Malaghan Institute of Medical Research

Summary

Organization: Malaghan Institute of Medical Research
Country: New Zealand

Top Publications

  1. ncbi Th2-dependent airway eosinophilia is regulated by preproenkephalin
    S Hook
    Malaghan Institute of Medical Research, Wellington School of Medicine, P O Box 7060, Wellington, New Zealand
    J Neuroimmunol 107:59-65. 2000
  2. ncbi Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction
    Michael V Berridge
    Malaghan Institute of Medical Research, PO Box 7060, Wellington, New Zealand
    Biotechnol Annu Rev 11:127-52. 2005
  3. pmc Recombinant Escherichia coli produces tailor-made biopolyester granules for applications in fluorescence activated cell sorting: functional display of the mouse interleukin-2 and myelin oligodendrocyte glycoprotein
    B Thomas Bäckström
    Malaghan Institute of Medical Research, Wellington, New Zealand
    BMC Biotechnol 7:3. 2007
  4. ncbi Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines
    Patries M Herst
    Malaghan Institute of Medical Research, P O Box 7060, Wellington, New Zealand
    Biochim Biophys Acta 1767:170-7. 2007
  5. ncbi Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60rho0 cells
    Patries M Herst
    Malaghan Institute of Medical Research, P O Box 7060, Wellington, New Zealand
    Leuk Res 32:327-33. 2008
  6. pmc What is the clinical and ethical importance of incidental abnormalities found by knee MRI?
    Rebecca Grainger
    Department of Medicine, Wellington School of Medicine, University of Otago, 23A Mein St, Newtown, Wellington South 6021, New Zealand
    Arthritis Res Ther 10:R18. 2008
  7. doi Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits
    Patries M Herst
    Malaghan Institute of Medical Research, Wellington, New Zealand
    FEMS Yeast Res 8:897-905. 2008
  8. doi Targeting mitochondrial permeability in cancer drug development
    Michael V Berridge
    Malaghan Institute of Medical Research, New Zealand
    Mol Nutr Food Res 53:76-86. 2009
  9. pmc The anti-cancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells
    Patries M Herst
    Malaghan Institute of Medical Research, Wellington 6005, New Zealand
    Haematologica 94:928-34. 2009
  10. doi Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand
    Troels R Petersen
    Malaghan Institute of Medical Research, Wellington, New Zealand
    Immunol Cell Biol 88:596-604. 2010

Detail Information

Publications24

  1. ncbi Th2-dependent airway eosinophilia is regulated by preproenkephalin
    S Hook
    Malaghan Institute of Medical Research, Wellington School of Medicine, P O Box 7060, Wellington, New Zealand
    J Neuroimmunol 107:59-65. 2000
    ..We conclude from this work that PPNK has a role in enhancing Th2 cell function and that this molecule may be an important target in asthma immunotherapy...
  2. ncbi Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction
    Michael V Berridge
    Malaghan Institute of Medical Research, PO Box 7060, Wellington, New Zealand
    Biotechnol Annu Rev 11:127-52. 2005
    ..The implications of these new findings are discussed in terms of the use of tetrazolium dyes as indicators of cell metabolism and their applications in cell biology...
  3. pmc Recombinant Escherichia coli produces tailor-made biopolyester granules for applications in fluorescence activated cell sorting: functional display of the mouse interleukin-2 and myelin oligodendrocyte glycoprotein
    B Thomas Bäckström
    Malaghan Institute of Medical Research, Wellington, New Zealand
    BMC Biotechnol 7:3. 2007
    ..As an alternative, we genetically engineered Escherichia coli to produce biopolyester (polyhdroxyalkanoate=PHA) granules displaying diagnostically relevant antigens in their native conformation and suitable for FACS analysis...
  4. ncbi Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines
    Patries M Herst
    Malaghan Institute of Medical Research, P O Box 7060, Wellington, New Zealand
    Biochim Biophys Acta 1767:170-7. 2007
    ..In summary, cell surface oxygen consumption contributes significantly to total cellular oxygen consumption, not only in rho(0) cells but also in mitochondrially competent tumour cell lines with glycolytic metabolism...
  5. ncbi Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60rho0 cells
    Patries M Herst
    Malaghan Institute of Medical Research, P O Box 7060, Wellington, New Zealand
    Leuk Res 32:327-33. 2008
    ..HL60rho0 cells were also significantly more resistant to apoptosis after combined ATO+ATRA treatment compared with HL60 cells, and this was associated with failure to upregulate Fas expression...
  6. pmc What is the clinical and ethical importance of incidental abnormalities found by knee MRI?
    Rebecca Grainger
    Department of Medicine, Wellington School of Medicine, University of Otago, 23A Mein St, Newtown, Wellington South 6021, New Zealand
    Arthritis Res Ther 10:R18. 2008
    ..The prevalence of incidental, potentially clinically significant abnormalities identified by MRI and their clinical significance in a population undergoing knee MRI in research studies are unknown...
  7. doi Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits
    Patries M Herst
    Malaghan Institute of Medical Research, Wellington, New Zealand
    FEMS Yeast Res 8:897-905. 2008
    ..In support of this, mitochondrial tubular networks in S. cerevisiae were shown to be located in close proximity to the plasma membrane using confocal microscopy...
  8. doi Targeting mitochondrial permeability in cancer drug development
    Michael V Berridge
    Malaghan Institute of Medical Research, New Zealand
    Mol Nutr Food Res 53:76-86. 2009
    ..Several compounds that interact directly with components of these pore complexes and have been shown to exhibit anticancer activity are discussed while other compounds appear to act indirectly through stress-related pathways...
  9. pmc The anti-cancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells
    Patries M Herst
    Malaghan Institute of Medical Research, Wellington 6005, New Zealand
    Haematologica 94:928-34. 2009
    ....
  10. doi Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand
    Troels R Petersen
    Malaghan Institute of Medical Research, Wellington, New Zealand
    Immunol Cell Biol 88:596-604. 2010
    ..Inactivating regulatory T cells and eliciting iNKT cell activation are therefore two useful strategies that can be used in combination to improve anti-tumor immunization with antigen-loaded DCs...
  11. doi Effects of mitochondrial gene deletion on tumorigenicity of metastatic melanoma: reassessing the Warburg effect
    Michael V Berridge
    Malaghan Institute of Medical Research, Wellington, New Zealand
    Rejuvenation Res 13:139-41. 2010
    ..The results suggest that mitochondrial reactive oxygen species (ROS) may be required for tumor metastasis...
  12. ncbi Passive donor-to-recipient transfer of antiphospholipid syndrome following allogeneic stem-cell transplantation
    D S Ritchie
    Malaghan Institute of Medical Research, Wellington, New Zealand
    Am J Hematol 79:299-302. 2005
    ....
  13. ncbi Autoimmune gastritis is a well-defined autoimmune disease model for the study of CD4+CD25+ T cell-mediated suppression
    R S McHugh
    Malaghan Institute of Medical Research, 6001 Wellington, New Zealand
    Curr Top Microbiol Immunol 293:153-77. 2005
    ..Evidence from this model indicates that immune responses must be initiated and then CD4+CD25+ T cells are recruited to control the quality of the immune response...
  14. ncbi Development of an asthma vaccine: research into BCG
    C B Scanga
    Malaghan Institute of Medical Research, Wellington South, New Zealand
    Drugs 59:1217-21. 2000
    ..The effectiveness of BCG in inhibiting atopic airway eosinophilia suggests its potential as a useful therapeutic agent in the treatment of atopic asthma...
  15. ncbi High-capacity redox control at the plasma membrane of mammalian cells: trans-membrane, cell surface, and serum NADH-oxidases
    M V Berridge
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Antioxid Redox Signal 2:231-42. 2000
    ..The glycolytic metabolism of cancer cells may be linked to changes in trans-plasma membrane NADH:WST-1-oxidoreductase activity and to increased serum NADH-oxidase in cancer...
  16. ncbi Cell-surface NAD(P)H-oxidase: relationship to trans-plasma membrane NADH-oxidoreductase and a potential source of circulating NADH-oxidase
    M V Berridge
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Antioxid Redox Signal 2:277-88. 2000
    ..These results do not support the view the surface NAD(P)H-oxidase is a terminal oxidase for trans-plasma membrane NADH-oxidoreductase...
  17. pmc Differential T cell function and fate in lymph node and nonlymphoid tissues
    Nicola L Harris
    Malaghan Institute of Medical Research, Wellington School of Medicine, 6002 Wellington, New Zealand
    J Exp Med 195:317-26. 2002
    ..These distinct regulatory events in lymph node and nonlymphoid tissues reveal simple key mechanisms for both inducing and limiting T cell immunity...
  18. ncbi The role of the cytokine milieu in protecting us from allergy
    Benjamin J Marsland
    Malaghan Institute of Medical Research, Wellington
    N Z Med J 115:76-7. 2002
  19. ncbi Tumour antigens on tap
    Franca Ronchese
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand
    Lancet 360:268. 2002
  20. ncbi Aplastic anemia as a late complication of thymoma in remission
    David S Ritchie
    Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital, Melbourne, Australia
    Eur J Haematol 68:389-91. 2002
    ..This observation suggests that auto-reactive T cells may be produced by the thymoma but not induce clinical auto-immune disease until a later time, even after eradication of thymoma has been achieved...
  21. ncbi Graft-versus-host disease, donor chimerism, and organ toxicity in stem cell transplantation after conditioning with fludarabine and melphalan
    David S Ritchie
    Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital, Melbourne, Australia
    Biol Blood Marrow Transplant 9:435-42. 2003
    ..Overall, the combination of fludarabine and melphalan is intensely immunosuppressive, leads to rapid T-cell engraftment and results in substantial toxicity and GVHD, particularly in heavily pretreated patients...
  22. ncbi DNA vaccination: the answer to stable, protective T-cell memory?
    Joanna R Kirman
    Malaghan Institute of Medical Research, PO Box 7060, Wellington South, New Zealand
    Curr Opin Immunol 15:471-6. 2003
    ..Utilising this knowledge could contribute to the refinement of DNA vaccine technology to induce more robust and longer-lasting protective T-cell based immunity...
  23. ncbi B-Lymphocytes activated by CD40 ligand induce an antigen-specific anti-tumour immune response by direct and indirect activation of CD8(+) T-cells
    D S Ritchie
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New Zealand
    Scand J Immunol 60:543-51. 2004
    ..Immunization with CD40L-activated B-cells may, therefore, represent a means by which to stimulate anti-tumour CD8(+) T-cell responses in vivo...
  24. doi Metabolic flexibility and cell hierarchy in metastatic cancer
    Michael V Berridge
    Malaghan Institute of Medical Research, PO Box 7060, Wellington 6242, New Zealand
    Mitochondrion 10:584-8. 2010
    ....