C J Charles

Summary

Affiliation: Christchurch School of Medicine and Health Sciences
Country: New Zealand

Publications

  1. doi request reprint Adrenomedullin in heart failure: potential therapeutic implications
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Future Cardiol 1:235-43. 2005
  2. ncbi request reprint Natriuretic peptides maintain sodium homoeostasis during chronic volume loading post-myocardial infarction in sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Clin Sci (Lond) 104:429-36. 2003
  3. ncbi request reprint Adrenomedullin and the renin-angiotensin-aldosterone system
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    Regul Pept 112:41-9. 2003
  4. ncbi request reprint Urocortin 1 modulates the neurohumoral response to acute nitroprusside-induced hypotension in sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Clin Sci (Lond) 112:485-91. 2007
  5. ncbi request reprint Urocortins: putative role in cardiovascular disease
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Curr Med Chem Cardiovasc Hematol Agents 2:43-7. 2004
  6. ncbi request reprint Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    J Endocrinol 189:701-10. 2006
  7. ncbi request reprint Regional sampling and the effects of experimental heart failure in sheep: differential responses in A, B and C-type natriuretic peptides
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, P O Box 4345, Christchurch, New Zealand
    Peptides 27:62-8. 2006
  8. ncbi request reprint Urotensin II: evidence for cardiac, hepatic and renal production
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch 8001, New Zealand
    Peptides 26:2211-4. 2005
  9. ncbi request reprint Plasma urocortin 1 in sheep: regional sampling and effects of experimental heart failure
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Peptides 27:1801-5. 2006
  10. ncbi request reprint Putative role for apelin in pressure/volume homeostasis and cardiovascular disease
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Cardiovasc Hematol Agents Med Chem 5:1-10. 2007

Detail Information

Publications30

  1. doi request reprint Adrenomedullin in heart failure: potential therapeutic implications
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Future Cardiol 1:235-43. 2005
    ..Manipulating the AM system may prove beneficial as an adjunctive therapeutic strategy in cardiac disease...
  2. ncbi request reprint Natriuretic peptides maintain sodium homoeostasis during chronic volume loading post-myocardial infarction in sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Clin Sci (Lond) 104:429-36. 2003
    ..This study provides evidence that natriuretic peptides play a pivotal role in preserving volume/electrolyte balance in the early stages of post-MI cardiac dysfunction...
  3. ncbi request reprint Adrenomedullin and the renin-angiotensin-aldosterone system
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    Regul Pept 112:41-9. 2003
    ..Thus, these results clearly point to a role for AM in pressure and volume homeostasis acting, at least in part, by interaction with the renin-angiotensin-aldosterone system (RAAS)...
  4. ncbi request reprint Urocortin 1 modulates the neurohumoral response to acute nitroprusside-induced hypotension in sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Clin Sci (Lond) 112:485-91. 2007
    ..The threshold for the action of Ucn1 on the natriuretic peptides and endothelin-1 appears to be below that of other actions of Ucn1...
  5. ncbi request reprint Urocortins: putative role in cardiovascular disease
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Curr Med Chem Cardiovasc Hematol Agents 2:43-7. 2004
    ..Clearly, further study is essential to confirm whether manipulation of this new family of peptides (especially Ucn II and Ucn III) offers benefit to the syndrome of heart failure with potential clinical applications in humans...
  6. ncbi request reprint Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    J Endocrinol 189:701-10. 2006
    ..Apelin also increases circulating levels of a number of vasoactive hormones. Taken together, these results suggest a potential role for apelin in pressure/volume homeostasis...
  7. ncbi request reprint Regional sampling and the effects of experimental heart failure in sheep: differential responses in A, B and C-type natriuretic peptides
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, P O Box 4345, Christchurch, New Zealand
    Peptides 27:62-8. 2006
    ..Circulating levels of CNP and NT-CNP were raised in heart failure but to a much lesser degree than ANP and BNP. There was no evidence of net extraction of CNP or NT-CNP across any tissue bed...
  8. ncbi request reprint Urotensin II: evidence for cardiac, hepatic and renal production
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch 8001, New Zealand
    Peptides 26:2211-4. 2005
    ..Significant arteriovenous gradients were observed across the heart (36%), liver (40%) and kidney (44%). This is the first report to identify the heart, liver and kidney as sources of UII in the circulation...
  9. ncbi request reprint Plasma urocortin 1 in sheep: regional sampling and effects of experimental heart failure
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Peptides 27:1801-5. 2006
    ..This is the first report identifying sources of circulating Ucn-1...
  10. ncbi request reprint Putative role for apelin in pressure/volume homeostasis and cardiovascular disease
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Cardiovasc Hematol Agents Med Chem 5:1-10. 2007
    ..As such, manipulation of this peptide system may offer benefit to the syndrome of heart failure with potential clinical applications in humans...
  11. ncbi request reprint Hemodynamic, hormonal, and renal actions of adrenomedullin-2 in normal conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, New Zealand
    Endocrinology 147:1871-7. 2006
    ..Thus, AM-2 may be another important regulator of volume and pressure homeostasis and may play a role in the pathophysiology of heart disease...
  12. ncbi request reprint Myocardial infarction with and without reperfusion in sheep: early cardiac and neurohumoral changes
    C J Charles
    Christchurch Cardioendocrine Research Group, Department of Medicine, Christchurch School of Medicine, P O Box 4345, Christchurch, New Zealand
    Clin Sci (Lond) 98:703-11. 2000
    ..Acute changes in biochemical markers, haemodynamics, neurohormones and LV function confirm that these are excellent models of open- and closed-artery myocardial infarction leading to asymptomatic LV dysfunction...
  13. ncbi request reprint Adrenomedullin attenuates pressor response to angiotensin II in conscious sheep
    C J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, New Zealand
    J Cardiovasc Pharmacol 36:526-32. 2000
    ..The data suggest a possible role for adrenomedullin in cardiovascular homeostasis in part through antagonism of the vasopressor action of angiotensin II...
  14. ncbi request reprint Adrenomedullin augments the neurohumoral response to haemorrhage in non-pregnant but not in pregnant sheep
    C J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    J Endocrinol 171:363-71. 2001
    ..039) and adrenocorticotrophic hormone (P=0.012) were decreased by ADM. In conclusion, ADM-induced augmentation of the RAS and HPA responses to hypotensive haemorrhage is abolished in the pregnant state...
  15. ncbi request reprint Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine
    C J Charles
    Cardioendocrine Research Group, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    Am J Physiol Regul Integr Comp Physiol 281:R1887-94. 2001
    ..001). In conclusion, ADM induces a different spectrum of hemodynamic, renal, and endocrine actions to NP. These results clarify mechanisms by which ADM might contribute to volume and pressure homeostasis...
  16. ncbi request reprint Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    J Hypertens 26:53-60. 2008
    ..Urocortin 1 (Ucn1) and the sympathetic nervous system both participate in cardiac and circulatory regulation, but little is known about their possible interactions...
  17. ncbi request reprint Adrenomedullin modulates the neurohumoral response to acute volume loading in normal conscious sheep
    C J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    J Endocrinol 173:123-9. 2002
    ..These results provide further evidence that ADM plays a physiological role in volume and pressure homeostasis...
  18. ncbi request reprint Neurohormones in an ovine model of compensated postinfarction left ventricular dysfunction
    M T Rademaker
    Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, Christchurch, New Zealand
    Am J Physiol Heart Circ Physiol 278:H731-40. 2000
    ..This is a reproducible model that reflects the clinical condition and should prove suitable for investigating the pathophysiology of, and experimental therapies in, early left ventricular dysfunction...
  19. ncbi request reprint Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep
    C J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    J Endocrinol 187:275-81. 2005
    ..In conclusion, we have demonstrated that AM is associated with a greater increase in CSNA and heart rate for a given change in arterial pressure than seen with the classic balanced vasodilator NP...
  20. ncbi request reprint Hemodynamic, hormonal, and renal effects of intracerebroventricular adrenomedullin in conscious sheep
    C J Charles
    Department of Medicine, Christchurch School of Medicine, New Zealand
    Endocrinology 139:1746-51. 1998
    ..In conclusion, adrenomedullin within the central nervous system may have at least two roles: modulation of the hypothalamo-pituitary-adrenal axis and protection against fluid overload...
  21. ncbi request reprint Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model
    D L Jardine
    Department of General Medicine, Christchurch Hospital, Christchurch, New Zealand
    Am J Physiol Heart Circ Physiol 293:H433-9. 2007
    ..14). CSNA slopes were -1.8 +/- 0.3 and -2.3 +/- 0.2%/mmHg (t(18) = -1.4, P = 0.2). An early increase in CSNA burst size indexes (before 60 min post-MI), mediated by an excitatory sympathetic reflex, is important in the genesis of VF/VT...
  22. ncbi request reprint Hemodynamic and hormonal effects of neutral endopeptidase inhibitor SCH 39370 in sheep
    C J Charles
    Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand
    Hypertension 17:643-51. 1991
    ..03) but not different from SCH 39370 alone. Inhibitory effects of SCH 39370 on aldosterone levels were similar in the presence of absence of exogenous atrial natriuretic factor.(ABSTRACT TRUNCATED AT 250 WORDS)..
  23. pmc Increased cardiac sympathetic nerve activity following acute myocardial infarction in a sheep model
    D L Jardine
    Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    J Physiol 565:325-33. 2005
    ..The duration of this response may be longer because the recording fields decrease with time. This result is consistent with a sustained cardiac excitatory sympathetic reflex...
  24. ncbi request reprint Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure
    Miriam T Rademaker
    Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    Circulation 112:3624-32. 2005
    ..Urocortin 2 (Ucn2) has potent cardiovascular actions and may participate in the pathophysiology of heart failure (HF). The integrated hemodynamic, endocrine, and renal effects of Ucn2 are unknown...
  25. ncbi request reprint Adrenomedullin and heart failure
    Miriam T Rademaker
    The Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    Regul Pept 112:51-60. 2003
    ..Manipulation of the AM system holds promise as a therapeutic strategy in cardiac disease...
  26. ncbi request reprint Adrenomedullin in heart failure
    M Gary Nicholls
    Department of Medicine, Christchurch Hospital, Christchurch, New Zealand
    Hypertens Res 26:S135-40. 2003
    ..An improved understanding of the role of adrenomedullin in heart failure might lead to the development of therapeutic agents acting through adrenomedullin receptors...
  27. ncbi request reprint Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: comparison with normal sheep
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    J Am Coll Cardiol 40:1495-505. 2002
    ..The goal of this study was to determine the bioactivity of urocortin (Ucn) in experimental heart failure (HF)...
  28. ncbi request reprint Urocortin 2 combined with angiotensin-converting enzyme inhibition in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Clin Sci (Lond) 114:635-42. 2008
    ..These results indicate that dual treatment with these two agents is beneficial...
  29. ncbi request reprint Continual recordings of cardiac sympathetic nerve activity in conscious sheep
    David L Jardine
    Department of General Medicine, PO Box 4710, Christchurch Hospital, School of Medicine, Christchurch, New Zealand
    Am J Physiol Heart Circ Physiol 282:H93-9. 2002
    ..In conclusion, CSNA that can be continually recorded in conscious sheep decreases during the first week postsurgery and, thereafter, stabilizes. This model should provide valuable insights in future investigations of cardiac disease...
  30. ncbi request reprint Treatment of Staphylococcus epidermidis central vascular catheter infection with 70% ethanol locks: efficacy in a sheep model
    Stephen T Chambers
    Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, PO Box 4345, Christchurch, New Zealand
    J Antimicrob Chemother 59:779-82. 2007
    ..To determine whether a single treatment with ethanol/water (70:30) will sterilize infected vascular catheters...