Sazaly AbuBakar

Summary

Affiliation: University of Malaya
Country: Malaysia

Publications

  1. ncbi Emergence of dengue virus type 4 genotype IIA in Malaysia
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Gen Virol 83:2437-42. 2002
  2. pmc Recombinant human enterovirus 71 in hand, foot and mouth disease patients
    Yoke Fun Chan
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 10:1468-70. 2004
  3. pmc Dengue virus type 1 clade replacement in recurring homotypic outbreaks
    Boon Teong Teoh
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    BMC Evol Biol 13:213. 2013
  4. pmc Detection of dengue viruses using reverse transcription-loop-mediated isothermal amplification
    Boon Teong Teoh
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    BMC Infect Dis 13:387. 2013
  5. pmc Colonized Aedes albopictus and its sexual performance in the wild: implications for SIT technology and containment
    Dieng Hamady
    School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia
    Parasit Vectors 6:206. 2013
  6. pmc Human neuronal cell protein responses to Nipah virus infection
    Li Yen Chang
    Center for Proteomics Research, Department of Forest Biotechnology, Forest Research Institute Malaysia, Selangor, Malaysia
    Virol J 4:54. 2007
  7. pmc Quantitative estimation of Nipah virus replication kinetics in vitro
    Li Yen Chang
    Center for Proteomics Research, Department of Forest Biotechnology, Forest Research Institute, 52109, Selangor, Malaysia
    Virol J 3:47. 2006
  8. pmc Human enterovirus 71 subgenotype B3 lacks coxsackievirus A16-like neurovirulence in mice infection
    Yoke Fun Chan
    Sime Darby Technology Centre, 2, Jalan Tandang, 46050 Petaling Jaya, Selangor, Malaysia
    Virol J 2:74. 2005
  9. pmc Enterovirus 71 outbreak, Brunei
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 15:79-82. 2009
  10. ncbi Outlook of dengue in Malaysia: a century later
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 24:23-7. 2002

Collaborators

Detail Information

Publications77

  1. ncbi Emergence of dengue virus type 4 genotype IIA in Malaysia
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Gen Virol 83:2437-42. 2002
    ..These results suggest that intra-serotypic recombination amongst DENV-4 from independent ancestral lineages may have contributed to the emergence of DENV-4 subgenotype IIA in Malaysia...
  2. pmc Recombinant human enterovirus 71 in hand, foot and mouth disease patients
    Yoke Fun Chan
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 10:1468-70. 2004
    ..When caused by CV-A16 infection, it is usually a mild disease, and patients normally recover without requiring any special medical attention...
  3. pmc Dengue virus type 1 clade replacement in recurring homotypic outbreaks
    Boon Teong Teoh
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    BMC Evol Biol 13:213. 2013
    ..Understanding the DENV evolutionary mechanism underlying the recurring dengue outbreaks has important implications for epidemic prediction and disease control...
  4. pmc Detection of dengue viruses using reverse transcription-loop-mediated isothermal amplification
    Boon Teong Teoh
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    BMC Infect Dis 13:387. 2013
    ..An easy to perform and highly sensitive method is needed for routine implementation especially in the resource-limited rural healthcare settings where dengue is endemic...
  5. pmc Colonized Aedes albopictus and its sexual performance in the wild: implications for SIT technology and containment
    Dieng Hamady
    School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia
    Parasit Vectors 6:206. 2013
    ..albopictus and wild populations...
  6. pmc Human neuronal cell protein responses to Nipah virus infection
    Li Yen Chang
    Center for Proteomics Research, Department of Forest Biotechnology, Forest Research Institute Malaysia, Selangor, Malaysia
    Virol J 4:54. 2007
    ..In the present study, the SK-N-MC human neuronal cell protein response to NiV infection is examined using proteomic approaches...
  7. pmc Quantitative estimation of Nipah virus replication kinetics in vitro
    Li Yen Chang
    Center for Proteomics Research, Department of Forest Biotechnology, Forest Research Institute, 52109, Selangor, Malaysia
    Virol J 3:47. 2006
    ....
  8. pmc Human enterovirus 71 subgenotype B3 lacks coxsackievirus A16-like neurovirulence in mice infection
    Yoke Fun Chan
    Sime Darby Technology Centre, 2, Jalan Tandang, 46050 Petaling Jaya, Selangor, Malaysia
    Virol J 2:74. 2005
    ....
  9. pmc Enterovirus 71 outbreak, Brunei
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 15:79-82. 2009
    ..Isolated EV71 strains formed a distinct lineage with low diversity within subgenogroup B5, suggesting recent introduction and rapid spread within Brunei...
  10. ncbi Outlook of dengue in Malaysia: a century later
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 24:23-7. 2002
    ....
  11. pmc Isolation and molecular identification of Nipah virus from pigs
    Sazaly AbuBakar
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 10:2228-30. 2004
    ..At least two different Nipah virus strains, including a previously unreported strain, were identified. The findings highlight the possibility that the Malaysia outbreaks had two origins of Nipah virus infections...
  12. pmc Novel antiviral activity of baicalein against dengue virus
    Keivan Zandi
    Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center TIDREC, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    BMC Complement Altern Med 12:214. 2012
    ..Among the natural compounds, bioflavonoids derived mainly from plants are of interest because of their biological and medicinal benefits...
  13. pmc Extract of Scutellaria baicalensis inhibits dengue virus replication
    Keivan Zandi
    Tropical Infectious Disease Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    BMC Complement Altern Med 13:91. 2013
    ..In the present study, we evaluated the in vitro antiviral activity of aqueous extract of the roots of S. baicalensis against all the four dengue virus (DENV) serotypes...
  14. doi Chikungunya virus of Asian and Central/East African genotypes in Malaysia
    I Ching Sam
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    J Clin Virol 46:180-3. 2009
    ..In Malaysia, limited CHIKV outbreaks of the endemic Asian and imported Central/East African genotypes were reported in 1998 and 2006. Since April 2008, an unprecedented nationwide outbreak has affected Malaysia...
  15. doi Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells
    Keivan Zandi
    Tropical Infectious Diseases Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia
    Molecules 17:2437-45. 2012
    ..The CC₅₀ value of flavone against Vero cells was 446 µg/mL. These results suggest that flavone might enhance dengue virus replication by acting antagonistically towards flavonoids known to inhibit dengue virus replication...
  16. doi Phylogenetic designation of enterovirus 71 genotypes and subgenotypes using complete genome sequences
    Yoke Fun Chan
    Department of Medical Microbiology, University Malaya, Kuala Lumpur, Malaysia
    Infect Genet Evol 10:404-12. 2010
    ..Hence, in the absence of full genome sequences, it is proposed here that a combination of VP1 and 3D RNA polymerase gene sequences be used for initial genotyping of EV-71 isolates...
  17. pmc Full genome SNP-based phylogenetic analysis reveals the origin and global spread of Brucella melitensis
    Kim Kee Tan
    Tropical Infectious Diseases Research and Education Centre TIDREC, University of Malaya, 50603, Kuala Lumpur, Malaysia
    BMC Genomics 16:93. 2015
    ..melitensis strains collected from around the world, to investigate the potential origin and the history of the global spread of B. melitensis...
  18. pmc Antiviral activity of four types of bioflavonoid against dengue virus type-2
    Keivan Zandi
    Tropical Infectious Disease Research and Education Center TIDREC, Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
    Virol J 8:560. 2011
    ..Selectivity Index value (SI) was determined as the ratio of cytotoxic concentration 50 (CC50) to inhibitory concentration 50 (IC50) for each compound...
  19. pmc Genotypic and phenotypic characterization of Chikungunya virus of different genotypes from Malaysia
    I Ching Sam
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 7:e50476. 2012
    ..To gain insight into these observed epidemiological differences, we compared genotypic and phenotypic characteristics of CHIKV of Asian and ECSA genotypes isolated in Malaysia...
  20. pmc Isolation of ancestral sylvatic dengue virus type 1, Malaysia
    Boon Teong Teoh
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 16:1783-5. 2010
    ..The virus is neutralized by serum of patients with endemic DENV-1 infection. Rare isolation of this virus suggests a limited spillover infection from an otherwise restricted sylvatic cycle...
  21. pmc Phylogenetic evidence for inter-typic recombination in the emergence of human enterovirus 71 subgenotypes
    Chan Yoke-Fun
    Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia
    BMC Microbiol 6:74. 2006
    ..Several new EV-71 subgenotypes were identified from these outbreaks. The mechanisms that contributed to the emergence of these subgenotypes are unknown...
  22. pmc Molecular identification of adenovirus causing respiratory tract infection in pediatric patients at the University of Malaya Medical Center
    Juraina Abd-Jamil
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Tropical Infectious Diseases Research and Education Center 50603 Kuala Lumpur, Malaysia
    BMC Pediatr 10:46. 2010
    ..Presently, there are no reports of the prevalent HAdV types found in Malaysia. The present study was undertaken to identify the HAdV types associated primarily with respiratory tract infections (RTI) of young children in Malaysia...
  23. pmc The Use of NS1 Rapid Diagnostic Test and qRT-PCR to Complement IgM ELISA for Improved Dengue Diagnosis from Single Specimen
    Boon Teong Teoh
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Sci Rep 6:27663. 2016
    ..If complemented with qRT-PCR, combined NS1 Ag Strip/IgM ELISA would improve detection of secondary dengue samples. ..
  24. doi Dengue virus type 2 envelope protein displayed as recombinant phage attachment protein reveals potential cell binding sites
    Juraina Abd-Jamil
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia
    Protein Eng Des Sel 21:605-11. 2008
    ..The phage displayed truncated DENV-2 E is a powerful and useful method for the direct determination of DENV-2 E cell binding sites...
  25. pmc Early detection of dengue virus by use of reverse transcription-recombinase polymerase amplification
    Boon Teong Teoh
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Clin Microbiol 53:830-7. 2015
    ..Hence, it is possible to use the RT-RPA assay in a laboratory to complement routine serology testing for dengue. ..
  26. doi MicroRNA 299-3p modulates replicative senescence in endothelial cells
    Hui Lan Jong
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Physiol Genomics 45:256-67. 2013
    ..Hence, these findings provide an early insight into the role of hsa-miR-299-3p in the modulation of replicative senescence in HUVECs...
  27. ncbi Antigenic cell associated dengue 2 virus proteins detected in vitro using dengue fever patients sera
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 24:29-36. 2002
    ..Detection of dengue 2 virus C antibody in some patients further suggested that C could be antigenic if presented in vivo...
  28. pmc Reemergence of endemic Chikungunya, Malaysia
    Sazaly AbuBakar
    University of Malaya, Kuala Lumpur, Malaysia
    Emerg Infect Dis 13:147-9. 2007
    ..The reemergence of the infection is not part of the epidemics in other Indian Ocean countries but raises the possibility that chikungunya virus is endemic in Malaysia...
  29. pmc Virus-specific read-through codon preference affects infectivity of chimeric cucumber green mottle mosaic viruses displaying a dengue virus epitope
    Pak Guan Teoh
    Center for Research in Biotechnology for Agriculture CEBAR and Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    J Biomed Biotechnol 2009:781712. 2009
    ....
  30. doi Bacterial community in Haemaphysalis ticks of domesticated animals from the Orang Asli communities in Malaysia
    Jing Jing Khoo
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia Electronic address
    Ticks Tick Borne Dis 7:929-37. 2016
    ..The role of the herein found Coxiella and Rickettsia in tick physiology or disease transmission merits further investigation. ..
  31. pmc Colorimetric Detection of Dengue by Single Tube Reverse-Transcription-Loop-Mediated Isothermal Amplification
    Yee Ling Lau
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
    PLoS ONE 10:e0138694. 2015
    ..With continuing efforts in the optimization of this assay, RT-LAMP may provide a simple and reliable test for detecting DENV in areas where dengue is prevalent. ..
  32. ncbi Enterovirus 71 infection induces apoptosis in Vero cells
    Yoke Fun Chan
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 25:29-35. 2003
    ..The induction, however, requires high level of HEV71 infectivity and the presence of live virus particles, suggesting the need for the presence of specific viral proteins for apoptosis to occur...
  33. pmc Coxiella Detection in Ticks from Wildlife and Livestock in Malaysia
    Jing Jing Khoo
    1 Tropical Infectious Diseases Research and Education Centre TIDREC, University of Malaya, Kuala Lumpur, Malaysia
    Vector Borne Zoonotic Dis 16:744-751. 2016
    ..The importance of C. burnetii found in ticks in Malaysia warrants further investigation...
  34. doi Tick-borne viruses: a review from the perspective of therapeutic approaches
    Rafidah Lani
    Tropical Infectious Disease Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Ticks Tick Borne Dis 5:457-65. 2014
    ..The lack of treatment and prevention approaches for these viruses is highlighted, and we hope that this review may increase public health awareness with regard to the threat posed by this group of viruses. ..
  35. pmc Review of Dengue hemorrhagic fever fatal cases seen among adults: a retrospective study
    Sing Sin Sam
    Tropical Infectious Diseases Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS Negl Trop Dis 7:e2194. 2013
    ..The disease affects mainly children, but in recent years it is becoming more of an adult disease. Malaysia experienced a large dengue outbreak in 2006 to 2007, involving mostly adults, with a high number of deaths...
  36. pmc Baicalin, a metabolite of baicalein with antiviral activity against dengue virus
    Ehsan Moghaddam
    Tropical Infectious Disease Research and Education Center, Department of Medical Microbiology Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sci Rep 4:5452. 2014
    ..07 ± 0.2 μg/ml. Our findings showed that baicalin as the main metabolite of baicalein exerting in vitro anti-DENV activity. Further investigations on baicalein and baicalin to deduce its antiviral therapeutic effects are warranted...
  37. pmc Anti-inflammatory, gastroprotective and anti-ulcerogenic effects of red algae Gracilaria changii (Gracilariales, Rhodophyta) extract
    Meng Hooi Shu
    Tropical Infectious Diseases Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    BMC Complement Altern Med 13:61. 2013
    ..The aim of the study was to investigate anti-inflammatory, gastroprotective and anti-ulcerogenic activities of a mass spectrometry standardized methanolic extract of Gracilaria changii...
  38. ncbi Nipah virus RNA synthesis in cultured pig and human cells
    Li Yen Chang
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia
    J Med Virol 78:1105-12. 2006
    ..However, there are differences between these cells and human neuronal cells and monocytes in the ability to support Nipah virus replication and virus release...
  39. ncbi Dengue virus type 2 NS3 protease and NS2B-NS3 protease precursor induce apoptosis
    Norazizah Shafee
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    J Gen Virol 84:2191-5. 2003
    ..These findings suggest the importance of NS2B as a cofactor to NS3 protease-induced apoptosis...
  40. ncbi Comparative transcriptional study of the effects of high intracellular zinc on prostate carcinoma cells
    Pooi Fong Wong
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Oncol Rep 23:1501-16. 2010
    ..This could be the antagonistic mechanism used to overcome the initial cell growth inhibitory effects of high Zn2+. These findings support a potential detrimental role of Zn2+ in prostate cancer...
  41. doi High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells
    Pooi Fong Wong
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Cell Mol Biol Lett 13:375-90. 2008
    ..These results highlight the importance of a high intracellular Zn(2+) content and the VHR/ZAP-70-associated pathways in the modulation of LNCaP prostate cancer cell growth...
  42. pmc Macrophage Activation Syndrome-Associated Markers in Severe Dengue
    Hasliana Azrah Ab-Rahman
    1 Tropical Infectious Disease Research and Education Centre TIDREC, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Int J Med Sci 13:179-86. 2016
    ..Our findings suggest that in addition to serum ferritin, sCD163 can differentiate severe dengue from that of dengue fever patients. Hence, sCD163 level can be considered for use as a predictive marker for impending severe dengue. ..
  43. pmc Genetic characterization of commensal Escherichia coli isolated from laboratory rodents
    Shih Keng Loong
    Tropical Infectious Diseases Research and Education Centre, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Springerplus 5:1035. 2016
    ..coli. Hence, in this study, the genetic structure of commensal E. coli found in laboratory rodents and their antimicrobial resistance profiles were investigated...
  44. doi Insertion of single-chain variable fragment (scFv) peptide linker improves surface display of influenza hemagglutinin (HA1) on non-recombinant Lactococcus lactis
    Pui Fong Jee
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Biotechnol Prog . 2016
    ..lactis using the AcmA binding domain. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 2016...
  45. pmc An Inactivated Antibiotic-Exposed Whole-Cell Vaccine Enhances Bactericidal Activities Against Multidrug-Resistant Acinetobacter baumannii
    Meng Hooi Shu
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sci Rep 6:22332. 2016
    ..baumannii. Therefore, the inactivated antibiotic-exposed whole-cell vaccine (I-M28-47-114) has potential for development as a candidate vaccine for broad clearance and protection against MDR A. baumannii infections. ..
  46. pmc Development of a Real-Time Cell Analysing (RTCA) method as a fast and accurate screen for the selection of chikungunya virus replication inhibitors
    Suria Marlina
    Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Parasit Vectors 8:579. 2015
    ..Therefore, in this study we developed an RTCA method as an accurate and time-based screen for antiviral compounds against CHIKV...
  47. pmc Detection of Langat virus by TaqMan real-time one-step qRT-PCR method
    Siti Fatimah Muhd Radzi
    Tropical Infectious Disease Research Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sci Rep 5:14007. 2015
    ..The sensitivity of the developed method also has been confirmed by determining the LGTV in infected tick cell line as well as LGTV- spiked tick tissues. ..
  48. pmc Potential Antiviral Agents from Marine Fungi: An Overview
    Soheil Zorofchian Moghadamtousi
    Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Mar Drugs 13:4520-38. 2015
    ..The present review strives to summarize all available knowledge on active compounds isolated from marine fungi with antiviral activity. ..
  49. pmc High producing tumor necrosis factor alpha gene alleles in protection against severe manifestations of dengue
    Sing Sin Sam
    1 Tropical Infectious Diseases Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Int J Med Sci 12:177-86. 2015
    ..In the present study, the association between IL-12B, IL-10 and TNF-α gene polymorphisms and dengue severity was investigated...
  50. pmc Evolution of Influenza B Virus in Kuala Lumpur, Malaysia, between 1995 and 2008
    I Ching Sam
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia Diagnostic Virology Laboratory, University Malaya Medical Centre, Kuala Lumpur, Malaysia
    J Virol 89:9689-92. 2015
    ..We also found poor lineage matches with recommended influenza virus vaccine strains. While most influenza B virus lineages in Malaysia were short-lived, one circulated for 3 to 4 years. ..
  51. pmc Senescence affects endothelial cells susceptibility to dengue virus infection
    Sazaly AbuBakar
    1 Tropical Infectious Diseases Research and Education Centre TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Int J Med Sci 11:538-44. 2014
    ..These results suggest that senescing HUVECs do not support DENV infection and DENV infection induces HUVECs senescence. The finding highlights the possible role of induction of senescence in DENV infection of the endothelial cells. ..
  52. doi Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28
    Pooi Fong Wong
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Phytomedicine 19:138-44. 2012
    ..The treatment also resulted in suppression of the lung cancer cell tumor markers and several known cancer cell growth-associated genes...
  53. pmc Antiviral activity of baicalein and quercetin against the Japanese encephalitis virus
    Jefree Johari
    Tropical Infectious Disease Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Int J Mol Sci 13:16785-95. 2012
    ....
  54. ncbi Zinc accelerates dengue virus type 2-induced apoptosis in Vero cells
    Norazizah Shafee
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    FEBS Lett 524:20-4. 2002
    ..These results suggest that (i) apoptosis is induced in African green monkey kidney cells infected with live DENV-2 and (ii) the addition of high extracellular Zn(2+) accelerates detection of apoptosis in the DENV-2-infected cells...
  55. doi Identification of the cell binding domain in Nipah virus G glycoprotein using a phage display system
    Chui Wan Lam
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol Methods . 2017
    ..This study employed an approach that is suitable for use in a biosafety level 2 containment laboratory without the need to use live virus to show that NiV G amino acids 498-602 play an important role for attachment to host cells...
  56. pmc The Self-Regulation Model of Illness: Comparison between Zika and Dengue and Its Application to Predict Mosquito Prevention Behaviours in Malaysia, a Dengue-Endemic Country
    Li Ping Wong
    Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    Int J Environ Res Public Health 13:. 2016
    ..Understanding the context in which a person perceives ZIKV may contribute to developing interventions that influence prevention behaviours...
  57. pmc Nationwide study of factors associated with public's willingness to use home self-test kit for dengue fever in Malaysia
    Li Ping Wong
    Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
    BMC Public Health 16:780. 2016
    ....
  58. doi Utility of 16S rDNA Sequencing for Identification of Rare Pathogenic Bacteria
    Shih Keng Loong
    Tropical Infectious Diseases Research and Education Centre TIDREC, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Clin Lab Anal 30:1056-1060. 2016
    ....
  59. doi Serum from Nipah Virus Patients Recognises Recombinant Viral Proteins Produced in Escherichia coli
    Vunjia Tiong
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya
    Jpn J Infect Dis 70:26-31. 2017
    ....
  60. pmc Computational Approach Towards Exploring Potential Anti-Chikungunya Activity of Selected Flavonoids
    Seyedeh Somayeh Seyedi
    Tropical Infectious Diseases Research and Education Center, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sci Rep 6:24027. 2016
    ..8 kcal/mol). Baicalin can be considered a good candidate for further evaluation as a potentially efficient antiviral against CHIKV...
  61. pmc Molecular and antimicrobial analyses of non-classical Bordetella isolated from a laboratory mouse
    Shih Keng Loong
    Tropical Infectious Diseases Research and Education Centre, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Vet Med Sci 78:715-7. 2016
    ..The nrdA gene was demonstrated to possess greater phylogenetic resolution as compared with 16S ribosomal DNA and ompA for the discrimination of non-classical Bordetella species. ..
  62. pmc Independent Emergence of the Cosmopolitan Asian Chikungunya Virus, Philippines 2012
    Kim Kee Tan
    1 Tropical Infectious Diseases Research and Education Centre TIDREC, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sci Rep 5:12279. 2015
    ..Molecular evidence, however, supports the Philippines outbreak as the possible origin of the CACV. ..
  63. pmc Seroprevalence screening for the West Nile virus in Malaysia's Orang Asli population
    Suria Marlina
    Tropical Infectious Disease Research and Education Center TIDREC, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Parasit Vectors 7:597. 2014
    ..To date, no studies have been carried out to determine the prevalence of the WNV antibody in Malaysia. The aim of this study was to screen for the seroprevalence of the WNV in Malaysia's Orang Asli population...
  64. doi Full genome SNP-based phylogenetic analysis reveals the origin and global spread of Brucella melitensis
    Kim Kee Tan
    Tropical Infectious Diseases Research and Education Centre TIDREC, University of Malaya, 50603, Kuala Lumpur, Malaysia
    BMC Genomics 16:1294. 2015
    ..melitensis strains collected from around the world, to investigate the potential origin and the history of the global spread of B. melitensis...
  65. pmc The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells
    Kind Leng Tong
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    PLoS ONE 10:e0121752. 2015
    ..Results from the present study suggest that the standardized total quassinoids composition from E. longifolia promotes anti-prostate cancer activities in LNCaP human prostate cancer cells. ..
  66. doi Updates on chikungunya epidemiology, clinical disease, and diagnostics
    I Ching Sam
    1 Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    Vector Borne Zoonotic Dis 15:223-30. 2015
    ..This review focuses on recent important work on the epidemiology, clinical disease and diagnostics of CHIKV. ..
  67. pmc A review on antibacterial, antiviral, and antifungal activity of curcumin
    Soheil Zorofchian Moghadamtousi
    Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Biomed Res Int 2014:186864. 2014
    ..This review aims to summarize previous antimicrobial studies of curcumin towards its application in the future studies as a natural antimicrobial agent. ..
  68. doi LNCaP prostate cancer cells are insensitive to zinc-induced senescence
    Pooi Fong Wong
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia
    J Trace Elem Med Biol 22:242-7. 2008
    ..These findings suggest that prostate cancer cells are insensitive to the senescence-inducing effects of zinc but the cancer cells retain the capacity to undergo senescence through other pathways...
  69. ncbi Identification of a 48kDa tubulin or tubulin-like C6/36 mosquito cells protein that binds dengue virus 2 using mass spectrometry
    Hui Yee Chee
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia
    Biochem Biophys Res Commun 320:11-7. 2004
    ..These findings suggest that DENV-2 through DENV-2 E binds directly to a 48 kDa tubulin or tubulin-like protein of C6/36 mosquito cells...
  70. pmc Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review
    Azin Ahmadi
    Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center TIDREC, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Biomed Res Int 2015:825203. 2015
    ..This review strives for compiling previous antiviral studies of algae-derived polysaccharides and their mechanism of action towards their development as natural antiviral agents for future investigations. ..
  71. pmc Practices of Dengue Fever Prevention and the Associated Factors among the Orang Asli in Peninsular Malaysia
    Josephine Rebecca Chandren
    Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS Negl Trop Dis 9:e0003954. 2015
    ..The study aims to look at the socio-demographic factors, health beliefs, and knowledge about dengue and its association to dengue prevention practices among Orang Asli communities in Peninsular Malaysia...
  72. doi Distribution and dynamics of Wolbachia infection in Malaysian Aedes albopictus
    Sylvia Joanne
    Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
    Acta Trop 148:38-45. 2015
    ..The removal of Wolbachia from Ae. albopictus resulted in reduced fecundity, longevity and egg viability, thus. Wolbachia seem to play a vital role in Ae. albopictus reproductive system. ..
  73. pmc Factors affecting dengue prevention practices: nationwide survey of the Malaysian public
    Li Ping Wong
    Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Julius Centre University of Malaya JCUM, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 10:e0122890. 2015
    ..This study aimed to examine the demographic factors, theoretical constructs of the Health Belief Model and knowledge about dengue and how these influence the practice of dengue prevention...
  74. pmc Community knowledge, health beliefs, practices and experiences related to dengue fever and its association with IgG seropositivity
    Li Ping Wong
    Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Julius Centre University of Malaya JCUM, University of Malaya, Kuala Lumpur, Malaysia
    PLoS Negl Trop Dis 8:e2789. 2014
    ..This study aimed to examine these factors and their association with the seroprevalence of this disease...
  75. pmc Health beliefs and practices related to dengue fever: a focus group study
    Li Ping Wong
    Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS Negl Trop Dis 7:e2310. 2013
    ..The Health Belief Model was used as a framework to explore and understand dengue prevention behaviours...
  76. ncbi Antibody neutralization and viral virulence in recurring dengue virus type 2 outbreaks
    Sook San Wong
    Macfarlane Burnet Institute for Medical Research and Public Health Limited, Melbourne, Australia
    Viral Immunol 20:359-68. 2007
    ..This could be an important contributing factor in the recurring homogenotypic dengue virus outbreaks seen in dengue-endemic regions...