Ivan F McMurtry

Summary

Publications

  1. doi request reprint Rho kinase-mediated vasoconstriction in pulmonary hypertension
    Ivan F McMurtry
    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, 36688, USA
    Adv Exp Med Biol 661:299-308. 2010
  2. pmc Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats
    Michie Toba
    Department of Pharmacology, University of South Alabama, Mobile, Alabama
    Am J Physiol Heart Circ Physiol 306:H243-50. 2014
  3. doi request reprint Tyrosine kinase inhibitors are potent acute pulmonary vasodilators in rats
    Kohtaro Abe
    Department of Pharmacology, University of South Alabama, Mobile, Alabama, USA
    Am J Respir Cell Mol Biol 45:804-8. 2011
  4. doi request reprint Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension
    Abdallah Alzoubi
    Department of Pharmacology, University of South Alabama, Mobile, AL 36688, USA
    Am J Physiol Heart Circ Physiol 304:H1708-18. 2013
  5. doi request reprint Serotonin passes through myoendothelial gap junctions to promote pulmonary arterial smooth muscle cell differentiation
    Salina Gairhe
    Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, Alabama, USA
    Am J Physiol Lung Cell Mol Physiol 303:L767-77. 2012
  6. doi request reprint TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension
    Abdallah Alzoubi
    Department of Pharmacology, Jordan University of Science and Technology, Irbid, Jordan Department of Pharmacology, University of South Alabama, Mobile, Alabama Center for Lung Biology, University of South Alabama, Mobile, Alabama
    Am J Pathol 183:1779-88. 2013
  7. doi request reprint Formation of plexiform lesions in experimental severe pulmonary arterial hypertension
    Kohtaro Abe
    Department of Pharmacology, Center for Lung Biology, University of South Alabama, AL, USA
    Circulation 121:2747-54. 2010
  8. pmc Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension
    Salina Gairhe
    Departments of Internal Medicine and Pharmacology, College of Medicine, University of South Alabama, Mobile, Alabama, USA Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, Alabama, USA
    Pulm Circ 6:369-80. 2016
  9. pmc S1P(4) receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs
    Hiroki Ota
    Department of Pharmacology and Internal Medicine, and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, Alabama, USA
    Pulm Circ 1:399-404. 2011
  10. pmc Chronic hypoxia does not cause wall thickening of intra-acinar pulmonary supernumerary arteries
    Kaori Oshima
    Department of Pharmacology, University of South Alabama, Mobile, Alabama Center for Lung Biology, University of South Alabama, Mobile, Alabama
    Physiol Rep 4:. 2016

Collaborators

Detail Information

Publications13

  1. doi request reprint Rho kinase-mediated vasoconstriction in pulmonary hypertension
    Ivan F McMurtry
    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, 36688, USA
    Adv Exp Med Biol 661:299-308. 2010
    ..We suspect the same will be true in at least some forms of human pulmonary arterial hypertension...
  2. pmc Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats
    Michie Toba
    Department of Pharmacology, University of South Alabama, Mobile, Alabama
    Am J Physiol Heart Circ Physiol 306:H243-50. 2014
    ....
  3. doi request reprint Tyrosine kinase inhibitors are potent acute pulmonary vasodilators in rats
    Kohtaro Abe
    Department of Pharmacology, University of South Alabama, Mobile, Alabama, USA
    Am J Respir Cell Mol Biol 45:804-8. 2011
    ..Vascular smooth muscle relaxation mediated via activation of myosin light chain phosphatase (Ca(2+) desensitization) appears to play a role in the imatinib-induced pulmonary vasodilation...
  4. doi request reprint Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension
    Abdallah Alzoubi
    Department of Pharmacology, University of South Alabama, Mobile, AL 36688, USA
    Am J Physiol Heart Circ Physiol 304:H1708-18. 2013
    ..The antioxidant activity of DHEA, by depleting NADPH, plays a central role in these cardioprotective effects...
  5. doi request reprint Serotonin passes through myoendothelial gap junctions to promote pulmonary arterial smooth muscle cell differentiation
    Salina Gairhe
    Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, Alabama, USA
    Am J Physiol Lung Cell Mol Physiol 303:L767-77. 2012
    ..This finding suggests a novel role of gap junction-mediated intercellular serotonin signaling in regulation of PASMC phenotype...
  6. doi request reprint TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension
    Abdallah Alzoubi
    Department of Pharmacology, Jordan University of Science and Technology, Irbid, Jordan Department of Pharmacology, University of South Alabama, Mobile, Alabama Center for Lung Biology, University of South Alabama, Mobile, Alabama
    Am J Pathol 183:1779-88. 2013
    ..TRPC4 inactivation therefore provides a survival benefit in severe PAH, associated with a decrease in the magnitude of occlusive remodeling...
  7. doi request reprint Formation of plexiform lesions in experimental severe pulmonary arterial hypertension
    Kohtaro Abe
    Department of Pharmacology, Center for Lung Biology, University of South Alabama, AL, USA
    Circulation 121:2747-54. 2010
    ..This study investigated whether rats with severe progressive pulmonary hypertension developed plexiform lesions...
  8. pmc Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension
    Salina Gairhe
    Departments of Internal Medicine and Pharmacology, College of Medicine, University of South Alabama, Mobile, Alabama, USA Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, Alabama, USA
    Pulm Circ 6:369-80. 2016
    ..Our study supports that S1P is involved in the pathogenesis of occlusive arteriopathy in PAH and provides further evidence that S1P signaling may be a novel therapeutic target. ..
  9. pmc S1P(4) receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs
    Hiroki Ota
    Department of Pharmacology and Internal Medicine, and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, Alabama, USA
    Pulm Circ 1:399-404. 2011
    ....
  10. pmc Chronic hypoxia does not cause wall thickening of intra-acinar pulmonary supernumerary arteries
    Kaori Oshima
    Department of Pharmacology, University of South Alabama, Mobile, Alabama Center for Lung Biology, University of South Alabama, Mobile, Alabama
    Physiol Rep 4:. 2016
    ..These findings are consistent with the idea that hemodynamic stress, rather than hypoxia alone, is the cause of structural remodeling during chronic exposure to hypoxia. ..
  11. pmc Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension
    Jared M McLendon
    Department of Biochemistry and Molecular Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA Center for Lung Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA Electronic address
    J Control Release 210:67-75. 2015
    ..The results establish effective and low toxicity of lung delivery of a miRNA-145 inhibitor using functionalized cationic lipopolyamine nanoparticles to repair pulmonary arteriopathy and improve cardiac function in rats with severe PAH. ..
  12. doi request reprint Myoendothelial gap junctional signaling induces differentiation of pulmonary arterial smooth muscle cells
    Salina Gairhe
    Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, 36688, USA
    Am J Physiol Lung Cell Mol Physiol 301:L527-35. 2011
    ....
  13. pmc Activation of glucose-6-phosphate dehydrogenase promotes acute hypoxic pulmonary artery contraction
    Rakhee S Gupte
    Department of Biochemistry and Molecular Biology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    J Biol Chem 285:19561-71. 2010
    ....