Patrick T Holland

Summary

Affiliation: Cawthron Institute
Country: New Zealand

Publications

  1. ncbi request reprint Amnesic shellfish poisoning toxins in shellfish: estimation of uncertainty of measurement for a liquid chromatography/tandem mass spectrometry method
    Patrick T Holland
    Cawthron Institute, Private Bag 2, 98 Halifax St E, Nelson, New Zealand
    J AOAC Int 86:1095-100. 2003
  2. doi request reprint Comment on "Effect of uncontrolled factors in a validated liquid chromatography-tandem mass spectrometry method question its use as a reference method for marine toxins: major causes for concern"
    Patrick T Holland
    Cawthron Institute, 98 Halifax Street East, Private Bag 2, Nelson 7042, New Zealand
    Anal Chem 84:478-80; discussion 481-3. 2012
  3. ncbi request reprint Isodomoic acid C, an unusual amnesic shellfish poisoning toxin from Pseudo-nitzschia australis
    Patrick T Holland
    Cawthron Institute, Private Bag 2, Nelson, New Zealand
    Chem Res Toxicol 18:814-6. 2005
  4. doi request reprint Determination of soluble immunoglobulin G in bovine colostrum products by Protein G affinity chromatography-turbidity correction and method validation
    Patrick T Holland
    Cawthron Institute, Nelson, New Zealand
    J Agric Food Chem 59:5248-56. 2011
  5. ncbi request reprint Determination of brevetoxins in shellfish by LC/MS/MS: single-laboratory validation
    Paul S McNabb
    Cawthron Institute, 98 Halifax St East, Nelson 7010, New Zealand
    J AOAC Int 95:1097-105. 2012
  6. doi request reprint Detection of tetrodotoxin from the grey side-gilled sea slug - Pleurobranchaea maculata, and associated dog neurotoxicosis on beaches adjacent to the Hauraki Gulf, Auckland, New Zealand
    Paul McNabb
    Cawthron Institute, Private Bag 2, Nelson, 7001, New Zealand
    Toxicon 56:466-73. 2010
  7. doi request reprint Identification of a benthic microcystin-producing filamentous cyanobacterium (Oscillatoriales) associated with a dog poisoning in New Zealand
    Susanna A Wood
    Cawthron Institute, Freshwater, Private Bag 2, Nelson 7001, New Zealand
    Toxicon 55:897-903. 2010
  8. doi request reprint Toxic dinoflagellates (Dinophyceae) from Rarotonga, Cook Islands
    Lesley L Rhodes
    Cawthron Institute, Nelson, 7010, New Zealand
    Toxicon 56:751-8. 2010
  9. pmc Widespread distribution and identification of eight novel microcystins in antarctic cyanobacterial mats
    Susanna A Wood
    Cawthron Institute, Nelson, New Zealand
    Appl Environ Microbiol 74:7243-51. 2008
  10. ncbi request reprint First report of homoanatoxin-a and associated dog neurotoxicosis in New Zealand
    Susanna A Wood
    Cawthron Institute, Private Bag 2, Nelson 7001, New Zealand
    Toxicon 50:292-301. 2007

Detail Information

Publications23

  1. ncbi request reprint Amnesic shellfish poisoning toxins in shellfish: estimation of uncertainty of measurement for a liquid chromatography/tandem mass spectrometry method
    Patrick T Holland
    Cawthron Institute, Private Bag 2, 98 Halifax St E, Nelson, New Zealand
    J AOAC Int 86:1095-100. 2003
    ..12 (12%) at 0.25-5 mg/kg and 0.079 (7.9%) at 5-50 mg/kg. The major contribution to the uncertainty was the repeatability of the LC/MS determination, probably arising from subtle matrix effects...
  2. doi request reprint Comment on "Effect of uncontrolled factors in a validated liquid chromatography-tandem mass spectrometry method question its use as a reference method for marine toxins: major causes for concern"
    Patrick T Holland
    Cawthron Institute, 98 Halifax Street East, Private Bag 2, Nelson 7042, New Zealand
    Anal Chem 84:478-80; discussion 481-3. 2012
    ..Therefore the specific conclusions they draw from their data are considered invalid...
  3. ncbi request reprint Isodomoic acid C, an unusual amnesic shellfish poisoning toxin from Pseudo-nitzschia australis
    Patrick T Holland
    Cawthron Institute, Private Bag 2, Nelson, New Zealand
    Chem Res Toxicol 18:814-6. 2005
    ..The affinity of 2 for GluR6 glutamate receptors was 240-fold lower than for 1, indicating low neurotoxic potential...
  4. doi request reprint Determination of soluble immunoglobulin G in bovine colostrum products by Protein G affinity chromatography-turbidity correction and method validation
    Patrick T Holland
    Cawthron Institute, Nelson, New Zealand
    J Agric Food Chem 59:5248-56. 2011
    ....
  5. ncbi request reprint Determination of brevetoxins in shellfish by LC/MS/MS: single-laboratory validation
    Paul S McNabb
    Cawthron Institute, 98 Halifax St East, Nelson 7010, New Zealand
    J AOAC Int 95:1097-105. 2012
    ..8 mg/kg is conservative with respect to the bioassay regulatory limit of 20 mouse units/100 g...
  6. doi request reprint Detection of tetrodotoxin from the grey side-gilled sea slug - Pleurobranchaea maculata, and associated dog neurotoxicosis on beaches adjacent to the Hauraki Gulf, Auckland, New Zealand
    Paul McNabb
    Cawthron Institute, Private Bag 2, Nelson, 7001, New Zealand
    Toxicon 56:466-73. 2010
    ..Tests for other marine toxins were negative and no other organisms from the area contained TTX. This is the first time TTX has been identified in New Zealand and the first detection of TTX in an opisthobranch...
  7. doi request reprint Identification of a benthic microcystin-producing filamentous cyanobacterium (Oscillatoriales) associated with a dog poisoning in New Zealand
    Susanna A Wood
    Cawthron Institute, Freshwater, Private Bag 2, Nelson 7001, New Zealand
    Toxicon 55:897-903. 2010
    ..To our knowledge, however, this is the first instance of a benthic microcystin-producing species causing an animal death in New Zealand...
  8. doi request reprint Toxic dinoflagellates (Dinophyceae) from Rarotonga, Cook Islands
    Lesley L Rhodes
    Cawthron Institute, Nelson, 7010, New Zealand
    Toxicon 56:751-8. 2010
    ..A crude extract of C. monotis was of low toxicity to mice by i.p. injection, and an extract of Ostreopsis sp. was negative in the palytoxin haemolysis neutralisation assay...
  9. pmc Widespread distribution and identification of eight novel microcystins in antarctic cyanobacterial mats
    Susanna A Wood
    Cawthron Institute, Nelson, New Zealand
    Appl Environ Microbiol 74:7243-51. 2008
    ..ARISA also enabled the putative identification of the MC-producing Nostoc sp. from multiple samples...
  10. ncbi request reprint First report of homoanatoxin-a and associated dog neurotoxicosis in New Zealand
    Susanna A Wood
    Cawthron Institute, Private Bag 2, Nelson 7001, New Zealand
    Toxicon 50:292-301. 2007
    ..Access restrictions were placed on over 60% of river catchments in the western Wellington region, severely affecting recreational users...
  11. doi request reprint A sensitive assay for palytoxins, ovatoxins and ostreocins using LC-MS/MS analysis of cleavage fragments from micro-scale oxidation
    Andrew I Selwood
    Cawthron Institute, Private Bag 2, Nelson 7010, New Zealand
    Toxicon 60:810-20. 2012
    ..The method has potential for use in research and is sufficiently sensitive for regulatory testing, should it be required...
  12. ncbi request reprint Multiresidue method for determination of algal toxins in shellfish: single-laboratory validation and interlaboratory study
    Paul McNabb
    Cawthron Institute, 98 Halifax St E, Nelson, New Zealand
    J AOAC Int 88:761-72. 2005
    ..Between-laboratories reproducibility (RSDR) values were compared with the Horwitz criterion and ranged from good to adequate for 7 key toxins (HorRat values of 0.8-2.0)...
  13. doi request reprint Development of solid phase adsorption toxin tracking (SPATT) for monitoring anatoxin-a and homoanatoxin-a in river water
    Susanna A Wood
    Cawthron Institute, Private Bag 2, Nelson 7042, New Zealand
    Chemosphere 82:888-94. 2011
    ..SPATT has the potential to be integrated into current cyanobacterial monitoring programmes and would be a very useful and economical tool for early warning of ATX and HTX contamination in water...
  14. ncbi request reprint Production of anatoxin-a and a novel biosynthetic precursor by the cyanobacterium Aphanizomenon issatschenkoi
    Andrew I Selwood
    Cawthron Institute, 98 Halifax Street E, Nelson 7010, New Zealand
    Environ Sci Technol 41:506-10. 2007
    ..The implications of the findings for mechanisms of biosynthesis of anatoxins by cyanobacteria and for monitoring of water bodies for cyanotoxins are discussed...
  15. pmc Further characterization of glycine-containing microcystins from the McMurdo dry Valleys of Antarctica
    Jonathan Puddick
    Cawthron Institute, Private Bag 2, Nelson 7010, New Zealand
    Toxins (Basel) 7:493-515. 2015
    ..A recently developed thiol derivatization technique showed that each microcystin contained dehydrobutyrine in position-7 instead of the commonly observed N-methyl dehydroalanine. ..
  16. doi request reprint A sensitive LC-MS/MS assay for brevisulcenal and brevisulcatic acid toxins produced by the dinoflagellate Karenia brevisulcata
    D Tim Harwood
    Cawthron Institute, Private Bag 2, Nelson 7010, New Zealand Electronic address
    Toxicon 84:19-27. 2014
    ..This method shows suitable performance characteristics to be regarded a useful tool to monitor toxin levels in a variety of sample matrices during future bloom events. ..
  17. doi request reprint Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants
    Andrew E Fidler
    Cawthron Institute, Private Bag 2, Nelson 7012, New Zealand
    Toxicon 59:365-72. 2012
    ..Bioassays based on tunicate xenobiotic receptor activation may find application in marine environmental monitoring and bioprospecting...
  18. ncbi request reprint Confirmation of brevetoxin metabolism in cockle, Austrovenus stutchburyi, and greenshell mussel, Perna canaliculus, associated with New Zealand neurotoxic shellfish poisoning, by controlled exposure to Karenia brevis culture
    Hitoshi Ishida
    School of Pharmaceutical Science, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Toxicon 43:701-12. 2004
    ..In P. canaliculus, initial levels of PbTx-3 were similar, while PbTx-2 and BTX-B5 accumulated after each dose. PbTx-3 and BTX-B5 are proposed to be suitable markers for monitoring shellfish toxicity after a red tide event...
  19. ncbi request reprint Acute toxicity of gymnodimine to mice
    Rex Munday
    AgResearch, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand
    Toxicon 44:173-8. 2004
    ....
  20. ncbi request reprint Detection of domoic acid in rat serum and brain by direct competitive enzyme-linked immunosorbent assay (cELISA)
    Blair R Hesp
    Department of Pharmacology and Toxicology, University of Otago, School of Medical Sciences, P O Box 913, Dunedin, New Zealand
    Anal Bioanal Chem 383:783-6. 2005
    ..In addition, we have developed an extraction method for analysis of DOM in rat brain by cELISA which yields complete recovery across a range of sample dilutions...
  21. ncbi request reprint Isolation and identification of pectenotoxins-13 and -14 from Dinophysis acuta in New Zealand
    Christopher Owen Miles
    AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand
    Toxicon 48:152-9. 2006
    ..J. Chromatogr. A 992, 141-150]. PTX-13 underwent slow deuteration at the 13beta-position during NMR analysis. PTX-14 corresponds to the 32,36-dehydration product of PTX-13, and may be an artifact...
  22. ncbi request reprint Isolation of pectenotoxin-2 from Dinophysis acuta and its conversion to pectenotoxin-2 seco acid, and preliminary assessment of their acute toxicities
    Christopher O Miles
    AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand
    Toxicon 43:1-9. 2004
    ..No diarrhea was observed in mice dosed with either compound, suggesting that pectenotoxins do not belong in the diarrhetic shellfish poison group...
  23. ncbi request reprint Field dissipation of acetochlor in two New Zealand soils at two application rates
    Qingli Ma
    AgResearch, Hamilton, New Zealand
    J Environ Qual 33:930-8. 2004
    ..Faster acetochlor loss in the Horotiu soil possibly resulted from the higher soil organic carbon content that retained more acetochlor near the soil surface where higher temperature and photolysis accelerated the loss...