- Validity of patient self-reported history of skin cancer
Michael E Ming
Departments of Dermatology and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Arch Dermatol 140:730-5. 2004
..To determine the validity of patient self-report of skin cancer history...
- Identification of high-risk patients among those diagnosed with thin cutaneous melanomas
Phyllis A Gimotty
The Melanoma Program of the Abramson Cancer Center, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Clin Oncol 25:1129-34. 2007
..However, some develop metastatic disease that is often fatal. We evaluated established prognostic factors to develop classification schemes with better discrimination than current American Joint Committee on Cancer (AJCC) staging...
- Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis
Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hum Pathol 39:901-9. 2008
..Lymphatic invasion is an underobserved phenomenon in primary melanomas that can be better detected by immunohistochemical staining. The presence of lymphatic invasion may be a clinically useful predictor of regionally metastatic disease...
- Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanoma
Phyllis A Gimotty
Melanoma Program of the Abramson Cancer Center, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Clin Oncol 23:8048-56. 2005
..In this study, we characterized three biomarkers of proliferation (Ki67 expression, dermal mitotic rate [MR], and tumorigenicity) in thin (< or = 1.00 mm) primary cutaneous melanomas and examined their association with prognosis...
- Does MC1R genotype convey information about melanoma risk beyond risk phenotypes?
Peter A Kanetsky
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Cancer 116:2416-28. 2010
..A study was carried out to describe associations of MC1R variants and melanoma in a US population and to investigate whether genetic risk is modified by pigmentation characteristics and sun exposure measures...
- The lack of a relationship between atopic dermatitis and nonmelanoma skin cancers
Michael E Ming
Department of Dermatology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
J Am Acad Dermatol 50:357-62. 2004
..Very little has been published on whether a relationship exists between atopic dermatitis (AD) and skin cancer...
- Variability in nomenclature used for nevi with architectural disorder and cytologic atypia (microscopically dysplastic nevi) by dermatologists and dermatopathologists
Department of Dermatology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
J Cutan Pathol 31:523-30. 2004
..A 1992 National Institutes of Health (NIH) Consensus Conference sought to unify nomenclature and suggested that the term "nevus with architectural disorder" be used along with a comment on melanocytic atypia...
- Thin primary cutaneous malignant melanoma: a prognostic tree for 10-year metastasis is more accurate than American Joint Committee on Cancer staging
Phyllis A Gimotty
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Oncol 22:3668-76. 2004
- The search for a chemoprevention agent effective against melanoma: considerations and challenges
Michael E Ming
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Invest Dermatol 131:1401-3. 2011
..The study by Curiel-Lewandrowski et al. reported in this issue is an important contribution to the literature, but the final verdict regarding the chemopreventive properties of NSAIDs against melanoma is yet to come...
- Regional nodal metastatic disease is the strongest predictor of survival in patients with thin vertical growth phase melanomas: a case for SLN Staging biopsy in these patients
Giorgos C Karakousis
Department of Surgery, Hospital of the University of Pennsylvania, 4th Floor Silverstein Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Ann Surg Oncol 14:1596-603. 2007
- Are en face frozen sections accurate for diagnosing margin status in melanocytic lesions?
Victor G Prieto
Dept of Pathology, Box 85, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Am J Clin Pathol 120:203-8. 2003
..1282 to 0.6615). If permanent histology is considered the "gold standard" for histologic evaluation, en face frozen sections are not suitable for accurate surgical margin assessment of melanocytic lesions...
- Psychosocial factors related to the correspondence of recipient and provider perceptions of social support among patients diagnosed with or at risk for malignant melanoma
Wendy G Lichtenthal
Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Health Psychol 8:705-19. 2003
..Male partners reported engaging in less emotional expression than female partners. Interventions might incorporate partner participation to resolve misperceptions of support and to foster factors that promote increased support...
- Eruptive disseminated Spitz nevi
Ross M Levy
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, USA
J Am Acad Dermatol 57:519-23. 2007
..We describe a unique case marked by the eruptive onset of numerous lesions posing considerable diagnostic difficulty...
- Merkel cell carcinoma
Michael S Lehrer
Department of Dermatology, Hospital of the University of Pennsylvania, 2 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
Curr Treat Options Oncol 5:195-9. 2004
..Adjuvant chemotherapy is offered to high-risk patients with local disease and to patients with metastases. Patients with distant metastases are treated with a combination of salvage chemotherapy and radiation therapy...
- Association between the anatomic distribution of melanoma and sex
Lily N Clark
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Acad Dermatol 56:768-73. 2007
..Anatomic distribution of melanoma, thought to be different between men and women, has not been studied in the United States since the 1970s, although lifestyle and clothing habits have changed since then...
- A rapidly growing nodule and dome-shaped yellow papules on the face
University of Pennsylvania, Philadelphia, USA
Arch Dermatol 141:515-20. 2005
- Predicting sentinel node status in AJCC stage I/II primary cutaneous melanoma
Laura L Kruper
Melanoma Program of the Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer 107:2436-45. 2006
- Melanoma chemoprevention
Shayla O Francis
Department of Dermatology, University of Colorado Health Sciences Center, Aurora, Colorado, USA
J Am Acad Dermatol 55:849-61. 2006
..The prognosis of advanced melanoma remains extremely poor in spite of treatment advances, emphasizing the importance of exploring additional preventive measures...
- Predictors of regional nodal disease in patients with thin melanomas
Giorgos C Karakousis
Department of Surgery, University of Pennsylvania Health System, Abramson Cancer Center, Philadelphia, Pennsylvania 19104, USA
Ann Surg Oncol 13:533-41. 2006
..In this study, we evaluated a large population of patients with thin melanoma from the pre-SLN era to identify predictors of regional nodal disease (RND) that may serve as a surrogate for SLN positivity...
- Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi
Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Dermatopathol 26:452-7. 2004
..Therefore, we investigated whether immunohistochemical staining for Melan-A and Ki-67 expression can be used to discriminate these lesions, distinguishing between epithelioid and spindle cell compartments of the lesions...
- Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas
Susan B Kesmodel
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Ann Surg Oncol 12:449-58. 2005
..We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL...
- Aggressive squamous cell carcinomas in persons infected with the human immunodeficiency virus
Department of Dermatology, University of California, San Francisco, CA 94143, USA
Arch Dermatol 138:758-63. 2002