Bikash Medhi

Summary

Publications

  1. ncbi request reprint Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice
    Bikash Medhi
    Indian J Exp Biol 48:793-9. 2010
  2. pmc Effect of esomeprazole on the pharmacokinetics of carbamazepine
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Pharmacol 43:73-5. 2011
  3. pmc Efficacy and safety of an advanced formula silicone gel for prevention of post-operative scars
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    Dermatol Ther (Heidelb) 3:157-67. 2013
  4. ncbi request reprint Comparative evaluation of different doses of PPAR-γ agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats
    Prasad Byrav D S
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Research Block B, Sector 12, PGIMER, Chandigarh, India 160012
    Pharmacol Rep 65:951-9. 2013
  5. doi request reprint Insulin resistance: an emerging link in Alzheimer's disease
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Research Block B, 4th Floor, Room No 4043, Chandigarh, 160012, India
    Neurol Sci 34:1719-25. 2013
  6. ncbi request reprint Effect of esomeprazole on pharmacokinetics of phenytoin in rabbits
    B Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Physiol Pharmacol 56:382-7. 2012
  7. ncbi request reprint Effect of aceclofenac on pharmacokinetic of phenytoin
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pak J Pharm Sci 25:295-9. 2012
  8. pmc Bacteria in cancer therapy: a novel experimental strategy
    S Patyar
    Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
    J Biomed Sci 17:21. 2010
  9. doi request reprint Comparative evaluation of different doses of green tea extract alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats
    D S Prasad Byrav
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Dig Dis Sci 56:1369-78. 2011
  10. doi request reprint Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Pharm Pharmacol 61:1359-64. 2009

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice
    Bikash Medhi
    Indian J Exp Biol 48:793-9. 2010
    ..Pioglitazone showed neuroprotection against ischemic insult suggesting the role of PPARgamma agonist in neuroprotective agents...
  2. pmc Effect of esomeprazole on the pharmacokinetics of carbamazepine
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Pharmacol 43:73-5. 2011
    ..Present study was carried out to evaluate effect of esomeprazole on the pharmacokinetics of carbamazepine in rabbits...
  3. pmc Efficacy and safety of an advanced formula silicone gel for prevention of post-operative scars
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    Dermatol Ther (Heidelb) 3:157-67. 2013
    ..The present study evaluated the safety and efficacy of an advanced formula topical silicone gel for prevention of post-operative hypertrophic and keloid scars...
  4. ncbi request reprint Comparative evaluation of different doses of PPAR-γ agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats
    Prasad Byrav D S
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Research Block B, Sector 12, PGIMER, Chandigarh, India 160012
    Pharmacol Rep 65:951-9. 2013
    ..The present study aimed to investigate the effect of different doses of pioglitazone alone and in combination with sulfasalazine in TNBS (trinitrobenzenesulfonic acid)-induced inflammatory bowel disease (IBD) in rats...
  5. doi request reprint Insulin resistance: an emerging link in Alzheimer's disease
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Research Block B, 4th Floor, Room No 4043, Chandigarh, 160012, India
    Neurol Sci 34:1719-25. 2013
    ..A relatively recent investigation finds the role of c-Jun-N-terminal kinase (JNK3) in AD which also seems to bear a link with insulin resistance. ..
  6. ncbi request reprint Effect of esomeprazole on pharmacokinetics of phenytoin in rabbits
    B Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Physiol Pharmacol 56:382-7. 2012
    ..These results suggest that esomeprazole alters the pharmacokinetics of phenytoin. Confirmation of these results in further clinical studies will warrant changes in phenytoin dose or frequency when esomeprazole is co-administered...
  7. ncbi request reprint Effect of aceclofenac on pharmacokinetic of phenytoin
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pak J Pharm Sci 25:295-9. 2012
    ..These results suggest that aceclofenac alter the pharmacokinetics of phenytoin. Confirmation of these results in human studies will warrant changes in phenytoin dose or frequency when aceclofenac is co-administered with it...
  8. pmc Bacteria in cancer therapy: a novel experimental strategy
    S Patyar
    Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
    J Biomed Sci 17:21. 2010
    ..Although it has shown successful results in vivo yet further investigation about the targeting mechanisms of the bacteria are required to make it a complete therapeutic approach in cancer treatment...
  9. doi request reprint Comparative evaluation of different doses of green tea extract alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats
    D S Prasad Byrav
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Dig Dis Sci 56:1369-78. 2011
    ..The present study was conducted to evaluate the effect of green tea in experimentally induced inflammatory bowel disease...
  10. doi request reprint Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Pharm Pharmacol 61:1359-64. 2009
    ..The aim of the study was to evaluate the correlation between colitis and susceptibility to seizures...
  11. ncbi request reprint Seasonal variation in plasma levels of lithium in the Indian population: is there a need to modify the dose?
    B Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Singapore Med J 49:724-7. 2008
    ..Variability in the lithium level can lead to lack of efficacy or toxicity, making seasonal variation clinically relevant...
  12. ncbi request reprint Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats
    B Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
    Indian J Exp Biol 46:583-90. 2008
    ..The results indicate the additive effect of Manuka honey with sulfasalazine in colitis...
  13. doi request reprint Recent advances in the pharmacotherapy of chronic anal fissure: an update
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Asian J Surg 31:154-63. 2008
    ..2% GTN ointment but was associated with fewer side effects. Other drugs that have been tried are lidocaine, the alpha-adrenergic antagonist indoramin, and the potassium channel opener minoxidil...
  14. ncbi request reprint Effects of etoricoxib on the pharmacokinetics of phenytoin
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pharmacol Rep 60:233-7. 2008
    ..These results suggest that etoricoxib alters the pharmacokinetics of phenytoin. Confirmation of these results in human studies will warrant changes in phenytoin dose or frequency when etoricoxib is co-administered with it...
  15. doi request reprint Comparative clinical trial of castor oil and diclofenac sodium in patients with osteoarthritis
    B Medhi
    Department of Pharmacology and Physical Medicine and Rehabilitation, Postgraduate Institute of Medical Education Research, Chandigarh and All India Institute of Medical Sciences, New Delhi, India
    Phytother Res 23:1469-73. 2009
    ..The present study indicates that castor oil can be used as an effective therapy in primary knee osteoarthritis...
  16. doi request reprint Effect of different doses of thalidomide in experimentally induced inflammatory bowel disease in rats
    Om Prakash
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Basic Clin Pharmacol Toxicol 103:9-16. 2008
    ..001). Our results indicate efficacy of thalidomide in TNBS induce experimental colitis model in rats but present findings requires further investigation to establish the real safety and efficacy in human beings...
  17. ncbi request reprint Effects of artemisinin, artemether, and arteether on the pharmacokinetics of phenytoin
    M Sukhija
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Methods Find Exp Clin Pharmacol 28:89-94. 2006
    ..Confirmation of these results in human studies will warrant changes in phenytoin dose or frequency, when either of these antimalarials is coadministered with it...
  18. doi request reprint Neuroprotective effect of progesterone on acute phase changes induced by partial global cerebral ischaemia in mice
    Raman Aggarwal
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Pharm Pharmacol 60:731-7. 2008
    ..The results demonstrate the neuroprotective effect of progesterone against ischaemic insult, suggesting a role for the steroid as a neuroprotective agent...
  19. ncbi request reprint Effects of artemisinin, artemether, arteether on the pharmacokinetics of carbamazepine
    Manpreet Sukhija
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pharmacology 76:110-6. 2006
    ..Confirmation of these results in human studies will warrant changes in carbamazepine dose or frequency when either of these antimalarials is co-administered with it...
  20. doi request reprint Correlation of seizures and biochemical parameters of oxidative stress in experimentally induced inflammatory rat models
    Ramya S Rao
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research PIGMER, Chandigarh 160012, India
    Fundam Clin Pharmacol 24:325-31. 2010
    ..As it increased lipid peroxidation and reduced SOD and GPx, further evaluation is necessary with respect to oxidative stress...
  21. ncbi request reprint Antiepileptic TDM pattern at a tertiary care hospital in India
    Vinu Mulavarickal Jose
    Department of Pharmacology, Postgraduate Institute of Medical, Education and Research, Chandigarh, India
    Nepal Med Coll J 8:107-10. 2006
    ..The number of abnormal values of phenytoin, phenobarbitone and carbamazepine did not show any significant difference over the years. The pattern was similar to that observed in other countries...
  22. doi request reprint Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice
    Nimisha Sood
    Department of Pharmacology, Indira Gandhi Medical College, Shimla, 171001, India
    J Biomed Sci 15:755-65. 2008
    ..The study bears significant clinical relevance particularly amongst epileptic smokers who may show failure of efficacy of antiepileptic agents and present with breakthrough seizure attacks on exposure to nicotine...
  23. doi request reprint Pharmacokinetic and toxicological profile of artemisinin compounds: an update
    Bikash Medhi
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India drbikashus yahoo com
    Pharmacology 84:323-32. 2009
    ..Moreover, it occurs in humans at very high doses. However, as a matter of precaution, the use of artemisinins in the first trimester of pregnancy has been contraindicated...
  24. doi request reprint Effect of mesenchymal stem cells and galantamine nanoparticles in rat model of Alzheimer's disease
    Shubham Misra
    Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
    Regen Med 11:629-46. 2016
    ....
  25. ncbi request reprint Role of vinpocetine in cerebrovascular diseases
    Sazal Patyar
    Department of Pharmacology and Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Chandigarh, India
    Pharmacol Rep 63:618-28. 2011
    ..This vasoactive alkaloid is widely marketed as a supplement for vasodilation and as a nootropic for the improvement of memory. The present review focuses on studies investigating the role of vinpocetine in cerebrovascular diseases...
  26. doi request reprint Dual inhibition: a novel promising pharmacological approach for different disease conditions
    Sazal Patyar
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, Delhi, India
    J Pharm Pharmacol 63:459-71. 2011
    ..This review article focuses on the conventional drugs used in different diseases which possess dual inhibition activity as well as those which are still in the preclinical/clinical phase...
  27. doi request reprint Granulocyte colony stimulating factor (GCSF) improves memory and neurobehavior in an amyloid-β induced experimental model of Alzheimer's disease
    Ajay Prakash
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Pharmacol Biochem Behav 110:46-57. 2013
    ..The present findings demonstrate an improvement of memory and neurobehavioral function with GCSF in Aβ-induced Alzheimer's disease model in rats...
  28. ncbi request reprint Lacosamide, a newer antiepileptic
    Sazal Patyar
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Neurosciences (Riyadh) 15:3-6. 2010
    ..Other potential indications of LCM are being investigated...
  29. doi request reprint Short-course of prednisolone in solitary cysticercus granuloma: a randomized, double-blind, placebo-controlled trial
    Monika Singla
    Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Epilepsia 52:1914-7. 2011
    ..To determine the effect of administration of a short course of prednisolone on seizure and radiologic outcome in patients with solitary cysticercus granuloma (SCG)...
  30. ncbi request reprint Longterm efficacy of topical nonsteroidal antiinflammatory drugs in knee osteoarthritis: metaanalysis of randomized placebo controlled clinical trials
    Shibadas Biswal
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Rheumatol 33:1841-4. 2006
    ..To evaluate the longterm efficacy of topical therapies for pain control in primary knee osteoarthritis (OA)...
  31. doi request reprint Effects of preoperative statin on liver reperfusion injury in major hepatic resection: a pilot study
    Shashwat Sarin
    Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India
    Updates Surg 68:191-7. 2016
    ..011) (p = 0.096) and (p = 0.237), respectively. Statins have the potential for pharmacological prevention of IRI. Further studies would be needed to substantiate the role of statins in prevention of IRI during liver resection...
  32. doi request reprint Galantamine-loaded solid-lipid nanoparticles for enhanced brain delivery: preparation, characterization, in vitro and in vivo evaluations
    Shubham Misra
    a Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
    Drug Deliv 23:1434-43. 2016
    ..Hence, the galantamine hydrobromide-loaded solid-lipid nanoparticles can be a promising vehicle for safe and effective delivery especially in disease like Alzheimer's. ..
  33. doi request reprint Potential of metabolomics in preclinical and clinical drug development
    Baldeep Kumar
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    Pharmacol Rep 66:956-63. 2014
    ..Metabolomics potentially offers an effective route to address all the issues associated with the drug discovery and development. ..
  34. pmc Granulocyte-colony stimulating factor improves Parkinson's disease associated with co-morbid depression: an experimental exploratory study
    Ajay Prakash
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Pharmacol 45:612-5. 2013
    ..PD is very difficult to treat. Hence, the present study was aimed to evaluate the effect of G-CSF in PD associated with depression...
  35. ncbi request reprint Drug therapy in autism: a present and future perspective
    Baldeep Kumar
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Pharmacol Rep 64:1291-304. 2012
    ..New classes of drugs with novel mechanisms of action should be there so that this disorder will become less prevalent in the future...
  36. ncbi request reprint Natural product and drugs interactions, its clinical implication in drug therapy management
    Rupa Joshi
    Department of Clinical Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Saudi Med J 29:333-9. 2008
    ..In this review, we describe details of drugs interaction with natural products and its impact on drug therapy management...
  37. ncbi request reprint Comparative study of low pressure versus standard pressure pneumoperitoneum in laparoscopic cholecystectomy--a randomised controlled trial
    Deepaesh Benjamin Kanwer
    Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
    Trop Gastroenterol 30:171-4. 2009
    ..Our study proposes to compare the use of low pressure pneumoperitoneum with the use of standard pressure pneumoperitoneum...
  38. doi request reprint Use of Bacteria in Cancer Therapy
    Pooja Sarotra
    Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India
    Recent Results Cancer Res 209:111-121. 2016
    ..The biosafety, genetic instability and the confounded interaction of the bacteria with treatment drugs, requires the more noteworthy consideration regarding the use of this novel treatment in the cancer treatment...
  39. pmc Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective
    Shringika Soni
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India
    Adv Pharm Bull 6:319-335. 2016
    ..But still, understanding of their toxicity level, optimization and standardization are a long way to go...
  40. pmc Effect of mesenchymal stem cells transplantation on glycaemic profile & their localization in streptozotocin induced diabetic Wistar rats
    Shobhit Bhansali
    Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Med Res 142:63-71. 2015
    ..This study examines the effect of high dose and multiple injections of MSCs on glycemic profile, their localization and regeneration of islet in diabetic Wistar rat...
  41. doi request reprint Forensic pharmacovigilance: Newer dimension of pharmacovigilance
    Rakesh K Sewal
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India
    J Forensic Leg Med 34:113-8. 2015
    ..Evidence based practice e.g. testing the biological samples for the presence of drugs may prove to be pivotal in the success of this collaboration of sciences. ..
  42. doi request reprint Status of colorectal cancer devices: present scenario
    Shammy Chandel
    Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India
    J Gastrointest Cancer 46:91-103. 2015
    ..The purpose of this study was the colonoscopic detection and removal of neoplasia from the colorectum to prevent the development of colorectal cancer...
  43. doi request reprint Comparison of the efficacy of chlorhexidine gluconate versus povidone iodine as preoperative skin preparation for the prevention of surgical site infections in clean-contaminated upper abdominal surgeries
    Anirudh Srinivas
    Department of General Surgery, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh, 160012, India
    Surg Today 45:1378-84. 2015
    ..To compare the efficacy of chlorhexidine-gluconate versus povidone iodine in preoperative skin preparation in the prevention of surgical site infections (SSIs) in clean-contaminated upper abdominal surgeries...
  44. doi request reprint Current scenario in inflammatory bowel disease: drug development prospects
    Shammy Chandel
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pharmacol Rep 67:224-9. 2015
    ..So that the thoroughly development of drug candidates and study design of clinical trials is done...
  45. doi request reprint Advances in drug development for Parkinson's disease: present status
    Dibbanti Harikrishna Reddy
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pharmacology 93:260-71. 2014
    ..The aim of the present review is to give an overview of the neuroprotective agents and their targets currently investigated for the treatment of PD in phase I-III clinical trials...
  46. doi request reprint Drug development status for Alzheimer's disease: present scenario
    Shubham Misra
    Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
    Neurol Sci 34:831-9. 2013
    ....
  47. doi request reprint Drug therapy in stroke: from preclinical to clinical studies
    Harjeet Kaur
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pharmacology 92:324-34. 2013
    ..The basic aim of neuroprotection is to interfere with the events of the ischemic cascade, halt the pathological processes and prevent the death of vulnerable nerve cells in the ischemic penumbra...
  48. pmc Comparison of observational and controlled clinical trials of diltiazem in the treatment of chronic anal fissure
    Bikash Medhi
    Department of Pharmacology and General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India Department of Clinical Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Surg 73:427-31. 2011
    ....