Rajesh Ramasamy

Summary

Affiliation: Universiti Putra Malaysia
Country: Malaysia

Publications

  1. doi request reprint The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function
    Rajesh Ramasamy
    Department of Pathology, Immunology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Cell Immunol 251:131-6. 2008
  2. doi request reprint Elevated neutrophil respiratory burst activity in essential hypertensive patients
    Rajesh Ramasamy
    Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia
    Cell Immunol 263:230-4. 2010
  3. ncbi request reprint Generation and characterisation of human umbilical cord derived mesenchymal stem cells by explant method
    Z Yusoff
    Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Pathology, Immunology Unit, 43400 Serdang, Selangor, Malaysia
    Med J Malaysia 71:105-10. 2016
  4. pmc Colostrum supplementation protects against exercise-induced oxidative stress in skeletal muscle in mice
    Mahenderan Appukutty
    Faculty of Sports Science and Recreation, University Technology MARA, Shah Alam 40450, Kuala Lumpur, Malaysia
    BMC Res Notes 5:649. 2012
  5. doi request reprint Basic fibroblast growth factor modulates cell cycle of human umbilical cord-derived mesenchymal stem cells
    R Ramasamy
    Immunology Laboratory, Universiti Putra Malaysia, Malaysia
    Cell Prolif 45:132-9. 2012
  6. doi request reprint Bone marrow-derived mesenchymal stem cells modulate BV2 microglia responses to lipopolysaccharide
    Yin Yin Ooi
    Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400UPM Serdang, Selangor, Malaysia
    Int Immunopharmacol 10:1532-40. 2010
  7. doi request reprint Mesenchymal stem cells of human placenta and umbilical cord suppress T-cell proliferation at G0 phase of cell cycle
    Shalini Vellasamy
    Immunology Laboratory, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Cell Biol Int 37:250-6. 2013
  8. doi request reprint Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) inhibit the proliferation of K562 (human erythromyeloblastoid leukaemic cell line)
    Malini Fonseka
    Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Cell Biol Int 36:793-801. 2012
  9. doi request reprint Generation of mesenchymal stem cell from human umbilical cord tissue using a combination enzymatic and mechanical disassociation method
    Chih Kong Tong
    Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia
    Cell Biol Int 35:221-6. 2011
  10. pmc Advancements in reprogramming strategies for the generation of induced pluripotent stem cells
    Mei I Lai
    Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang UPM, Selangor, Malaysia
    J Assist Reprod Genet 28:291-301. 2011

Collaborators

  • Sharmili Vidyadaran
  • Maha Abdullah
  • Yin Yin Ooi
  • Elizabeth George
  • Syahril Abdullah
  • Shi Wei Tan
  • Asmah Rahmat
  • Hossein Hosseinkhani
  • Francesco Dazzi
  • H F Seow
  • Shalini Vellasamy
  • Noridzzaida Ridzuan
  • Pratheep Sandrasaigaran
  • Maryam Maqbool
  • Chih Kong Tong
  • Cini Mathew John
  • Z Yusoff
  • Maisarah Abdul Mutalib
  • Hoo Mun-Fun
  • Shinsmon Jose
  • Mansooreh Sadat Mojani
  • Abhi Veerakumarasivam
  • Norshariza Nordin
  • Malini Fonseka
  • Mahenderan Appukutty
  • Boon Chong Tan
  • Aishah Adam
  • Mei I Lai
  • Cini M John
  • Faisal Ali
  • Akram Al Abbar
  • Radha Kodiappan
  • Nur Atiqah Azhar
  • Fauziah Othman
  • Soon Choy Chan
  • M Maqbool
  • Lee Chuen Liew
  • Wai Kien Yip
  • R Hassan
  • Jonathan Lim
  • Nurul Afiqah Hisham
  • Siti Nurusaadah Hamzah
  • Karrupiah Thilakavathy
  • Pike See Cheah
  • Mohd Nazri Yazid
  • Nurfarhana Ferdaos
  • Vahid Hosseinpour Sarmadi
  • Loh Su Peng
  • Mohd Ismail Noor
  • Nik Shanita Safii
  • Poh Bee Koon
  • Karuthan Chinna
  • Abu Bakar Abdul Majeed
  • Kalavathy Ramasamy
  • Nagaraja Haleagrahara
  • Ghanya Al Naqeeb
  • Abdulameer H Dhiab Al-Nuaimi
  • Ammu Kutty Radhakrishnan
  • Rozita Rosli
  • Wai Yeng Wendy-Yeo

Detail Information

Publications29

  1. doi request reprint The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function
    Rajesh Ramasamy
    Department of Pathology, Immunology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Cell Immunol 251:131-6. 2008
    ..For this reason, they have the potential to be exploited in the control of unwanted immune responses such as graft versus host disease (GVHD) and autoimmunity...
  2. doi request reprint Elevated neutrophil respiratory burst activity in essential hypertensive patients
    Rajesh Ramasamy
    Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia
    Cell Immunol 263:230-4. 2010
    ..In conclusion, the respiratory burst activity of neutrophils is affected by hypertension and their elevated superoxide anions production could be an aggravating factor in hypertension-related complication...
  3. ncbi request reprint Generation and characterisation of human umbilical cord derived mesenchymal stem cells by explant method
    Z Yusoff
    Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Pathology, Immunology Unit, 43400 Serdang, Selangor, Malaysia
    Med J Malaysia 71:105-10. 2016
    ..The current laboratory findings have reinforced the application of explant method to generate UCMSCs thus, exploring an ideal platform to fulfil the increasing demand of MSCs for research and potential clinical use. ..
  4. pmc Colostrum supplementation protects against exercise-induced oxidative stress in skeletal muscle in mice
    Mahenderan Appukutty
    Faculty of Sports Science and Recreation, University Technology MARA, Shah Alam 40450, Kuala Lumpur, Malaysia
    BMC Res Notes 5:649. 2012
    ..Total antioxidants, lipid hydroperoxides, xanthine oxidase and super oxide dismutase level was assayed from the homogenate of hind limb skeletal muscle...
  5. doi request reprint Basic fibroblast growth factor modulates cell cycle of human umbilical cord-derived mesenchymal stem cells
    R Ramasamy
    Immunology Laboratory, Universiti Putra Malaysia, Malaysia
    Cell Prolif 45:132-9. 2012
    ..However, production of MSC at sufficient clinical scale remains an issue as in vitro generation of MSC inadequately fulfils the demand with respect to patients...
  6. doi request reprint Bone marrow-derived mesenchymal stem cells modulate BV2 microglia responses to lipopolysaccharide
    Yin Yin Ooi
    Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400UPM Serdang, Selangor, Malaysia
    Int Immunopharmacol 10:1532-40. 2010
    ..Collectively, these regulatory effects of MSC on microglia offer insight into the potential moderating properties of MSC on inflammatory responses within the CNS...
  7. doi request reprint Mesenchymal stem cells of human placenta and umbilical cord suppress T-cell proliferation at G0 phase of cell cycle
    Shalini Vellasamy
    Immunology Laboratory, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Cell Biol Int 37:250-6. 2013
    ..The anti-proliferative activity of MSC was related to this cell cycle arrest of T-cell. UC-MSC produced a greater inhibition than PLC-MSC in all measured parameters...
  8. doi request reprint Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) inhibit the proliferation of K562 (human erythromyeloblastoid leukaemic cell line)
    Malini Fonseka
    Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Cell Biol Int 36:793-801. 2012
    ..The anti-proliferative effect of hUCB-MSC was due to arrest of the growth of K562 in the G0 /G1 phase. The mechanisms underlying increased IL-6 and IL-8 secretion and LAP (latency-associated peptide; TGFβ1) by hUCB-MSC remains unknown. ..
  9. doi request reprint Generation of mesenchymal stem cell from human umbilical cord tissue using a combination enzymatic and mechanical disassociation method
    Chih Kong Tong
    Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia
    Cell Biol Int 35:221-6. 2011
    ..The present study demonstrates a new and efficient approach in generating MSC from UC, hence serving as ideal alternative source of mesenchymal stem cell for clinical and research use...
  10. pmc Advancements in reprogramming strategies for the generation of induced pluripotent stem cells
    Mei I Lai
    Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang UPM, Selangor, Malaysia
    J Assist Reprod Genet 28:291-301. 2011
    ....
  11. doi request reprint Immunomodulatory activity of polyphenols derived from Cassia auriculata flowers in aged rats
    Cini M John
    Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
    Cell Immunol 271:474-9. 2011
    ....
  12. doi request reprint Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia
    Shi Wei Tan
    Immunology Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia
    Cell Immunol 271:205-9. 2011
    ..Of the isoforms tested, δ-tocotrienol lowered NO levels the most, reducing NO by approximately 50% at 48 h post-LPS treatment (p<.05). None of the tocotrienol doses tested affected microglia viability...
  13. pmc Mesenchymal stem cells exert anti-proliferative effect on lipopolysaccharide-stimulated BV2 microglia by reducing tumour necrosis factor-α levels
    Shinsmon Jose
    Neuroinflammation Group, Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia
    J Neuroinflammation 11:149. 2014
    ..In the present study, we describe the mechanism through which bone marrow-derived MSC modulate the proliferative responses of lipopolysaccharide-stimulated BV2 microglia...
  14. pmc Isolation and characterisation of mesenchymal stem cells derived from human placenta tissue
    Shalini Vellasamy
    Shalini Vellasamy, Pratheep Sandrasaigaran, Sharmili Vidyadaran, Rajesh Ramasamy, Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    World J Stem Cells 4:53-61. 2012
    ..To explore the feasibility of placenta tissue as a reliable and efficient source for generating mesenchymal stem cells (MSC)...
  15. doi request reprint Human mesenchymal stem cells protect neutrophils from serum-deprived cell death
    Maryam Maqbool
    Immunology Laboratory, Department of Pathology, Universiti Putra Malaysia, Selangor, Malaysia
    Cell Biol Int 35:1247-51. 2011
    ..However, whether this effect is exerted through a specific signalling pathway or confining neutrophils in resting state by MSC requires further investigation...
  16. pmc Preliminary study on overproduction of reactive oxygen species by neutrophils in diabetes mellitus
    Noridzzaida Ridzuan
    Noridzzaida Ridzuan, Cini Mathew John, Pratheep Sandrasaigaran, Maryam Maqbool, Lee Chuen Liew, Rajesh Ramasamy, Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
    World J Diabetes 7:271-8. 2016
    ..To assess the amount and pattern of reactive oxygen species (ROS) production in diabetic patient-derived neutrophils...
  17. doi request reprint Human mesenchymal stromal cells modulate T-cell immune response via transcriptomic regulation
    Shalini Vellasamy
    Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Cytotherapy 18:1270-83. 2016
    ..Although the immunosuppressive activity of MSCs has been explored in various contexts, the precise molecular signaling pathways that govern inhibitory functions remain poorly elucidated...
  18. doi request reprint Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats
    Mansooreh Sadat Mojani
    Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia
    Cell Immunol 289:145-9. 2014
    ..05). This model of diabetic animals may represent some but not all symptoms of human type 2 diabetes...
  19. pmc Immunophenotype and differentiation capacity of bone marrow-derived mesenchymal stem cells from CBA/Ca, ICR and Balb/c mice
    Yin Yin Ooi
    Yin Yin Ooi, Zul atfi Rahmat, Shinsmon Jose, Rajesh Ramasamy, Sharmili Vidyadaran, Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
    World J Stem Cells 5:34-42. 2013
    ..To assess the capacity to isolate and expand mesenchymal stem cells (MSC) from bone marrow of CBA/Ca, ICR and Balb/c mice...
  20. doi request reprint Gender effect on in vitro lymphocyte subset levels of healthy individuals
    Maha Abdullah
    Immunology Unit, Department of Pathology, Universiti Putra Malaysia, Malaysia
    Cell Immunol 272:214-9. 2012
    ..Our results showed significant gender differences in lymphocyte subsets in cultured conditions. This may affect experimental outcome...
  21. ncbi request reprint Enhanced CD4+CD25+ regulatory T cells with splenic proliferation and protection against oxidative stress by nicotinamide in gestational diabetes
    Cini Mathew John
    Pharmacology and Toxicology Research Laboratory, Faculty of Pharmacy, Universiti Teknologi Mara UiTM, 42300 Puncak Alam, Selangor, Malaysia
    Curr Med Chem . 2012
    ..These findings provide evidence for usage of nicotinamide as a supplement or as adjunct to therapeutic agents in gestational diabetes and in pregnant individuals with weakened immune systems...
  22. pmc Characterization and Expression of Senescence Marker in Prolonged Passages of Rat Bone Marrow-Derived Mesenchymal Stem Cells
    Noridzzaida Ridzuan
    Stem Cell and Immunity Group, Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia Regenerative Medicine Research Program, Genetic and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
    Stem Cells Int 2016:8487264. 2016
    ..Although the currently optimized protocols had successfully yielded rBM-MSCs, the culture-mediated cellular senescence limits the growth of rBM-MSCs and its potential use in rat-based MSC research. ..
  23. ncbi request reprint Screening for intermediate and severe forms of thalassaemia in discarded red blood cells: optimization and feasibility
    Elizabeth George
    Dept of Pathology hematology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia
    Med J Malaysia 66:429-34. 2011
    ..Cord blood with severe and intermediate forms of thalassaemia can be preselected and not stored...
  24. pmc Phenolics profile and anti-proliferative activity of Cyphomandra Betacea fruit in breast and liver cancer cells
    Maisarah Abdul Mutalib
    Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia UPM, 43400 Serdang, Selangor Malaysia
    Springerplus 5:2105. 2016
    ..Anti-proliferative effect of the extracts was examined using MTT (3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide) assay, followed by cell morphology analysis using acridine orange and propidium iodide double staining...
  25. doi request reprint Rat full term amniotic fluid harbors highly potent stem cells
    Hoo Mun-Fun
    Genetics and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor Darul Ehsan, Malaysia Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor Darul Ehsan, Malaysia
    Res Vet Sci 102:89-99. 2015
    ..Their strong stemness and potent neurogenic properties highlight the presence of highly potent stem cells in AF of full-term pregnancies, which could serve as a potential source of stem cells for regenerative medicine. ..
  26. pmc Gene transfer into the lung by nanoparticle dextran-spermine/plasmid DNA complexes
    Syahril Abdullah
    UPM MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    J Biomed Biotechnol 2010:284840. 2010
    ..The study also showed that there was a clear trend of increasing size of the complexes as the amount of pDNA was increased, where the sizes of the D-SPM/pDNA complexes were within the nanometer range...
  27. doi request reprint Effects of macrophage colony-stimulating factor on microglial responses to lipopolysaccharide and beta amyloid
    Sharmili Vidyadaran
    Immunology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia
    Cell Immunol 259:105-10. 2009
    ..M-CSF supplementation in BV-2 cells had no effect on nitric oxide (NO) production. Therefore, M-CSF can be considered for improving microglia yield in culture without introducing activation artefacts...
  28. ncbi request reprint Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle
    Rajesh Ramasamy
    Department of Immunology, Imperial College Faculty of Medicine, London, U K
    Transplantation 83:71-6. 2007
    ..In this study, we investigated the effect of bone marrow MSC on the differentiation and function of peripheral blood monocytes into dendritic cells (DCs)...
  29. ncbi request reprint The role of mesenchymal stem cells in haemopoiesis
    Francesco Dazzi
    Department of Immunology, Faculty of Medicine, Hammersmith Campus, Imperial College London, Du Cane Road, London, UK
    Blood Rev 20:161-71. 2006
    ..Thus, the multipotent capacity of MSC, their role in supporting haemopoiesis, and their immunoregulatory activity make MSC particularly attractive for therapeutic exploitation...