Zhi qiang Ling

Summary

Publications

  1. ncbi request reprint [Screening of specific miRNA in early gastric cancer]
    Jing Han
    Examination Science and Life Science College, Wenzhou Medical University, Wenzhou 325035, China
    Zhonghua Wei Chang Wai Ke Za Zhi 17:175-9. 2014
  2. doi request reprint MSH2 promoter hypermethylation in circulating tumor DNA is a valuable predictor of disease-free survival for patients with esophageal squamous cell carcinoma
    Z Q Ling
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, No 38 Guangji Rd, Banshanqiao District, Hangzhou 310022, PR China
    Eur J Surg Oncol 38:326-32. 2012
  3. pmc Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous?
    Takahisa Nakayama
    Department of Pathology, Shiga University of Medical Science, Otsu, 520 2192 Japan
    BMC Cancer 10:311. 2010
  4. doi request reprint Aberrant methylation of different DNA repair genes demonstrates distinct prognostic value for esophageal cancer
    Zhi qiang Ling
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, No 38 Guangji Rd, Banshanqiao District, 310022, Hangzhou, People s Republic of China
    Dig Dis Sci 56:2992-3004. 2011
  5. doi request reprint Hypermethylation-modulated down-regulation of CDH1 expression contributes to the progression of esophageal cancer
    Zhi qiang Ling
    Zhejiang Cancer Research Institute, Hangzhou 310022, PR China
    Int J Mol Med 27:625-35. 2011
  6. doi request reprint Circulating methylated MINT2 promoter DNA is a potential poor prognostic factor in gastric cancer
    Jing Han
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, No 38 Guangji Rd, Banshanqiao District, Hangzhou, 310022, People s Republic of China
    Dig Dis Sci 59:1160-8. 2014
  7. doi request reprint Stepwise cumulation of RUNX3 methylation mediated by Helicobacter pylori infection contributes to gastric carcinoma progression
    Xiao Xiao Lu
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, People s Republic of China
    Cancer 118:5507-17. 2012
  8. pmc CDH1 methylation in preoperative peritoneal washes is an independent prognostic factor for gastric cancer
    Qi Ming Yu
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Banshanqiao District, Hangzhou, China
    J Surg Oncol 106:765-71. 2012
  9. ncbi request reprint [Aberrant methylation of hMLH1 gene promoter in papillary thyroid cancer and its clinical significance]
    Xiao Xiao Lu
    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou 310022, China
    Zhonghua Zhong Liu Za Zhi 35:833-6. 2013
  10. doi request reprint Hypermethylation-modulated downregulation of RASSF1A expression is associated with the progression of esophageal cancer
    Wei min Mao
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, PR China
    Arch Med Res 42:182-8. 2011

Collaborators

Detail Information

Publications44

  1. ncbi request reprint [Screening of specific miRNA in early gastric cancer]
    Jing Han
    Examination Science and Life Science College, Wenzhou Medical University, Wenzhou 325035, China
    Zhonghua Wei Chang Wai Ke Za Zhi 17:175-9. 2014
    ..To examine the micro-RNA (mirna) expression profile in tissues of early gastric cancer and to screen the specific mirna associated with gastric cancer...
  2. doi request reprint MSH2 promoter hypermethylation in circulating tumor DNA is a valuable predictor of disease-free survival for patients with esophageal squamous cell carcinoma
    Z Q Ling
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, No 38 Guangji Rd, Banshanqiao District, Hangzhou 310022, PR China
    Eur J Surg Oncol 38:326-32. 2012
    ..In this study, we examined prospectively whether the presence of plasma DNA with tumor characteristics before oesophagectomy is a predictive factor related to disease-free survival (DFS)...
  3. pmc Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous?
    Takahisa Nakayama
    Department of Pathology, Shiga University of Medical Science, Otsu, 520 2192 Japan
    BMC Cancer 10:311. 2010
    ..The aim of this study was to clarify the extent of overlap of genetic lineages between early and advanced tubular adenocarcinomas (TUBs) of the stomach...
  4. doi request reprint Aberrant methylation of different DNA repair genes demonstrates distinct prognostic value for esophageal cancer
    Zhi qiang Ling
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, No 38 Guangji Rd, Banshanqiao District, 310022, Hangzhou, People s Republic of China
    Dig Dis Sci 56:2992-3004. 2011
    ..DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of many tumors...
  5. doi request reprint Hypermethylation-modulated down-regulation of CDH1 expression contributes to the progression of esophageal cancer
    Zhi qiang Ling
    Zhejiang Cancer Research Institute, Hangzhou 310022, PR China
    Int J Mol Med 27:625-35. 2011
    ..CDH1 methylation was a significant predictor of survival in ESCC patients after surgery...
  6. doi request reprint Circulating methylated MINT2 promoter DNA is a potential poor prognostic factor in gastric cancer
    Jing Han
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, No 38 Guangji Rd, Banshanqiao District, Hangzhou, 310022, People s Republic of China
    Dig Dis Sci 59:1160-8. 2014
    ..Methylated DNAs may be suitable biomarkers for cancer patients. Here, we investigated whether circulating methylated MINT2 DNAs represent a potential poor prognostic factor in gastric cancer (GC)...
  7. doi request reprint Stepwise cumulation of RUNX3 methylation mediated by Helicobacter pylori infection contributes to gastric carcinoma progression
    Xiao Xiao Lu
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, People s Republic of China
    Cancer 118:5507-17. 2012
    ..Runt-related transcription factor 3 (RUNX3) is a candidate tumor suppressor gene whose deficiency is causally related to GC. However, in H. pylori infection-associated GC, the role of RUNX3 has not been studied...
  8. pmc CDH1 methylation in preoperative peritoneal washes is an independent prognostic factor for gastric cancer
    Qi Ming Yu
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Banshanqiao District, Hangzhou, China
    J Surg Oncol 106:765-71. 2012
    ..To investigate the clinical value of CDH1 methylation in preoperative peritoneal washes (PPW) from gastric cancer patients...
  9. ncbi request reprint [Aberrant methylation of hMLH1 gene promoter in papillary thyroid cancer and its clinical significance]
    Xiao Xiao Lu
    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou 310022, China
    Zhonghua Zhong Liu Za Zhi 35:833-6. 2013
    ..To investigate the aberrant promoter methylation of hMLH1 gene promoter and its clinical significance in papillary thyroid cancer (PTC)...
  10. doi request reprint Hypermethylation-modulated downregulation of RASSF1A expression is associated with the progression of esophageal cancer
    Wei min Mao
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, PR China
    Arch Med Res 42:182-8. 2011
    ..We undertook this study to investigate the methylation status of RASSF1A and its significance in esophageal squamous cell carcinoma (ESCC)...
  11. doi request reprint miR-21 regulates tumor progression through the miR-21-PDCD4-Stat3 pathway in human salivary adenoid cystic carcinoma
    Lie Hao Jiang
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou 310022, China
    Lab Invest 95:1398-408. 2015
    ..Dysregulation of miR-21 has an important role in tumor growth and invasion by targeting PDCD4. Therefore, suppression of miR-21 may provide a potential approach for the treatment of advanced SACC patients. ..
  12. doi request reprint Methylated TIMP-3 DNA in body fluids is an independent prognostic factor for gastric cancer
    Jiang Liu Yu
    From the Zhejiang Cancer Research Institute Drs Yu, HAN, X Zhu, Wu, Hong, and Ling and the Department of Surgical Oncology Dr Wang, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, China the Department of Surgical Oncology Dr Lv and the Central Laboratory Dr W Y Zhu, Zhoushan Hospital, Zhoushan, China and the Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China Dr Li
    Arch Pathol Lab Med 138:1466-73. 2014
    ..Fluid methylated DNA may be a suitable biomarker for cancer patients...
  13. doi request reprint Critical regions and spreading of runt-related transcription factor-3 C-phosphate-G (CpG) island methylation in human salivary gland adenoid cystic carcinoma
    Ming Hua Ge
    Department of Surgical Oncology, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, No 38 Guangji Rd, Banshanqiao District, Hangzhou 310022, PR China
    Hum Pathol 42:1862-72. 2011
    ..The spreading pattern of the runt-related transcription factor-3 methylation may play an a role in the progression of adenoid cystic carcinoma...
  14. ncbi request reprint [Effect of miRNA-106a expression on the prognosis of patients with esophageal squamous cell carcinoma]
    Jia Min Yuan
    Zhejiang Cancer Research Institute, Zhejiang Provincial Cancer Hospital Hangzhou 310022, China
    Zhonghua Zhong Liu Za Zhi 35:590-4. 2013
    ..To study the expression of miRNA-106a gene in esophageal squamous cell carcinoma (ESCC) and its association with clinicopathological features and prognosis of ESCC patients...
  15. doi request reprint [Expression of epidermal growth factor receptor in salivary adenoid cystic carcinoma and its role in cancer invasion]
    Ming Hua Ge
    Department of Surgical Oncology, Zhejiang Province Cancer Hospital, Hangzhou 310022, China
    Zhonghua Zhong Liu Za Zhi 34:278-80. 2012
    ..To assess the epidermal growth factor receptor (EGFR) status in salivary adenoid cystic carcinoma and explore its role in cancer invasion...
  16. doi request reprint Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma
    Ming Hua Ge
    Department of Surgical Oncology, Zhejiang Province Cancer Hospital, Hangzhou 310022, PR China
    Oncol Rep 26:349-57. 2011
    ..Our findings indicate that RUNX3 methylation may occur as a common event in the development of ACC and that methylation may be a major mechanism for inactivation of RUNX3 in ACC...
  17. ncbi request reprint [RUNX3 expression and its methylation of 5'-CpG island in salivary gland adenoid cystic carcinoma cell lines ACC-2, ACC-3 and ACC-M]
    Ming Hua Ge
    Department of Surgical Oncology, Zhejiang Province Cancer Hospital, Hangzhou 310022, China
    Zhonghua Yi Xue Za Zhi 90:3426-30. 2010
    ..To investigate the methylation of 5'-CpG island and expression of RUNX3 in salivary gland adenoid cystic carcinoma cell lines...
  18. ncbi request reprint [Expression and significance of E-cadherin in adenoid cystic carcinoma of salivary glands]
    Ming Hua Ge
    Department of Head and Neck Tumor Surgery, Zhejiang Cancer Research Institute, Hangzhou, China
    Zhonghua Yi Xue Za Zhi 92:106-9. 2012
    ..To examine the expression of E-cadherin and the methylation status of CDH1 and explore their clinical significance in salivary adenoid cystic carcinoma (SACC)...
  19. ncbi request reprint [DNA methylation status of RARβ2 and p16(INK4α) in peripheral blood and tumor tissue in patients with esophageal squamous cell carcinoma]
    Chang Chun Wang
    Department of Molecular Genetics of Tumors, Zhejiang Cancer Research Institute, Zhejiang Provincial Cancer Hospital, Key Laboratory of Diagnosis and Treatment Technology of Thoracic Tumors, Hangzhou 310022, China
    Zhonghua Zhong Liu Za Zhi 34:441-5. 2012
    ....
  20. ncbi request reprint [Methylation status of CDH1 gene in preoperative abdominal lavage of patients with gastric cancer and its clinical significance]
    Jun Luo
    Zhejiang Cancer Research Institute, Hangzhou, China
    Zhonghua Wei Chang Wai Ke Za Zhi 15:710-4. 2012
    ..To explore the association between the progression of gastric cancer and the aberrant methylation of CDH1 gene in preoperative abdominal lavage fluid...
  21. pmc Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma
    Xin Zhu
    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, 310022, Hangzhou, China
    J Exp Clin Cancer Res 33:114. 2014
    ..In this study, we aimed to clarify the function of Pim-1 in ACC in vitro. Meanwhile, we measured the levels of Pim-1 and RUNX3 in the ACC tissues. The correlations between Pim-1/RUNX3 levels and clinical parameters were also analyzed...
  22. doi request reprint Unfavorable clinical implications of circulating CD44+ lymphocytes in patients with nasopharyngeal carcinoma undergoing radiochemotherapy
    Fu Jun Hu
    Department of Radiotherapy, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Banshanqiao District, Hangzhou, PR China
    Clin Chim Acta 413:213-8. 2012
    ..To evaluate the use of cellular immunity parameters as predictors of therapy response...
  23. pmc Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma
    Zhi qiang Ling
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, China
    Oncotarget 6:8210-25. 2015
    ..We found that H. pylori silenced Ndrg2 by activating the NF-κB pathway and up-regulating DNMT3b, promoting gastric cancer progression. These findings uncover a previously unrecognized role for H. pylori infection in gastric cancer. ..
  24. pmc Enhanced serum methylated p16 DNAs is associated with the progression of gastric cancer
    Yi Chen Wu
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center No 38 Guangji Rd, Banshanqiao District, Hangzhou 310022, P R China
    Int J Clin Exp Pathol 7:1553-62. 2014
    ..The present study is to evaluate the effect of methylated p16 on the progression in patients with gastric cancer (GC), and develop a useful biomarker for predicting patient's prognosis...
  25. doi request reprint The overexpression of VEGF in esophageal cancer is associated with a more advanced TMN stage: a meta-analysis
    Xiao Ling Xu
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, Zhejiang, China
    Cancer Biomark 13:105-13. 2013
    ..The aim of this study was to quantitatively assess the impact of VEGF overexpression on prognosis in patients with esophageal cancer (EC)...
  26. doi request reprint Enhanced RegIV expression predicts the intrinsic 5-fluorouracil (5-FU) resistance in advanced gastric cancer
    Li Sha Ying
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, No 38 Guangji Rd, Banshanqiao District, Hangzhou, 310022, People s Republic of China
    Dig Dis Sci 58:414-22. 2013
    ..However, the relationship between the intrinsic drug resistance of gastric cancer (GC) cells to 5-FU used alone (single FU) or in multidrug therapeutic regimens (5-FU combinations) and RegIV expression has not been investigated...
  27. ncbi request reprint Elevated circulating CD19+ lymphocytes predict survival advantage in patients with gastric cancer
    Qi Ming Yu
    Zhejiang Cancer Research Institute, Hangzhou, China
    Asian Pac J Cancer Prev 13:2219-24. 2012
    ..Our aim was to evaluate the clinical significance of circulating lymphocyte subset in gastric cancer (GC) cases...
  28. doi request reprint Overexpression of ILK1 in breast cancer associates with poor prognosis
    Hong Jian Yang
    Department of Breast Surgery, Zhejiang Cancer Hospital, No 38, Guangji Road, Hangzhou, 310022, China
    Tumour Biol 34:3933-8. 2013
    ..ILK1 may be an important molecular marker for predicting the carcinogenesis, progression, and prognosis of breast cancer...
  29. ncbi request reprint [Expression of DNA methylation of APC in peripheral blood and tumor tissue in patients with esophageal squamous cell carcinoma]
    Chang Chun Wang
    Zhejiang Province Cancer Hospital, Zhejiang Cancer Research Institute, Hangzhou 310022, China
    Zhonghua Wei Chang Wai Ke Za Zhi 14:719-22. 2011
    ....
  30. ncbi request reprint [cDNA microarray-based study of gene expression profile changes in human esophageal squamous cell carcinoma]
    Pei Li
    Department of Pathophysiology, School for Basic Medical Sciences of Zhengzhou University, Zhengzhou 450052, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:632-4. 2006
    ....
  31. pmc Expression of E-selectin, integrin beta1 and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance
    Jin Jing Ke
    Zhejiang Provincial People s Hospital, Hangzhou 310014, Zhejiang Province, China
    World J Gastroenterol 12:3609-11. 2006
    ....
  32. pmc Heterogeneity of chemosensitivity in esophageal cancer using ATP-tumor chemosensitivity assay
    Zhi qiang Ling
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, China
    Acta Pharmacol Sin 33:401-6. 2012
    ..This study was aimed to demonstrate the degree of heterogeneity of chemosensitivity in esophageal cancers...
  33. ncbi request reprint [Evolution pattern of the Runx3 gene 5'-CpG island methylation in human salivary gland adenoid cystic carcinoma]
    Zhuo Tan
    Department of Surgical Oncology, Zhejiang Province Cancer Hospital, Hangzhou 310022, China
    Zhonghua Zhong Liu Za Zhi 32:907-12. 2010
    ..To investigate the evolution pattern of the Runx3 gene 5'-CpG island ~3478 bp region methylation in human salivary gland adenoid cystic carcinoma (SGACC)...
  34. pmc Fbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human Tumorigenesis
    Jun Cao
    From the Zhejiang Cancer Research Institute JC, Z QL and Department of Surgical Oncology, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, China JC, M HG
    Medicine (Baltimore) 95:e2496. 2016
    ..Fbxw7 is strongly associated with tumorigenesis, and the mechanisms and consequences of Fbxw7 deregulation in cancers may soon enable the development of novel therapeutic approaches. ..
  35. pmc Chemoprevention of Low-Molecular-Weight Citrus Pectin (LCP) in Gastrointestinal Cancer Cells
    Shi Wang
    1 Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, No 38 Guangji Rd, Banshanqiao District, Hangzhou 310022, P R China 2 Department of Digestive Endoscopy, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, No 38 Guangji Rd, Banshanqiao District, Hangzhou 310022, P R China
    Int J Biol Sci 12:746-56. 2016
    ..e., sugar carbohydrate) residues. In this study, we evaluated the anti-tumor properties of LCP that lead to Bcl-xL -mediated dampening of apoptosis in gastrointestinal cancer cells...
  36. ncbi request reprint [Impact of lymphocytes subgroups in peripheral blood on survival rate of patients with gastric cancer]
    Jia Min Yuan
    Department of Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou, China
    Zhonghua Wei Chang Wai Ke Za Zhi 14:796-8. 2011
    ..To study the change of lymphocyte subgroups in the peripheral blood of patients with gastric carcinoma and its association with survival...
  37. ncbi request reprint Epidemiologic risk factors for esophageal cancer development
    Wei min Mao
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, China
    Asian Pac J Cancer Prev 12:2461-6. 2011
    ..Here, we review the epidemiologic studies that have investigated the epidemiologic patterns and causes of EC...
  38. doi request reprint Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors
    Xiang Liu
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, P R China
    Histol Histopathol 30:1155-60. 2015
    ..In this study, the current research on IDH1/IDH2 mutation, especially the mechanisms and clinical characteristics related to tumor, are reviewed. ..
  39. doi request reprint Elevated levels of preoperative circulating CD44⁺ lymphocytes and neutrophils predict poor survival for non-small cell lung cancer patients
    Shi Zhou Yang
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, No 38 Guangji Rd, Banshanqiao District, Hangzhou 310022, P R China
    Clin Chim Acta 439:172-7. 2015
    ..The objective of this study was to identify clinical, hematological and immunological predictors of prognosis in non-small cell lung cancer (NSCLC) patients...
  40. ncbi request reprint The role of TET family proteins and 5-hydroxymethylcytosine in human tumors
    Yi Chen Wu
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, P R China
    Histol Histopathol 29:991-7. 2014
    ..As a new epigenetic modification, 5-hmC may be a useful biomarker for the diagnosis of cancers. To better understand the roles of TET and 5-hmC in tumors, the biological functions of TET and 5-hmC should be studied further. ..
  41. doi request reprint Novel statistical framework to identify differentially expressed genes allowing transcriptomic background differences
    Zhi qiang Ling
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Banshanqiao Guangji Road 38, Hangzhou 310022, China
    Bioinformatics 26:1431-6. 2010
    ..These differences lead to increased false positives, which have little biological/medical significance...
  42. pmc Cell cycle arrest and apoptotic cell death in cultured human gastric carcinoma cells mediated by arsenic trioxide
    Qin shu Shao
    Zhejiang Provincial People s Hospital, Hangzhou, Zhejiang Province, China
    World J Gastroenterol 11:3451-6. 2005
    ..To investigate the effect of arsenic trioxide on human gastric cancer cell line MKN45 with respect to both cytotoxicity and induction of apoptosis in vitro...
  43. ncbi request reprint Comprehensive profiling of the low molecular weight proteins and peptides in weak cation exchange beads human serum retentate
    Zhi Guo Zheng
    Zhejiang Cancer Hospital Zhejiang Cancer Research Institute, Hangzhou, China
    Protein Pept Lett 18:498-506. 2011
    ..11(11/96) proteins were documented cancer associated proteins. We also observed about 109 proteins/peptides in SELDI mass spectrum, and 13 of the SELDI features were identified...