Jianguo Lin

Summary

Publications

  1. ncbi pH sensitive chitosan-mesoporous silica nanoparticles for targeted delivery of a ruthenium complex with enhanced anticancer effects
    Gaochao Lv
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Dalton Trans 45:18147-18155. 2016
  2. doi Lipophilicity-dependent ruthenium N-heterocyclic carbene complexes as potential anticancer agents
    Gaochao Lv
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Dalton Trans 44:7324-31. 2015
  3. ncbi A novel (99m)Tc-labeled diphosphonic acid as potential bone seeking agent: synthesis and biological evaluation
    Ling Qiu
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Curr Radiopharm 6:28-35. 2013
  4. doi Preparation and in vivo biological investigations on a novel radioligand for bone scanning: technetium-99m-labeled zoledronic acid derivative
    Jianguo Lin
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, PR China
    Nucl Med Biol 38:619-29. 2011
  5. doi Synthesis and pharmacological evaluation of 99mTc-labeled imidazolyl-containing diphosphonic acid as a novel bone imaging agent
    Ling Qiu
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China
    J Labelled Comp Radiopharm 56:573-80. 2013
  6. doi Animal studies of 99mTc-i-PIDP: a new bone imaging agent
    Yan Wang
    Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, PR China
    Appl Radiat Isot 69:1169-75. 2011
  7. doi Synthesis and biological evaluation of novel (99m)Tc-labelled bisphosphonates as superior bone imaging agents
    Ling Qiu
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Molecules 16:6165-78. 2011
  8. doi Development of superior bone scintigraphic agent from a series of (99m)Tc-labeled zoledronic acid derivatives
    Jianguo Lin
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi, PR China
    Appl Radiat Isot 70:848-55. 2012
  9. doi Preparation and preclinical pharmacological study on a novel bone imaging agent (99m)Tc-EMIDP
    Jianguo Lin
    Key Laboratory of Nuclear Medicine, Ministry of Health and Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, PR China
    Appl Radiat Isot 68:1616-22. 2010
  10. doi Synthesis and preliminary biological evaluation of a 99m Tc-chlorambucil derivative as a potential tumor imaging agent
    Jianguo Lin
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China
    J Labelled Comp Radiopharm . 2016

Collaborators

  • Wei Wang
  • Yang Wang
  • Li Zhang
  • Ling Qiu
  • Gaochao Lv
  • Shineng Luo
  • Liubin Guo
  • Hui Yang
  • Wen Cheng
  • Meifen Zou
  • Ke Li
  • Qingzhu Liu
  • Guiqing Liu
  • Hong Liu
  • Liping Chen
  • Shu Zhang
  • Xueyu Zhao
  • Shanshan Wang
  • Huixin Yu
  • Xiaofeng Qin
  • Beibei Nan
  • Yang Cao
  • Edward J Bertaccini
  • Tengfei Wang
  • Jing Pan
  • Li Xue

Detail Information

Publications18

  1. ncbi pH sensitive chitosan-mesoporous silica nanoparticles for targeted delivery of a ruthenium complex with enhanced anticancer effects
    Gaochao Lv
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Dalton Trans 45:18147-18155. 2016
    ..This multifunctional nanocarrier system provides a promising platform for the development of precisely controllable cancer therapy...
  2. doi Lipophilicity-dependent ruthenium N-heterocyclic carbene complexes as potential anticancer agents
    Gaochao Lv
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Dalton Trans 44:7324-31. 2015
    ..The DNA binding experiments further demonstrate that complex 5 has a better binding ability for DNA (Kb = 2.2 × 10(6) M(-1)) than complexes 1-4 (3.8 × 10(5), 7.0 × 10(5), 5.7 × 10(5), and 1.9 × 10(5) respectively)...
  3. ncbi A novel (99m)Tc-labeled diphosphonic acid as potential bone seeking agent: synthesis and biological evaluation
    Ling Qiu
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Curr Radiopharm 6:28-35. 2013
    ..A plain and clear bone image was obtained at 1 h with SPECT bone imaging. The present findings indicate that (99m)Tc- BIBDP holds great potential for bone imaging...
  4. doi Preparation and in vivo biological investigations on a novel radioligand for bone scanning: technetium-99m-labeled zoledronic acid derivative
    Jianguo Lin
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, PR China
    Nucl Med Biol 38:619-29. 2011
    ..The purpose of this study is to optimize the linker chain between the imidazolyl and geminal diphosphonate group in the zoledronic acid (ZL) to develop novel single photon emission computed tomography (SPECT) bone imaging agent...
  5. doi Synthesis and pharmacological evaluation of 99mTc-labeled imidazolyl-containing diphosphonic acid as a novel bone imaging agent
    Ling Qiu
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China
    J Labelled Comp Radiopharm 56:573-80. 2013
    ....
  6. doi Animal studies of 99mTc-i-PIDP: a new bone imaging agent
    Yan Wang
    Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, PR China
    Appl Radiat Isot 69:1169-75. 2011
    ..80e(-0.20t)+2.66e(-0.01t). A plain bone image was obtained at 1 h. All of the results suggested that (99m)Tc-i-PIDP is worthy of future investigation as a novel bone imaging agent...
  7. doi Synthesis and biological evaluation of novel (99m)Tc-labelled bisphosphonates as superior bone imaging agents
    Ling Qiu
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Molecules 16:6165-78. 2011
    ..The present findings indicate that (99m)Tc-MIPrDP holds great potential for use in bone imaging...
  8. doi Development of superior bone scintigraphic agent from a series of (99m)Tc-labeled zoledronic acid derivatives
    Jianguo Lin
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi, PR China
    Appl Radiat Isot 70:848-55. 2012
    ..These preclinical studies suggest that (99m)Tc-IPeDP would be a novel superior bone scintigraphic agent...
  9. doi Preparation and preclinical pharmacological study on a novel bone imaging agent (99m)Tc-EMIDP
    Jianguo Lin
    Key Laboratory of Nuclear Medicine, Ministry of Health and Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, PR China
    Appl Radiat Isot 68:1616-22. 2010
    ..The present findings indicate that (99)(m)Tc-EMIDP holds great potential for bone scintigraphy...
  10. doi Synthesis and preliminary biological evaluation of a 99m Tc-chlorambucil derivative as a potential tumor imaging agent
    Jianguo Lin
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China
    J Labelled Comp Radiopharm . 2016
    ..i.). It had moderate uptake ratios of tumor to blood and tumor to muscle. These results suggested 99m Tc-DPA-CLB might be a promising SPECT imaging agent for tumor diagnosis...
  11. doi Synthesis and biological evaluation of novel platinum complexes of imidazolyl-containing bisphosphonates as potential anticancer agents
    Ling Qiu
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, People s Republic of China
    J Biol Inorg Chem 20:1263-75. 2015
    ..The binding interaction of complex with DNA has been explored by circular dichroism (CD) and UV-Vis absorption spectra, demonstrating these new complexes have moderate binding affinity for DNA...
  12. doi Preparation and Biological Evaluation of Two Novel Platinum(II) Complexes Based on the Ligands of Dipicolyamine Bisphosphonate Esters
    Ling Qiu
    Jiangsu Key Laboratory of Molecular Nuclear Medicine, Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Molecules 21:255. 2016
    ....
  13. doi Solvent effect on molecular structure, IR spectra, thermodynamic properties and chemical stability of zoledronic acid: DFT study
    Qingzhu Liu
    Key Laboratory of Nuclear Medicine, Ministry of Health and Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, People s Republic of China
    J Mol Model 22:84. 2016
    ....
  14. doi Insights into anticancer activity and mechanism of action of a ruthenium(II) complex in human esophageal squamous carcinoma EC109 cells
    Liubin Guo
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Eur J Pharmacol 786:60-71. 2016
    ..These findings suggested that the ruthenium(II) complex might be a potential effective chemotherapeutic agent for human esophageal squamous carcinoma (ESCC) and worthy of further investigation. ..
  15. ncbi Pharmacokinetic and imaging evaluation of (99m)Tc-HBIDP as a potential bone imaging agent
    Ling Qiu
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, PR China
    Pak J Pharm Sci 28:815-8. 2015
    ..All results indicate that (99m)Tc-HBIDP holds great potential as a novel improved bone imaging agent...
  16. doi Synthesis, crystal structure and antitumor effect of a novel copper(II) complex bearing zoledronic acid derivative
    Ling Qiu
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, PR China
    Eur J Med Chem 89:42-50. 2015
    ..The binding interaction of complex 2 with calf thymus DNA (CT-DNA) has been explored by UV-vis absorption and circular dichroism (CD), demonstrating complex 2 has a moderate binding affinity for DNA through intercalation. ..
  17. doi Molecular structure, IR spectra, and chemical reactivity of cisplatin and transplatin: DFT studies, basis set effect and solvent effect
    Yang Wang
    School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, PR China Key Laboratory of Nuclear Medicine, Ministry of Health and Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 150:902-8. 2015
    ..The molecular electrostatic potential (MESP) surfaces showed that the amino groups were the most favorable sites that nucleophilic reagents tend to attack, and CDDP was easier to be attacked by nucleophilic reagents than TDDP. ..
  18. doi Insights into the Nature of Anesthetic-Protein Interactions: An ONIOM Study
    Ling Qiu
    Key Laboratory of Nuclear Medicine, Ministry of Health and Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, P R China
    J Phys Chem B 119:12771-82. 2015
    ..Future rational design of safer anesthetics for an aging and more physiologically vulnerable population will be predicated on this greater understanding of such specific interactions. ..