R Scott McClelland

Summary

Publications

  1. pmc Association between participant self-report and biological outcomes used to measure sexual risk behavior in human immunodeficiency virus-1-seropositive female sex workers in Mombasa, Kenya
    R Scott McClelland
    Departments of Medicine, University of Washington, Seattle, WA, USA
    Sex Transm Dis 38:429-33. 2011
  2. ncbi request reprint A comparison of genital HIV-1 shedding and sexual risk behavior among Kenyan women based on eligibility for initiation of HAART according to WHO guidelines
    R Scott McClelland
    Departments of Medicine, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 41:611-5. 2006
  3. pmc The posttrial effect of oral periodic presumptive treatment for vaginal infections on the incidence of bacterial vaginosis and Lactobacillus colonization
    Jennifer E Balkus
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 39:361-5. 2012
  4. ncbi request reprint A decrease in albumin in early HIV type 1 infection predicts subsequent disease progression
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS Res Hum Retroviruses 23:1197-200. 2007
  5. ncbi request reprint Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:1466-71. 2004
  6. pmc Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trial
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, USA
    J Infect Dis 197:1361-8. 2008
  7. pmc Antiretroviral adherence and development of drug resistance are the strongest predictors of genital HIV-1 shedding among women initiating treatment
    Susan M Graham
    University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 202:1538-42. 2010
  8. ncbi request reprint Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan women
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Int J STD AIDS 18:202-6. 2007
  9. pmc Prospective study of vaginal bacterial flora and other risk factors for vulvovaginal candidiasis
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 199:1883-90. 2009
  10. pmc A prospective cohort study comparing the effect of single-dose 2 g metronidazole on Trichomonas vaginalis infection in HIV-seropositive versus HIV-seronegative women
    Jennifer E Balkus
    Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA
    Sex Transm Dis 40:499-505. 2013

Collaborators

Detail Information

Publications76

  1. pmc Association between participant self-report and biological outcomes used to measure sexual risk behavior in human immunodeficiency virus-1-seropositive female sex workers in Mombasa, Kenya
    R Scott McClelland
    Departments of Medicine, University of Washington, Seattle, WA, USA
    Sex Transm Dis 38:429-33. 2011
    ..Few studies have examined the association between self-reported sexual risk behaviors and biologic outcomes in human immunodeficiency virus (HIV)-1-seropositive African adults...
  2. ncbi request reprint A comparison of genital HIV-1 shedding and sexual risk behavior among Kenyan women based on eligibility for initiation of HAART according to WHO guidelines
    R Scott McClelland
    Departments of Medicine, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 41:611-5. 2006
    ..Guidelines for initiating antiretrovirals are based on markers of advanced disease and are not directly linked to markers of HIV-1 transmission such as viral shedding...
  3. pmc The posttrial effect of oral periodic presumptive treatment for vaginal infections on the incidence of bacterial vaginosis and Lactobacillus colonization
    Jennifer E Balkus
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 39:361-5. 2012
    ..Posttrial data were analyzed to test the hypothesis that the treatment effect would persist after completion of 1 year of PPT...
  4. ncbi request reprint A decrease in albumin in early HIV type 1 infection predicts subsequent disease progression
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS Res Hum Retroviruses 23:1197-200. 2007
    ..0, p = 0.008). Trends for an increased risk of mortality were also seen. A greater decrease in albumin levels accompanying HIV-1 acquisition may be a marker for changes in early infection associated with more rapid disease progression...
  5. ncbi request reprint Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:1466-71. 2004
    ..Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity...
  6. pmc Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trial
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, USA
    J Infect Dis 197:1361-8. 2008
    ..Vaginal infections are common and have been associated with increased risk for acquisition of human immunodeficiency virus type 1 (HIV-1)...
  7. pmc Antiretroviral adherence and development of drug resistance are the strongest predictors of genital HIV-1 shedding among women initiating treatment
    Susan M Graham
    University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 202:1538-42. 2010
    ..04). These results emphasize the importance of adherence to optimize the potential benefits of ART for reducing HIV-1 transmission risk...
  8. ncbi request reprint Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan women
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Int J STD AIDS 18:202-6. 2007
    ....
  9. pmc Prospective study of vaginal bacterial flora and other risk factors for vulvovaginal candidiasis
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 199:1883-90. 2009
    ..Our objective was to determine the relationship between vaginal bacterial flora and VVC...
  10. pmc A prospective cohort study comparing the effect of single-dose 2 g metronidazole on Trichomonas vaginalis infection in HIV-seropositive versus HIV-seronegative women
    Jennifer E Balkus
    Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA
    Sex Transm Dis 40:499-505. 2013
    ..This analysis compared the frequency of persistent Trichomonas vaginalis (TV) among HIV-seropositive and HIV-seronegative women...
  11. pmc A prospective study of vaginal trichomoniasis and HIV-1 shedding in women on antiretroviral therapy
    Linnet N Masese
    Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
    BMC Infect Dis 11:307. 2011
    ..We tested the hypothesis that T. vaginalis infection would increase vaginal HIV-1 RNA shedding in women on ART, and that successful treatment would reduce vaginal HIV-1 RNA levels...
  12. pmc Increased risk of genital ulcer disease in women during the first month after initiating antiretroviral therapy
    Susan M Graham
    Departments of Medicine, Epidemiology and Global Health, University of Washington, Seattle, WA 98104 2499, USA
    J Acquir Immune Defic Syndr 52:600-3. 2009
    ..To better define this risk, we monitored 134 women at ART initiation and monthly thereafter...
  13. ncbi request reprint HIV-1 acquisition and disease progression are associated with decreased high-risk sexual behaviour among Kenyan female sex workers
    R Scott McClelland
    Departments of Medicine, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    AIDS 20:1969-73. 2006
    ..Changes in sexual risk behaviour may occur following HIV-1 infection...
  14. ncbi request reprint Association between cervical shedding of herpes simplex virus and HIV-1
    R Scott McClelland
    International AIDS Research and Training Program, Department of Medicine, University of Washington, Box 359909, 325 9th Avenue, Seattle, WA 98104, USA
    AIDS 16:2425-30. 2002
    ..To investigate the association between the cervical shedding of herpes simplex virus (HSV) and HIV-1...
  15. pmc Genital ulceration does not increase HIV-1 shedding in cervical or vaginal secretions of women taking antiretroviral therapy
    Susan M Graham
    University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    Sex Transm Infect 87:114-7. 2011
    ..The effect of GUD on HIV-1 shedding among ART-treated women is not known. The objective of this study was to test the hypothesis that genital ulcerations increase genital HIV-1-RNA shedding in women receiving ART...
  16. ncbi request reprint Micronutrient supplementation increases genital tract shedding of HIV-1 in women: results of a randomized trial
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 37:1657-63. 2004
    ..The potential benefit of micronutrient supplementation in HIV-1-seropositive women should be considered in relation to the potential for increased infectivity...
  17. pmc Quantification of genital human immunodeficiency virus type 1 (HIV-1) DNA in specimens from women with low plasma HIV-1 RNA levels typical of HIV-1 nontransmitters
    Sarah Benki
    Department of Microbiology, University of Washington, Seattle, WA 98109, USA, and Coast Provincial General Hospital, Mombasa, Kenya
    J Clin Microbiol 44:4357-62. 2006
    ..The assay described here can be utilized in future efforts to examine the role of cell-associated HIV-1 in transmission...
  18. ncbi request reprint Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan women
    Jared M Baeten
    Seattle HIV Prevention Trials Unit, Department of Medicine, University of Washington, 9012 Boren Avenue, Seattle, WA 98104, USA
    AIDS 21:1771-7. 2007
    ..A recent study from Uganda and Zimbabwe found that women using hormonal contraception were at increased risk for HIV-1 if they were seronegative for herpes simplex virus type 2 (HSV-2), but not if they were HSV-2 seropositive...
  19. ncbi request reprint HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Infect Dis 195:1177-80. 2007
    ..There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads...
  20. pmc A prospective study of risk factors for bacterial vaginosis in HIV-1-seronegative African women
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 35:617-23. 2008
    ..Bacterial vaginosis (BV) is common and has been associated with increased HIV-1 susceptibility. The objective of this study was to identify risk factors for BV in African women at high risk for acquiring HIV-1...
  21. pmc Genital Inflammation Predicts HIV-1 Shedding Independent of Plasma Viral Load and Systemic Inflammation
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Acquir Immune Defic Syndr 61:436-40. 2012
    ..Thus, efforts to decrease HIV-1 transmission must take into account the role of local inflammation, which is not necessarily reflected in plasma measurements...
  22. doi request reprint A pilot study of the feasibility of a vaginal washing cessation intervention among Kenyan female sex workers
    Linnet Masese
    Department of Epidemiology, University of Washington, HMC Box 359909, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Sex Transm Infect 89:217-22. 2013
    ..This association may be mediated by mucosal disruption, changes in vaginal flora or genital tract inflammatory responses. Reducing vaginal washing could lower women's risk of HIV-1 acquisition...
  23. pmc Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective study
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    BMC Infect Dis 7:63. 2007
    ..However, vitamin E supplementation has also been reported to increase CCR5 expression, which could increase HIV-1 replication. We hypothesized that vitamin E levels at HIV-1 acquisition may influence disease progression...
  24. ncbi request reprint Use of serum retinol-binding protein for prediction of vitamin A deficiency: effects of HIV-1 infection, protein malnutrition, and the acute phase response
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Am J Clin Nutr 79:218-25. 2004
    ..The performance of RBP in the context of infection or protein malnutrition, however, has not been evaluated...
  25. pmc Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women
    Paul K Drain
    Department of Medicine, University of Washington, 1959 NE Pacific, A 300 Health Sciences, Box 356340, Seattle, WA 98105, USA
    BMC Infect Dis 6:85. 2006
    ..Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response...
  26. ncbi request reprint The effect of hormonal contraception on genital tract shedding of HIV-1
    Chia C Wang
    Department of Medicine, University of Washington, Seattle, Washington 98104 2499, USA
    AIDS 18:205-9. 2004
    ..We conducted a prospective study to determine if cervical shedding of HIV-1 increased after initiating hormonal contraception...
  27. pmc Treatment with antiretroviral therapy is not associated with increased sexual risk behavior in Kenyan female sex workers
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, USA
    AIDS 24:891-7. 2010
    ..The objective of this study was to test the hypothesis that sexual risk behavior would increase following initiation of antiretroviral therapy (ART) in Kenyan female sex workers (FSWs)...
  28. ncbi request reprint Initiation of antiretroviral therapy leads to a rapid decline in cervical and vaginal HIV-1 shedding
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington, USA
    AIDS 21:501-7. 2007
    ..Antiretroviral therapy (ART) may decrease HIV-1 infectivity in women by reducing genital HIV-1 shedding...
  29. pmc Antiretroviral treatment interruptions predict female genital shedding of genotypically resistant HIV-1 RNA
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, WA 98104 2499, USA
    J Acquir Immune Defic Syndr 60:511-8. 2012
    ..Our objective was to identify predictors of drug-resistant HIV-1 RNA in genital secretions after initiation of nonnucleoside reverse transcriptase inhibitor-based therapy...
  30. ncbi request reprint Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisition
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 195:698-702. 2007
    ..52-fold (95% confidence interval, 1.04-2.24-fold) increased risk of HIV-1 acquisition after adjustment for potential confounding factors. Treatment and prevention of T. vaginalis infection could reduce HIV-1 risk in women...
  31. ncbi request reprint High levels of cervical HIV-1 RNA during early HIV-1 infection
    Ludo Lavreys
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    AIDS 20:2389-90. 2006
    ..43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006)...
  32. ncbi request reprint HIV-1 infection alters the retinol-binding protein:transthyretin ratio even in the absence of the acute phase response
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Nutr 136:1624-9. 2006
    ..Our results raise questions about the utility of this measurement given the high prevalence of HIV-1 infection in areas where vitamin A deficiency is common...
  33. ncbi request reprint Contribution of HIV-1 infection to acquisition of sexually transmitted disease: a 10-year prospective study
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    J Infect Dis 191:333-8. 2005
    ..Sexually transmitted diseases (STDs) enhance human immunodeficiency virus (HIV)-1 susceptibility, but few studies have examined the reciprocal effect of HIV-1 on STD acquisition...
  34. ncbi request reprint Associations between intravaginal practices and bacterial vaginosis in Kenyan female sex workers without symptoms of vaginal infections
    Wisal M Hassan
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 34:384-8. 2007
    ..Bacterial vaginosis (BV) is highly prevalent among African women and has been associated with adverse pregnancy outcomes, sexually transmitted diseases, and HIV-1...
  35. ncbi request reprint Hormonal contraception and risk of cervical infections among HIV-1-seropositive Kenyan women
    Ludo Lavreys
    Departments of Epidemiology and Medicine, University of Washington, Seattle 98104 2499, USA
    AIDS 18:2179-84. 2004
    ..To evaluate the relationship between hormonal contraceptive use and the acquisition of cervical sexually transmitted infections (STI) among HIV-1-infected women...
  36. pmc Effect of text messaging to deter early resumption of sexual activity after male circumcision for HIV prevention: a randomized controlled trial
    Thomas A Odeny
    Department of Epidemiology, University of Washington, Seattle, WA Kenya Medical Research Institute KEMRI, Nairobi, Kenya Chicago Developmental Center for AIDS Research, University of Illinois at Chicago Departments of Global Health Obstetrics and Gynecology and Psychology, University of Washington, Seattle, WA Center for AIDS and STD, University of Washington, Seattle, WA and Department of Medicine, University of Washington, Seattle, WA
    J Acquir Immune Defic Syndr 65:e50-7. 2014
    ..We aimed to determine the effect of text messaging to deter resumption of sex before 42 days postcircumcision...
  37. pmc Loss to follow-up as a competing risk in an observational study of HIV-1 incidence
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e59480. 2013
    ..Our goal was to assess whether the association between sexual risk behavior and HIV-1 acquisition changed after accounting for LTF with competing risks regression...
  38. ncbi request reprint Higher set point plasma viral load and more-severe acute HIV type 1 (HIV-1) illness predict mortality among high-risk HIV-1-infected African women
    Ludo Lavreys
    Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, WA 98104 2499, USA
    Clin Infect Dis 42:1333-9. 2006
    ..We used data from a prospective cohort study of female sex workers in Mombasa, Kenya, who were followed up monthly from before the date of HIV-1 infection...
  39. pmc Systemic cytokine levels show limited correlation with risk of HIV-1 acquisition
    Dara A Lehman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Global Health, University of Washington, Seattle, WA Department of Medicine, Stanford Immunology, Stanford University School of Medicine, Stanford, CA Departments of Medicine Epidemiology, University of Washington, Seattle, WA Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya Coast Provincial General Hospital, Women s Health Project, Mombasa, Kenya Department of Biostatistics, University of Washington, Seattle, WA Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA
    J Acquir Immune Defic Syndr 66:135-9. 2014
    ..Inconsistent results within our study and among previous studies suggest that reproducible findings are needed before cytokines are useful biomarkers for HIV-1 susceptibility...
  40. pmc Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progression
    Anne Piantadosi
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Virol 83:10269-74. 2009
    ..Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection...
  41. pmc Incidence and correlates of Chlamydia trachomatis infection in a high-risk cohort of Kenyan women
    Linnet Masese
    Department of Epidemiology, University of Washington, Seattle, WA 98104 2499, USA
    Sex Transm Dis 40:221-5. 2013
    ..Our objective was to evaluate the incidence and correlates of C. trachomatis infection among high-risk Kenyan women...
  42. pmc Establishing and sustaining a healthy vaginal environment: analysis of data from a randomized trial of periodic presumptive treatment for vaginal infections
    Jennifer E Balkus
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 204:323-6. 2011
    ..69; 95% CI, 1.23-2.33). PPT is effective at establishing and sustaining a healthy vaginal environment...
  43. pmc Changes in the contribution of genital tract infections to HIV acquisition among Kenyan high-risk women from 1993 to 2012
    Linnet Masese
    aDepartment of Epidemiology bDepartment of Medicine cDepartment of Global Health dDepartment of Biostatistics eDepartment of Pediatrics, University of Washington, Seattle fVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA gDepartment of Obstetrics and Gynecology hDepartment of Medical Microbiology, University of Nairobi iKenya Medical Research Institute, Nairobi, Kenya jHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA kInstitute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya
    AIDS 29:1077-85. 2015
    ..The objective of this study was to understand temporal trends in the contribution of different genital tract infections to HIV incidence over 20 years of follow-up in a cohort of high-risk women...
  44. pmc Prevalence, clinical and virologic outcomes of hepatitis B virus co-infection in HIV-1 positive Kenyan women on antiretroviral therapy
    Summer L Day
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e59346. 2013
    ..We aimed to determine the prevalence, clinical, and virologic outcomes of chronic HBV infection, including HBV resistance to lamivudine, in a cohort of HIV-1 seropositive Kenyan women on long-term ART...
  45. pmc Association between cellular immune activation, target cell frequency, and risk of human immunodeficiency virus type 1 superinfection
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Virol 88:5894-9. 2014
    ..7-fold increase in the odds of superinfection. This suggests that HIV-1 acquisition risk is influenced more by the frequency of target cells than by the generalized level of immune activation. ..
  46. pmc HIV-1 superinfection occurs less frequently than initial infection in a cohort of high-risk Kenyan women
    Keshet Ronen
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Pathog 9:e1003593. 2013
    ..The observation that superinfection risk changes with time implies a window of protection that coincides with the maturation of HIV-specific immunity...
  47. pmc Endothelial activation biomarkers increase after HIV-1 acquisition: plasma vascular cell adhesion molecule-1 predicts disease progression
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98104 2499, USA
    AIDS 27:1803-13. 2013
    ..We aimed to determine whether endothelial activation biomarkers increase after HIV-1 acquisition, and whether biomarker levels measured in chronic infection would predict disease progression and death in HIV-1 seroconverters...
  48. pmc HIV-1 RNA may decline more slowly in semen than in blood following initiation of efavirenz-based antiretroviral therapy
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e43086. 2012
    ..Our objective was to study the time course and magnitude of seminal HIV-1 RNA decay after initiation of efavirenz-based ART among 13 antiretroviral-naïve Kenyan men...
  49. pmc Alcohol Use and Associations With Biological Markers and Self-Reported Indicators of Unprotected Sex in Human Immunodeficiency Virus-Positive Female Sex Workers in Mombasa, Kenya
    Darcy White
    From the Department of Epidemiology, Department of Global Health, Department of Medicine, University of Washington, Seattle, WA University of Washington Kenya Non Governmental Organization, Nairobi, Kenya Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya Department of Biostatistics, University of Washington, Seattle, WA Division of Public Health Sciences, Division of Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya Department of Psychology, University of Washington, Seattle, WA Institute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya
    Sex Transm Dis 43:642-7. 2016
    ..Few have focused on human immunodeficiency virus (HIV)-positive women...
  50. pmc A prospective cohort study of the effect of depot medroxyprogesterone acetate on detection of plasma and cervical HIV-1 in women initiating and continuing antiretroviral therapy
    Summer Day
    Department of Medicine, University of Washington, Seattle, WA Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya Departments of Epidemiology Biostatistics Global Health, University of Washington, Seattle WA Fred Hutchinson Cancer Research Center, Seattle, WA Department of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya and Pathcare Laboratories, Mombasa, Kenya
    J Acquir Immune Defic Syndr 66:452-6. 2014
    ..39) or cervical HIV-1 RNA (adjusted odds ratio: 1.41, 95% confidence interval: 0.54 to 3.67). Our results suggest that DMPA is unlikely to increase infectivity in HIV-positive women who are adherent to effective antiretroviral therapy...
  51. ncbi request reprint Vaginal washing and increased risk of HIV-1 acquisition among African women: a 10-year prospective study
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    AIDS 20:269-73. 2006
    ..No prospective study has examined the risk of HIV-1 acquisition associated with vaginal washing, although intravaginal practices have been identified as potentially important contributors to HIV-1 susceptibility...
  52. pmc Prevalence and correlates of intimate partner violence in HIV-positive women engaged in transactional sex in Mombasa, Kenya
    Kate S Wilson
    Department of Epidemiology, University of Washington, Seattle, USA
    Int J STD AIDS 27:1194-1203. 2016
    ..Interventions targeting risk factors for IPV, including alcohol problems and partner controlling behaviours, could help to reduce recurrent violence and negative health outcomes in this key population...
  53. pmc Association between alcohol use and sexually transmitted infection incidence among kenyan women engaged in transactional sex
    Kate S Wilson
    Department of Epidemiology, University of Washington, 325 Ninth Ave, Box 359909, Seattle, WA, 98104, USA
    AIDS Behav 18:1324-9. 2014
    ..However, no association between alcohol use and STIs was observed among 335 HIV-negative women. Addressing alcohol use within comprehensive HIV care may also reduce the burden of STIs among high-risk women...
  54. pmc Antibody-dependent cell-mediated virus inhibition antibody activity does not correlate with risk of HIV-1 superinfection
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92967, USA
    J Acquir Immune Defic Syndr 63:31-3. 2013
    ..We found no association between plasma ADCVI activity and superinfection status. ADCVI antibody activity against heterologous virus elicited by the original infection may not contribute to preventing a superinfecting HIV-1...
  55. pmc Chronic HIV-1 infection frequently fails to protect against superinfection
    Anne Piantadosi
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Pathog 3:e177. 2007
    ..Implications from HIV-1 superinfection cases, in which natural re-exposure leads to re-infection, will need to be considered in developing strategies for eliciting protective immunity to HIV-1...
  56. ncbi request reprint Reducing HIV-1 transmission through prevention strategies targeting HIV-1-seropositive individuals
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Antimicrob Chemother 57:163-6. 2006
    ..Further work is urgently needed to develop, test and implement comprehensive strategies for prevention in positives...
  57. pmc Understanding the context of HIV risk behavior among HIV-positive and HIV-negative female sex workers and male bar clients following antiretroviral therapy rollout in Mombasa, Kenya
    Lauren McClelland
    School of Nursing, University of Washington, Seattle, USA
    AIDS Educ Prev 23:299-312. 2011
    ..Incorporation of context- and serostatus-specific factors (e.g., self-protection for HIV-positive women) into tailored prevention counseling may support high-risk women to reduce risk behaviors...
  58. doi request reprint A Prospective Cohort Study of Intimate Partner Violence and Unprotected Sex in HIV-Positive Female Sex Workers in Mombasa, Kenya
    Kate S Wilson
    Department of Global Health, University of Washington, Box 359931, Seattle, 98104, USA
    AIDS Behav 20:2054-64. 2016
    ..Addressing IPV in comprehensive HIV programs for HIV-positive women in this key population is important to improve wellbeing and reduce risk of sexual transmission of HIV. ..
  59. ncbi request reprint Vitamin A deficiency and the acute phase response among HIV-1-infected and -uninfected women in Kenya
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
    J Acquir Immune Defic Syndr 31:243-9. 2002
    ..These results provide possible explanations for the disparity between observational studies and randomized trials of vitamin A for HIV-1 infection...
  60. doi request reprint Male partner circumcision associated with lower Trichomonas vaginalis incidence among pregnant and postpartum Kenyan women: a prospective cohort study
    Jillian Pintye
    Department of Global Health, University of Washington, Seattle, USA Department of Nursing, University of Washington, Seattle, USA
    Sex Transm Infect . 2016
    ..Trichomonas vaginalis is the world's most common curable STI and has implications for reproductive health in women. We determined incidence and correlates of T. vaginalis in an HIV-uninfected peripartum cohort...
  61. pmc A 15-year study of the impact of community antiretroviral therapy coverage on HIV incidence in Kenyan female sex workers
    R Scott McClelland
    aDepartment of Medicine bDepartment of Epidemiology cDepartment of Global Health dDepartment of Biostatistics, University of Washington, Seattle, Washington, USA eInstitute of Tropical and Infectious Diseases fDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya gDivision of Human Biology hDivision of Public Health Sciences iDivision of Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA jNational AIDS and STD Control Programme, Nairobi kMombasa County Department of Policy and Research, Mombasa, Kenya
    AIDS 29:2279-86. 2015
    ..To test the hypothesis that increasing community antiretroviral therapy (ART) coverage would be associated with lower HIV incidence in female sex workers (FSWs) in Mombasa District, Kenya...
  62. pmc HIV-1 superinfection is associated with an accelerated viral load increase but has a limited impact on disease progression
    Keshet Ronen
    aHuman Biology Division bPublic Health Sciences Division cVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center dDepartment of Global Health eDepartment of Biostatistics fDepartment of Medicine gDepartment of Epidemiology, University of Washington, Seattle, Washington, USA hInstitute of Tropical and Infectious Diseases iDepartment of Medical Microbiology, University of Nairobi, Nairobi jCoast Provincial General Hospital, Mombasa, Kenya
    AIDS 28:2281-6. 2014
    ..HIV-1 superinfection occurs frequently in high-risk populations, but its clinical consequences remain poorly characterized. We undertook this study to determine the impact of HIV-1 superinfection on disease progression...
  63. pmc Elevation of soluble intercellular adhesion molecule-1 levels, but not angiopoietin 2, in the plasma of human immunodeficiency virus-infected African women with clinical Kaposi sarcoma
    Susan M Graham
    Departments of Medicine, Global Health, and Epidemiology, and Department of Biostatistics, University of Washington, Seattle, Washington Institute of Tropical and Infectious Diseases, and Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya Office of Research Trainees, Toronto General Hospital University Health Network, and Division of Infectious Diseases, Department of Medicine University of Toronto, Toronto, Ontario, Canada Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington
    Am J Trop Med Hyg 91:705-8. 2014
    ..2, 95% confidence interval = 2.3-87.7). Circulating ICAM-1 levels should be evaluated as a potential biomarker for disease progression and treatment response among HIV-infected KS patients. ..
  64. pmc HIV-1 superinfection in women broadens and strengthens the neutralizing antibody response
    Valerie Cortez
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 8:e1002611. 2012
    ..Therefore, a successful vaccination strategy that mimics superinfection may lead to the development of broad NAbs in immunized individuals...
  65. pmc Analysis of the percentage of human immunodeficiency virus type 1 sequences that are hypermutated and markers of disease progression in a longitudinal cohort, including one individual with a partially defective Vif
    Anne Piantadosi
    Fred Hutchinson Cancer Center, Seattle, WA 98109 1024, USA
    J Virol 83:7805-14. 2009
    ....
  66. ncbi request reprint Effect of exogenous hormones
    R Scott McClelland
    University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 38:S38-9. 2005
  67. pmc Texting improves testing: a randomized trial of two-way SMS to increase postpartum prevention of mother-to-child transmission retention and infant HIV testing
    Thomas A Odeny
    aKenya Medical Research Institute KEMRI, Nairobi, Kenya bDepartment of Epidemiology cDepartment of Global Health dDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington eDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California fDepartment of Medicine, University of Washington, Seattle, Washington, USA gInstitute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya
    AIDS 28:2307-12. 2014
    ..We aimed to determine whether interactive text messages improved rates of clinic attendance and early infant HIV testing in the Nyanza region of Kenya...
  68. pmc Changes in sexual risk behavior in the Mombasa cohort: 1993-2007
    Susan M Graham
    Departments of Medicine and Global Health, University of Washington, Seattle, Washington, United States of America Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
    PLoS ONE 9:e113543. 2014
    ..Although sexual risk has declined among women participating in the Mombasa Cohort, HIV acquisition continues to occur and interventions to promote and reinforce safer sex are clearly needed. ..
  69. pmc Cellular immune responses and susceptibility to HIV-1 superinfection: a case-control study
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    AIDS 26:643-6. 2012
    ....
  70. doi request reprint Global epidemiology of Trichomonas vaginalis
    Danielle N Poole
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Sex Transm Infect 89:418-22. 2013
    ..Further characterisation of the global epidemiology of TV could enhance our ability to respond to the TV epidemic. ..
  71. pmc Genital tract infections, bacterial vaginosis, HIV, and reproductive health issues among Lima-based clandestine female sex workers
    M E Perla
    Department of Epidemiology, School of Public Health, University of Washington, Box 357236, Seattle, WA 98195, USA
    Infect Dis Obstet Gynecol 2012:739624. 2012
    ..Continued health outreach programs and integrating family planning and reproductive health services into existing STI clinic services are recommended...
  72. ncbi request reprint Risk factors for human immunodeficiency virus type-1 acquisition in women in Africa
    Sarah Benki
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Neurovirol 11:58-65. 2005
    ..In addition, they are a potential source of transmission to their infants. A better understanding of the factors that influence HIV-1 susceptibility is key to developing interventions to control the epidemic...
  73. pmc Text messaging to improve attendance at post-operative clinic visits after adult male circumcision for HIV prevention: a randomized controlled trial
    Thomas A Odeny
    Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e43832. 2012
    ..We evaluated the effect of short message service (SMS) text messages on attendance at this important visit...
  74. pmc Post-prostatic massage fluid/urine as an alternative to semen for studying male genitourinary HIV-1 shedding
    Susan M Graham
    University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    Sex Transm Infect 87:232-7. 2011
    ..Because semen collection is often impractical, the acceptability, feasibility and validity of post-prostatic massage fluid/urine (post-PMF/U) was evaluated for studying male genitourinary HIV-1 shedding...
  75. pmc High HIV-1 incidence, correlates of HIV-1 acquisition, and high viral loads following seroconversion among MSM
    Eduard J Sanders
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    AIDS 27:437-46. 2013
    ..HIV-1 incidence estimates and correlates of HIV-1 acquisition in African MSM are largely unknown...
  76. ncbi request reprint A prospective study of hormonal contraceptive use and cervical shedding of herpes simplex virus in human immunodeficiency virus type 1-seropositive women
    R Scott McClelland
    Departments of Medicine, International AIDS Research and Training Program, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Infect Dis 185:1822-5. 2002
    ..In this prospective study, use of hormonal contraceptives did not increase detection of cervical HSV...