Mahmoud N Nagi

Summary

Publications

  1. doi request reprint Prophylactic and Therapeutic Potential of Acetyl-L-carnitine against Acetaminophen-Induced Hepatotoxicity in Mice
    Salman A Alotaibi
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 30:5-11. 2016
  2. doi request reprint Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats
    Mahmoud N Nagi
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 25:135-42. 2011
  3. doi request reprint Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver
    Mahmoud N Nagi
    Department of Pharmacology, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
    Food Chem Toxicol 48:2361-5. 2010
  4. doi request reprint Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity
    Mahmoud N Nagi
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Kingdom of Saudi Arabia
    Phytother Res 23:1295-8. 2009
  5. ncbi request reprint Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
    Clin Exp Pharmacol Physiol 34:399-405. 2007
  6. ncbi request reprint Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice
    Ayman M Gamal el-din
    Department of Pharmacology, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
    Pharmacol Res 48:631-5. 2003
  7. ncbi request reprint Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Eur J Pharmacol 543:40-7. 2006
  8. ncbi request reprint Protective effect of arabic gum against cardiotoxicity induced by doxorubicin in mice: a possible mechanism of protection
    Adel R A Abd-Allah
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    J Biochem Mol Toxicol 16:254-9. 2002
  9. ncbi request reprint Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats
    Mahmoud M Khattab
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Phytother Res 21:410-4. 2007
  10. doi request reprint Nonclassical antifolates, part 3: synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones
    Fatmah A M Al-Omary
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Eur J Med Chem 63:33-45. 2013

Collaborators

Detail Information

Publications22

  1. doi request reprint Prophylactic and Therapeutic Potential of Acetyl-L-carnitine against Acetaminophen-Induced Hepatotoxicity in Mice
    Salman A Alotaibi
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 30:5-11. 2016
    ..o. At equimolar doses, N-acetylcystiene was superior as therapeutic agent to acetylcarnitine. However, acetylcarnitine potentiated the effect of N-acetylcystiene in the treatment of acetaminophen toxicity. ..
  2. doi request reprint Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats
    Mahmoud N Nagi
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 25:135-42. 2011
    ....
  3. doi request reprint Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver
    Mahmoud N Nagi
    Department of Pharmacology, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
    Food Chem Toxicol 48:2361-5. 2010
    ..In conclusion, TQ is effective in protecting mice against acetaminophen-induced hepatotoxicity possibly via increased resistance to oxidative and nitrosative stress as well as its ability to improve the mitochondrial energy production...
  4. doi request reprint Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity
    Mahmoud N Nagi
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Kingdom of Saudi Arabia
    Phytother Res 23:1295-8. 2009
    ..In conclusion, oral administration of TQ is effective in increasing the activities of quinone reductase and glutathione transferase and makes TQ a promising prophylactic agent against chemical carcinogenesis and toxicity...
  5. ncbi request reprint Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
    Clin Exp Pharmacol Physiol 34:399-405. 2007
    ....
  6. ncbi request reprint Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice
    Ayman M Gamal el-din
    Department of Pharmacology, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
    Pharmacol Res 48:631-5. 2003
    ..In conclusion, arabic gum is effective in protecting mice against acetaminophen-induced hepatotoxicity. This protection may involve the reduction of oxidative stress...
  7. ncbi request reprint Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Eur J Pharmacol 543:40-7. 2006
    ..This spectacular protection makes thymoquinone a promising agent in pathologies implicating neurodegenaration such as cerebral ischemia...
  8. ncbi request reprint Protective effect of arabic gum against cardiotoxicity induced by doxorubicin in mice: a possible mechanism of protection
    Adel R A Abd-Allah
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    J Biochem Mol Toxicol 16:254-9. 2002
    ..The results indicate that AG is a potent superoxide scavenger. The superoxide scavenging effect of AG may explain, at least in part, the protective effect of AG against cardiotoxicity induced by DOX...
  9. ncbi request reprint Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats
    Mahmoud M Khattab
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Phytother Res 21:410-4. 2007
    ..TQ inhibited the in vitro production of superoxide radical in enzymatic and non-enzymatic systems. In conclusion, TQ is effective in protecting rats against l-NAME-induced hypertension and renal damage possibly via antioxidant activity...
  10. doi request reprint Nonclassical antifolates, part 3: synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones
    Fatmah A M Al-Omary
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Eur J Med Chem 63:33-45. 2013
    ..Flexible alignment; electrostatic and hydrophobic mappings revealed that the obtained model could be useful for the development of new DHFR inhibitors...
  11. ncbi request reprint Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus
    Fadhel A Al-Omar
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, 11451 Riyadh, Kingdom of Saudi Arabia
    Neurochem Res 31:611-8. 2006
    ..Thus treatment with curcumin immediately or even delayed until 24 h may have the potential to be used as a protective agent in forebrain ischemic insult in human...
  12. doi request reprint Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones
    Fatmah A M Al-Omary
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Bioorg Med Chem 18:2849-63. 2010
    ..The substitution pattern and spatial considerations of the pi-systems in regard to the quinazoline nucleus proved critical for biological activity...
  13. ncbi request reprint Protective effect of aminoguanidine against nephrotoxicity induced by cisplatin in normal rats
    Mahmoud A Mansour
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Comp Biochem Physiol C Toxicol Pharmacol 132:123-8. 2002
    ..These results suggest that AG has a protective effect on nephrotoxicity induced by CDDP and it may therefore improve the therapeutic index of CDDP...
  14. ncbi request reprint Nomega-nitro-L-arginine methylester ameliorates myocardial toxicity induced by doxorubicin
    Mahmoud Ahmed Mansour
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    J Biochem Mol Biol 36:593-6. 2003
    ..L-NAME may, therefore, be a beneficial remedy for cardiotoxicity that is induced by Dox and can then be used to improve the therapeutic index of Dox...
  15. doi request reprint Synthesis, biological evaluation and molecular modeling study of 2-(1,3,4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors
    Sarah T Al-Rashood
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
    Bioorg Med Chem Lett 24:4557-67. 2014
    ..ADMET properties prediction of the active compounds suggested that compounds 29 and 34 could be orally absorbed with diminished toxicity...
  16. ncbi request reprint Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action
    Mahmoud A Mansour
    Department of Pharmacology, Faculty of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Cell Biochem Funct 20:143-51. 2002
    ..Our data may explain at least partly the reported beneficial in vivo protective effects of TQ through the combined antioxidant properties of TQ and its metabolite DHTQ...
  17. doi request reprint Rutin Attenuates Carfilzomib-Induced Cardiotoxicity Through Inhibition of NF-κB, Hypertrophic Gene Expression and Oxidative Stress
    Faisal Imam
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Post Box 2457, Riyadh, 11451, Kingdom of Saudi Arabia
    Cardiovasc Toxicol 17:58-66. 2017
    ..Rutin also attenuated the effects of carfilzomib on oxidant-antioxidant including malondialdehyde and reduced glutathione. Histopathological study clearly confirmed that rutin attenuated carfilzomib-induced cardiotoxicity in rats...
  18. doi request reprint Therapeutic potential of carfilzomib, an irreversible proteasome inhibitor, against acetaminophen-induced hepatotoxicity in mice
    Abdulrazaq Alanazi
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol . 2016
    ..CFZ may exert its hepatoprotective action by alleviating inflammatory, oxidative, and nitrosative stress via inhibition of TNF-α, COX-II, and iNOS...
  19. ncbi request reprint Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs
    Sarah T Al-Rashood
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
    Bioorg Med Chem 14:8608-21. 2006
    ..Alternatively, the compounds could differ significantly in uptake or concentration within mammalian cells...
  20. ncbi request reprint Melatonin inhibits the contractile effect of vanadate in the isolated pulmonary arterial rings of rats: possible role of hydrogen peroxide
    Mahmoud N Nagi
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh, 11451, Saudi Arabia
    J Biochem Mol Toxicol 16:273-8. 2002
    ..Furthermore, the contractile effect of vanadate on the pulmonary arterial rings may be attributed to the intracellular generation of hydrogen peroxide...
  21. doi request reprint Riboflavin attenuates lipopolysaccharide-induced lung injury in rats
    Naif O Al-Harbi
    a Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, KSA and
    Toxicol Mech Methods 25:417-23. 2015
    ..In conclusion, the present study clearly demonstrated that riboflavin caused a protective effect against LPS-induced ALI. These results suggest that riboflavin may be used to protect against toxic effect of LPS in lungs...
  22. doi request reprint A possible antineoplastic potential of selective, irreversible proteasome inhibitor, carfilzomib on chemically induced hepatocarcinogenesis in rats
    Mahmoud A Mansour
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, 11426, Saudi Arabia
    J Biochem Mol Toxicol 28:400-6. 2014
    ..Treatment with CFZ confers an antineoplastic activity against chemically induced hepatocarcinogenesis. These findings suggest that CFZ plays a pivotal role in the treatment of hepatocarcinogenesis. ..