Patrick L McGeer

Summary

Publications

  1. doi request reprint A review of human diseases caused or exacerbated by aberrant complement activation
    Patrick L McGeer
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada Electronic address
    Neurobiol Aging 52:12-22. 2016
  2. doi request reprint Targeting microglia for the treatment of Alzheimer's disease
    Patrick L McGeer
    University of British Columbia, Kinsmen Laboratory of Neurological Research, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada
    Expert Opin Ther Targets 19:497-506. 2015
  3. doi request reprint The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy
    Patrick L McGeer
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T1Z3, Canada
    Acta Neuropathol 126:479-97. 2013
  4. pmc Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada
    J Neuroinflammation 13:32. 2016
  5. doi request reprint NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: a new candidate for treatment of neurodegenerative disorders
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Glia 61:1724-34. 2013
  6. doi request reprint Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    Neurobiol Aging 34:1451-61. 2013
  7. doi request reprint Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    Neurobiol Aging 33:2237-46. 2012
  8. doi request reprint GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    J Alzheimers Dis 33:1073-88. 2013
  9. doi request reprint Optineurin in Huntington's disease intranuclear inclusions
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada
    Neurosci Lett 506:149-54. 2012
  10. pmc Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver, BC Canada
    BMC Neurosci 15:18. 2014

Collaborators

Detail Information

Publications27

  1. doi request reprint A review of human diseases caused or exacerbated by aberrant complement activation
    Patrick L McGeer
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada Electronic address
    Neurobiol Aging 52:12-22. 2016
    ..Molecules under development include other monoclonal antibodies directed at C5, C3, and properdin, various aptamers to C3, and small molecules that are orally available...
  2. doi request reprint Targeting microglia for the treatment of Alzheimer's disease
    Patrick L McGeer
    University of British Columbia, Kinsmen Laboratory of Neurological Research, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada
    Expert Opin Ther Targets 19:497-506. 2015
    ..Activated microglia are associated with the progression of Alzheimer's disease (AD), as well as many other neurodegenerative diseases of aging. Microglia are therefore key targets for therapeutic intervention...
  3. doi request reprint The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy
    Patrick L McGeer
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T1Z3, Canada
    Acta Neuropathol 126:479-97. 2013
    ..Since there is more than a decade between disease onset and cognitive decline, a window of opportunity exists to introduce truly effective disease-modifying regimens. Taking advantage of this opportunity is the challenge for the future. ..
  4. pmc Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada
    J Neuroinflammation 13:32. 2016
    ..These include cyanide poisoning and calciphylaxis in hemodialysis patients with end-stage kidney disease. Here, we investigated the anti-inflammatory activity of STS in our glial-mediated neuroinflammatory model...
  5. doi request reprint NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: a new candidate for treatment of neurodegenerative disorders
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Glia 61:1724-34. 2013
    ....
  6. doi request reprint Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    Neurobiol Aging 34:1451-61. 2013
    ....
  7. doi request reprint Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    Neurobiol Aging 33:2237-46. 2012
    ..Aurin tricarboxylic acid, aurin quadracarboxylic acid, and aurin hexacarboxylic acid may be effective therapeutic agents in Alzheimer disease and other degenerative disorders where self damage from the MAC occurs...
  8. doi request reprint GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    J Alzheimers Dis 33:1073-88. 2013
    ..Our results suggest that the GABAergic system is more severely affected in AD than previously reported. This deficit may contribute to AD pathogenesis by loss of GABAergic inhibitory activity...
  9. doi request reprint Optineurin in Huntington's disease intranuclear inclusions
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada
    Neurosci Lett 506:149-54. 2012
    ..It is not clear whether this indicates a primary involvement in the disease process. In HD, the known interaction of htt and optineurin may suggest that a different process takes place as compared to other neurodegenerative disorders...
  10. pmc Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver, BC Canada
    BMC Neurosci 15:18. 2014
    ..RT-PCR was also performed to confirm human astrocyte expression of specific purinoceptors which were indicated from imaging studies...
  11. pmc The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada
    J Neuroinflammation 9:113. 2012
    ..It is tempting to evaluate the potential of SAHA as a therapeutic agent in various neuroinflammatory and neurodegenerative disorders...
  12. doi request reprint Inhibition of human astrocyte and microglia neurotoxicity by calcium channel blockers
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, B C, V6T 2A1 Canada
    Neuropharmacology 63:685-91. 2012
    ..L-type CCBs, especially NDP, might be a useful treatment option for a broad spectrum of neurodegenerative diseases, including Alzheimer disease, where the pathology is believed to be exacerbated by neurotoxic glial activation...
  13. doi request reprint Effects of obovatol on GSH depleted glia-mediated neurotoxicity and oxidative damage
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
    J Neuroimmune Pharmacol 7:173-86. 2012
    ....
  14. pmc Aurin tricarboxylic acid protects against red blood cell hemolysis in patients with paroxysmal nocturnal hemoglobinemia
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 9:e87316. 2014
    ..We have previously reported that aurin tricarboxylic acid (ATA) is an orally effective agent that selectively blocks complement activation at the C3 convertase stage as well as MAC formation at the C9 insertion stage...
  15. doi request reprint Quercetin, not caffeine, is a major neuroprotective component in coffee
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia Canada
    Neurobiol Aging 46:113-23. 2016
    ..There was a resultant increase in [GSH]i in SH-SY5Y cells. The data indicate that quercetin is the major neuroprotective component in coffee against Parkinson's disease and Alzheimer's disease. ..
  16. doi request reprint Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Neurobiol Aging 36:2748-56. 2015
    ..Consequently, there is a high priority for the discovery and development of agents that can successfully treat such conditions. DAS holds considerable promise for being such an agent...
  17. pmc Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye
    Tom Zhao
    Department of Ophthalmology and Visual Sciences, Faculty of Medicine, University of British Columbia, 2550 Willow Street, Vancouver, V5Z 3N9, BC, Canada
    J Neuroinflammation 12:121. 2015
    ....
  18. ncbi request reprint Interferon-γ-induced neurotoxicity of human astrocytes
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, B C, V6T 2A1 Canada
    CNS Neurol Disord Drug Targets 14:251-6. 2015
    ..Therefore, control of STAT3 activation in human astrocytes may be a promising new therapeutic strategy for a broad spectrum of neurodegenerative and neuroinflammatory disorders where activated astrocytes may contribute to the pathology. ..
  19. doi request reprint Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
    Biochem Pharmacol 94:130-41. 2015
    ..Our data suggest that LL-37, in addition to its established roles, may play a role in the chronic neuroinflammation which is observed in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. ..
  20. doi request reprint Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Neurobiol Aging 36:42-52. 2015
    ..They provide further evidence that appropriate anti-inflammatory treatment should be beneficial in AD...
  21. doi request reprint Weak BMAA toxicity compares with that of the dietary supplement β-alanine
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    Neurobiol Aging 33:1440-7. 2012
    ....
  22. pmc Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs
    Masato Hosokawa
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada
    J Neuroinflammation 1:17. 2004
    ..CONCLUSION: The lower mRNA expression of C1-inh and MCP by oligodendrocytes could contribute to their vulnerability in several neurodegenerative and inflammatory diseases of the central nervous system...
  23. ncbi request reprint Inflammation, Antiinflammatory Agents, and Alzheimer's Disease: The Last 22 Years
    Patrick L McGeer
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver BC, Canada
    J Alzheimers Dis 54:853-857. 2016
    ..Neuroinflammation, discovered in AD more than 30 years ago, has now become a major field of brain research today. Inhibiting it may be the key to successful treatment of many chronic neurological disorders...
  24. pmc History of innate immunity in neurodegenerative disorders
    Patrick L McGeer
    Kinsmen Laboratory of Neurological Research, University of British Columbia Vancouver, BC, Canada
    Front Pharmacol 2:77. 2011
    ..Ways of reducing the neurotoxic innate immune response and stimulating a healing response continue to be sought as a means for ameliorating the pathology in a spectrum of chronic degenerative disorders...
  25. pmc Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 286:41230-45. 2011
    ....
  26. doi request reprint Mechanisms of GABA release from human astrocytes
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Glia 59:1600-11. 2011
    ..These data indicate that astrocytes continuously synthesize GABA and that there are multiple mechanisms which can mediate its release. Each of these may play a role in the physiological functioning of astrocytes...
  27. doi request reprint Mechanisms of Mg2+ inhibition of BzATP-dependent Ca2+ responses in THP-1 monocytes
    Nattinee Jantaratnotai
    Department of Anesthesiology, Pharmacology and Therapeutics, 2176 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada
    Brain Res 1442:1-8. 2012
    ..A model is proposed to account for BzATP stimulation of both ionotropic P2XR and metabotropic P2YR which provides a mechanistic basis for elevated Mg2+ anti-inflammatory and neuroprotective actions in inflamed brain...