Monica Longo

Summary

Publications

  1. doi request reprint Comparative embryotoxicity of different antimalarial peroxides: in vitro study using the rat whole embryo culture model (WEC)
    Monica Longo
    Accelera S r l, Viale Pasteur 10, Nerviano, Milan, Italy
    Reprod Toxicol 30:583-90. 2010
  2. doi request reprint In vivo preliminary investigations of the effects of the benzimidazole anthelmintic drug flubendazole on rat embryos and fetuses
    Monica Longo
    Accelera S r l, Viale Pasteur 10, 20014 Nerviano MI, Italy Electronic address
    Reprod Toxicol 49:33-42. 2014
  3. doi request reprint Tolerability and toxicological profile of pixantrone (Pixuvri®) in juvenile mice. Comparative study with doxorubicin
    Monica Longo
    Accelera S r l, Viale Pasteur 10, 20014 Nerviano, Milan, Italy Electronic address
    Reprod Toxicol 46:20-30. 2014
  4. doi request reprint Effects of the benzimidazole anthelmintic drug flubendazole on rat embryos in vitro
    Monica Longo
    Accelera S r l, Viale Pasteur 10, 20014 Nerviano, Milan, Italy
    Reprod Toxicol 36:78-87. 2013
  5. doi request reprint Piperaquine phosphate: reproduction studies
    Monica Longo
    Accelera Srl, Viale Pasteur 10, 20014 Nerviano, Milan, Italy
    Reprod Toxicol 34:584-97. 2012
  6. ncbi request reprint In vivo and in vitro investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos
    Monica Longo
    Department of Preclinical Development, Nerviano Medical Sciences Srl, Viale Pasteur 10, Nerviano, Milan, Italy
    Reprod Toxicol 22:797-810. 2006
  7. doi request reprint Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX)
    Monica Longo
    Department of Preclinical Development, Nerviano Medical Sciences S r l, Viale Pasteur 10, 20014 Nerviano, Milan, Italy
    Reprod Toxicol 25:433-41. 2008
  8. ncbi request reprint Effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro
    Monica Longo
    Department of Preclinical Development, Nerviano Medical Sciences S r l, Viale Pasteur 10, 20014 Nerviano, Milan, Italy
    Reprod Toxicol 21:83-93. 2006

Detail Information

Publications8

  1. doi request reprint Comparative embryotoxicity of different antimalarial peroxides: in vitro study using the rat whole embryo culture model (WEC)
    Monica Longo
    Accelera S r l, Viale Pasteur 10, Nerviano, Milan, Italy
    Reprod Toxicol 30:583-90. 2010
    ..From this comparison, arterolane showed a better safety margin than artemisinin...
  2. doi request reprint In vivo preliminary investigations of the effects of the benzimidazole anthelmintic drug flubendazole on rat embryos and fetuses
    Monica Longo
    Accelera S r l, Viale Pasteur 10, 20014 Nerviano MI, Italy Electronic address
    Reprod Toxicol 49:33-42. 2014
    ..5 without causing cell death. On GD 20, 80% of fetuses showed malformations. At 2mg/kg/day (Cmax=0.389μg/mL after single administration), it did not interfere with rat embryofetal development. ..
  3. doi request reprint Tolerability and toxicological profile of pixantrone (Pixuvri®) in juvenile mice. Comparative study with doxorubicin
    Monica Longo
    Accelera S r l, Viale Pasteur 10, 20014 Nerviano, Milan, Italy Electronic address
    Reprod Toxicol 46:20-30. 2014
    ..Pixantrone showed minimal cardiotoxicity in males and negligible in females at PND 96. Doxorubicin induced significant heart weight reduction at PND 42, however early sacrifice impeded further cardiac assessments...
  4. doi request reprint Effects of the benzimidazole anthelmintic drug flubendazole on rat embryos in vitro
    Monica Longo
    Accelera S r l, Viale Pasteur 10, 20014 Nerviano, Milan, Italy
    Reprod Toxicol 36:78-87. 2013
    ..The No Observed Effect Level (NOEL) was 0.25 μg/mL for both drugs. Reduced and hydrolyzed flubendazole were less embryotoxic than the parent compound, with NOELs 4-fold and >40-fold higher than that of flubendazole, respectively...
  5. doi request reprint Piperaquine phosphate: reproduction studies
    Monica Longo
    Accelera Srl, Viale Pasteur 10, 20014 Nerviano, Milan, Italy
    Reprod Toxicol 34:584-97. 2012
    ..It was not possible to identify the mechanism leading to the delivery delay. In a comparative study using other antimalarials, only Mefloquine gave similar findings to PQP...
  6. ncbi request reprint In vivo and in vitro investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos
    Monica Longo
    Department of Preclinical Development, Nerviano Medical Sciences Srl, Viale Pasteur 10, Nerviano, Milan, Italy
    Reprod Toxicol 22:797-810. 2006
    ....
  7. doi request reprint Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX)
    Monica Longo
    Department of Preclinical Development, Nerviano Medical Sciences S r l, Viale Pasteur 10, 20014 Nerviano, Milan, Italy
    Reprod Toxicol 25:433-41. 2008
    ..The window of susceptibility and duration of exposure must be considered to evaluate the clinical relevance of these findings...
  8. ncbi request reprint Effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro
    Monica Longo
    Department of Preclinical Development, Nerviano Medical Sciences S r l, Viale Pasteur 10, 20014 Nerviano, Milan, Italy
    Reprod Toxicol 21:83-93. 2006
    ..Extrapolating results to pregnant women exposed in the first trimester remains difficult. Pharmacovigilance and further studies of the mechanism of damage are needed...