Kalpana Luthra

Summary

Publications

  1. ncbi Apolipoprotein E polymorphism in Northern Indian patients with coronary heart disease: phenotype distribution and relation to serum lipids and lipoproteins
    Kalpana Luthra
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi
    Mol Cell Biochem 232:97-102. 2002
  2. doi Proton magnetic resonance spectroscopy and biochemical investigation of type 2 diabetes mellitus in Asian Indians: observation of high muscle lipids and C-reactive protein levels
    Sanjeev Sinha
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110 029, India
    Magn Reson Imaging 27:94-100. 2009
  3. ncbi Distribution and cutoff points of fasting insulin in Asian Indian adolescents and their association with metabolic syndrome
    N K Vikram
    Department of Medicine, Fortis Hospitals, New Delhi, 110070, India
    J Assoc Physicians India 56:949-54. 2008
  4. doi Nonalcoholic fatty liver disease is associated with subclinical atherosclerosis independent of obesity and metabolic syndrome in Asian Indians
    Manik Lal Thakur
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    Atherosclerosis 223:507-11. 2012
  5. doi Genotypic variation of Pneumocystis jirovecii isolates in India based on sequence diversity at mitochondrial large subunit rRNA
    Rashmi Gupta
    Dept of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Int J Med Microbiol 301:267-72. 2011
  6. doi Association of peroxisome proliferator activated receptor-γ gene with non-alcoholic fatty liver disease in Asian Indians residing in north India
    Surya Prakash Bhatt
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Gene 512:143-7. 2013
  7. pmc Ala/Ala genotype of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-γ2 gene is associated with obesity and insulin resistance in Asian Indians
    Surya Prakash Bhatt
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Diabetes Technol Ther 14:828-34. 2012
  8. pmc Apolipoprotein E in temporal lobe epilepsy: a case-control study
    Amit Kumar
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India
    Dis Markers 22:335-42. 2006
  9. ncbi Heterogeneous phenotypes of insulin resistance and its implications for defining metabolic syndrome in Asian Indian adolescents
    Naval K Vikram
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    Atherosclerosis 186:193-9. 2006
  10. pmc Association of the Myostatin gene with obesity, abdominal obesity and low lean body mass and in non-diabetic Asian Indians in north India
    Surya Prakash Bhatt
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 7:e40977. 2012

Collaborators

Detail Information

Publications66

  1. ncbi Apolipoprotein E polymorphism in Northern Indian patients with coronary heart disease: phenotype distribution and relation to serum lipids and lipoproteins
    Kalpana Luthra
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi
    Mol Cell Biochem 232:97-102. 2002
    ..Further, apo E phenotype is positively correlated with high Lp(a) levels in the CHD subjects having at least one E4 allele. However, these relationships need to be explored in a larger sample of subjects...
  2. doi Proton magnetic resonance spectroscopy and biochemical investigation of type 2 diabetes mellitus in Asian Indians: observation of high muscle lipids and C-reactive protein levels
    Sanjeev Sinha
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110 029, India
    Magn Reson Imaging 27:94-100. 2009
    ..These findings have strong implications of increased cardiovascular risk in Asian Indians with T2DM. The absence of relationship between CRP and IMCL needs to be explored further in a study using a large sample size...
  3. ncbi Distribution and cutoff points of fasting insulin in Asian Indian adolescents and their association with metabolic syndrome
    N K Vikram
    Department of Medicine, Fortis Hospitals, New Delhi, 110070, India
    J Assoc Physicians India 56:949-54. 2008
    ..To evaluate the levels and appropriate cutoff points of fasting insulin, and their association with the metabolic syndrome (MS) in Asian Indian adolescents...
  4. doi Nonalcoholic fatty liver disease is associated with subclinical atherosclerosis independent of obesity and metabolic syndrome in Asian Indians
    Manik Lal Thakur
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    Atherosclerosis 223:507-11. 2012
    ..We examined the association of subclinical atherosclerosis and endothelial dysfunction with nonalcoholic fatty liver disease (NAFLD) in Asian Indians...
  5. doi Genotypic variation of Pneumocystis jirovecii isolates in India based on sequence diversity at mitochondrial large subunit rRNA
    Rashmi Gupta
    Dept of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Int J Med Microbiol 301:267-72. 2011
    ..The most prevalent genotype observed was type 2 in contrast to many studies from other parts of the world where genotype 1 was the most prevalent type, suggesting geographical variation...
  6. doi Association of peroxisome proliferator activated receptor-γ gene with non-alcoholic fatty liver disease in Asian Indians residing in north India
    Surya Prakash Bhatt
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Gene 512:143-7. 2013
    ..We investigated the association of polymorphisms C161T and Pro12Ala of peroxisome proliferator-activated receptor gamma (PPARγ) with clinical and biochemical parameters in Asian Indians with NAFLD...
  7. pmc Ala/Ala genotype of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-γ2 gene is associated with obesity and insulin resistance in Asian Indians
    Surya Prakash Bhatt
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Diabetes Technol Ther 14:828-34. 2012
    ..We determined the association of the Pro12Ala polymorphism of the peroxisome proliferator activated receptor (PPAR)-γ2 gene with obesity, insulin resistance (IR), and lipids in Asian Indians without diabetes in north India...
  8. pmc Apolipoprotein E in temporal lobe epilepsy: a case-control study
    Amit Kumar
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India
    Dis Markers 22:335-42. 2006
    ..Status of plasma levels of Apo E in epilepsy patients has not been reported till date...
  9. ncbi Heterogeneous phenotypes of insulin resistance and its implications for defining metabolic syndrome in Asian Indian adolescents
    Naval K Vikram
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    Atherosclerosis 186:193-9. 2006
    ..To assess the phenotypic correlations of insulin resistance with obesity and its relationship with the metabolic syndrome in Asian Indian adolescents...
  10. pmc Association of the Myostatin gene with obesity, abdominal obesity and low lean body mass and in non-diabetic Asian Indians in north India
    Surya Prakash Bhatt
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 7:e40977. 2012
    ..To determine the association of the A55T and K153R polymorphisms of the Myostatin gene with obesity, abdominal obesity and lean body mass (LBM) in Asian Indians in north India...
  11. doi TNF-alpha gene polymorphism and TNF-alpha levels in obese Asian Indians with obstructive sleep apnea
    Bharat Bhushan
    Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Respir Med 103:386-92. 2009
    ..Recent data indicate that inflammation may be an important correlate of OSA. The relationships of OSA with TNFalpha levels and TNFalpha gene promoter polymorphism (-308G/A) have not been investigated in obese Asian Indians with OSA...
  12. pmc Effect of supervised progressive resistance-exercise training protocol on insulin sensitivity, glycemia, lipids, and body composition in Asian Indians with type 2 diabetes
    Anoop Misra
    Department of Diabetes and Metabolic Diseases, Fortis Flt Lt Rajan Dhall Hospital, New Delhi, India
    Diabetes Care 31:1282-7. 2008
    ..To evaluate the effect of supervised progressive resistance-exercise training (PRT) protocol on insulin sensitivity, glycemia (blood glucose and A1C levels), lipids, and body composition in Asian Indians with type 2 diabetes...
  13. pmc SREBP-2 1784 G/C genotype is associated with non-alcoholic fatty liver disease in north Indians
    Surya Prakash Bhatt
    Department of Biochemistry, New Delhi, India
    Dis Markers 31:371-7. 2011
    ..Genetics of non-alcoholic fatty liver (NAFLD) in Asian Indians has been inadequately investigated. This study aims to determine the association of the 1784G>C polymorphism in the SREBP-2 gene with NAFLD in Asian Indians in north India...
  14. doi Polymorphic variants in DC-SIGN, DC-SIGNR and SDF-1 in high risk seronegative and HIV-1 patients in Northern Asian Indians
    Omkar Chaudhary
    Department of Biochemistry, Room No 3002, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    J Clin Virol 43:196-201. 2008
    ..DC-SIGNR was highly polymorphic and 11 genotypes were observed among the different study groups. The precise role of the polymorphic variants of DC-SIGNR needs to be elucidated in the population...
  15. ncbi Correlations of C-reactive protein levels with anthropometric profile, percentage of body fat and lipids in healthy adolescents and young adults in urban North India
    Naval K Vikram
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110 029, India
    Atherosclerosis 168:305-13. 2003
    ..To investigate the relationships of sub-clinical inflammation and regional and generalized obesity and lipids in adolescent and young adult Asian Indians in north India...
  16. doi Genotyping and phylogenetic analysis of Pneumocystis jirovecii isolates from India
    Rashmi Gupta
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India
    Infect Genet Evol 10:712-9. 2010
    ..The present study is the first study that describes the haplotypes of P. jirovecii based on the ITS gene from India. The study suggests a high diversity of P. jirovecii haplotypes in the population...
  17. doi The DC-SIGNR 7/5 genotype is associated with high dendritic cell counts and their subsets in patients infected with HIV-1
    Omkar Chaudhary
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
    J Clin Immunol 33:788-97. 2013
    ....
  18. pmc Binding antibody responses to the immunogenic regions of viral envelope in HIV-1-infected Indian children
    S S Prakash
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Viral Immunol 24:463-9. 2011
    ..This is the first report on the antibody responses elicited in HIV-1-infected children in India. The study may help to understand the humoral antibody responses directed against viral envelope in HIV-1-infected children...
  19. pmc Associations of -308G/A polymorphism of tumor necrosis factor (TNF)-α gene and serum TNF-α levels with measures of obesity, intra-abdominal and subcutaneous abdominal fat, subclinical inflammation and insulin resistance in Asian Indians in north India
    Naval K Vikram
    Departments of Medicine, All India Institute of Medical Sciences, New Delhi
    Dis Markers 31:39-46. 2011
    ..We evaluated the relationship of -308G/A polymorphism of TNF-α gene with obesity and insulin resistance in Asian Indians in north India...
  20. ncbi Subclinical inflammation and soleus muscle intramyocellular lipids in healthy Asian Indian males
    Sanjeev Sinha
    Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India
    Clin Endocrinol (Oxf) 63:350-5. 2005
    ..The relationship between C-reactive protein (CRP), a marker of subclinical inflammation, and intramyocellular lipid (IMCL) content, a novel correlate of insulin resistance, has not previously been investigated...
  21. doi Dietary nutrients and insulin resistance in urban Asian Indian adolescents and young adults
    Sumit Isharwal
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Ann Nutr Metab 52:145-51. 2008
    ..Asian Indians have a high prevalence of insulin resistance that may underlie their higher tendency to develop type 2 diabetes mellitus and early-onset atherosclerosis...
  22. pmc Centile values for serum lipids and blood pressure for Asian Indian adolescents
    Malini Madhavan
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    Lipids Health Dis 4:20. 2005
    ..Smoothed age- and sex- specific 5th, 10th, 25th, 50th, 75th, 85th, 90th and 95th percentiles where derived using LMS regression...
  23. pmc Production and characterization of human anti-V3 monoclonal antibodies from the cells of HIV-1 infected Indian donors
    Raiees Andrabi
    Department of Biochemistry, All India Institute of Medical Sciences AIIMS, New Delhi, India
    Virol J 9:196. 2012
    ..The third variable region (V3) is a crucial target on gp120, primarily due to its involvement in co-receptor (CXCR4 or CCR5) binding and presence of epitopes recognized by broadly neutralizing antibodies...
  24. doi Neutralization potential of the plasma of HIV-1 infected Indian patients in the context of anti-V3 antibody content and antiretroviral therapy. [corrected]
    Alok Kumar Choudhary
    Department of Biochemistry, All India Institute of Medical Sciences, 110029, New Delhi, India
    J Microbiol 50:149-54. 2012
    ..The plasma of antiretroviral-treated patients exhibited higher neutralization potential than that of the drug-naïve plasmas against the four PIs tested which was further evidenced by a follow-up study...
  25. doi Genotype of the LMNA 1908C>T variant is associated with generalized obesity in Asian Indians in North India
    Mukti Sharma
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Clin Endocrinol (Oxf) 75:642-9. 2011
    ..To determine the frequency distribution of LMNA 1908C>T SNP and its association with generalized obesity, abdominal obesity and coexistent metabolic disorders in nondiabetic Asian Indians living in a metropolitan city of north India...
  26. doi Synergistic epistasis of paraoxonase 1 (rs662 and rs85460) and apolipoprotein E4 genes in pathogenesis of Alzheimer's disease and vascular dementia
    Rizwan Alam
    Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India
    Am J Alzheimers Dis Other Demen 29:769-76. 2014
    ..On the other hand, low serum level of high-density lipoprotein and low level of serum PON activity were found associated significantly (P ≤ .001 in both cases) only in patients with VaD as compared to healthy control. ..
  27. doi Genetic characterization of UCS region of Pneumocystis jirovecii and construction of allelic profiles of Indian isolates based on sequence typing at three regions
    Rashmi Gupta
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
    Infect Genet Evol 13:180-6. 2013
    ..A total of 36 allelic profiles were observed in 43 isolates indicating high genetic variability. A statistically significant association was observed between mtLSU rRNA genotype 1, ITS type Ea and UCS repeat pattern 4...
  28. ncbi Apolipoprotein E gene polymorphisms in patients with premature myocardial infarction: a case-controlled study in Asian Indians in North India
    Prabhat Kumar
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110 029, India
    Ann Clin Biochem 40:382-7. 2003
    ..This study aimed to study the role of apo E gene polymorphisms in premature MI patients and their relation to serum lipid levels...
  29. pmc A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C
    Rajesh Kumar
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    BMC Biotechnol 12:87. 2012
    ....
  30. pmc Neutralization of tier-2 viruses and epitope profiling of plasma antibodies from human immunodeficiency virus type 1 infected donors from India
    Raiees Andrabi
    Department of Biochemistry, C N Centre, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 7:e43704. 2012
    ..Overall, the data suggest that, despite the low immunogenicity of HIV-1 MPER, the antibodies directed to this region may serve as crucial reagents for HIV-1 vaccine design...
  31. doi MTHFR (677 and 1298) and IL-6-174 G/C genes in pathogenesis of Alzheimer's and vascular dementia and their epistatic interaction
    Nasim Mansoori
    Department of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Neurobiol Aging 33:1003.e1-8. 2012
    ..2-fold, the presence of CC genotype of rs1801131 nullified this effect. The findings support the hypothesis that multiple genes are involved to alter the odds of developing AD and VaD...
  32. pmc Soluble inter-cellular adhesion molecule-1 in urban Asian north Indians: relationships with anthropometric and metabolic covariates
    Astha Sethi
    Department of Medicine, All India Institute of Medical Sciences, New Delhi
    Dis Markers 18:111-20. 2002
    ....
  33. ncbi Association between subclinical inflammation & fasting insulin in urban young adult north Indian males
    N K Vikram
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 124:677-82. 2006
    ..We therefore studied the association of serum high-sensitivity C-reactive protein (hs-CRP) with fasting insulin and insulin resistance in urban adolescent and young adult males in north India...
  34. ncbi Adiponectin, insulin resistance, and C-reactive protein in postpubertal Asian Indian adolescents
    Naval K Vikram
    Department of Medicine, All India Institute of Medical Sciences, New Delhi
    Metabolism 53:1336-41. 2004
    ..We conclude that generalized obesity affects the adiponectin-insulin relationship in postpubertal Asian Indian males; however, the relationship of adiponectin with hs-CRP needs further evaluation...
  35. ncbi Dihydropteroate synthase (DHPS) gene mutation study in HIV-Infected Indian patients with Pneumocystis jirovecii pneumonia
    Anuj Kumar Tyagi
    All India Institute of Medical Sciences AIIMS, New Delhi, India
    J Infect Dev Ctries 4:761-6. 2010
    ..jirovecii isolates obtained from HIV-infected patients with a clinical diagnosis of Pneumocystis carinii pneumonia (PCP) admitted to our tertiary care reference health center in New Delhi, India...
  36. doi Obstructive sleep apnoea correlates with C-reactive protein in obese Asian Indians
    Bharat Bhushan
    Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Nutr Metab Cardiovasc Dis 19:184-9. 2009
    ..Whether the relationship of obstructive sleep apnoea (OSA) and CRP is independent of adiposity, needs to be investigated...
  37. doi Envelope diversity, characteristics of V3 region and predicted co-receptor usage of human immunodeficiency viruses infecting north Indians
    Raiees Andrabi
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    J Microbiol 50:869-73. 2012
    ..Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population...
  38. doi Association of DC-SIGNR Expression in Peripheral Blood Mononuclear Cells with DC-SIGNR Genotypes in HIV-1 Infection
    Omkar Chaudhary
    1 Department of Biochemistry, Cardiothoracic and Neurosciences Center, All India Institute of Medical Sciences, New Delhi, India
    Viral Immunol 28:472-5. 2015
    ....
  39. pmc Diversity of HIV type 1 envelope (V3-V5) sequence in HIV type 1-infected Indian children
    Somi Sankaran Prakash
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    AIDS Res Hum Retroviruses 28:505-9. 2012
    ..A unique finding was the complete deletion of the V4 region of another virus (AIIMS_363). High sequence diversity was observed in the envelope of the HIV-1-infected Indian children...
  40. pmc Vitamin D insufficiency is associated with abdominal obesity in urban Asian Indians without diabetes in North India
    Surya Prakash Bhatt
    1 Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Diabetes Technol Ther 16:392-7. 2014
    ....
  41. doi IL-6-174 G/C and ApoE gene polymorphisms in Alzheimer's and vascular dementia patients attending the cognitive disorder clinic of the All India Institute of Medical Sciences, New Delhi
    Nasim Mansoori
    Department of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Dement Geriatr Cogn Disord 30:461-8. 2010
    ..We evaluated the role of apolipoprotein E (ApoE) and interleukin-6 (IL-6)-174 G/C gene polymorphism along with serum IL-6 levels in AD and VaD patients...
  42. doi Cholesterol ester transfer protein and apolipoprotein E gene polymorphisms in hyperlipidemic Asian Indians in North India
    Kiran Meena
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Mol Cell Biochem 352:189-96. 2011
    ..07 (1.29-3.30) and 2.05 (1.30-3.24), respectively] as compared to the other genotypes. ApoE ε4 allele and E3E4 genotype emerged as important genetic markers for hyperlipidemia in this study population...
  43. ncbi Waist-to-Height Ratio Compared to Standard Obesity Measures as Predictor of Cardiometabolic Risk Factors in Asian Indians in North India
    Naval K Vikram
    1 Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Metab Syndr Relat Disord 14:492-499. 2016
    ....
  44. ncbi Apolipoprotein E gene polymorphism in Indian patients with Alzheimer's disease and vascular dementia
    Kalpana Luthra
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Dement Geriatr Cogn Disord 17:132-5. 2004
    ..7 times higher, respectively, in the presence of even a single epsilon4 allele. Our results suggest that the increased risk of developing AD or VaD is similar among Asian Indians with ApoE epsilon4 compared with the Caucasian population...
  45. doi CXCL12-CXCR7 signaling activates ERK and Akt pathways in human choriocarcinoma cells
    Vishwas Tripathi
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Cell Commun Adhes 21:221-8. 2014
    ..Our findings suggest a possible role of CXCR7 in activating the cell survival pathways ERK and Akt in human choriocarcinoma JAR cells. ..
  46. doi Serum folic acid and RFC A80G polymorphism in Alzheimer's disease and vascular dementia
    Nasim Mansoori
    1Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India
    Am J Alzheimers Dis Other Demen 29:38-44. 2014
    ..No direct association was found between variant (G) allele or genotype of rs1051266 with AD and VaD cases. On serum folate level no association was observed with gene polymorphism. ..
  47. doi Relative reactivity of HIV-1 polyclonal plasma antibodies directed to V3 and MPER regions suggests immunodominance of V3 over MPER and dependence of high anti-V3 antibody titers on virus persistence
    Raiees Andrabi
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Arch Virol 156:1787-94. 2011
    ..These findings strongly suggest that high titers of V3-specific antibodies are dependent on persistence of virus in circulation, while antibodies to MPER are probably not...
  48. pmc Identification of CD4-Binding Site Dependent Plasma Neutralizing Antibodies in an HIV-1 Infected Indian Individual
    Lubina Khan
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 10:e0125575. 2015
    ..The identification of CD4bs dependent neutralizing antibodies in an HIV-1 infected Indian donor is a salient finding of this study and is supportive of ongoing efforts to induce similar antibodies by immunization. ..
  49. doi Antiretroviral drug resistance mutations in the reverse transcriptase gene of HIV-1 isolates from Northern Indian patients: a follow-up study
    Shubhasree Dutta Choudhury
    Department of Biochemistry, All India Institute of Medical Sciences, Room No 3002, Ansari Nagar, New Delhi, India
    Arch Virol 155:563-9. 2010
    ..The major DRMs found in two 6-month follow-up samples were absent in their baseline blood samples. This is the first follow-up study to determine anti-retroviral drug resistance mutations in Indian HIV patients...
  50. pmc Mutations in the reverse transcriptase and protease genes of human immunodeficiency virus-1 from antiretroviral naïve and treated pediatric patients
    Dinesh Bure
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India
    Viruses 7:590-603. 2015
    ..The screening of ART naïve children for mutations in HIV-1 RT and protease genes, before and after initiation of ART is desirable for drug efficacy and good prognosis...
  51. doi Neutralization resistant HIV-1 primary isolates from antiretroviral naïve chronically infected children in India
    Muzamil Ashraf Makhdoomi
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India
    Virology 499:105-113. 2016
    ..Our findings suggest that primary isolates, due to close resemblance to viruses in natural infection, should be used to evaluate NAbs as effective vaccine candidates in both children and adults...
  52. pmc Relationship of adipocyte size with adiposity and metabolic risk factors in Asian Indians
    Ved Prakash Meena
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 9:e108421. 2014
    ..Enlargement of adipocyte is associated with their dysfunction and alterations in metabolic functions...
  53. doi Highly efficient neutralization by plasma antibodies from human immunodeficiency virus type-1 infected individuals on antiretroviral drug therapy
    Raiees Andrabi
    Department of Biochemistry, All India Institute of Medical Sciences AIIMS, Ansari Nagar, New Delhi, India
    J Clin Immunol 34:504-13. 2014
    ..09) and plasma total IgG (p = 0.46). Our study suggests that the plasma antibodies from ART patients display high neutralizing activity most likely due to an improved B cell function induced by ART despite low antigenic stimulation...
  54. ncbi Dyslipidemia in Asian Indians: determinants and significance
    A Misra
    Dept of Medicine, All India Institute of Medical Sciences, New Delhi 110 029, India
    J Assoc Physicians India 52:137-42. 2004
    ..However, optimal management requires consideration of ethnic-specific dietary, lifestyle and management factors to formulate individual treatment guidelines...
  55. doi CXCR7 mediated Giα independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells
    Romsha Kumar
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Cell Immunol 272:230-41. 2012
    ..Our findings suggest that CXCR7 promotes cell survival and does not induce cell death in T cells. The CXCL12 signaling via CXCR7 may be crucial in determining the fate of the activated T cells...
  56. doi Efficient neutralization of primary isolates by the plasma from HIV-1 infected Indian children
    S S Prakash
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Viral Immunol 24:409-13. 2011
    ..We report here for the first time the neutralization potential of the plasma of HIV-1-infected Indian children...
  57. ncbi Distribution of CCR5delta32, CCR2-64I and SDF1-3'A and plasma levels of SDF-1 in HIV-1 seronegative North Indians
    Romsha Verma
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    J Clin Virol 38:198-203. 2007
    ..Low frequency of the protective allele CCR5delta32 observed in this study suggests high vulnerability of North Indians to HIV-1 infection. The precise role of SDF1-3'A in HIV-1 infection needs to be elucidated...
  58. doi Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA
    Anand Singh
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India
    J Antimicrob Chemother 69:404-15. 2014
    ....
  59. pmc Apo E genotyping from blood stored on filter paper
    Rizwana Quraishi
    Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 135:318-21. 2012
    ..In tropical countries with varying temperature conditions the use of dried blood needs to be validated. We carried out this study to assess the use of blood spotted filter paper as a transport system to study genotyping of Apo E gene...
  60. doi Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis
    Neena Malhotra
    Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India
    Gynecol Endocrinol 28:224-7. 2012
    ..Pelvic endometriosis is a chronic inflammatory disease with an immunological background. Yet there is paucity of contemporary research exploring both the angiogenic cytokines, leptin and IL-8 for a possible role in its pathophysiology...
  61. doi Differential expression of RDC1/CXCR7 in the human placenta
    Vishwas Tripathi
    All India Institute of Medical Sciences, New Delhi, India
    J Clin Immunol 29:379-86. 2009
    ..The differential expression of CXCR7 in the human placenta is not yet reported...
  62. ncbi Hyperhomocysteinemia, and low intakes of folic acid and vitamin B12 in urban North India
    Anoop Misra
    Department of Medicine, All India Institute of Medical Sciences, New Delhi
    Eur J Nutr 41:68-77. 2002
    ..To test this hypothesis, we studied serum levels of Hcy in subjects living in an urban slum of North India and healthy subjects from urban nonslum area...
  63. ncbi Use of different primer directed sequence amplification by polymerase chain reaction for identification of Pneumocystis jirovecii in clinical samples
    Rashmi Gupta
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
    Indian J Chest Dis Allied Sci 50:321-7. 2008
    ..Pneumocystis carinii pneumonia (PCP), caused by opportunistic agent Pneumocystis jirovecii (formerly, Pneumocystis carinii is one of the most serious respiratory infection in immunocompromised patients...
  64. ncbi Analysis of the apo(a) size polymorphism in Asian Indian populations: association with Lp(a) concentration and coronary heart disease
    F S Geethanjali
    Institute of Medical Biology and Human Genetics, University of Innsbruck, 6020 Innsbruck, Austria
    Atherosclerosis 169:121-30. 2003
    ....
  65. ncbi Simple anthropometric measures identify fasting hyperinsulinemia and clustering of cardiovascular risk factors in Asian Indian adolescents
    Anoop Misra
    Department of Diabetes and Metabolic Disorders, Fortis Hospital, New Delhi 110016, India
    Metabolism 55:1569-73. 2006
    ..These simple measurements are useful for preventing and predicting cardiovascular risk and for generating a correct definition of the metabolic syndrome...
  66. pmc APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome
    Michael Miller
    University of Maryland Hospital and Veterans Affairs Medical Center, Baltimore, Maryland, USA
    Arch Med Res 38:444-51. 2007
    ..One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss of insulin downregulation...