Hidenari Nagai

Summary

Publications

  1. pmc Twenty-four hour intra-arterial infusion of 5-fluorouracil, cisplatin, and leucovorin is more effective than 6-hour infusion for advanced hepatocellular carcinoma
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1, Omorinishi, Ota ku, Tokyo 143 8541, Japan
    World J Gastroenterol 13:280-4. 2007
  2. doi request reprint Changes of host immunity in relation to efficacy in liver cirrhosis patients with advanced hepatocellular carcinoma treated by intra-arterial chemotherapy
    Kouichi Momiyama
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Cancer Chemother Pharmacol 64:271-7. 2009
  3. ncbi request reprint Sorafenib and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombus
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori School of Medicine, Faculty of Medicine, Toho University, Ota ku, Tokyo, Japan
    Anticancer Res 35:2269-77. 2015
  4. doi request reprint Changes of cytokines in patients with liver cirrhosis and advanced hepatocellular carcinoma treated by sorafenib
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, Faculty of Medicine, School of Medicine, Toho University, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Cancer Chemother Pharmacol 73:223-9. 2014
  5. ncbi request reprint Serum VEGF as a tumor marker in patients with HCV-related liver cirrhosis and hepatocellular carcinoma
    Takanori Mukozu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, Faculty of Medicine, Toho University School of Medicine, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Anticancer Res 33:1013-21. 2013
  6. pmc Sorafenib prevents escape from host immunity in liver cirrhosis patients with advanced hepatocellular carcinoma
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1, Omorinishi, Ota ku, Tokyo 143 8541, Japan
    Clin Dev Immunol 2012:607851. 2012
  7. doi request reprint Hepatotoxicity of intra-arterial combination chemotherapy in patients with liver cirrhosis and advanced hepatocellular carcinoma
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, School of Medicine, Faculty of Medicine, Toho University, 6 11 1, Omorinishi, Ota ku, Tokyo 143 8541, Japan
    Cancer Chemother Pharmacol 66:1123-9. 2010
  8. ncbi request reprint Therapeutic strategy of advanced hepatocellular carcinoma by using combined intra-arterial chemotherapy
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Recent Pat Anticancer Drug Discov 3:220-6. 2008
  9. doi request reprint Multimodal therapy for liver cirrhosis patients with advanced hepatocellular carcinoma
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, School of Medicine, Faculty of Medicine, Toho University, 6 11 1, Omorinishi, Ota ku, Tokyo 143 8541, Japan
    Cancer Chemother Pharmacol 68:139-45. 2011
  10. doi request reprint Th1/Th2 balance: an important indicator of efficacy for intra-arterial chemotherapy
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Cancer Chemother Pharmacol 62:959-63. 2008

Collaborators

Detail Information

Publications27

  1. pmc Twenty-four hour intra-arterial infusion of 5-fluorouracil, cisplatin, and leucovorin is more effective than 6-hour infusion for advanced hepatocellular carcinoma
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1, Omorinishi, Ota ku, Tokyo 143 8541, Japan
    World J Gastroenterol 13:280-4. 2007
    ..To evaluate the time dependence of intra-arterial 5-fluorouracil (5-FU) therapy for advanced hepatocellular carcinoma (aHCC)...
  2. doi request reprint Changes of host immunity in relation to efficacy in liver cirrhosis patients with advanced hepatocellular carcinoma treated by intra-arterial chemotherapy
    Kouichi Momiyama
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Cancer Chemother Pharmacol 64:271-7. 2009
    ..The aim of this study was to retrospectively assess changes of host immunity in relation to efficacy in liver cirrhosis (LC) patients with advanced hepatocellular carcinoma (aHCC) treated by combined intra-arterial chemotherapy...
  3. ncbi request reprint Sorafenib and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombus
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori School of Medicine, Faculty of Medicine, Toho University, Ota ku, Tokyo, Japan
    Anticancer Res 35:2269-77. 2015
    ..Standardization of multimodal therapy for aHCC with PVTT has not yet been achieved...
  4. doi request reprint Changes of cytokines in patients with liver cirrhosis and advanced hepatocellular carcinoma treated by sorafenib
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, Faculty of Medicine, School of Medicine, Toho University, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Cancer Chemother Pharmacol 73:223-9. 2014
    ..The aim of this study was to retrospectively evaluate changes of cytokines in patients with liver cirrhosis (LC) and aHCC receiving sorafenib therapy...
  5. ncbi request reprint Serum VEGF as a tumor marker in patients with HCV-related liver cirrhosis and hepatocellular carcinoma
    Takanori Mukozu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, Faculty of Medicine, Toho University School of Medicine, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Anticancer Res 33:1013-21. 2013
    ..The aim of this study was to retrospectively clarify the usefulness of serum VEGF levels as a tumor marker in patients with hepatitis C virus (HCV)-related liver cirrhosis (CLC) and HCC...
  6. pmc Sorafenib prevents escape from host immunity in liver cirrhosis patients with advanced hepatocellular carcinoma
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1, Omorinishi, Ota ku, Tokyo 143 8541, Japan
    Clin Dev Immunol 2012:607851. 2012
    ..The aim of this paper was to evaluate host immunity in liver cirrhosis (LC) patients with advanced hepatocellular carcinoma (aHCC) receiving sorafenib therapy...
  7. doi request reprint Hepatotoxicity of intra-arterial combination chemotherapy in patients with liver cirrhosis and advanced hepatocellular carcinoma
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, School of Medicine, Faculty of Medicine, Toho University, 6 11 1, Omorinishi, Ota ku, Tokyo 143 8541, Japan
    Cancer Chemother Pharmacol 66:1123-9. 2010
    ..However, it has also been reported that 5-fluorouracil (5-FU) exacerbates liver damage in patients with liver cirrhosis (LC). The aim of this study was to clarify the hepatotoxicity of IACC in LC patients with aHCC...
  8. ncbi request reprint Therapeutic strategy of advanced hepatocellular carcinoma by using combined intra-arterial chemotherapy
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Recent Pat Anticancer Drug Discov 3:220-6. 2008
    ..The present article shows some recent patents related to the field...
  9. doi request reprint Multimodal therapy for liver cirrhosis patients with advanced hepatocellular carcinoma
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, School of Medicine, Faculty of Medicine, Toho University, 6 11 1, Omorinishi, Ota ku, Tokyo 143 8541, Japan
    Cancer Chemother Pharmacol 68:139-45. 2011
    ..The aim of this study was to retrospectively assess the influence of IACC on the prognosis of aHCC...
  10. doi request reprint Th1/Th2 balance: an important indicator of efficacy for intra-arterial chemotherapy
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Cancer Chemother Pharmacol 62:959-63. 2008
    ..The aim of this study was to assess the influence of intra-arterial combination chemotherapy on the Th1/Th2 balance in LC patients with aHCC...
  11. ncbi request reprint Changes of cytokines in cirrhosis patients with advanced hepatocellular carcinoma treated by intra-arterial chemotherapy
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Cancer Chemother Pharmacol 62:271-6. 2008
    ..The aim of this study was to clarify changes of cytokines in patients with liver cirrhosis (LC) and advanced hepatocellular carcinoma (aHCC) receiving intra-arterial combination chemotherapy...
  12. doi request reprint Influence of the etiology of liver cirrhosis on the response to combined intra-arterial chemotherapy in patients with advanced hepatocellular carcinoma
    Masahiro Kanayama
    Division of Gastroenterology and Hepatology, Omori Hospital, Toho University Medical Center, Tokyo, Japan
    Cancer Chemother Pharmacol 64:109-14. 2009
    ....
  13. ncbi request reprint Recurrence incidence of small HCC in cirrhosis patients by ablation versus injection
    Noritaka Wakui
    Division of Gastroenterology and Hepatology, Toho University Omori Medical Center, 6 11 1, Omorinishi, Ota ku, Tokyo, Japan 143 8541
    Hepatogastroenterology 57:195-201. 2010
    ....
  14. ncbi request reprint Tumor lysis syndrome after sorafenib for hepatocellular carcinoma: a case report
    Kazue Shiozawa
    Department of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, Tokyo, Japan
    Hepatogastroenterology 57:688-90. 2010
    ..This is a very rare complication developed in a short period treated with sorafenib as a single-agent for an advanced HCC...
  15. ncbi request reprint Cool-tip 10-mm electrode useful for radiofrequency ablation of hepatocellular carcinoma
    Noritaka Wakui
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1, Omorinishi, Ota ku, Tokyo, Japan 143 8541
    Hepatogastroenterology 56:1585-91. 2009
    ..Whether a cool-tip 10mm electrode is useful for radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) has not been established. Accordingly, the present study goal was to determine this electrode is indicated for RFA of HCC...
  16. ncbi request reprint Relationship of peripheral blood CD4-positive T cells to carcinogenesis in patients with HCV-related chronic hepatitis and liver cirrhosis
    Teppei Matsui
    Division of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6 11 1 Omorinishi, Ota ku, Tokyo, Japan
    Cancer Chemother Pharmacol 62:401-6. 2008
    ..The objectives of this study were to evaluate the Th1/Th2 balance and to investigate the relation between carcinogenesis and host immunity in patients with chronic hepatitis C, HCV-related liver cirrhosis (LC), or HCC...
  17. doi request reprint Diagnosis of hepatic hemangioma by parametric imaging using sonazoid-enhanced US
    Noritaka Wakui
    Toho University, Omori Medical Center, Tokyo, Japan
    Hepatogastroenterology 58:1431-5. 2011
    ..Comparison of Parametric Imaging (PI) using Sonazoid-enhanced ultrasonography (US) and microflow imaging (MFI) to determine the possibility of hepatic hemangioma diagnosis using PI...
  18. doi request reprint Effects of mutation number in interferon sensitivity determining region on peripheral blood CD4(+) T cell subsets (Th1, Th2) in chronic hepatitis C patients with hepatitis C virus genotype 1b and high viral load
    Koji Ishii
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Toho University School of Medicine, 6 11 1, Omorinishi, Otaku, Tokyo, 143 8541, Japan
    Hepatol Int 6:468-74. 2012
    ..The aim of this study was to clarify whether host immunity is influenced by the number of AA mutations in the ISDR...
  19. pmc The Importance of Lamivudine Therapy in Liver Cirrhosis Patients Related HBV with Advanced Hepatocellular Carcinoma Receiving Hepatic Arterial Infusion Chemotherapy
    Koichi Momiyama
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, School of Medicine, Faculty of Medicine, Toho University, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Clin Cancer Drugs 2:112-118. 2015
    ..The aim of the present study was to retrospectively assess the efficacy of lamivudine therapy for B-LC patients with aHCC undergoing HAIC...
  20. doi request reprint Splenic artery aneurysm that gradually increased in size over 4 years until threatening rupture
    Noritaka Wakui
    Division of Gastroenterology and Hepatology, Toho University Omori Medical Center, 6 11 1 Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    J Med Ultrason (2001) 38:167-71. 2011
    ..It is important to compare the findings not only with those from the previous examination but also with earlier results. ..
  21. ncbi request reprint Disappearance of HCV after cessation of immunosuppression in a patient with ulcerative colitis and renal transplantation
    Hidenari Nagai
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University School of Medicine, 6 11 1 Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    J Gastroenterol 40:848-53. 2005
    ..To confirm clearance of HCV, liver biopsy was performed, and no HCV-RNA was detected in the liver tissue by RT-PCR. These findings suggested that HCV was cleared by the cessation of immunosuppressive therapy, as a rebound effect...
  22. doi request reprint Comparison of the hemodynamics between patients with alcoholic or HCV-related cirrhosis
    Kouichi Momiyama
    Department of Internal Medicine, Toho University, Tokyo, Japan
    Hepatogastroenterology 58:2036-40. 2011
    ..The aim of the present study was to compare hemodynamics between patients with alcoholic LC and patients with HCV-related LC (CLC)...
  23. ncbi request reprint Th2 Dominance Might Induce Carcinogenesis in Patients with HCV-related Liver Cirrhosis
    Michio Kogame
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
    Anticancer Res 36:4529-36. 2016
    ..The aim of the study was to clarify whether Th2 dominance induces carcinogenesis or vice versa in patients with HCV-related liver diseases...
  24. ncbi request reprint VEGF in patients with advanced hepatocellular carcinoma receiving intra-arterial chemotherapy
    Daigo Matsui
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
    Anticancer Res 35:2205-10. 2015
    ..The aim of the present study was to clarify the usefulness of VEGF for monitoring the response to intra-arterial chemotherapy in patients with HCC...
  25. doi request reprint Importance of branched-chain amino acids in patients with liver cirrhosis and advanced hepatocellular carcinoma receiving hepatic arterial infusion chemotherapy
    Takenori Kanekawa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, Faculty of Medicine, School of Medicine, Toho University, 6 11 1, Omorinishi, Ota ku, Tokyo, 143 8541, Japan
    Cancer Chemother Pharmacol 74:899-909. 2014
    ....
  26. ncbi request reprint Effect of probiotics on serum bile acids in patients with ulcerative colitis
    Shinji Sato
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Omori, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
    Hepatogastroenterology 59:1804-8. 2012
    ..The aim of the present study was to investigate the effects of probiotics in patients with UC by examining changes of the serum BA profile...
  27. ncbi request reprint Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes
    Hidenari Nagai
    USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic and Pancreatic Disease, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Hepatology 36:55-64. 2002
    ..In conclusion, depletion of GSH by APAP, DEM, or phorone causes oxidative stress-induced necrosis and sensitizes to an oxidative stress independent TNF-alpha-induced apoptosis...