- Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance
Department of Endocrinology and Diabetes, Saint Louis Hospital and University of Paris VII Medical School, France
Clin Endocrinol (Oxf) 57:1-9. 2002
..The development of type 2 diabetes is linked to insulin resistance coupled with a failure of pancreatic beta-cells to compensate by adequate insulin secretion...
- Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance
Department of Endocrinology and Diabetes, Saint Louis Hospital and University of Paris VII School of Medicine, Paris, France
Diabetes 53:645-53. 2004
- High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes
Department of Endocrinology and Diabetes, St Louis Hospital, University of Paris VII School of Medicine, France
J Clin Endocrinol Metab 90:4446-51. 2005
..Ketosis-prone diabetes (KPD) is mostly observed in males of West African descent and is characterized by phasic or permanent insulin dependence without apparent autoimmune process...
- Antidiabetic actions of estrogen: insight from human and genetic mouse models
Jean Francois Louet
Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, One Baylor Plaza, 520B, Houston, TX 77030, USA
Curr Atheroscler Rep 6:180-5. 2004
- Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 109:141-9. 2002
..Furthermore, Pik3r1 heterozygosity protects mice with genetic insulin resistance from developing diabetes. These data suggest that regulation of p85alpha levels may provide a novel therapeutic target for the treatment of type 2 diabetes...
- Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice
Department of Endocrinology, Institut National de la Sante et de la Recherche Medicale, Unité 567 Centre National de la Recherche Scientifique, Paris, France
Endocrinology 145:1926-32. 2004
..The MIRKO mouse confirms the importance of WAT plasticity in the maintenance of whole body insulin sensitivity and represents an interesting model to search for new secreted molecules that positively alter adipose tissue biology...
- p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity
Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Mol Cell Biol 24:320-9. 2004
..Taken together, these data indicate that p50alpha and p55alpha play an important role in insulin signaling and action, especially in lipid and glucose metabolism...
- Endocrine regulation of energy metabolism by the skeleton
Na Kyung Lee
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Cell 130:456-69. 2007
..By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis this study expands the biological importance of this organ and our understanding of energy metabolism...
- Effect of a diabetic environment in utero on predisposition to type 2 diabetes
Department of Endocrinology and Diabetes, Saint Louis Hospital, Assistance Publique, Hopitaux de Paris, University of Paris VII Medical School, Paris, France
Lancet 361:1861-5. 2003
..Type 2 diabetes is affected by genetics and environmental factors. We aimed to assess the effect of an in-utero diabetic environment independently of the genetic background for type 2 diabetes...
- PAX4 gene variations predispose to ketosis-prone diabetes
Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 13:3151-9. 2004
- Leptin-replacement therapy in lipodystrophy
N Engl J Med 346:2008; author reply 2009-10. 2002
- Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice
Cedric Le May
Division of Diabetes, Endocrinology and Metabolism, Department of, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:9232-7. 2006
..This study demonstrates that estradiol, acting, at least in part, through ERalpha, protects beta-cells from oxidative injury and prevents diabetes in mice of both genders...