Walter T Linde-Zwirble

Summary

Publications

  1. ncbi Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States
    Vladimir Kaplan
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 165:766-72. 2002
  2. pmc Severe sepsis epidemiology: sampling, selection, and society
    Walter T Linde-Zwirble
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care 8:222-6. 2004
  3. doi Clinical and economic effects of iNO in premature newborns with respiratory failure at 1 year
    R Scott Watson
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 124:1333-43. 2009
  4. doi Trends in the epidemiology of pediatric severe sepsis*
    Mary E Hartman
    1Department of Pediatrics, St Louis Children s Hospital, Washington University in St Louis, St Louis, MO 2ZD Associates, LLC, Perkasie, PA 3Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 4Clinical Research, Investigation, and Systems Modeling in Acute illness CRISMA Center, Pittsburgh, PA
    Pediatr Crit Care Med 14:686-93. 2013
  5. ncbi Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
    Crit Care Med 31:1-11. 2003
  6. doi Growth of intensive care unit resource use and its estimated cost in Medicare
    Eric B Milbrandt
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:2504-10. 2008
  7. pmc Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis
    Florian B Mayr
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    JAMA 303:2495-503. 2010
  8. ncbi Dynamic microsimulation to model multiple outcomes in cohorts of critically ill patients
    Gilles Clermont
    Room 606B, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 30:2237-44. 2004
  9. ncbi Pneumonia: still the old man's friend?
    Vladimir Kaplan
    Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Arch Intern Med 163:317-23. 2003
  10. ncbi Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States
    Derek C Angus
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 112:1351-60. 2003

Detail Information

Publications31

  1. ncbi Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States
    Vladimir Kaplan
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 165:766-72. 2002
    ..The sex differences are of concern and require further investigation...
  2. pmc Severe sepsis epidemiology: sampling, selection, and society
    Walter T Linde-Zwirble
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care 8:222-6. 2004
    ..In the future, we must focus on whether all severe sepsis should be treated, and, consequently, what level of ICU services is optimal...
  3. doi Clinical and economic effects of iNO in premature newborns with respiratory failure at 1 year
    R Scott Watson
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 124:1333-43. 2009
    ..We therefore studied the clinical and economic outcomes to 1 year of corrected age after a randomized controlled trial of prophylactic iNO...
  4. doi Trends in the epidemiology of pediatric severe sepsis*
    Mary E Hartman
    1Department of Pediatrics, St Louis Children s Hospital, Washington University in St Louis, St Louis, MO 2ZD Associates, LLC, Perkasie, PA 3Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 4Clinical Research, Investigation, and Systems Modeling in Acute illness CRISMA Center, Pittsburgh, PA
    Pediatr Crit Care Med 14:686-93. 2013
    ..We present data from 1995, 2000, and 2005 in seven U.S. states, examining how case mix, outcome, and resource use for pediatric severe sepsis have changed over time...
  5. ncbi Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
    Crit Care Med 31:1-11. 2003
    ..To assess the cost-effectiveness of drotrecogin alfa (activated) therapy, which was recently shown to reduce mortality in severe sepsis...
  6. doi Growth of intensive care unit resource use and its estimated cost in Medicare
    Eric B Milbrandt
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:2504-10. 2008
    ..We sought to determine contemporary Medicare intensive care unit resource use, costs, and R values; whether these vary by patient and hospital characteristics; and the impact of updated values on estimated intensive care unit costs...
  7. pmc Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis
    Florian B Mayr
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    JAMA 303:2495-503. 2010
    ..Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear...
  8. ncbi Dynamic microsimulation to model multiple outcomes in cohorts of critically ill patients
    Gilles Clermont
    Room 606B, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 30:2237-44. 2004
    ..Existing intensive care unit (ICU) prediction tools forecast single outcomes, (e.g., risk of death) and do not provide information on timing...
  9. ncbi Pneumonia: still the old man's friend?
    Vladimir Kaplan
    Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Arch Intern Med 163:317-23. 2003
    ..However, the long-term survival of those discharged alive is less clear. We sought to determine long-term survival of patients hospitalized with CAP and compare the outcome with controls hospitalized for reasons other than CAP...
  10. ncbi Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States
    Derek C Angus
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 112:1351-60. 2003
    ..Our objective was to estimate the cost-effectiveness ratio of iNO in this population...
  11. pmc Racial variation in end-of-life intensive care use: a race or hospital effect?
    Amber E Barnato
    Department of Medicine, School of Medicine, Graduate School of Public Health, Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Health Serv Res 41:2219-37. 2006
    ....
  12. ncbi Continuous versus intermittent renal replacement therapy: a meta-analysis
    John A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Division of Critical Care Medicine, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Intensive Care Med 28:29-37. 2002
    ..As controversy exists regarding which modality should be used for most patients with critically illness, we sought to determine whether CRRT or IRRT is associated with better survival...
  13. pmc Hospitalizations of children with neurologic disorders in the United States
    Jacqueline F Moreau
    1Department of Critical Care Medicine, The CRISMA Center Clinical Research, Investigation, and Systems Modeling of Acute Illness, University of Pittsburgh, Pittsburgh, PA 2Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, the Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 3Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 4ZD Associates LLC, Perkasie, PA
    Pediatr Crit Care Med 14:801-10. 2013
    ..Although neurologic disorders are among the most serious acute pediatric illnesses, epidemiologic data are scarce. We sought to determine the scope and outcomes of children with these disorders in the United States...
  14. ncbi Use of intensive care at the end of life in the United States: an epidemiologic study
    Derek C Angus
    Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:638-43. 2004
    ..We sought to describe the use of ICU care at the end of life in the United States using hospital discharge data from 1999 for six states and the National Death Index...
  15. ncbi The epidemiology of severe sepsis in children in the United States
    R Scott Watson
    Department of Critical Care Medicine, Center for Research on Health Care, and the CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 167:695-701. 2003
    ..97 billion US dollars nationally. Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources. Infants are at highest risk, especially those with a low birth weight...
  16. pmc Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics
    Amber E Barnato
    Center for Research on Health Care, 200 Meyran Ave, Suite 200, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 177:279-84. 2008
    ..Higher rates of sepsis have been reported in minorities...
  17. ncbi Healthcare costs and long-term outcomes after acute respiratory distress syndrome: A phase III trial of inhaled nitric oxide
    Derek C Angus
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 34:2883-90. 2006
    ..To determine the costs and long-term outcomes of acute respiratory distress syndrome (ARDS) in previously healthy adults. To determine whether treatment with inhaled nitric oxide affects these costs and outcomes...
  18. ncbi Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modeling
    Gilles Clermont
    Department of Critical Care Medicine, University of Pittsburgh, PA, USA
    Crit Care Med 31:2627-33. 2003
    ..This may be partly due to the use of insensitive mortality end points. We explored whether modeling survival was more sensitive than traditional end points in detecting mortality differences in cohorts of patients with sepsis...
  19. ncbi Does acute organ dysfunction predict patient-centered outcomes?
    Gilles Clermont
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Chest 121:1963-71. 2002
    ..Long-term patient-centered outcomes after acute illness may be associated with baseline health status, the development of acute organ dysfunction (AOD), or both...
  20. ncbi Cost-effectiveness of fixed-dose combination of isosorbide dinitrate and hydralazine therapy for blacks with heart failure
    Derek C Angus
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Circulation 112:3745-53. 2005
    ..We assessed the resource use, costs of care, and cost-effectiveness of ISDN/HYD therapy in the A-HeFT trial population...
  21. pmc Epidemiology of ophthalmologic disease associated with erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis in hospitalized children in the United States
    Jacqueline F Moreau
    School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania The CRISMA Center Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    Pediatr Dermatol 31:163-8. 2014
    ..Children with EM, SJS, or TEN should be screened and treated early for ophthalmologic disease to prevent morbidity and minimize long-term sequellae...
  22. pmc The effects of trauma center care, admission volume, and surgical volume on paralysis after traumatic spinal cord injury
    Carlos Aitor Macias
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Surg 249:10-7. 2009
    ..We hypothesized a priori that trauma center care, by contrast to nontrauma center care, is associated with reduced paralysis at discharge...
  23. ncbi Medicare intensive care unit use: analysis of incidence, cost, and payment
    Liesl M Cooper
    U S Outcomes Research, U S Medical Division, Eli Lilly and Company, Indianapolis, IN, USA
    Crit Care Med 32:2247-53. 2004
    ..To determine the incidence, cost, and payment for intensive care unit services among Medicare beneficiaries...
  24. ncbi Incidence, cost, and mortality of neutropenia hospitalization associated with chemotherapy
    Vincent Caggiano
    Sutter Cancer Center and Sutter Institute for Medical Research, Sacramento, California 95816, USA
    Cancer 103:1916-24. 2005
    ..Neutropenia is a common side effect of chemotherapy, often requiring hospitalization for treatment of severe cases. Neutropenia hospitalization (NH) rates have been reported in individual studies, but national estimates are needed...
  25. ncbi Estimated frequency of nursing facility-acquired pneumonia?
    Mark Metersky
    Am J Respir Crit Care Med 167:1287-8; author reply 1288. 2003
  26. doi Variation in critical care services across North America and Western Europe
    Hannah Wunsch
    Department of Anesthesiology, Columbia University, New York, NY, USA
    Crit Care Med 36:2787-93, e1-9. 2008
    ..Yet, little is known regarding international variation in critical care services. We sought to understand differences in critical care delivery by comparing data on the distribution of services in eight countries...
  27. pmc Impact of HIV/AIDS on care and outcomes of severe sepsis
    Joseph M Mrus
    Health Services Research and Development, Cincinnati VA Medical Center, Cincinnati, OH, USA
    Crit Care 9:R623-30. 2005
    ..The purpose of this study was to examine patterns of care and outcomes for patients with severe sepsis and HIV/AIDS and compare them with those of patients with severe sepsis without HIV/AIDS...
  28. ncbi Annual rates of arterial thromboembolic events in medicare neovascular age-related macular degeneration patients
    Sherri L Alexander
    Genentech, Inc, South San Francisco, California, USA
    Ophthalmology 114:2174-8. 2007
    ..This study assesses annual rates of ATEs in new-onset neovascular AMD patients compared with matched controls...
  29. ncbi Evaluating the clinical and financial impact of severe sepsis with Medicare or other administrative hospital data
    Frank R Ernst
    Outcomes Research U S Medical Division, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Am J Health Syst Pharm 63:575-81. 2006
  30. ncbi How does lack of insurance affect use of intensive care? A population-based study
    Marion Danis
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 34:2043-8. 2006
    ..We sought to compare the use of intensive care by insured and uninsured populations...
  31. pmc Potential value of regionalized intensive care for mechanically ventilated medical patients
    Jeremy M Kahn
    Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, 723 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 177:285-91. 2008
    ..Regionalization has been proposed as a method to improve outcomes for medical patients receiving mechanical ventilation in the intensive care unit...