin in rat kidney tissue and its inhibitory effect on the growth of cultured rat mesangial cells
    Xueguang Liu
    Department of Pathology, School of Basic Medical Sciences, Medical Center, Fudan University, Shanghai 200032
    Chin Med Sci J 17:129-33. 2002
    ..To observe the localization of adrenomedullin (AM) in rat kidney tissue and its inhibitory effect on the growth of cultured rat mesangial cells (MsC)...
  2. doi request reprint Phagocytosis of apoptotic trophoblastic debris protects endothelial cells against activation
    Q Chen
    Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand
    Placenta 33:548-53. 2012
    ..This phenomenon may also contribute to the maternal vascular adaptation that occurs in normal pregnancy...
  3. doi request reprint Serum levels of GDF15 are reduced in preeclampsia and the reduction is more profound in late-onset than early-onset cases
    Qi Chen
    The Hospital of Obstetrics and Gynaecology, Fudan University, China Department of Obstetrics and Gynaecology, University of Auckland, New Zealand Electronic address
    Cytokine 83:226-30. 2016
    ..However, it is unclear whether the circulating levels of GDF15 are altered in preeclampsia at the time of or prior to disease presentation...
  4. doi request reprint Increased expression of high mobility group box 1 (HMGB1) in the cytoplasm of placental syncytiotrophoblast from preeclamptic placentae
    Q Chen
    The Hospital of Obstetrics and Gynaecology, Fudan University, China Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand Electronic address
    Cytokine 85:30-6. 2016
    ..The aim of this study was to investigate whether the expression of HMGB1differed between early onset and late onset preeclampsia or severe and mild preeclampsia and whether its expression correlated with the levels of uric acid...
  5. doi request reprint Calcium channel blockers prevent endothelial cell activation in response to necrotic trophoblast debris: possible relevance to pre-eclampsia
    Qi Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, 85 Park Road, Grafton 1011, New Zealand
    Cardiovasc Res 96:484-93. 2012
    ..We investigated whether nifedipine could reverse the endothelial cell activation induced by NTD...
  6. doi request reprint Antiphospholipid antibodies prolong the activation of endothelial cells induced by necrotic trophoblastic debris: implications for the pathogenesis of preeclampsia
    Q Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Placenta 33:810-5. 2012
    ..This might in part explain why antiphospholipid antibodies are such a strong maternal risk factor for preeclampsia...
  7. doi request reprint A role for interleukin-6 in spreading endothelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia
    Q Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    J Pathol 217:122-30. 2009
    ....
  8. ncbi request reprint Antiphospholipid antibodies bind to activated but not resting endothelial cells: is an independent triggering event required to induce antiphospholipid antibody-mediated disease?
    Q Chen
    Department of Obstetrics and Gynecology, Faculty of Medical and Health Science, The University of Auckland Auckland, New Zealand
    Thromb Res 114:101-11. 2004
    ..However, as phosphatidyl serine is absent from resting endothelial cell membranes, we questioned this hypothesis...
  9. doi request reprint Does oxygen concentration affect shedding of trophoblastic debris or production of inflammatory mediators from first trimester human placenta?
    Q Chen
    Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand
    Placenta 32:362-6. 2011
    ..This study supports the growing evidence that levels of oxygen in the placental environment during the first trimester of pregnancy may not in itself be the essential component contributing to the pathogenesis of preeclampsia...
  10. doi request reprint Spreading endothelial cell dysfunction in response to necrotic trophoblasts. Soluble factors released from endothelial cells that have phagocytosed necrotic shed trophoblasts reduce the proliferation of additional endothelial cells
    Q Chen
    Department of Obstetrics and Gynaecology, The University of Auckland, 85 Park Rd, Grafton, Auckland 1001, New Zealand
    Placenta 31:976-81. 2010
    ....
  11. doi request reprint The role of autocrine TGFbeta1 in endothelial cell activation induced by phagocytosis of necrotic trophoblasts: a possible role in the pathogenesis of pre-eclampsia
    Qi Chen
    Department of Obstetrics and Gynaecology, University of Auckland, New Zealand
    J Pathol 221:87-95. 2010
    ..These interactions between the IL-6 and TGFbeta1 pathways in both the endothelium and placenta may help to regulate the maternal response to deported trophoblasts in pregnancy...
  12. ncbi request reprint Activated endothelial cells resist displacement by trophoblast in vitro
    Q Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, 85 Park Road, Grafton, Auckland 1001, New Zealand
    Placenta 28:743-7. 2007
    ..The aim of this study was to investigate further the hypothesis that spiral artery endothelial cells can contribute to the mechanism of shallow trophoblast invasion...
  13. ncbi request reprint Interaction of Jar choriocarcinoma cells with endothelial cell monolayers
    Q Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Placenta 26:617-25. 2005
    ..Our results suggest that endothelial cells may not simply be passive targets for invading trophoblasts during the remodeling of the spiral arteries...
  14. ncbi request reprint Phagocytosis of necrotic but not apoptotic trophoblasts induces endothelial cell activation
    Qi Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Hypertension 47:116-21. 2006
    ..This work suggests that endothelial cells can phagocytose deported trophoblasts and that the mechanism of trophoblast death (apoptotic or necrotic) could have major effects on the maternal vascular response to shed trophoblasts...
  15. doi request reprint Anti-phospholipid antibodies increase non-apoptotic trophoblast shedding: a contribution to the pathogenesis of pre-eclampsia in affected women?
    Q Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Placenta 30:767-73. 2009
    ..If reflected in vivo this might explain, at least in part, how anti-phospholipid antibodies contribute to the pathogenesis of pre-eclampsia...
  16. doi request reprint Vitamin C enhances phagocytosis of necrotic trophoblasts by endothelial cells and protects the phagocytosing endothelial cells from activation
    Q Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Placenta 30:163-8. 2009
    ..Thus treatment of endothelial cells with vitamin C appears to modify both the phagocytosis of necrotic trophoblasts and the response of the endothelial cells to the necrotic trophoblastic material...
  17. doi request reprint Pre-treatment with calcium prevents endothelial cell activation induced by multiple activators, necrotic trophoblastic debris or IL-6 or preeclamptic sera: possible relevance to the pathogenesis of preeclampsia
    Q Chen
    Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand The Hospital of Obstetrics and Gynaecology, Fudan University, China Wuxi Maternity and Child Health Hospital, Nanjing Medical University, China
    Placenta 34:1196-201. 2013
    ..In this study we investigate whether the addition of high levels of calcium to endothelial cells prior to their exposure to the preeclampsia-associated activators could reduce the endothelial cell activation...
  18. doi request reprint Trophoblast debris extruded from preeclamptic placentae activates endothelial cells: a mechanism by which the placenta communicates with the maternal endothelium
    F Shen
    The Hospital of Obstetrics and Gynaecology, Fudan University, China Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand
    Placenta 35:839-47. 2014
    ..In this study, we investigated whether trophoblast debris from preeclamptic placentae triggered endothelial cell activation...
  19. doi request reprint The anti-inflammatory effect of calcium for preventing endothelial cell activation in preeclampsia
    J Desousa
    Maternal Fetal Medicine, Auckland City Hospital, Auckland, New Zealand
    J Hum Hypertens 30:303-8. 2016
    ..These findings may suggest, at least in part, the protective mechanism of calcium supplementation on preeclampsia. ..
  20. doi request reprint Serum uric acid may not be involved in the development of preeclampsia
    Q Chen
    Department of Obstetrics, The Hospital of Obstetrics and Gynaecology, Fudan University, Fudan, China
    J Hum Hypertens 30:136-40. 2016
    ..Therefore, it is likely that uric acid is not involved in the development of preeclampsia and cannot be an early prediction biomarker of this disease. ..
  21. doi request reprint The reduction of circulating levels of IL-6 in pregnant women with preeclampsia by magnesium sulphate and nifedipine: In vitro evidence for potential mechanisms
    Q Chen
    Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand The Obstetrics and Gynaecology Hospital of Fudan University, China
    Placenta 36:661-6. 2015
    ..MgSO4 is a major therapy for the prevention of seizures in preeclampsia but it has been suggested to also have anti-inflammatory and vasodilatory properties...
  22. pmc Trophoblastic debris modifies endothelial cell transcriptome in vitro: a mechanism by which fetal cells might control maternal responses to pregnancy
    J Wei
    Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand
    Sci Rep 6:30632. 2016
    ..Our data suggest that the deportation of trophoblastic debris is an important part of the complex network of feto-maternal communication. ..
  23. doi request reprint IL-1 beta but not the NALP3 inflammasome is an important determinant of endothelial cell responses to necrotic/dangerous trophoblastic debris
    J Wei
    Department of Obstetrics and Gynaecology, University of Auckland, New Zealand Electronic address
    Placenta 36:1385-92. 2015
    ..In this study, we hypothesized that endothelial cells can identify and respond to necrotic trophoblastic debris via the NALP3 inflammasome...
  24. doi request reprint Review: where is the maternofetal interface?
    L W Chamley
    Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand Gravida the National Centre for Growth and Development, Auckland, New Zealand Electronic address
    Placenta 35:S74-80. 2014
    ..Trophoblast debris greatly expands the maternofetal interface and the nature of that debris is likely to strongly influence the responses of the maternal vascular and immune systems to the debris. ..
  25. doi request reprint Trophoblast deportation: just a waste disposal system or antigen sharing?
    L W Chamley
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Park Rd, Grafton, Auckland, New Zealand
    J Reprod Immunol 88:99-105. 2011
    ....
  26. doi request reprint International Conference on Reproductive Immunology, 29 August to 1 September 2008, Shanghai, People's Republic of China
    Larry W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    J Reprod Immunol 80:146-9. 2009
    ..This report describes some of the highlights of the meeting...
  27. ncbi request reprint The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase
    Andrew Grey
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Endocrinology 143:4755-63. 2002
    ..These data demonstrate that LPA and S1P potently promote osteoblast survival in vitro, and that cell-type specificity exists in the antiapoptotic signaling pathways activated by phospholipids...
  28. ncbi request reprint Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo
    Jillian Cornish
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland 1001, New Zealand
    Endocrinology 145:4366-74. 2004
    ..Lactoferrin is a potential therapeutic target in bone disorders such as osteoporosis and is possibly an important physiological regulator of bone growth...
  29. ncbi request reprint Parallel phosphatidylinositol-3 kinase and p42/44 mitogen-activated protein kinase signaling pathways subserve the mitogenic and antiapoptotic actions of insulin-like growth factor I in osteoblastic cells
    Andrew Grey
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Endocrinology 144:4886-93. 2003
    ..These data suggest that IGF-I signals osteoblast mitogenesis and survival through parallel, partly overlapping intracellular pathways involving PI-3 kinase, p42/44 MAPKs, and G beta gamma subunits...
  30. doi request reprint Reduction in the severity of early onset severe preeclampsia during gestation may be associated with changes in endothelial cell activation: A pathological case report
    Q Chen
    a Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand
    Hypertens Pregnancy 35:32-41. 2016
    ..The improvement in the clinical condition occurred along with the changes in endothelial cell activation. ..
  31. doi request reprint Transcriptomic analysis of placenta affected by antiphospholipid antibodies: following the TRAIL of trophoblast death
    P Pantham
    Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand
    J Reprod Immunol 94:151-4. 2012
    ..These results may help to understand how antiphospholipid antibodies affect trophoblast cell death and how the antibodies could contribute to the pathogenesis of preeclampsia...
  32. doi request reprint An analysis of expectant management in women with early-onset preeclampsia in China
    Q Chen
    The Hospital of Obstetrics and Gynaecology, Fudan University, Wuxi, China
    J Hum Hypertens 29:379-84. 2015
    ..However, the risk of stillbirth should still be taken into consideration when making the decision for immediate delivery or expectant management in the clinic...
  33. doi request reprint Development of a simple, cost-effective, semi-correlative light and electron microscopy method to allow the immunoelectron localisation of non-uniformly distributed placental proteins
    C A Viall
    Department of Obstetrics and Gynaecology, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand Electronic address
    Placenta 35:223-7. 2014
    ..This simple, cost-effective method is likely to find widespread application in placental research. ..
  34. doi request reprint The relationship between TGFβ, low oxygen and the outgrowth of extravillous trophoblasts from anchoring villi during the first trimester of pregnancy
    J Prossler
    Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland, New Zealand Electronic address
    Cytokine 68:9-15. 2014
    ..This work aimed to determine the role of TGFβ1, β2 and β3 in regulating EVT outgrowth in the low oxygen environment of early pregnancy...
  35. ncbi request reprint NF-kappaB-independent induction of endothelial cell apoptosis by the vascular disrupting agent DMXAA
    See Tarn Woon
    Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Anticancer Res 27:327-34. 2007
    ..DMXAA activates NF-kappaB in many different cell types. In this study, whether DMXAA-induced endothelial cell apoptosis was NF-kappaB dependent was determined...
  36. doi request reprint Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentation
    Sha Peng
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China
    Reproduction 135:367-75. 2008
    ..Taken together, Dkk1 secreted by decidual cells may induce trophoblast cell invasion in the mouse and beta-catenin may be involved in such functions of Dkk1...
  37. ncbi request reprint Caveolin-1 inhibits the growth of human laryngeal squamous cell carcinoma and down regulates EGFR-MAPKs signaling pathway
    Donghua Gu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China
    Laryngoscope 117:1782-9. 2007
    ..To investigate the effects of caveolin-1 on the growth of laryngeal squamous cell cancer HEp2 cell line in vitro and in vivo...
  38. ncbi request reprint [Effects of caveolin-1 on biologic behavior of laryngeal squamous cell carcinoma HEp2 cell line GU]
    Dong hua Gu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Zhonghua Zhong Liu Za Zhi 29:329-33. 2007
    ..To investigate the effects of caveolin-1 on the biologic behavior of laryngeal squamous cell carcinoma HEp2 cell line in vitro...
  39. ncbi request reprint Ultrasound/microbubble enhances foreign gene expression in ECV304 cells and murine myocardium
    Dong ping Guo
    Atherosclerosis Research Center, Nanjing Medical University, Nanjing 210029, China
    Acta Biochim Biophys Sin (Shanghai) 36:824-31. 2004
    ....
  40. ncbi request reprint Single nucleotide polymorphisms in the coding region of the apolipoprotein H (beta2-glycoprotein I) gene and their correlation with the protein polymorphism, anti-beta2glycoprotein I antibodies and cardiolipin binding: description of novel haplotypes and
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Hum Genet 68:285-99. 2004
    ..We also found that these haplotypes are associated with the occurrence of APA. Recombinant APOH haplotypes, expressed in COS-1 cells, showed that these mutations also affect the binding of APOH to anionic PL...
  41. ncbi request reprint Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
    Cynthia M Grimsley
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 279:6087-97. 2004
    ..This finding suggests that Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 rather than generalized Rac activation plays a role in cell migration...
  42. ncbi request reprint The effect of fibrinolytic enzyme FIIa from Agkistrodon acutus venom on disseminated intravascular coagulation in rabbits
    Xi Lin
    Department of Pharmacology, Zhongshan Medical College, Sun Yat Sen University, Guangzhou, China
    Transl Res 150:295-302. 2007
    ..We conclude that FII(a) may be useful in the treatment of DIC...
  43. doi request reprint 17beta-estradiol attenuates cardiac dysfunction and decreases NF-kappaB binding activity in mechanically stretched rat hearts
    Jing Li
    Department of Pathophysiology, Nanjing Medical University, Nanjing 210029, China
    Steroids 73:720-6. 2008
    ..The results suggest that pharmacological dose of 17beta-estradiol will attenuate stretching-induced cardiac dysfunction in an isolated heart model. The mechanisms could involve in blunting p38 MAPK and NF-kappaB signaling...
  44. doi request reprint The toxicity of beta-amyloid is attenuated by interaction with its specific human scFv E3 in vitro
    Shen Yue
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, People s Republic of China
    Life Sci 82:1249-55. 2008
    ..Moreover, the Abeta toxicity to SK-N-SH cells was attenuated by addition of E3 scFv. Our results indicate that site-directed human scFv might be a potential therapeutic agent for Alzheimer's disease...
  45. ncbi request reprint Up-regulation of CD147 and matrix metalloproteinase-2, -9 induced by P-glycoprotein substrates in multidrug resistant breast cancer cells
    Qing Quan Li
    Department of Pathology, Shanghai Medical College, Fudan University, No 138, Yixueyuan Road, Shanghai 200032, China
    Cancer Sci 98:1767-74. 2007
    ....
  46. ncbi request reprint Involvement of MAPK/ERK kinase-ERK pathway in exogenous bFGF-induced Egr-1 binding activity enhancement in anoxia-reoxygenation injured astrocytes
    Ying Liu
    Department of Pathology, Shanghai Medical College Fudan University, Shanghai, China
    Neurosci Bull 23:221-8. 2007
    ..This study was designed to investigate the molecular mechanism, especially the signal transduction pathways, involved in this protective role of bFGF...
  47. ncbi request reprint A functional polymorphism at the transcriptional initiation site in beta2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of beta2-glycoprotein I
    Haider Mehdi
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh 15261, USA
    Eur J Biochem 270:230-8. 2003
    ....
  48. ncbi request reprint Overexpression of cyclin L2 induces apoptosis and cell-cycle arrest in human lung cancer cells
    Hong Li Li
    Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
    Chin Med J (Engl) 120:905-9. 2007
    ..The present study aimed to investigate the anti-proliferative effect of cyclin L2, and to define its growth regulatory mechanisms using human lung adenocarcinoma cell line A549...
  49. ncbi request reprint Synthesis of sporiolide B from D-glucal
    Qi Chen
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China
    Carbohydr Res 342:1405-11. 2007
    ..Yamaguchi esterification and ring closing metathesis greatly improved the access to the target compound...
  50. doi request reprint Isolation of a type 3 vaccine-derived poliovirus (VDPV) from an Iranian child with X-linked agammaglobulinemia
    Shohreh Shahmahmoodi
    National Polio Laboratory, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
    Virus Res 137:168-72. 2008
    ..No secondary AFP cases were found, and none of the seven tested contacts of the patient were found to be infected with poliovirus...
  51. ncbi request reprint Involvement of CD147 in regulation of multidrug resistance to P-gp substrate drugs and in vitro invasion in breast cancer cells
    Qing Quan Li
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Cancer Sci 98:1064-9. 2007
    ..Thus, CD147 may assume a dual role, since it had intrinsic stimulative effects on tumor invasion in vitro as well as increasing resistance to P-gp substrate drugs...
  52. pmc CTCF-dependent chromatin boundary element between the latency-associated transcript and ICP0 promoters in the herpes simplex virus type 1 genome
    Qi Chen
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    J Virol 81:5192-201. 2007
    ....
  53. ncbi request reprint Inhibition of endothelial nitric oxide generation by low-density lipoprotein is partially prevented by L-arginine and L-ascorbate
    Yong Ji
    Atherosclerosis Research Centre, Nanjing Medical University, Nanjing 210029, PR China
    Atherosclerosis 176:345-53. 2004
    ....
  54. ncbi request reprint [Overexpression of HER2/neu downregulates wild p53 protein expression via PI3K and Ras/Raf/MEK/ERK pathways in human breast cancer cells]
    Li Zheng
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Zhonghua Bing Li Xue Za Zhi 33:358-62. 2004
    ..To evaluate the effect of HER2/neu overexpression on wild p53 protein expression and to delineate the related signal pathways...
  55. ncbi request reprint Inhibitory effects of praeruptorin C on cattle aortic smooth muscle cell proliferation
    En hui Wei
    Department of Cardiovascular Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Acta Pharmacol Sin 23:129-32. 2002
    ..To study the effects of praeruptorin C (pra-C) on proliferation of cattle aortic smooth muscle cells (SMC)...
  56. ncbi request reprint Genistein ameliorates beta-amyloid peptide (25-35)-induced hippocampal neuronal apoptosis
    Haiyan Zeng
    Center of Brain and Cognitive Science, Institute of Biophysics, Academia Sinica, Beijing, People s Republic of China
    Free Radic Biol Med 36:180-8. 2004
    ..Our data suggest that genistein attenuates neuronal apoptosis induced by Abeta25-35 via various mechanisms...
  57. pmc Rabbit aortic endothelial dysfunction by low-density lipoprotein is attenuated by L-arginine, L-ascorbate and pyridoxine
    Yong Ji
    Department of Physiology and Pharmacology, Nanjing Medical University, Nanjing, China
    Br J Pharmacol 140:1272-82. 2003
    ....
  58. ncbi request reprint Role of connective tissue growth factor in mediating hypertrophy of human proximal tubular cells induced by angiotensin II
    Bi Cheng Liu
    Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu Province, China
    Am J Nephrol 23:429-37. 2003
    ..The aim of our present work was to investigate the possible role of a newly clarified fibrogenic factor, connective tissue growth factor (CTGF), in mediating the effect of Ang II-induced tubular cell hypertrophy...
  59. ncbi request reprint [Study of adhesion-related molecule beta1-integrin and focal adhesion kinase in chronic myeloid leukemia]
    Xuan Chang
    Department of Hematology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 23:1047-9. 2003
    ....
  60. ncbi request reprint [Analysis of low density lipoprotein receptor function and gene mutation in familial hypercholesterolemic patients]
    Xiaoxiang Guan
    Atherosclerosis Research Center, Nanjing Medical University, Nanjing, Jiangsu, 210029 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:138-42. 2003
    ..To investigate low density lipoprotein receptor (LDLR) function and gene mutation in Chinese patients with familial hypercholesterolemia(FH)...
  61. ncbi request reprint Calyculin A-induced actin phosphorylation and depolymerization in renal epithelial cells
    Luo Gu
    Department of Life Sciences, Indiana State University, Terre Haute, IN 47809, USA
    Cell Motil Cytoskeleton 54:286-95. 2003
    ..Actin phosphorylation may play an important role in regulating the organization of the actin cytoskeleton in renal epithelium...
  62. ncbi request reprint [Inhibitory effects of ginkgolide B on proliferation of bovine aortic smooth muscle cells]
    En hui Wei
    Department of Cardiovascular Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Yao Xue Xue Bao 37:90-3. 2002
    ..To investigate the effects of ginkgolide B (GB) on proliferation of bovine aortic smooth muscle cells (SMC) and its related mechanisms...
  63. ncbi request reprint [Effect of RAR-beta transfection on the proliferation and phenotype of rat hepatic stellate cells]
    Hua Li
    Department of Pathology, Shanghai Medical College of Fudan University, Shanghai 200032, China
    Zhonghua Gan Zang Bing Za Zhi 10:297-300. 2002
    ..To study the effect of RAR-beta transfection plus treatment with the corresponding ligand ATRA on the proliferation and phenotype of platelet-derived growth factor (PDGF)-activated hepatic stellate cells (HSC)...
  64. ncbi request reprint [Modification and application of anterior skull base microsurgery with navigation system]
    Zhengmin Wang
    Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University Shanghai 200031, China
    Zhonghua Yi Xue Za Zhi 82:879-82. 2002
    ..To investigate the accuracy and safety of the modified techniques in anterior skull base microsurgery with navigation system...
  65. ncbi request reprint Effect of retinoid kappa receptor alpha (RXRalpha) transfection on the proliferation and phenotype of rat hepatic stellate cells in vitro
    Hua Li
    Department of Pathology, Medical School, Fudan University, Shanghai 200032, China
    Chin Med J (Engl) 115:928-32. 2002
    ....
  66. ncbi request reprint Apoptosis of human highly metastatic lung cancer cell line 95-D induced by acutiaporberine, a novel bisalkaloid derived from Thalictrum acutifolium
    Qi Chen
    Planta Med 68:550-3. 2002
    ..These results suggest that acutiaporberine may be a natural potential apoptosis-inducing agent for highly metastatic lung cancer...
  67. ncbi request reprint Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons
    Lixia Zhao
    Department of Molecular Pharmacology and Toxicology and Neuroscience Program, Pharmaceutical Sciences Center, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Exp Biol Med (Maywood) 227:509-19. 2002
    ....
  68. ncbi request reprint [Role of connective tissue growth factor in angiotensin II induced human proximal tubular cell hypertrophy]
    Bi Cheng Liu
    Institute of Nephrology, Southeast University School of Clinical Medicine, Nanjing 210009, China
    Zhonghua Yi Xue Za Zhi 84:1470-4. 2004
    ..The present study was to investigate the role of connective tissue growth factor (CTGF) in mediating the effect of angiotensin (AngII) induced human proximal tubular cell (HK-2) hypertrophy...
  69. ncbi request reprint Ectopic overexpression of tomato JERF3 in tobacco activates downstream gene expression and enhances salt tolerance
    Hui Wang
    The National Plant Gene Research Center Beijing, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 10081, China
    Plant Mol Biol 55:183-92. 2004
    ..These results indicate that JERF3 functions as a linker in ethylene- and osmotic stress-signaling pathways...
  70. ncbi request reprint Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis
    Qi Chen
    Department of Biochemistry and Center for Biopharmaceutical Research, School of Life Sciences, Sun Yat Sen University, Guangzhou, Peoples Republic of China
    Int J Cancer 114:675-82. 2005
    ..Further studies on the effects of harmine derivatives on key regulators for tumor cell apoptosis are needed...
  71. ncbi request reprint Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model
    Qiang Liu
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Academia Sinica, Beijing, China
    FASEB J 21:61-73. 2007
    ..The dissected signaling pathway of nicotine-mediated neuroprotection in the present study provides a mechanistic basis for the potential development of drug targets for treating AD...
  72. ncbi request reprint Effects of beta-adrenoceptors overexpression on cell survival are mediated by Bax/Bcl-2 pathway in rat cardiac myocytes
    Hong Sun
    Atherosclerosis Research Center, Nanjing Medical University, Nanjing, 210029 Jiangsu, PR China
    Pharmacology 78:98-104. 2006
    ..Chronic activation of beta-adrenoceptors (beta-ARs) results in cardiac myocyte injury, even death, and diminishes the number of beta-ARs...
  73. ncbi request reprint [Overexpression of NDRG1: relationship with proliferative activity and invasiveness of breast cancer cell line and breast cancer metastasis]
    Zhen Wang
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Zhonghua Bing Li Xue Za Zhi 35:333-8. 2006
    ..To investigate the relationship between NDRG1 and metastasis of breast cancer and the effects of NDRG1 overexpression on the proliferation and invasion of breast cancer cells...
  74. ncbi request reprint Expression changes of ERK1/2, STAT3 and SHP-2 in bone marrow cells from gamma-ray induced leukemia mice
    Zhichao Fu
    Department of Radiotherapy, General Hospital of Fuzhou Military Command, China
    J Radiat Res 47:121-30. 2006
    ....
  75. ncbi request reprint [Expressions of homing-related adhesion molecules in hematopoietic stem/progenitor cells derived from human placenta, umbilical cord arterial and venous blood]
    Rui Su
    Department of Hemotology, Affiliated Hospital of Zunyi Medical College, Key Laboratory of Cell Engineering of Guizhou Province, Zunyi 563003, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:582-6. 2006
    ..Moreover, the expression levels of most HRAM in CD34(+) cells from PT are higher than those from UCAB and UCVB or are close to them. It suggested that HSPCs derived from PT might have stronger homing capabilities than those from UCB...
  76. ncbi request reprint Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus
    Laura M Tripi
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Arthritis Rheum 54:1928-39. 2006
    ..This study was undertaken to examine the relationship of PON1 activity and genotype to risk of systemic lupus erythematosus (SLE)...
  77. ncbi request reprint Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis
    Jie Zhang
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Academia Sinica, 15 Datun Rd, Chaoyang District, Beijing 100101, Peoples Republic of China
    FASEB J 20:1212-4. 2006
    ..These data suggest that the effect of nicotine on reducing beta-amyloidosis is partly mediated by regulating metal homeostasis...
  78. ncbi request reprint Ultrasound-targeted microbubble destruction improves the low density lipoprotein receptor gene expression in HepG2 cells
    Dong ping Guo
    Institute of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China
    Biochem Biophys Res Commun 343:470-4. 2006
    ..With further refinement, it may represent an effective nonviral avenue of gene therapy for liver-involved genetic diseases...
  79. pmc A unique role of the DNA fragmentation factor in maintaining genomic stability
    Bin Yan
    Departments of Radiation Oncology and Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:1504-9. 2006
    ....
  80. ncbi request reprint Pyridoxine prevents dysfunction of endothelial cell nitric oxide production in response to low-density lipoprotein
    Yong Ji
    Institute of Reproductive Medicine, Atherosclerosis Research Centre, Nanjing Medical University, Nanjing 210029, China
    Atherosclerosis 188:84-94. 2006
    ..This has important potential therapeutic implications for cardiovascular disease prevention...
  81. ncbi request reprint Synthesis of a C3-symmetric (1-->6)-N-acetyl-beta-D-glucosamine octadecasaccharide using click chemistry
    Qi Chen
    The State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Carbohydr Res 340:2476-82. 2005
    ..The target octadecasaccharide showed good antitumor activity against H22 in the preliminary mice tests...
  82. pmc Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues
    Qi Chen
    Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13604-9. 2005
    ..These findings give plausibility to i.v. ascorbic acid in cancer treatment, and have unexpected implications for treatment of infections where H(2)O(2) may be beneficial...
  83. pmc Cytoprotection by glycine against ATP-depletion-induced injury is mediated by glycine receptor in renal cells
    Chao Pan
    Atherosclerosis Research Centre, Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, People s Republic of China
    Biochem J 390:447-53. 2005
    ..Our results suggested that the cytoprotection of glycine against ATP-depletion-induced injury might be mediated by GlyR...
  84. ncbi request reprint A family-based association study of schizophrenia with polymorphisms at three candidate genes
    Shiwei Duan
    Bio X Life Science Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China
    Neurosci Lett 379:32-6. 2005
    ..However, we found significant evidence of preferential transmission of the -432C allele of the PIK3C3 gene in the entire trios (Z=2.91, d.f.=1, P=0.0036) and the male probands trios (Z=2.66, d.f.=1, P=0.0079)...
  85. ncbi request reprint Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth
    Qi Chen
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 25:281-90. 2005
    ..MOCA accumulates during neuronal differentiation, and its expression enhances NGF-induced neurite outgrowth and morphological complexity. We conclude that MOCA regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth...
  86. ncbi request reprint [The effect of HER2/neu overexpression on p53 gene expression, cell proliferation and sensitivity to gamma-irradiation via the PI3K/Akt pathway in breast cancer cell MCF7]
    Li Zheng
    Department of Pathology, Shanghai Medical School, Fudan University, Shanghai 200032, China
    Zhonghua Zhong Liu Za Zhi 26:594-7. 2004
    ..To investigate the effect of HER2/neu overexpression on the wild p53 gene expression, cell proliferation and sensitivity to gamma-irradiation via phosphatidylinositol 3-kinase (PI3K) pathway in human breast cancer cell MCF7...
  87. pmc A novel mechanism for the regulation of amyloid precursor protein metabolism
    Qi Chen
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Cell Biol 158:79-89. 2002
    ..This is a new mechanism by which the expression of APP is regulated...