Kok Gan Chan

Summary

Affiliation: University of Malaya
Country: Malaysia

Publications

  1. doi request reprint Complete genome sequence of Pandoraea oxalativorans DSM 23570(T), an oxalate metabolizing soil bacterium
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia Electronic address
    J Biotechnol 219:124-5. 2016
  2. pmc Unusual long-chain N-acyl homoserine lactone production by and presence of quorum quenching activity in bacterial isolates from diseased tilapia fish
    Chien Yi Chang
    School of Molecular Medical Sciences, Centre for Biomolecular Science, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 7:e44034. 2012
  3. pmc Anti-quorum sensing activity of the traditional Chinese herb, Phyllanthus amarus
    Kumutha Priya
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:14558-69. 2013
  4. pmc Pandoraea sp. RB-44, a novel quorum sensing soil bacterium
    Robson Ee Han-Jen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 13:14121-32. 2013
  5. pmc Short chain N-acyl homoserine lactone production by soil isolate Burkholderia sp. strain A9
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:13217-27. 2013
  6. pmc N-acyl homoserine lactone-producing Pseudomonas putida strain T2-2 from human tongue surface
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:13192-203. 2013
  7. pmc Degradation of bacterial quorum sensing signaling molecules by the microscopic yeast Trichosporon loubieri isolated from tropical wetland waters
    Cheng Siang Wong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:12943-57. 2013
  8. pmc Quorum sensing activity of Enterobacter asburiae isolated from lettuce leaves
    Yin Yin Lau
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:14189-99. 2013
  9. pmc Short chain N-acylhomoserine lactone production by clinical multidrug resistant Klebsiella pneumoniae strain CSG20
    Yun Fong Ngeow
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:15242-51. 2013
  10. pmc Comparative genomic analysis of six bacteria belonging to the genus Novosphingobium: insights into marine adaptation, cell-cell signaling and bioremediation
    Han Ming Gan
    Science Vision SB, Shah Alam, Selangor, Malaysia
    BMC Genomics 14:431. 2013

Collaborators

  • Wai Fong Yin
  • Kok Keng Tee
  • Yun Fong Ngeow
  • Han Ming Gan
  • David A Pearce
  • Thiba Krishnan
  • Phaik Eem Lim
  • Praphathip Eamsobhana
  • Siti Nur Maisarah Norizan
  • Kek Heng Chua
  • Sabriye Canakci
  • Tommy Tsan Yuk Lam
  • Steve Atkinson
  • Kalai Mathee
  • Paul Williams
  • Khalijah Awang
  • Yan Lue Lim
  • Robson Ee
  • Chong Lek Koh
  • Wen Si Tan
  • Choon Kook Sam
  • Kar Wai Hong
  • Nina Yusrina Muhamad Yunos
  • Jian Woon Chen
  • Xin Yue Chan
  • Pui Wan Tan
  • Nur Izzati Mohamad
  • Tan Guan Sheng Adrian
  • Delicia Yong
  • Cheng Siang Wong
  • Teik Min Chong
  • Adeeba Kamarulzaman
  • Yeun Mun Choo
  • Li Ying Tan
  • Yee Meng Chong
  • Wah Seng See-Too
  • Ann Chee Yap
  • Share Yuan Goh
  • Jack Bee Chook
  • Yutaka Takebe
  • Hui Ting Cheong
  • Norshazliza Ab Ghani
  • Yin Yin Lau
  • Geik Yong Ang
  • Wei Zhen Chow
  • Peter Convey
  • Kae Shin Sim
  • Choo Yee Yu
  • Hien Fuh Ng
  • Noor Hayaty Abu Kasim
  • Xiang Yong Oong
  • Kah Yan How
  • Hoi Sen Yong
  • Saad Ahmed Khan
  • Clayton Koh
  • Lai Yee Ong
  • Haider Abdulrazzaq Abed Al-Darraji
  • Kim Tien Ng
  • Jia Yi Tan
  • Huey Jia Cheng
  • Joanita Sulaiman
  • Robson Ee Han-Jen
  • Kumutha Priya
  • Chien Yi Chang
  • Shenyang Chin
  • Kathiravan Purmal
  • Wan Loo Chow
  • Wuen Yew Teoh
  • Yean Chan Yean
  • Nik Sherina Hanafi
  • Martin Choo
  • Kirnpal Kaur Banga Singh
  • Kin Fah Chin
  • Yong Kek Pang
  • Sze Looi Song
  • Hooi Pin Chew
  • Lin Xin Kin
  • Malarvelli Soorya Prakasa
  • Yuet Meng Cheong
  • Zahidah Ismail
  • Nur Ezreen Syafina
  • Yin Wai-Fong
  • Chan Kok-Gan
  • Yves Dessaux
  • Catherine Grandcl√©ment
  • Hun Jiat Tung
  • Samuel Mondy
  • Dinaiz Al Thinagaran
  • Siew Moon Low
  • Savithri D Puthucheary

Detail Information

Publications80

  1. doi request reprint Complete genome sequence of Pandoraea oxalativorans DSM 23570(T), an oxalate metabolizing soil bacterium
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia Electronic address
    J Biotechnol 219:124-5. 2016
    ..Here, we report the first complete genome of P. oxalativorans DSM 23570(T) which would allow its potential biotechnological applications to be unravelled. ..
  2. pmc Unusual long-chain N-acyl homoserine lactone production by and presence of quorum quenching activity in bacterial isolates from diseased tilapia fish
    Chien Yi Chang
    School of Molecular Medical Sciences, Centre for Biomolecular Science, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 7:e44034. 2012
    ..This study is the first documentation that shows unusual long-chain AHLs production in Serratia sp. and Pseudomonas sp. isolated from diseased fish and the latter also produce a wide range of PQS molecules...
  3. pmc Anti-quorum sensing activity of the traditional Chinese herb, Phyllanthus amarus
    Kumutha Priya
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:14558-69. 2013
    ..amarus could be useful for attenuating pathogens and hence, more local traditional herbs should be screened for its anti-quorum sensing properties as their active compounds may serve as promising anti-pathogenic drugs...
  4. pmc Pandoraea sp. RB-44, a novel quorum sensing soil bacterium
    Robson Ee Han-Jen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 13:14121-32. 2013
    ..To the best of our knowledge, this is the first report that showed quorum sensing activity exhibited by Pandoraea sp. Our data add Pandoraea sp. to the growing number of bacteria that possess QS systems. ..
  5. pmc Short chain N-acyl homoserine lactone production by soil isolate Burkholderia sp. strain A9
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:13217-27. 2013
    ..We have demonstrated that Burkholderia sp. strain A9 produces AHLs that are known to be produced by other Burkholderia spp. with CepI/CepR homologs. ..
  6. pmc N-acyl homoserine lactone-producing Pseudomonas putida strain T2-2 from human tongue surface
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:13192-203. 2013
    ..This is the first report of the finding of quorum sensing of P. putida strain T2-2 isolated from the human tongue surface and their quorum sensing molecules were identified. ..
  7. pmc Degradation of bacterial quorum sensing signaling molecules by the microscopic yeast Trichosporon loubieri isolated from tropical wetland waters
    Cheng Siang Wong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:12943-57. 2013
    ....
  8. pmc Quorum sensing activity of Enterobacter asburiae isolated from lettuce leaves
    Yin Yin Lau
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:14189-99. 2013
    ..asburiae spent supernatant confirmed the production of N-butanoyl homoserine lactone (C4-HSL) and N-hexanoyl homoserine lactone (C6-HSL). To the best of our knowledge, this is the first report of AHL production by E. asburiae. ..
  9. pmc Short chain N-acylhomoserine lactone production by clinical multidrug resistant Klebsiella pneumoniae strain CSG20
    Yun Fong Ngeow
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:15242-51. 2013
    ..pneumoniae strain CSG20 produced N-hexanoyl-homoserine lactone (C6-HSL). To the best of our knowledge, this is the first report on the production of N-hexanoylhomoserine lactone (C6-HSL) in clinical isolate K. pneumoniae. ..
  10. pmc Comparative genomic analysis of six bacteria belonging to the genus Novosphingobium: insights into marine adaptation, cell-cell signaling and bioremediation
    Han Ming Gan
    Science Vision SB, Shah Alam, Selangor, Malaysia
    BMC Genomics 14:431. 2013
    ..Additionally, we show the taxonomic relationship between the sequenced bacteria based on phylogenomic analysis, average amino acid identity (AAI) and genomic signatures...
  11. pmc Exochelin production in Mycobacterium neoaurum
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia
    Int J Mol Sci 10:345-53. 2009
    ..neoaurum by semi-preparative chromatography. When saturated ferric chloride solution was added into the purified exochelin, a ferri-exochelin complex was formed. It is proposed that iron uptake in M. neoaurum is exochelin-mediated...
  12. pmc Plant-derived natural products as sources of anti-quorum sensing compounds
    Chong Lek Koh
    Natural Sciences and Science Education AG, National Institute of Education, Nanyang Technological University, Singapore
    Sensors (Basel) 13:6217-28. 2013
    ..In this review, we have surveyed the various types of plant-based natural products that exhibit anti-quorum sensing properties and their anti-quorum sensing mechanisms...
  13. doi request reprint A novel medium for the isolation of N-acylhomoserine lactone-degrading bacteria
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
    J Ind Microbiol Biotechnol 36:247-51. 2009
    ..To the best of our knowledge, this is the first documentation of the isolation of an AHL-degrading proteobacterium from sewage...
  14. doi request reprint Quorum sensing in Aeromonas species isolated from patients in Malaysia
    Kok Gan Chan
    Institute of Biological Sciences Division of Genetics and Molecular Biology, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
    Curr Microbiol 62:167-72. 2011
    ..Our data provides a better understanding of the mechanism(s) of this environmental bacterium emerging as a human pathogen...
  15. doi request reprint Rapid degradation of N-3-oxo-acylhomoserine lactones by a Bacillus cereus isolate from Malaysian rainforest soil
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Antonie Van Leeuwenhoek 98:299-305. 2010
    ..Sequence analysis indicated the presence of the motif (106)HXDH-59 amino acids-H(169)-21 amino acids-D(191) for N-acylhomoserine lactone lactonases...
  16. pmc Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    BMC Microbiol 11:51. 2011
    ..Here we sought to discover novel N-acylhomoserine lactone (AHL)-dependent QS and QQ strains by investigating a bacterial community associated with the rhizosphere of ginger (Zingiber officinale) growing in the Malaysian rainforest...
  17. pmc N-acyl homoserine lactone production by Klebsiella pneumoniae isolated from human tongue surface
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:3472-83. 2012
    ..To the best of our knowledge, this is the first report of the isolation of K. pneumoniae from the posterior dorsal surface of the human tongue and the production of these AHLs by this bacterium...
  18. doi request reprint Complete genome sequence of Pandoraea thiooxydans DSM 25325(T), a thiosulfate-oxidizing bacterium
    Delicia Yong
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Biotechnol 217:51-2. 2016
    ..Here, we present the first complete genome of P. thiooxydans DSM 25325(T). Several genes involved in thiosulfate oxidation and biodegradation of aromatic compounds were identified. ..
  19. pmc Genetic Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF74_01B) Identified among Intravenous Drug Users in Malaysia: Recombination History and Phylogenetic Linkage with Previously Defined Recombinant Lineages
    Hui Ting Cheong
    Centre of Excellence for Research in AIDS CERiA, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 10:e0133883. 2015
    ..The characterization of the novel CRF74_01B is of considerable significance towards the understanding of the genetic diversity and population dynamics of HIV-1 circulating in the region. ..
  20. pmc Pseudomonas cremoricolorata strain ND07 produces N-acyl homoserine lactones as quorum sensing molecules
    Nina Yusrina Muhamad Yunos
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 14:11595-604. 2014
    ..To the best of our knowledge, this is the first documentation on the production of C10-HSL in P. cremoricolorata strain ND07...
  21. ncbi request reprint Characterization of wetland quorum quenching Pseudomonas aeruginosa strain 2SW8 and its 2-heptyl-3-hydroxy-4-quinolone production
    Cheng Siang Wong
    Division of Genetics and Molecular Biology, University of Malaya, Kuala Lumpur, Malaysia
    New Microbiol 35:43-51. 2012
    ..Strain 2SW8 also showed 2-heptyl-3-hydroxy-4-quinolone production...
  22. pmc Characterization of quorum sensing and quorum quenching soil bacteria isolated from Malaysian tropical montane forest
    Teik Min Chong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:4846-59. 2012
    ..To the best of our knowledge, this is the first documentation of Arthrobacter and Pseudomonas spp. capable of degrading p-coumaroyl-homoserine lactone and the production of C12-HSL by P. frederiksbergensis...
  23. doi request reprint Coexistence of quorum-quenching and quorum-sensing in tropical marine Pseudomonas aeruginosa strain MW3A
    Cheng Siang Wong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
    World J Microbiol Biotechnol 28:453-61. 2012
    ..Hence, we report here a novel marine P. aeruginosa strain MW3A possessing both quorum-quenching and quorum-sensing properties...
  24. doi request reprint Complete genome of Pseudomonas sp. strain L10.10, a psychrotolerant biofertilizer that could promote plant growth
    Wah Seng See-Too
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia National Antarctic Research Centre NARC, Institute of Postgraduate Studies, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Biotechnol 222:84-5. 2016
    ....
  25. doi request reprint Complete genome sequence of Serratia fonticola DSM 4576 T, a potential plant growth promoting bacterium
    Yan Lue Lim
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Biotechnol 214:43-4. 2015
    ..This genome sequence is valuable for functional genomics and ecological studies which are related to PGP and biocontrol activities. ..
  26. pmc Short chain N-acyl homoserine lactone production in tropical marine Vibrio sinaloensis strain T47
    Pui Wan Tan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:12958-67. 2014
    ..sinaloensis strain T47. To our knowledge, this is the first documentation of AHL and biofilm production in V. sinaloensis strain T47. ..
  27. pmc Discovery of Pantoea rodasii strain ND03 that produces N-(3-Oxo-hexanoyl)-L-homoserine lactone
    Nina Yusrina Muhamad Yunos
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 14:9145-52. 2014
    ..rodasii strain ND03 produced N-(3-oxo-hexanoyl)-L-homoserine lactone (3-oxo-C6-HSL). To the best of our knowledge, this is the first report for such a discovery in P. rodasii strain ND03. ..
  28. pmc Characterisation of a marine bacterium Vibrio brasiliensis T33 producing N-acyl homoserine lactone quorum sensing molecules
    Wen Si Tan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:12104-13. 2014
    ..We demonstrated that this isolate formed biofilms which could be inhibited by catechin. To the best of our knowledge, this is the first report that documents the production of these AHLs by Vibrio brasiliensis strain T33...
  29. pmc Freshwater-borne bacteria isolated from a Malaysian rainforest waterfall exhibiting quorum sensing properties
    Wen Si Tan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:10527-37. 2014
    ..To the best of our knowledge, this is the first documentation of an Enterobacter sp. that produced both 3-oxo-C6-HSL and 3-oxo-C8-HSL as QS signaling molecules. ..
  30. doi request reprint Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity
    Yee Meng Chong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 74:2261-4. 2011
    ..These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further...
  31. pmc Long chain N-acyl homoserine lactone production by Enterobacter sp. isolated from human tongue surfaces
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:14307-14. 2012
    ..To the best of our knowledge, this is the first isolation of Enterobacter sp., strain T1-1 from the posterior dorsal surface of the human tongue and N-acyl homoserine lactones production by this bacterium...
  32. pmc Piper nigrum, Piper betle and Gnetum gnemon--natural food sources with anti-quorum sensing properties
    Li Ying Tan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:3975-85. 2013
    ..Since there is a variety of plants that serve as food sources in Malaysia that have yet to be tested for anti-QS activity, future work should focus on identification of these plants and isolation of the anti-QS compounds...
  33. pmc Complete genome sequence of Burkholderia sp. Strain GG4, a betaproteobacterium that reduces 3-oxo-N-acylhomoserine lactones and produces different N-acylhomoserine lactones
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6317. 2012
    ..To the best of our knowledge, this is the first sequenced genome from a bacterium of the genus Burkholderia that shows both quorum-sensing and signaling confusion activities...
  34. pmc Whole-genome sequence of N-acylhomoserine lactone-synthesizing and -degrading Acinetobacter sp. strain GG2
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6318. 2012
    ..It degrades a broad range of N-acylhomoserine lactone molecules via lactonase. The genome sequence of strain GG2 may provide insights on the regulation of quorum-sensing and quorum-quenching mechanisms in this bacterium...
  35. pmc Quorum sensing activity of Citrobacter amalonaticus L8A, a bacterium isolated from dental plaque
    Share Yuan Goh
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sci Rep 6:20702. 2016
    ....
  36. doi request reprint Complete genome of Pandoraea pnomenusa RB-38, an oxalotrophic bacterium isolated from municipal solid waste landfill site
    Yan Lue Lim
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Biotechnol 214:83-4. 2015
    ..pnomenusa RB38 in which an oxalate utilization pathway was identified. The genome analysis suggested the potential of this strain as an effective biocontrol agent against oxalate-producing phytopathogens. ..
  37. pmc Complete mitochondrial genome of Bactrocera arecae (Insecta: Tephritidae) by next-generation sequencing and molecular phylogeny of Dacini tribe
    Hoi Sen Yong
    Institute of Biological Sciences, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sci Rep 5:15155. 2015
    ..The whole mitogenome of B. arecae will serve as a useful dataset for studying the genetics, systematics and phylogenetic relationships of the many species of Bactrocera genus in particular, and tephritid fruit flies in general...
  38. doi request reprint Complete genome sequence of Serratia multitudinisentens RB-25(T), a novel chitinolytic bacterium
    Yan Lue Lim
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Biotechnol 207:32-3. 2015
    ..To our knowledge, this is the first report of the complete genome sequence of this novel isolate and its chitinase gene discovery. ..
  39. pmc Molecular detection of HIV-1 subtype B, CRF01_AE, CRF33_01B, and newly emerging recombinant lineages in Malaysia
    Jack Bee Chook
    Centre of Excellence for Research in AIDS CERiA, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku ku, Tokyo, Japan Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    Am J Trop Med Hyg 92:507-12. 2015
    ..The newly developed real-time PCR assay offers a rapid and cost-effective alternative for large-scale molecular epidemiological surveillance for HIV-1. ..
  40. pmc Pantoea sp. isolated from tropical fresh water exhibiting N-acyl homoserine lactone production
    Wen Si Tan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    ScientificWorldJournal 2014:828971. 2014
    ..The isolated Pantoea sp. was confirmed to produce N-3-oxohexanoyl-L-HSL (3-oxo-C6-HSL) through analysis of high resolution mass tandem mass spectrometry. ..
  41. pmc Insights from the genome sequence of quorum-quenching Staphylococcus sp. strain AL1, isolated from traditional Chinese soy sauce brine fermentation
    Teik Min Chong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6611-2. 2012
    ..To the best of our knowledge, this is the first documentation that reports the whole genome sequence and quorum-quenching activity of Staphylococcus sp. strain AL1...
  42. pmc Genome sequence of Roseomonas sp. strain B5, a quorum-quenching N-acylhomoserine lactone-degrading bacterium isolated from Malaysian tropical soil
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6681-2. 2012
    ..This is the first genome announcement of a member from the genus of Roseomonas and the first report on the quorum-quenching activity of Roseomonas spp...
  43. pmc Draft genome sequence of an Aeromonas sp. strain 159 clinical isolate that shows quorum-sensing activity
    Xin Yue Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6350. 2012
    ..In the draft genome of strain 159, luxI and luxR homologue genes were found to be located at contig 47, and these genes are believed to be important for the quorum-sensing system present in this pathogen...
  44. doi request reprint Complete genome sequence of oxalate-degrading bacterium Pandoraea vervacti DSM 23571(T)
    Robson Ee
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Biotechnol 204:5-6. 2015
    ..vervacti DSM 23571(T). A complete pathway for degradation of oxalate was revealed from the genome analysis. These data are important to path new opportunities for genetic engineering in the field of biotechnology. ..
  45. pmc Quorum sensing activity of Serratia fonticola strain RB-25 isolated from an ex-landfill site
    Robson Ee
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:5136-46. 2014
    ..This is the first report of the production of these AHLs in S. fonticola. ..
  46. pmc Detection of quorum sensing activity in the multidrug-resistant clinical isolate Pseudomonas aeruginosa strain GB11
    Huey Jia Cheng
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:12511-22. 2014
    ..Of these detected AHLs, 3-oxo-C12-HSL was found to be the most abundant AHL produced by P. aeruginosa GB11. ..
  47. pmc Tandem mass spectrometry detection of quorum sensing activity in multidrug resistant clinical isolate Acinetobacter baumannii
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    ScientificWorldJournal 2014:891041. 2014
    ..baumannii 4KT was studied. Production of short chain AHL, namely, N-hexanoyl-homoserine lactone (C6-HSL) and N-octanoyl-homoserine lactone (C8-HSL), was detected. ..
  48. pmc Labrenzia sp. BM1: a quorum quenching bacterium that degrades N-acyl homoserine lactones via lactonase activity
    Norshazliza Ab Ghani
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:11760-9. 2014
    ..To the best of our knowledge, this is the first documentation of a Labrenzia sp. capable of degrading N-acylhomoserine lactones and confirmation of its lactonase-based mechanism of action...
  49. pmc Caffeine as a potential quorum sensing inhibitor
    Siti Nur Maisarah Norizan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:5117-29. 2013
    ..To the best of our knowledge, this is the first documentation providing evidence on the presence of anti-quorum sensing activity in caffeine. Our work will allow caffeine to be explored as anti-infective drugs...
  50. pmc Draft genome sequence of Pantoea sp. strain A4, a Rafflesia-associated bacterium that produces N-acylhomoserine lactones as quorum-sensing molecules
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6610. 2012
    ..Pantoea sp. strain A4 is a Gram-negative bacterium isolated from the Rafflesia flower. We present here, for the first time, the genome sequence of Rafflesia-associated Pantoea sp. strain A4, which exhibited quorum-sensing activity...
  51. doi request reprint A new oxolane from Enterobacter cloacae
    Ann Chee Yap
    a Faculty of Science, Chemistry Department, University of Malaya, Kuala Lumpur 50603, Malaysia
    Nat Prod Res 30:783-8. 2016
    ..e. Maculosine (2), phenylacetic acid (3) and methyl myristate (4). These compounds were isolated and characterised using extensive chromatographic and spectroscopic methods, and were subjected to cytotoxicity evaluations. ..
  52. doi request reprint Complete genome of Planococcus rifietoensis M8(T), a halotolerant and potentially plant growth promoting bacterium
    Wah Seng See-Too
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia National Antarctic Research Centre NARC, Institute of Postgraduate Studies, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Biotechnol 221:114-5. 2016
    ..This paper presents the first complete genome of P. rifietoensis M8(T). Genes coding for various potentially plant growth promoting properties were identified within its genome. ..
  53. pmc Microbiome and Biocatalytic Bacteria in Monkey Cup (Nepenthes Pitcher) Digestive Fluid
    Xin Yue Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Malaysia
    Sci Rep 6:20016. 2016
    ....
  54. pmc Epidemiological and Evolutionary Dynamics of Influenza B Viruses in Malaysia, 2012-2014
    Xiang Yong Oong
    Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 10:e0136254. 2015
    ..This study describes the evolution of influenza B viruses in Malaysia and highlights the importance of continuous surveillance for better vaccination policy in this region...
  55. pmc Cross-border sexual transmission of the newly emerging HIV-1 clade CRF51_01B
    Hui Ting Cheong
    Centre of Excellence for Research in AIDS CERiA, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 9:e111236. 2014
    ..Understanding the cross-border transmission of HIV-1 involving sexual networks is crucial for effective intervention strategies in the region. ..
  56. pmc Quorum quenching revisited--from signal decays to signalling confusion
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 12:4661-96. 2012
    ..While quorum quenching has been explored as a novel anti-infective therapy targeting, quorum sensing evidence begins to show the development of resistance against quorum quenching...
  57. pmc Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa PAO1 by Ayurveda spice clove (Syzygium aromaticum) bud extract
    Thiba Krishnan
    Division of Genetics and Molecular Biology, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 12:4016-30. 2012
    ..This study shows that the presence of natural compounds that exhibit anti-quorum sensing activity in the clove extracts may be useful as the lead of anti-infective drugs...
  58. pmc Quorum sensing activity in Pandoraea pnomenusa RB38
    Robson Ee
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:10177-86. 2014
    ..pnomenusa strain RB38, which validated that this isolate produced N-octanoyl homoserine lactone as a quorum sensing molecule. This is the first report of the production of N-octanoyl homoserine lactone by P. pnomenusa strain RB38. ..
  59. pmc Quorum sensing activity of Aeromonas caviae strain YL12, a bacterium isolated from compost
    Yan Lue Lim
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 14:7026-40. 2014
    ..coli [pSB401]. The data presented in this study will be the leading steps in understanding the role of quorum sensing in Aeromonas caviae strain YL12. ..
  60. pmc Rhodotorula mucilaginosa, a quorum quenching yeast exhibiting lactonase activity isolated from a tropical shoreline
    Norshazliza Ab Ghani
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:6463-73. 2014
    ..To the best of our knowledge, this is the first documentation of the fact that Rh. mucilaginosa has activity against a broad range of AHLs namely C6-HSL, 3-oxo-C6-HSL and 3-hydroxy-C6-HSL. ..
  61. pmc Genome sequence of Dyella japonica strain A8, a quorum-quenching bacterium that degrades N-acylhomoserine lactones, isolated from Malaysian tropical soil
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6331. 2012
    ..To the best of our knowledge, this is the first genome announcement of a member from the genus of Dyella, and this is also the first work that reports the quorum-quenching activity of Dyella japonica...
  62. pmc Heavy-metal resistance of a France vineyard soil bacterium, Pseudomonas mendocina strain S5.2, revealed by whole-genome sequencing
    Teik Min Chong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6366. 2012
    ..In addition to being copper resistant, the genome of P. mendocina strain S5.2 contains a number of heavy-metal-resistant genes known to confer resistance to multiple heavy-metal ions...
  63. pmc Quorum quenching Bacillus sonorensis isolated from soya sauce fermentation brine
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:4065-73. 2012
    ..To the best of our knowledge, this is the first report of AHL-degrading B. sonorensis from soya sauce liquid state fermentation...
  64. doi request reprint The mRNA expression of soluble urokinase plasminogen activator surface receptor in human adipose tissue is positively correlated with body mass index
    Hien Fuh Ng
    a Department of Surgery, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Genome 58:315-21. 2015
    ..These findings suggest an important role for suPLAUR in the recruitment of immune cells to obese adipose tissue, in the pathogenesis of obesity. ..
  65. doi request reprint Development of a dry-reagent-based nucleic acid-sensing platform by coupling thermostabilised LATE-PCR assay to an oligonucleotide-modified lateral flow biosensor
    Geik Yong Ang
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia Electronic address
    J Microbiol Methods 118:99-105. 2015
    ....
  66. pmc Enterobacter asburiae strain L1: complete genome and whole genome optical mapping analysis of a quorum sensing bacterium
    Yin Yin Lau
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:13913-24. 2014
    ..asburiae. To the best of our knowledge, this is the first documentation of both a complete genome sequence and the establishment of the molecular basis of QS properties of E. asburiae. ..
  67. pmc Identification of new genomospecies in the Mycobacterium terrae complex
    Yun Fong Ngeow
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 10:e0120789. 2015
    ..terrae complex. This paper illustrates the versatile utilization of whole genome data for the delineation of new bacterial species and introduces four new genomospecies to add to current members in the M. terrae complex. ..
  68. pmc Global genome comparative analysis reveals insights of resistome and life-style adaptation of Pseudomonas putida strain T2-2 in oral cavity
    Xin Yue Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    ScientificWorldJournal 2014:930727. 2014
    ..In summary, it is believed that multiple metabolic characteristics and drug resistance in P. putida strain T2-2 helped in its survival in human oral cavity. ..
  69. pmc Unusual multiple production of N-acylhomoserine lactones a by Burkholderia sp. strain C10B isolated from dentine caries
    Share Yuan Goh
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 14:8940-9. 2014
    ..The isolated Burkholderia sp. was confirmed to produce N-hexanoyl-L-homoserine lactone (C6-HSL), N-octanoyl-L-homoserine lactone (C8-HSL), N-decanoyl-L-homoserine lactone (C10-HSL) and N-dodecanoyl-L-homoserine lactone (C12-HSL). ..
  70. pmc Silencing quorum sensing through extracts of Melicope lunu-ankenda
    Li Ying Tan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:4339-51. 2012
    ..Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds...
  71. pmc Whole-genome sequence of Cupriavidus sp. strain BIS7, a heavy-metal-resistant bacterium
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6324. 2012
    ..It is particularly resistant to Fe(II), Fe(III), and Zn(II). Here we present the assembly and annotation of its genome...
  72. doi request reprint A new oxathiolane from Enterobacter cloacae
    Ann Chee Yap
    a Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Nat Prod Res 29:722-6. 2015
    ..3,4-Di-t-butylaniline (4) is isolated for the first time from a natural resource. These compounds were isolated and characterised using extensive chromatographic and spectroscopic methods, and were subjected to cytotoxicity evaluations. ..
  73. pmc Quorum sensing activity of a Kluyvera sp. isolated from a Malaysian waterfall
    Nina Yusrina Muhamad Yunos
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 14:8305-12. 2014
    ....
  74. pmc Quorum sensing activity of Hafnia alvei isolated from packed food
    Jia Yi Tan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 14:6788-96. 2014
    ..To our knowledge, this is the first report of the production of AHLs, especially 3-oxo-C8-HSL, by H. alvei. ..
  75. pmc A newly emerging HIV-1 recombinant lineage (CRF58_01B) disseminating among people who inject drugs in Malaysia
    Wei Zhen Chow
    Centre of Excellence for Research in AIDS CERiA, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 9:e85250. 2014
    ....
  76. pmc Microbial contamination of orthodontic buccal tubes from manufacturers
    Kathiravan Purmal
    Department of General Dental Practice and Oral and Maxillofacial Imaging, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia e mail
    Int J Mol Sci 11:3349-56. 2010
    ..We also suggest that manufacturers should list the sterility state of orthodontic buccal tubes on their packaging or instructions stating the need for sterilization...