Mark Mercola

Summary

Publications

  1. pmc Inhibition of miR-25 improves cardiac contractility in the failing heart
    Christine Wahlquist
    1 Department of Bioengineering, University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA 2
    Nature 508:531-5. 2014
  2. pmc Induced pluripotent stem cells in cardiovascular drug discovery
    Mark Mercola
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 112:534-48. 2013
  3. pmc Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment
    Wenqing Cai
    Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 27:2332-44. 2013
  4. pmc A Nodal-to-TGFβ cascade exerts biphasic control over cardiopoiesis
    Wenqing Cai
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 111:876-81. 2012
  5. pmc High content screening for modulators of cardiac differentiation in human pluripotent stem cells
    Sean Spiering
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA
    Methods Mol Biol 1263:43-61. 2015
  6. pmc Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis
    Alexandre R Colas
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Genes Dev 26:2567-79. 2012
  7. pmc Quantitative transcriptomics using designed primer-based amplification
    Vipul Bhargava
    Bioinformatics and Systems Biology Graduate Program, University of California at San Diego, La Jolla, CA, USA
    Sci Rep 3:1740. 2013
  8. pmc BAF60 A, B, and Cs of muscle determination and renewal
    Pier Lorenzo Puri
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 26:2673-83. 2012
  9. pmc Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm
    Erik Willems
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Circ Res 109:360-4. 2011
  10. pmc Cholesterol-derived glucocorticoids control early fate specification in embryonic stem cells
    Joaquim Cabral-Teixeira
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, CA, USA Graduate Program in Molecular Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA
    Stem Cell Res 15:88-95. 2015

Research Grants

Collaborators

Detail Information

Publications16

  1. pmc Inhibition of miR-25 improves cardiac contractility in the failing heart
    Christine Wahlquist
    1 Department of Bioengineering, University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA 2
    Nature 508:531-5. 2014
    ..These data reveal that increased expression of endogenous miR-25 contributes to declining cardiac function during heart failure and suggest that it might be targeted therapeutically to restore function. ..
  2. pmc Induced pluripotent stem cells in cardiovascular drug discovery
    Mark Mercola
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 112:534-48. 2013
    ..Here we review recent progress in generating induced pluripotent stem cell-based models of cardiovascular disease and their multiple applications in drug development...
  3. pmc Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment
    Wenqing Cai
    Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 27:2332-44. 2013
    ..This is the first demonstration that cues from the progenitor cell environment direct the subunit variant composition of SWI/SNF to remodel the transcriptional landscape for lineage-specific differentiation...
  4. pmc A Nodal-to-TGFβ cascade exerts biphasic control over cardiopoiesis
    Wenqing Cai
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 111:876-81. 2012
    ..The transforming growth factor-β (TGFβ) family member Nodal promotes cardiogenesis, but the mechanism is unclear despite the relevance of TGFβ family proteins for myocardial remodeling and regeneration...
  5. pmc High content screening for modulators of cardiac differentiation in human pluripotent stem cells
    Sean Spiering
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA
    Methods Mol Biol 1263:43-61. 2015
    ....
  6. pmc Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis
    Alexandre R Colas
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Genes Dev 26:2567-79. 2012
    ..These findings suggest a crucial role for the let-7 and miR-18 families in germ layer specification and reveal a remarkable conservation of function from amphibians to mammals...
  7. pmc Quantitative transcriptomics using designed primer-based amplification
    Vipul Bhargava
    Bioinformatics and Systems Biology Graduate Program, University of California at San Diego, La Jolla, CA, USA
    Sci Rep 3:1740. 2013
    ....
  8. pmc BAF60 A, B, and Cs of muscle determination and renewal
    Pier Lorenzo Puri
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 26:2673-83. 2012
    ....
  9. pmc Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm
    Erik Willems
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Circ Res 109:360-4. 2011
    ..Although the initiating step of mesoderm formation is well characterized, the subsequent steps that promote for cardiac lineages are poorly understood and limit the yield of cardiomyocytes...
  10. pmc Cholesterol-derived glucocorticoids control early fate specification in embryonic stem cells
    Joaquim Cabral-Teixeira
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, CA, USA Graduate Program in Molecular Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA
    Stem Cell Res 15:88-95. 2015
    ..These results establish a novel function for cholesterol-derived steroid hormones and identify Gcrt signaling in visceral endoderm cells as a regulator of Cer1 and cardiac fate. ..
  11. pmc Serum-free generation of multipotent mesoderm (Kdr+) progenitor cells in mouse embryonic stem cells for functional genomics screening
    Wesley L McKeithan
    Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Curr Protoc Stem Cell Biol . 2012
    ..Technical limitations, troubleshooting, and potential applications of these methods are discussed...
  12. pmc Technical variations in low-input RNA-seq methodologies
    Vipul Bhargava
    Bioinformatics and Systems Biology Graduate Program, University of California at San Diego, La Jolla, California, USA
    Sci Rep 4:3678. 2014
    ..High technical variations ultimately masked subtle biological differences mandating the development of improved amplification-based strategies for quantitative transcriptomics from limiting amounts of mRNA. ..
  13. pmc Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells
    Erik Willems
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cell Stem Cell 11:242-52. 2012
    ..ITD-1 is a highly selective TGF-β inhibitor and reveals an unexpected role for TGF-β signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors...
  14. pmc Developmental origin of age-related coronary artery disease
    Ke Wei
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA Sanford Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL 32827, USA Department of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92037, USA
    Cardiovasc Res 107:287-94. 2015
    ..Although paracrine signalling is widely believed to drive phenotypic changes in caSMCs, here we show that developmental origin within the fetal epicardium can have a profound effect as well...
  15. pmc Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
    Ke Wei
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92037, USA
    Nature 525:479-85. 2015
    ..The data suggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration would be an effective way to reverse myocardial death and remodelling following myocardial infarction in humans. ..
  16. pmc A chemical biology approach to myocardial regeneration
    Erik Willems
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Cardiovasc Transl Res 4:340-50. 2011
    ....

Research Grants1