Andrew J McLachlan

Summary

Publications

  1. pmc Clinical pharmacology of chemotherapy agents in older people with cancer
    Xiaoye He
    Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Curr Gerontol Geriatr Res 2011:628670. 2011
  2. pmc Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment
    Andrew J McLachlan
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia
    Br J Clin Pharmacol 71:351-64. 2011
  3. doi Drug metabolism in older people--a key consideration in achieving optimal outcomes with medicines
    Andrew J McLachlan
    Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    J Gerontol A Biol Sci Med Sci 67:175-80. 2012
  4. ncbi Generic medicines literacy - minimising the potential for patient confusion
    Andrew J McLachlan
    Faculty of Pharmacy, University of Sydney, and Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Sydney, NSW, Australia
    Med J Aust 192:368-9. 2010
  5. pmc PACE--the first placebo controlled trial of paracetamol for acute low back pain: statistical analysis plan
    Christopher M Williams
    The George Institute for Global Health and Sydney Medical School, University of Sydney, PO Box M201, Missenden Rd, 2040 Camperdown, NSW, Australia
    Trials 14:248. 2013
  6. pmc Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
    Xuemin Jiang
    Faculty of Pharmacy, The University of Sydney, NSW, Australia
    Br J Clin Pharmacol 59:425-32. 2005
  7. pmc PACE--the first placebo controlled trial of paracetamol for acute low back pain: design of a randomised controlled trial
    Christopher M Williams
    The George Institute for International Health, University of Sydney, PO Box M201 Missenden Rd, Camperdown, NSW 2040, Australia
    BMC Musculoskelet Disord 11:169. 2010
  8. ncbi Plasma protein distribution and its impact on pharmacokinetics of liposomal amphotericin B in paediatric patients with malignant diseases
    Ying Hong
    Faculty of Pharmacy, University of Sydney, Pharmacy Building A15, Sydney, NSW 2006, Australia
    Eur J Clin Pharmacol 63:165-72. 2007
  9. pmc PRECISE - pregabalin in addition to usual care for sciatica: study protocol for a randomised controlled trial
    Stephanie Mathieson
    The George Institute for Global Health and Sydney Medical School, University of Sydney, PO Box M201, Missenden Rd, Camperdown, Sydney, NSW 2050, Australia
    Trials 14:213. 2013
  10. pmc Multicenter study of posaconazole therapeutic drug monitoring: exposure-response relationship and factors affecting concentration
    Michael J Dolton
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Antimicrob Agents Chemother 56:5503-10. 2012

Detail Information

Publications85

  1. pmc Clinical pharmacology of chemotherapy agents in older people with cancer
    Xiaoye He
    Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Curr Gerontol Geriatr Res 2011:628670. 2011
    ..These issues highlight the need to individualize the management of cancer in the older people with consideration of age-related changes in the clinical pharmacology of cancer drugs, analgesics, and adjunctive therapies...
  2. pmc Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment
    Andrew J McLachlan
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia
    Br J Clin Pharmacol 71:351-64. 2011
    ....
  3. doi Drug metabolism in older people--a key consideration in achieving optimal outcomes with medicines
    Andrew J McLachlan
    Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    J Gerontol A Biol Sci Med Sci 67:175-80. 2012
    ..There is growing evidence that the age-related changes in the liver not only result in a decrease in the hepatic clearance of unbound drug but also influence variability in response to medicines in older people...
  4. ncbi Generic medicines literacy - minimising the potential for patient confusion
    Andrew J McLachlan
    Faculty of Pharmacy, University of Sydney, and Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Sydney, NSW, Australia
    Med J Aust 192:368-9. 2010
    ..For generic substitution to be safe, consumers and clinicians need to fully understand what is the same or different about various brands of the same medicine...
  5. pmc PACE--the first placebo controlled trial of paracetamol for acute low back pain: statistical analysis plan
    Christopher M Williams
    The George Institute for Global Health and Sydney Medical School, University of Sydney, PO Box M201, Missenden Rd, 2040 Camperdown, NSW, Australia
    Trials 14:248. 2013
    ..The PACE trial is the first placebo controlled trial of paracetamol for acute low back pain. This article describes the statistical analysis plan...
  6. pmc Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
    Xuemin Jiang
    Faculty of Pharmacy, The University of Sydney, NSW, Australia
    Br J Clin Pharmacol 59:425-32. 2005
    ..The aim of this study was to investigate the effect of two common herbal medicines, ginkgo and ginger, on the pharmacokinetics and pharmacodynamics of warfarin and the independent effect of these herbs on clotting status...
  7. pmc PACE--the first placebo controlled trial of paracetamol for acute low back pain: design of a randomised controlled trial
    Christopher M Williams
    The George Institute for International Health, University of Sydney, PO Box M201 Missenden Rd, Camperdown, NSW 2040, Australia
    BMC Musculoskelet Disord 11:169. 2010
    ..A secondary aim is to determine if ingesting paracetamol in a time-contingent manner is more effective than paracetamol taken when required (PRN) for recovery from acute LBP...
  8. ncbi Plasma protein distribution and its impact on pharmacokinetics of liposomal amphotericin B in paediatric patients with malignant diseases
    Ying Hong
    Faculty of Pharmacy, University of Sydney, Pharmacy Building A15, Sydney, NSW 2006, Australia
    Eur J Clin Pharmacol 63:165-72. 2007
    ..This study investigates the association of liposomal amphotericin B (L-AmB) with plasma proteins and its impact on the pharmacokinetics of L-AmB in paediatric patients with malignant diseases...
  9. pmc PRECISE - pregabalin in addition to usual care for sciatica: study protocol for a randomised controlled trial
    Stephanie Mathieson
    The George Institute for Global Health and Sydney Medical School, University of Sydney, PO Box M201, Missenden Rd, Camperdown, Sydney, NSW 2050, Australia
    Trials 14:213. 2013
    ..Our objectives are to determine the efficacy of pregabalin on reducing leg pain intensity and its cost-effectiveness in patients with sciatica...
  10. pmc Multicenter study of posaconazole therapeutic drug monitoring: exposure-response relationship and factors affecting concentration
    Michael J Dolton
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Antimicrob Agents Chemother 56:5503-10. 2012
    ..01). Low posaconazole concentrations are common and are associated with breakthrough fungal infection, supporting the utility of monitoring posaconazole concentrations to ensure optimal systemic exposure...
  11. doi The influence of old age and poloxamer-407 on the hepatic disposition of diazepam in the isolated perfused rat liver
    Sarah J Mitchell
    Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, NSW, Australia
    Pharmacology 90:233-41. 2012
    ..We hypothesized that defenestration will reduce the hepatic extraction of drugs which are highly bound to albumin...
  12. pmc The pharmacokinetics of oxypurinol in people with gout
    Sophie L Stocker
    Faculty of Pharmacy, University of Sydney, NSW, Australia
    Br J Clin Pharmacol 74:477-89. 2012
    ..Our aim was to identify and quantify the sources of variability in oxypurinol pharmacokinetics and explore relationships with plasma urate concentrations...
  13. pmc Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects
    Mohi Iqbal Mohammed Abdul
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
    Br J Clin Pharmacol 69:508-15. 2010
    ..This study investigated the pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects...
  14. ncbi Investigation of the effects of herbal medicines on warfarin response in healthy subjects: a population pharmacokinetic-pharmacodynamic modeling approach
    Xuemin Jiang
    Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
    J Clin Pharmacol 46:1370-8. 2006
    ..None of the herbs studied had a direct effect on warfarin pharmacodynamics. Studies in anticoagulated patients are warranted to assess the clinical significance of these herb-drug interactions...
  15. ncbi Epidural corticosteroid injections in the management of sciatica: a systematic review and meta-analysis
    Rafael Zambelli Pinto
    The George Institute for Global Health, Sydney Medical School, University of Sydney, Sydney, Australia
    Ann Intern Med 157:865-77. 2012
    ..Key limitations of existing reviews are the inclusion of trials with active controls of unknown efficacy and failure to provide an estimate of the size of the treatment effect...
  16. pmc Multicenter study of voriconazole pharmacokinetics and therapeutic drug monitoring
    Michael J Dolton
    Faculty of Pharmacy, University of Sydney, Camperdown, Australia
    Antimicrob Agents Chemother 56:4793-9. 2012
    ..Coadministration of glucocorticoids was found to significantly reduce voriconazole concentrations, inferring a previously unreported drug interaction between glucocorticoids and voriconazole...
  17. ncbi Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in healthy subjects
    Sophie L Stocker
    Faculty of Pharmacy, University of Sydney, Department of Clinical Pharmacology and Toxicology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Clin Pharmacokinet 47:111-8. 2008
    ..The objective of this study was to investigate the pharmacokinetics and hypouricaemic effect of oxypurinol (the active metabolite of allopurinol) and probenecid when administered alone and in combination in healthy subjects...
  18. doi Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout
    Sophie L Stocker
    Department of Clinical Pharmacology, St Vincent s Hospital, NSW 2010, Sydney, Australia
    J Rheumatol 38:904-10. 2011
    ..To investigate the pharmacokinetic and pharmacodynamic interaction between probenecid and oxypurinol (the active metabolite of allopurinol) in patients with gout...
  19. ncbi Assessment of diclofenac or spinal manipulative therapy, or both, in addition to recommended first-line treatment for acute low back pain: a randomised controlled trial
    Mark J Hancock
    Back Pain Research Group, University of Sydney, Sydney, Australia
    Lancet 370:1638-43. 2007
    ..We aimed to investigate whether the addition of non-steroidal anti-inflammatory drugs or spinal manipulative therapy, or both, would result in faster recovery for patients with acute low back pain receiving recommended first-line care...
  20. pmc PRECISE - pregabalin in addition to usual care: statistical analysis plan
    Stephanie Mathieson
    The George Institute for Global Health and Sydney Medical School, University of Sydney, P O Box M201, Missenden Road, Sydney, NSW, 2050, Australia
    Trials 17:53. 2016
    ..Sciatica is a severe, disabling condition that lacks high quality evidence for effective treatment strategies. This a priori statistical analysis plan describes the methodology of analysis for the PRECISE study...
  21. doi Diurnal variation in CYP1A2 enzyme activity in South Asians and Europeans
    Vidya Perera
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia
    J Pharm Pharmacol 65:264-70. 2013
    ..Response to some medications can depend on time of administration throughout the day. This study investigated diurnal variation in cytochrome P450 1A2 (CYP1A2) activity in people of South Asian and European ancestry...
  22. ncbi Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: effect of induction by rifampin and ethnicity
    Katarzyna K Loboz
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Clin Pharmacol Ther 80:75-84. 2006
    ....
  23. doi Can predictors of response to NSAIDs be identified in patients with acute low back pain?
    Mark J Hancock
    Back Pain Research Group, Faculty of Health Sciences, University of Sydney, NSW, Australia
    Clin J Pain 25:659-65. 2009
    ....
  24. doi Anticholinergic activity of commonly prescribed medications and neuropsychiatric adverse events in older people
    Prasad S Nishtala
    Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
    J Clin Pharmacol 49:1176-84. 2009
    ....
  25. doi Determinants of antipsychotic medication use among older people living in aged care homes in Australia
    Prasad S Nishtala
    Faculty of Pharmacy, The University of Sydney, NSW, Australia
    Int J Geriatr Psychiatry 25:449-57. 2010
    ..To investigate determinants of antipsychotic medication use among older people living in aged care homes in Australia...
  26. doi Determinants of antidepressant medication prescribing in elderly residents of aged care homes in Australia: a retrospective study
    Prasad S Nishtala
    Faculty of Pharmacy, The University of Sydney, Sydney, Australia
    Am J Geriatr Pharmacother 7:210-9. 2009
    ..Depression is underrecognized and poorly treated among older people living in aged care homes worldwide. Depression has been associated with higher rates of recurrence, disability, and death in older people...
  27. doi Low back pain and best practice care: A survey of general practice physicians
    Christopher M Williams
    The George Institute for International Health, Camperdown, NSW, Australia
    Arch Intern Med 170:271-7. 2010
    ..We aimed to describe the usual care provided by general practitioners (GPs) and to compare this with recommendations of best practice in international evidence-based guidelines for the management of acute LBP...
  28. doi Measurement of urinary oxypurinol by high performance liquid chromatography-tandem mass spectrometry
    Sophie L Stocker
    Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 878:2363-8. 2010
    ..The method was suitable for the quantification of oxypurinol in the urine of patients (n=34) participating in a clinical trial to optimize therapy of gout with allopurinol...
  29. doi Pharmacokinetics of caffeine in plasma and saliva, and the influence of caffeine abstinence on CYP1A2 metrics
    Vidya Perera
    Faculty of Pharmacy, The University of Sydney, NSW, Australia
    J Pharm Pharmacol 63:1161-8. 2011
    ..To investigate the utility of metrics of CYP1A2 activity using caffeine as a probe, and saliva and plasma sampling with or without a 24-h caffeine abstinence...
  30. ncbi Hepatobiliary disposition of liposomal amphotericin B in the isolated perfused rat liver
    Ying Hong
    Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
    J Pharm Sci 94:169-76. 2005
    ....
  31. doi Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial
    Christopher M Williams
    The George Institute for Global Health, Sydney Medical School, University of Sydney, Camperdown, NSW, Australia Hunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia Electronic address
    Lancet 384:1586-96. 2014
    ..We aimed to assess the efficacy of paracetamol taken regularly or as-needed to improve time to recovery from pain, compared with placebo, in patients with low-back pain...
  32. doi A pharmacometric approach to investigate the impact of methylxanthine abstinence and caffeine consumption on CYP1A2 activity
    Vidya Perera
    School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York V P, A F, S A O Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia V P, A S G, A J M Centre for Research and Education on Ageing, Concord Hospital, Concord, New South Wales, Australia V P, A J M Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline R and D, Sydney, New South Wales, Australia A S G School of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia C B L and Clinical Pharmacology and Pharmacometrics, AstraZeneca Pharmaceuticals, Wilmington, Delaware H X
    Drug Metab Dispos 41:1957-66. 2013
    ..48 (5.62-15.33 l/h)] compared with the no MA period [6.30 (3.40-9.20 l/h)] (P < 0.05). The decrease in CL in the no MA period among HCC appears to be due to alternative caffeine elimination pathways, rather than CYP1A2. ..
  33. pmc Population pharmacokinetics of liposomal amphotericin B in pediatric patients with malignant diseases
    Ying Hong
    Faculty of Pharmacy, Pharmacy Building A15, Camperdown Campus, University of Sydney, Sydney, NSW 2006, Australia
    Antimicrob Agents Chemother 50:935-42. 2006
    ..The model has been evaluated and can be used in the design of rational dosing strategies for L-AmB antifungal therapy in this special population...
  34. doi An update on ethnic differences in drug metabolism and toxicity from anti-cancer drugs
    Viet Hong Phan
    The University of Sydney, Concord Repatriation General Hospital, Sydney Cancer Centre, Concord, NSW, Sydney, Australia
    Expert Opin Drug Metab Toxicol 7:1395-410. 2011
    ..Ultimately, this will promote improved understanding of inter-individual differences in the pharmacokinetics and tolerance of cytotoxic drugs...
  35. doi A retrospective study of drug-related problems in Australian aged care homes: medication reviews involving pharmacists and general practitioners
    Prasad S Nishtala
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia
    J Eval Clin Pract 17:97-103. 2011
    ..Drug-related problems (DRPs) in Australian aged care homes have been studied previously. However, little is known about the acceptance and implementation of pharmacists' recommendations by general practitioners (GPs) to resolve DRPs...
  36. doi Atrial fibrillation screening in pharmacies using an iPhone ECG: a qualitative review of implementation
    Nicole Lowres
    Cardiology Department, Concord Repatriation General Hospital, Hospital Road, Concord, Sydney, NSW, 2137, Australia
    Int J Clin Pharm 37:1111-20. 2015
    ..Atrial fibrillation guidelines advocate screening to identify undiagnosed atrial fibrillation. Community pharmacies may provide an opportunistic venue for such screening...
  37. pmc Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials
    Gustavo C Machado
    The George Institute for Global Health, Sydney Medical School, University of Sydney, Sydney, NSW 2000, Australia
    BMJ 350:h1225. 2015
    ..To investigate the efficacy and safety of paracetamol (acetaminophen) in the management of spinal pain and osteoarthritis of the hip or knee...
  38. doi Nonsteroidal anti-inflammatory drugs (NSAIDs) in older people: prescribing patterns according to pain prevalence and adherence to clinical guidelines
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia Centre for Education and Research on Ageing and Concord RG Hospital, Sydney, NSW, Australia Electronic address
    Pain 155:1814-20. 2014
    ..This difference between the guideline recommendations and what is happening in the real world should be explored further...
  39. ncbi Loperamide inhibits the biliary excretion of irinotecan (CPT-11) in the rat isolated perfused liver
    Peter J Tobin
    Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    J Pharm Pharmacol 57:39-45. 2005
    ..Loperamide appeared to selectively inhibit the biliary excretion of CPT-11, although the extent to which loperamide altered the disposition of CPT-11 in the clinical setting remains to be determined...
  40. ncbi Ethnic differences in drug metabolism and toxicity from chemotherapy
    Viet Hong Phan
    Concord Repatriation General Hospital, ANZAC Research Institute, Department of Medicine and Cancer Pharmacology Unit, Concord, NSW, Australia
    Expert Opin Drug Metab Toxicol 5:243-57. 2009
    ....
  41. pmc High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level
    Danijela Gnjidic
    Faculty of Pharmacy, University of Sydney, Bank Building A15, Science Rd, Sydney, NSW, Australia
    BMC Public Health 13:115. 2013
    ..The aims of this project are to determine the prevalence, risk factors, clinical consequences, and costs of high risk prescribing, and to assess the impact of interventions on high risk prescribing in older people...
  42. ncbi Measurement of CYP1A2 activity: a focus on caffeine as a probe
    Vidya Perera
    Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
    Curr Drug Metab 13:667-78. 2012
    ..This review aims to discuss the various CYP1A2 matrices and metrics with a particular focus on unresolved methodological issues...
  43. doi Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma
    Vidya Perera
    Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
    Biomed Chromatogr 24:1136-44. 2010
    ..The assay developed is a robust, simple and precise technique to measure caffeine and paraxanthine in saliva and plasma of healthy volunteers after a single oral dose of caffeine...
  44. doi Characterizing specialized compounding in community pharmacies
    Jennifer Anne Giam
    Faculty of Pharmacy, The University of Sydney, Pharmacy Building A15, Sydney, NSW 2006, Australia
    Res Social Adm Pharm 8:240-52. 2012
    ..Compounding is now increasingly offered by community pharmacies as a specialized service, and there are calls for regulatory and practice standard changes. However, the characteristics of specialized compounding are not well understood...
  45. doi A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients
    Sussan Ghassabian
    Faculty of Pharmacy, University of Sydney, Camperdown, New South Wales, Australia
    Ther Drug Monit 31:239-46. 2009
    ..The simultaneous assay of all these analytes in a single matrix (plasma) will increase the feasibility of CYP phenotyping in patients...
  46. doi Impact of residential medication management reviews on drug burden index in aged-care homes: a retrospective analysis
    Prasad S Nishtala
    Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
    Drugs Aging 26:677-86. 2009
    ..Accredited clinical pharmacists performing medication reviews could consider including the DBI in their medication reviews to optimize prescribing in older people...
  47. pmc Population pharmacokinetics of melphalan in patients with multiple myeloma undergoing high dose therapy
    Christa E Nath
    The Children s Hospital at Westmead, Sydney, NSW, Australia
    Br J Clin Pharmacol 69:484-97. 2010
    ....
  48. ncbi Stereoselective analysis of hydroxybupropion and application to drug interaction studies
    Hongmei Xu
    Faculty of Pharmacy, University of Sydney, Australia
    Chirality 19:163-70. 2007
    ....
  49. pmc Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats
    Sarah J Mitchell
    Laboratory of Ageing and Pharmacology, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, Australia
    J Gerontol A Biol Sci Med Sci 66:400-8. 2011
    ..Age-related pseudocapillarization of the liver sinusoid resulted in increased acetaminophen recovery and decreased transfer of acetaminophen into the liver...
  50. pmc Optimal sampling of antipsychotic medicines: a pharmacometric approach for clinical practice
    Vidya Perera
    School of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, SUNY at Buffalo, Buffalo, NY, USA Schizophrenia Research Institute, Sydney, Australia
    Br J Clin Pharmacol 78:800-14. 2014
    ..To determine optimal sampling strategies to allow the calculation of clinical pharmacokinetic parameters for selected antipsychotic medicines using a pharmacometric approach...
  51. doi Investigating paracetamol pharmacokinetics using venous and capillary blood and saliva sampling
    Anneliese M Rittau
    Faculty of Pharmacy, University of Sydney and Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Sydney, NSW, Australia
    J Pharm Pharmacol 64:705-11. 2012
    ....
  52. doi Medication withdrawal trials in people aged 65 years and older: a systematic review
    Shoba Iyer
    Centre for Education and Research on Ageing, Concord RG Hospital and University of Sydney, Sydney, New South Wales, Australia
    Drugs Aging 25:1021-31. 2008
    ..In conclusion, there is some clinical trial evidence for the short-term effectiveness and/or lack of significant harm when medication withdrawal is undertaken for antihypertensive, benzodiazepine and psychotropic agents in older people...
  53. doi Community pharmacy compounding-impact on professional status
    Jennifer Anne Giam
    Faculty of Pharmacy, The University of Sydney, Pharmacy Building A15, Sydney, NSW, 2006, Australia
    Int J Clin Pharm 33:177-82. 2011
    ..The aim of this study was to investigate the contribution of extemporaneous compounding to the professional status of pharmacists in community practice...
  54. pmc Population pharmacokinetics of gemcitabine and its metabolite in patients with cancer: effect of oxaliplatin and infusion rate
    Xuemin Jiang
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia
    Br J Clin Pharmacol 65:326-33. 2008
    ..the clinical implications of this observation remain to be established...
  55. pmc Population pharmacokinetics of mycophenolic acid in children and young people undergoing blood or marrow and solid organ transplantation
    Lihua Zeng
    Faculty of Pharmacy Department of Paediatrics and Child Health, University of Sydney, Sydney
    Br J Clin Pharmacol 70:567-79. 2010
    ....
  56. ncbi Statin Therapy and Cognition in Older People: What is the Evidence?
    Danijela Gnjidic
    Lecturer and NHMRC Early Career Fellow, Faculty of Pharmacy, Bank Building A15, Science Rd, University of Sydney, The University of Sydney NSW 2006
    Curr Clin Pharmacol 10:185-93. 2015
    ..The objective of this narrative review is to analyse the current evidence in relation to statin therapy and cognition, and discuss challenges in translating the current evidence to older people. ..
  57. pmc Evaluating the effectiveness of a peer-led education intervention to improve the patient safety attitudes of junior pharmacy students: a cross-sectional study using a latent growth curve modelling approach
    Ramesh L Walpola
    Faculty of Pharmacy, The University of Sydney, Camperdown, New South Wales, Australia
    BMJ Open 5:e010045. 2015
    ..Therefore, this study aimed to evaluate the effectiveness of a peer-led patient safety education programme for junior pharmacy students...
  58. doi The effects of educational interventions on pharmacists' knowledge, attitudes and beliefs towards low back pain
    Christina Abdel Shaheed
    Faculty of Pharmacy, University of Sydney, Pharmacy Building A15, Sydney, NSW, 2006, Australia
    Int J Clin Pharm 37:616-25. 2015
    ..Practitioner beliefs and attitudes towards low back pain (LBP) influence treatment decisions. Little is known about pharmacists' knowledge, attitudes and beliefs towards LBP...
  59. doi Investigating the Primary Care Management of Low Back Pain: A Simulated Patient Study
    Christina Abdel Shaheed
    Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia School of Medicine, Western Sydney University, Sydney, New South Wales, Australia
    J Pain 17:27-35. 2016
    ..4%) and imaging (22.7%). For the fracture scenario, the concerns were a low rate of prompt medical referrals (50.0%) and low endorsement of rest (1.0%)...
  60. doi Participation of pharmacists in clinical trial recruitment for low back pain
    Christina Abdel Shaheed
    Faculty of Pharmacy, University of Sydney, Pharmacy Building A15, Sydney, NSW, 2006, Australia
    Int J Clin Pharm 36:986-94. 2014
    ..Clinician involvement in clinical trials research represents a significant contribution to addressing important research questions in primary care...
  61. doi Interventions available over the counter and advice for acute low back pain: systematic review and meta-analysis
    Christina Abdel Shaheed
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    J Pain 15:2-15. 2014
    ..5 [95% confidence interval = -21.3 to -5.7] and 17.5, P < .001, respectively), but there was no information on longer-term outcomes...
  62. pmc Terbinafine in combination with other antifungal agents for treatment of resistant or refractory mycoses: investigating optimal dosing regimens using a physiologically based pharmacokinetic model
    Michael J Dolton
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia
    Antimicrob Agents Chemother 58:48-54. 2014
    ..This study provides the first report of predicted terbinafine exposure in plasma with a range of high-dose regimens. ..
  63. ncbi HPLC assay for bupropion and its major metabolites in human plasma
    Katarzyna K Loboz
    Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 823:115-21. 2005
    ....
  64. pmc Posaconazole exposure-response relationship: evaluating the utility of therapeutic drug monitoring
    Michael J Dolton
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Antimicrob Agents Chemother 56:2806-13. 2012
    ..In patients with subtherapeutic posaconazole concentrations, increased dose frequency, administration with high-fat meals, and withdrawal of interacting medications from therapy are useful strategies to improve systemic absorption...
  65. ncbi Decision support tool to individualize cyclosporine dose in stable, long-term heart transplant recipients receiving metabolic inhibitors: overcoming limitations of cyclosporine C2 monitoring
    John E Ray
    Department of Clinical Pharmacology and Toxicology, SydPath, St Vincent s Hospital, Sydney, Australia
    J Heart Lung Transplant 25:1223-9. 2006
    ....
  66. doi Psychotropic prescribing in long-term care facilities: impact of medication reviews and educational interventions
    Prasad S Nishtala
    Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia
    Am J Geriatr Psychiatry 16:621-32. 2008
    ..However, research on the benefits of these interventions in reducing psychotropic drug use on total health care costs and resident health outcomes is lacking...
  67. doi The impact of frailty on pharmacokinetics in older people: using gentamicin population pharmacokinetic modeling to investigate changes in renal drug clearance by glomerular filtration
    Claire Johnston
    Sydney Medical School, University of Sydney, Sydney, NSW, Australia
    Eur J Clin Pharmacol 70:549-55. 2014
    ..The aim of this study was to quantify the effect of frailty on glomerular filtration of drugs, using the probe drug gentamicin...
  68. doi Understanding variability with voriconazole using a population pharmacokinetic approach: implications for optimal dosing
    Michael J Dolton
    Faculty of Pharmacy, University of Sydney, Camperdown, Australia Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Concord, Australia
    J Antimicrob Chemother 69:1633-41. 2014
    ..This study aimed to investigate the population pharmacokinetics of voriconazole in adults, including the effect of CYP2C19 genotype and drug-drug interactions...
  69. pmc Vincristine chemotherapy trials and pharmacokinetics in tasmanian devils with tasmanian devil facial tumor disease
    David N Phalen
    Faculty of Veterinary Science, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e65133. 2013
    ....
  70. doi Evidence-based toxicity evaluation and scheduling of Chinese herbal medicines
    Ellie J Y Kim
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia
    J Ethnopharmacol 146:40-61. 2013
    ..While there is an increasing number of toxicity report cases and toxicological studies on Chinese herbal medicines, the guidelines for toxicity evaluation and scheduling of Chinese herbal medicines are lacking...
  71. pmc Drugs for relief of pain in patients with sciatica: systematic review and meta-analysis
    Rafael Zambelli Pinto
    George Institute For Global Health, University of Sydney, PO Box M201, Camperdown, Sydney, NSW 2050, Australia
    BMJ 344:e497. 2012
    ..To investigate the efficacy and tolerability of analgesic and adjuvant pain drugs typically administered in primary care for the management of patients with sciatica...
  72. doi Vancomycin pharmacokinetics in patients with severe burn injuries
    Michael Dolton
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, 2006, Australia
    Burns 36:469-76. 2010
    ..8 mg/L). Higher clearance and lower serum vancomycin concentrations in people with severe burn may increase the risk of suboptimal bactericidal action and the development of resistance highlighting the need for dosage individualization...
  73. ncbi A phase I study of the pharmacokinetics and safety of passive immunotherapy with caprine anti-HIV antibodies, (PE)HRG214, in HIV-1-infected individuals
    Sarah L Pett
    HIV, Immunology and Infectious Diseases Clinical Services, St Vincent s Hospital, Sydney, and National Centre in HIV Epidemiology and Clinical Research, University of NSW, Darlinghurst, Sydney, Australia
    HIV Clin Trials 5:91-8. 2004
    ..To establish the pharmacokinetics and safety of single-dose polyclonal caprine anti-HIV antibodies ((PE)HRG214)in HIV-1-infected individuals...
  74. ncbi Compounded medicines and 'off label' prescribing - a case for more guidance
    Romano A Fois
    Faculty of Pharmacy, University of Sydney, New South Wales
    Aust Fam Physician 38:16-20. 2009
    ..However, there have also been a number of case reports of patient harm associated with these medicines...
  75. ncbi Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol
    Richard O Day
    School of Medical Sciences, Faculty of Medicine, University of New South Wales and Department of Clinical Pharmacology and Toxicology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Clin Pharmacokinet 46:623-44. 2007
    ..The net effect is an increased degree of hypouricaemia, but the interaction is probably limited to patients with normal renal function or only moderate impairment...
  76. ncbi Treatment for osteoporosis in Australian residential aged care facilities: consensus recommendations for fracture prevention
    Gustavo Duque
    Ageing Bone Research Program, Sydney Medical School Nepean Campus, University of Sydney, Sydney, NSW, Australia
    Med J Aust 193:173-9. 2010
    ..In general, teriparatide should not be considered as a first-line treatment for fracture prevention, particularly for people in RACFs...
  77. doi Specialized compounding in community pharmacies: organizational perspective
    Jennifer Ann Giam
    Faculty of Pharmacy, University of Sydney, Sydney, New South Wales 2006, Australia
    J Am Pharm Assoc (2003) 50:354-61. 2010
    ..To compare Australian pharmacies that did and did not provide a specialized or enhanced compounding service using a framework based on organization theory...
  78. doi Adherence, persistence and continuation with cholinesterase inhibitors in Alzheimer's disease
    David G Le Couteur
    Centre for Education and Research on Ageing, University of Sydney and Concord RG Hospital, Sydney, New South Wales, Australia
    Australas J Ageing 31:164-9. 2012
    ..To determine adherence, persistence and continuation beyond 6 months with cholinesterase inhibitors in Australians with Alzheimer's disease...
  79. ncbi Drug-related problems in the community setting: pharmacists' findings and recommendations for people with mental illnesses
    J Simon Bell
    Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
    Clin Drug Investig 26:415-25. 2006
    ..People taking psychotropic drugs for mental illnesses may be particularly susceptible. This study aimed to classify and describe pharmacists' Home Medicines Review (HMR) findings and recommendations for people with mental illnesses...
  80. pmc Therapeutic drug monitoring of atazanavir: surveillance of pharmacotherapy in the clinic
    John E Ray
    Division of Clinical Pharmacology and Toxicology, Institute of Laboratory Medicine, St Vincent s Hospital, Sydney, Australia
    Br J Clin Pharmacol 60:291-9. 2005
    ....
  81. pmc Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
    Xuemin Jiang
    Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
    Br J Clin Pharmacol 57:592-9. 2004
    ..M: The aim of this study was to investigate the effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin...
  82. ncbi Comparison of the pharmacokinetics of two von Willebrand factor concentrates [Biostate and AHF (High Purity)] in people with von Willebrand disorder. A randomised cross-over, multi-centre study
    Emmanuel J Favaloro
    Haematology, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, SWAHS, Westmead, NSW, 2145, Australia
    Thromb Haemost 97:922-30. 2007
    ..PFA-100 CTs did not adequately reflect changes in these VWF parameters. Based on these results, one would expect Biostate to be at least as effective, if not superior to AHF (High Purity) for the treatment of VWD...
  83. ncbi Disposition of amphotericin B in the isolated perfused rat liver
    Ying Hong
    Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
    J Pharm Pharmacol 56:35-41. 2004
    ....
  84. pmc Manipulative therapy and/or NSAIDs for acute low back pain: design of a randomized controlled trial [ACTRN012605000036617]
    Mark J Hancock
    Back Pain Research Group, University of Sydney, PO Box 170, Lidcombe, NSW, 1825, Australia
    BMC Musculoskelet Disord 6:57. 2005
    ....
  85. pmc Population pharmacokinetics and dosing regimen design of milrinone in preterm infants
    Mary Paradisis
    Department of Newborn Care, RPA Women and Babies Hospital, Camperdown, NSW, Australia
    Arch Dis Child Fetal Neonatal Ed 92:F204-9. 2007
    ..To define the pharmacokinetics of milrinone in very preterm infants and determine an optimal dose regimen to prevent low systemic blood flow in the first 12 h after birth...