W Chen

Summary

Affiliation: Private Bag
Country: New Zealand

Publications

  1. ncbi request reprint Helicobacter pylori infection: mechanism of colonization and functional dyspepsia Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10
    W Chen
    The Wakefield Gastroenterology Research Laboratory, Wakefield Hospital, Newtown, Wellington, New Zealand
    J Gastroenterol Hepatol 16:377-83. 2001
  2. ncbi request reprint Increased serum levels of eotaxin in patients with inflammatory bowel disease
    W Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Wellington South, New Zealand
    Scand J Gastroenterol 36:515-20. 2001
  3. ncbi request reprint Detection of Listeria monocytogenes by polymerase chain reaction in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
    W Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Newtown, Wellington, New Zealand
    J Gastroenterol Hepatol 15:1145-50. 2000
  4. ncbi request reprint Inhibition of mitogen-induced murine lymphocyte proliferation by Helicobacter pylori cell-free extract
    W Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Wellington, New Zealand
    J Gastroenterol Hepatol 15:1000-6. 2000
  5. ncbi request reprint Dendritic cell-based cancer immunotherapy: potential for treatment of colorectal cancer?
    W Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Wellington, New Zealand
    J Gastroenterol Hepatol 15:698-705. 2000
  6. ncbi request reprint Rapid elimination of Helicobacter pylori and reduction of histocompatibility leucocyte antigen-DR expression 12 h after a single dose of omeprazole, amoxycillin and metronidazole triple therapy
    W Chen
    Wakefield Gastroenterology Centre, Wakefield Hospital, Wellington, New Zealand
    J Gastroenterol Hepatol 14:322-7. 1999
  7. ncbi request reprint High prevalence of Mycoplasma pneumoniae in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
    W Chen
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Newtown, New Zealand
    Dig Dis Sci 46:2529-35. 2001
  8. ncbi request reprint Common presence of Helicobacter DNA in the gallbladder of patients with gallstone diseases and controls
    W Chen
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, New Zealand
    Dig Liver Dis 35:237-43. 2003
  9. ncbi request reprint Development of a dendritic cell (DC)-based vaccine for patients with advanced colorectal cancer
    N Rains
    Wakefield Gastroenterology Centre and Research Institute, Wellington, New Zealand
    Hepatogastroenterology 48:347-51. 2001
  10. ncbi request reprint Serum proinflammatory cytokine response in patients with advanced liver tumors following selective internal radiation therapy (SIRT) with (90)Yttrium microspheres
    J K Wickremesekera
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, Newtown, New Zealand
    Int J Radiat Oncol Biol Phys 49:1015-21. 2001

Collaborators

  • R S Stubbs
  • D Li
  • I Wilson
  • D Young
  • Yin Liang
  • J W Conlan
  • Shimon Efrat
  • D Shu
  • M Li
  • Ping I Hsu
  • Malcolm J Low
  • ALAN RICHARD TALL
  • Yun Jiang
  • R KuoLee
  • K C Yu
  • X Zhao
  • G Harris
  • A Wu
  • Y Jia
  • K N Couper
  • L Rossetti
  • N Rains
  • N S Ningaraj
  • S A Prasad
  • A R Leventhal
  • J K Wickremesekera
  • R J Cannan
  • X Chai
  • M Fan
  • A D Cooper
  • H Zhou
  • G B Patel
  • T S Tsao
  • H Qiu
  • Y P Li
  • T Arai
  • S Oh
  • Z L Demorest
  • I Vengco
  • J Austin
  • K Ericson
  • J R Ohlfest
  • W C Low
  • S Gharagozlou
  • H Li
  • M Lv
  • H Hu
  • P Feng
  • L Zhang
  • L L Johnson
  • W Harnett
  • K M Houston
  • J W Yewdell
  • J R Bennink
  • J L Napoli
  • J V Schloss
  • I Tabas
  • J Y Wu
  • C C Norbury
  • M D Faiman
  • Z Bian
  • V Fairchild-Huntress
  • A E Stenbit
  • F Rinninger
  • S M Factor
  • E Li
  • P Stashenko
  • D Huszar
  • T Seo
  • C P Liang
  • L Varban
  • R Deckelbaum
  • M J Charron
  • M Hawkins
  • N Barzilai
  • M Hu

Detail Information

Publications34

  1. ncbi request reprint Helicobacter pylori infection: mechanism of colonization and functional dyspepsia Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10
    W Chen
    The Wakefield Gastroenterology Research Laboratory, Wakefield Hospital, Newtown, Wellington, New Zealand
    J Gastroenterol Hepatol 16:377-83. 2001
    ..The objective of this study was to determine the role of endogenous IL-10 in the host defense against gastric colonization by Helicobacter pylori by using IL-10-deficient mice...
  2. ncbi request reprint Increased serum levels of eotaxin in patients with inflammatory bowel disease
    W Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Wellington South, New Zealand
    Scand J Gastroenterol 36:515-20. 2001
    ..In this study we investigated the serum concentrations of eotaxin and eotaxin-2 in patients with Crohn disease and ulcerative colitis...
  3. ncbi request reprint Detection of Listeria monocytogenes by polymerase chain reaction in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
    W Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Newtown, Wellington, New Zealand
    J Gastroenterol Hepatol 15:1145-50. 2000
    ..The objective of the present study was to investigate the prevalence of L. monocytogenes DNA in intestinal biopsies from patients with IBD and from non-IBD controls by using nested polymerase chain reaction (PCR)...
  4. ncbi request reprint Inhibition of mitogen-induced murine lymphocyte proliferation by Helicobacter pylori cell-free extract
    W Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Wellington, New Zealand
    J Gastroenterol Hepatol 15:1000-6. 2000
    ..pylori cell-free extract (HPCE) has similar effects on murine lymphoid cells and could, therefore, be used to further delineate the mechanisms of alteration of lymphocyte function by H. pylori...
  5. ncbi request reprint Dendritic cell-based cancer immunotherapy: potential for treatment of colorectal cancer?
    W Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Wellington, New Zealand
    J Gastroenterol Hepatol 15:698-705. 2000
    ..There is reason to believe that DC-based vaccination could become an adjunct to current treatments for human cancers including colorectal cancer in the foreseeable future...
  6. ncbi request reprint Rapid elimination of Helicobacter pylori and reduction of histocompatibility leucocyte antigen-DR expression 12 h after a single dose of omeprazole, amoxycillin and metronidazole triple therapy
    W Chen
    Wakefield Gastroenterology Centre, Wakefield Hospital, Wellington, New Zealand
    J Gastroenterol Hepatol 14:322-7. 1999
    ..pylori, and the severity of gastric mucosal inflammation in the gastric biopsy specimens of patients before (0 h group, n = 14) and 12 h (12 h group, n = 14) after initiating anti-H. pylori treatment...
  7. ncbi request reprint High prevalence of Mycoplasma pneumoniae in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
    W Chen
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Newtown, New Zealand
    Dig Dis Sci 46:2529-35. 2001
    ..Epidemiological studies in IBD suggest acquisition of some agents early in life probably during epidemics in temperate latitudes. M. pneumoniae could be one of the ubiquitous agents implicated in the pathogenesis of IBD...
  8. ncbi request reprint Common presence of Helicobacter DNA in the gallbladder of patients with gallstone diseases and controls
    W Chen
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, New Zealand
    Dig Liver Dis 35:237-43. 2003
    ..Several species of Helicobacter colonise the biliary tract of animals and cause hepatobiliary diseases. Helicobacter species have also been identified in the gallbladder of a high proportion of Chilean patients with gallbladder cancer...
  9. ncbi request reprint Development of a dendritic cell (DC)-based vaccine for patients with advanced colorectal cancer
    N Rains
    Wakefield Gastroenterology Centre and Research Institute, Wellington, New Zealand
    Hepatogastroenterology 48:347-51. 2001
    ..The positive keyhole limpet hemocyanin skin test confirms in vivo function by effective vaccination to keyhole limpet hemocyanin. Demonstration of any anticancer efficacy will require further follow-up...
  10. ncbi request reprint Serum proinflammatory cytokine response in patients with advanced liver tumors following selective internal radiation therapy (SIRT) with (90)Yttrium microspheres
    J K Wickremesekera
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, Newtown, New Zealand
    Int J Radiat Oncol Biol Phys 49:1015-21. 2001
    ....
  11. ncbi request reprint Structure, promoter and chromosomal localization of rdh6
    X Chai
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Gene 274:27-33. 2001
    ..The approximately 2000 kb sequenced of the 5'-flanking region contains multiple potential transcription factor binding sites, including sites for AP-1, C/EBP beta, GATA, c-Rel, ER, ROR alpha, SREBP, and CREB...
  12. pmc Human papillomavirus causes an angiogenic switch in keratinocytes which is sufficient to alter endothelial cell behavior
    W Chen
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
    Virology 367:168-74. 2007
    ..These novel data support the hypothesis that HPV proteins contribute not only to the uncontrolled keratinocyte growth seen following HPV infection but also to the angiogenic response needed for tumor formation...
  13. ncbi request reprint [Effects of immune bovine whey on sucrose-dependent adherence of Streptococcus mutans]
    M Fan
    College of Stomatology, Hubei Medical University
    Hua Xi Kou Qiang Yi Xue Za Zhi 19:71-3. 2001
    ..CONCLUSION: The immune whey has inhibitory potential against the sucrose-dependent adherence of S. mutans...
  14. pmc Mouse model of oral infection with virulent type A Francisella tularensis
    R KuoLee
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada
    Infect Immun 75:1651-60. 2007
    ..tularensis is an effective oral pathogen that can cause fatal systemic infection and could pose a public health concern, particularly to immunocompromised individuals, if ingested in contaminated water and food...
  15. ncbi request reprint Infusion of in vitro-generated DN T regulatory cells induces permanent cardiac allograft survival in mice
    W Chen
    Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, Toronto, Canada
    Transplant Proc 35:2479-80. 2003
    ..They also suggest that DN Tr cells may provide a novel therapy for the treatment of allograft rejection...
  16. ncbi request reprint Single-nucleotide polymorphisms in the COL1A1 regulatory regions are associated with otosclerosis
    W Chen
    Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, The University of Iowa, Iowa City, Iowa 52242, USA
    Clin Genet 71:406-14. 2007
    ..Consistent with this hypothesis, mouse mutants homozygous for a Col1a2 frameshift mutation on a C57BL/6J background that deposit only homotrimeric type I collagen have hearing loss...
  17. ncbi request reprint ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology
    K N Couper
    Trudeau Institute Inc, Saranac Lake, New York 12983, USA
    Parasite Immunol 27:147-50. 2005
    ..The nematode product was shown to elevate mitogen and T. gondii-specific IL-10 production but was unable to inhibit Th1 responses. Consequently ES-62 could not prevent Th1 generated immunopathology...
  18. ncbi request reprint Transposon-based interferon gamma gene transfer overcomes limitations of episomal plasmid for immunogene therapy of glioblastoma
    A Wu
    Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cancer Gene Ther 14:550-60. 2007
    ..SB appears to improve the efficacy of cytokine gene therapy using nonviral vectors by enhancing the duration of transgene expression...
  19. ncbi request reprint Prevention of murine experimental autoimmune encephalomyelitis by in vivo expression of a novel recombinant immunotoxin DT390-RANTES
    Y Jia
    West China School of Preclinical and Forensic Medicine, Sichuan University, Sichuan, People s Republic of China
    Gene Ther 13:1351-9. 2006
    ..This study indicates that recombinant immunotoxin can be expressed in vivo, and targeting CCR5 can attenuate the disease activity of EAE in mice...
  20. ncbi request reprint Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux
    A R Leventhal
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 276:44976-83. 2001
    ..This model may explain the low plasma high density lipoprotein found in ASM-deficient humans and may implicate L-SMase deficiency and/or sphingomyelin enrichment of lipoproteins as novel atherosclerosis risk factors...
  21. pmc Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens
    W Chen
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 193:1319-26. 2001
    ..These findings indicate that in addition to their effects on the presentation of foreign antigens, immunoproteasomes influence T(CD8+) responses by modifying the repertoire of responding T(CD8+)...
  22. pmc LDL receptor-related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in LDLR-deficient mice
    K C Yu
    Department of Medicine, Division of Gastroenterology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 107:1387-94. 2001
    ....
  23. ncbi request reprint Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides
    W Chen
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Cell 91:789-98. 1997
    ..These data show a requirement for the MC5-R in multiple exocrine glands for the production of numerous products, indicative of a coordinated system for regulation of exocrine gland function by melanocortin peptides...
  24. pmc Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells
    W Chen
    Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 188:1849-57. 1998
    ..CTLA-4, through TGF-beta, may serve as a counterbalance for CD28 costimulation of IL-2 and CD4(+) T cell activation...
  25. ncbi request reprint Prevention of insulin resistance and diabetes in mice heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle
    T S Tsao
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 48:775-82. 1999
    ..Based on these results, we propose that the onset of a diabetic phenotype in GLUT4+/- mice can be avoided by preventing decreases in muscle GLUT4 expression and glucose uptake...
  26. pmc Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice
    T Arai
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 96:12050-5. 1999
    ..The results suggest that apoE plays a major role in the selective clearance of HDL CE by the liver and adrenal gland, possibly by facilitating the presentation of HDL to SR-BI at the cell surface...
  27. ncbi request reprint Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification
    Y P Li
    Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
    Nat Genet 23:447-51. 1999
    ..Atp6i-/- mice exhibit a normal acid-base balance in blood and urine. Our results demonstrate that Atp6i is unique and necessary for osteoclast-mediated extracellular acidification...
  28. ncbi request reprint Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E
    K C Yu
    Research Institute, Palo Alto Medical Foundation, Palo Alto, CA 94301, USA
    J Lipid Res 41:1715-27. 2000
    ....
  29. ncbi request reprint Eradication of Helicobacter pylori prevents ulcer development in patients with ulcer-like functional dyspepsia
    P I Hsu
    Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Taiwan, Republic of China
    Aliment Pharmacol Ther 15:195-201. 2001
    ..pylori can prevent the subsequent development of peptic ulcers in the patients with 'ulcer-like' functional dyspepsia. However, this approach does not significantly reduce the symptoms of functional dyspepsia patients...
  30. ncbi request reprint S-methyl-N,N-diethylthiocarbamate sulfoxide elicits neuroprotective effect against N-methyl-D-aspartate receptor-mediated neurotoxicity
    N S Ningaraj
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045-2106, USA
    J Biomed Sci 8:104-13. 2001
    ..These data demonstrate that DETC-MeSO produces the neuroprotective effect through antagonism of NMDA receptors in vivo...
  31. ncbi request reprint Cutting edge: recombinant adenoviruses induce CD8 T cell responses to an inserted protein whose expression is limited to nonimmune cells
    S A Prasad
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:4809-12. 2001
    ..While this bodes well for recombinant adenoviruses as vaccines, it dims their prospects as gene therapy vectors...
  32. ncbi request reprint Enhancement of antigen-presenting ability of B lymphoma cells by immunostimulatory CpG-oligonucleotides and anti-CD40 antibody
    W Chen
    Institute of Immunology, Zhejiang University, Hangzhou 310031, Zhejiang, People's Republic of China
    Immunol Lett 77:17-23. 2001
    ..Our data expanded the potential application of CpG-ODN as an immunotherapeutic agent in cancer treatment...
  33. ncbi request reprint Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele
    L Rossetti
    Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 273:E743-50. 1997
    ....
  34. doi request reprint Inhibition of airway eosinophilia and pulmonary pathology in a mouse model of allergic asthma by the live vaccine strain of Francisella tularensis
    R KuoLee
    Institute for Biological Sciences, National Research Council Canada, Ottawa, ON, Canada
    Clin Exp Allergy 38:1003-15. 2008
    ....