Chwan Fwu Lin

Summary

Publications

  1. doi A new hydroxychavicol dimer from the roots of Piper betle
    Chwan Fwu Lin
    Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
    Molecules 18:2563-70. 2013
  2. doi Maximizing dermal targeting and minimizing transdermal penetration by magnolol/honokiol methoxylation
    Chwan Fwu Lin
    Department of Cosmetic Science, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan
    Int J Pharm 445:153-62. 2013
  3. pmc Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα
    Po Jen Chen
    Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Sci Rep 6:26554. 2016
  4. doi Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species
    Shih Chun Yang
    Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, 259 Wen Hwa 1st Road, Kweishan, Taoyuan 333, Taiwan
    Nanomedicine (Lond) 11:657-71. 2016
  5. doi Conjugated linoleic acids suppress inflammatory response and ICAM-1 expression through inhibition of NF-κB and MAPK signaling in human bronchial epithelial cells
    Wen Chung Huang
    Graduate Institute of Health Industry Technology and Research Center for Industry of Human Ecology, College of Human Ecology, Chang Gung University of Science and Technology, No 261, Wenhua 1st Rd, Guishan Dist, Taoyuan City 33303, Taiwan and Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Guishan Dist, Taoyuan City 33303, Taiwan
    Food Funct 7:2025-33. 2016
  6. doi Methylation and Esterification of Magnolol for Ameliorating Cutaneous Targeting and Therapeutic Index by Topical Application
    Chwan Fwu Lin
    Department of Cosmetic Science, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan
    Pharm Res 33:2152-67. 2016
  7. doi Water extract of Helminthostachys zeylanica attenuates LPS-induced acute lung injury in mice by modulating NF-κB and MAPK pathways
    Chian Jiun Liou
    Department of Nursing, Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, No 261, Wenhua 1st Rd, Guishan Dist, Taoyuan City 333 03, Taiwan D ivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Guishan Dist, Taoyuan City 33303, Taiwan
    J Ethnopharmacol . 2017
  8. doi Casticin inhibits COX-2 and iNOS expression via suppression of NF-κB and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages
    Chian Jiun Liou
    Department of Nursing, Chang Gung University of Science and Technology, 261 Wen Hwa 1st Road, Kwei Shan, Tao Yuan 333, Taiwan, ROC
    J Ethnopharmacol 158:310-6. 2014
  9. doi Anti-inflammatory activity and percutaneous absorption of quercetin and its polymethoxylated compound and glycosides: the relationships to chemical structures
    Chwan Fwu Lin
    Department of Cosmetic Science, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan
    Eur J Pharm Sci 47:857-64. 2012
  10. doi Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation
    Zih Ying Li
    Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan
    Am J Chin Med 44:165-76. 2016

Collaborators

  • Jia You Fang
  • Yann Lii Leu
  • Cheng Hsun Chiu
  • Sien Hung Yang
  • Chian Jiun Liou
  • Wen Chung Huang
  • Chun Yu Chen
  • Hsi Lung Hsieh
  • Po Jen Chen
  • Ta Jen Lin
  • Zih Ying Li
  • Rong Syuan Tu
  • Tsong Long Hwang
  • Liang Mou Kuo
  • Ming Chung Lee
  • Yung Fong Tsai
  • Yu Ling Huang
  • Shu Ju Wu
  • Zih Yi Wun
  • Kuo Wei Yeh
  • Tzu Yi Huang
  • Yun Yun Tsai
  • Jim Tong Horng
  • Ya Ling Chen
  • Tsong Hai Lee
  • Jiann Jong Shen
  • Yu Ling Wang
  • Pei Yu Gu
  • Pei Jen Chung
  • Wei Che Sung
  • Yu Ting Kuo
  • Hsuan Wu Yang
  • Yu Fang
  • Xin Ling Wu
  • Wen Bin Len
  • Pei Yin Xu
  • Wei Tien Chang

Detail Information

Publications15

  1. doi A new hydroxychavicol dimer from the roots of Piper betle
    Chwan Fwu Lin
    Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
    Molecules 18:2563-70. 2013
    ..The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils...
  2. doi Maximizing dermal targeting and minimizing transdermal penetration by magnolol/honokiol methoxylation
    Chwan Fwu Lin
    Department of Cosmetic Science, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan
    Int J Pharm 445:153-62. 2013
    ..Daily administration of methoxylated permeants, especially dimethylhonokiol, produced no skin irritation for up to 7 days. Methoxylated magnolol and honokiol can be efficient and safe candidates for treating inflammatory skin disorders...
  3. pmc Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα
    Po Jen Chen
    Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Sci Rep 6:26554. 2016
    ....
  4. doi Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species
    Shih Chun Yang
    Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, 259 Wen Hwa 1st Road, Kweishan, Taoyuan 333, Taiwan
    Nanomedicine (Lond) 11:657-71. 2016
    ..Here we evaluated the antibacterial efficacy of soyaethyl morpholinium ethosulfate (SME) micelles as an inherent bactericide against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA)...
  5. doi Conjugated linoleic acids suppress inflammatory response and ICAM-1 expression through inhibition of NF-κB and MAPK signaling in human bronchial epithelial cells
    Wen Chung Huang
    Graduate Institute of Health Industry Technology and Research Center for Industry of Human Ecology, College of Human Ecology, Chang Gung University of Science and Technology, No 261, Wenhua 1st Rd, Guishan Dist, Taoyuan City 33303, Taiwan and Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Guishan Dist, Taoyuan City 33303, Taiwan
    Food Funct 7:2025-33. 2016
    ....
  6. doi Methylation and Esterification of Magnolol for Ameliorating Cutaneous Targeting and Therapeutic Index by Topical Application
    Chwan Fwu Lin
    Department of Cosmetic Science, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan
    Pharm Res 33:2152-67. 2016
    ..As a continuing effort to elucidate the impact of structure modification upon cutaneous absorption behavior, we attempted to assess the skin permeation of magnolol by methylation and acetylation...
  7. doi Water extract of Helminthostachys zeylanica attenuates LPS-induced acute lung injury in mice by modulating NF-κB and MAPK pathways
    Chian Jiun Liou
    Department of Nursing, Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, No 261, Wenhua 1st Rd, Guishan Dist, Taoyuan City 333 03, Taiwan D ivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Guishan Dist, Taoyuan City 33303, Taiwan
    J Ethnopharmacol . 2017
    ..Previous studies showed that Helminthostachys zeylanica (L.) Hook. could reduce inflammatory responses in macrophage and brain astrocytes...
  8. doi Casticin inhibits COX-2 and iNOS expression via suppression of NF-κB and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages
    Chian Jiun Liou
    Department of Nursing, Chang Gung University of Science and Technology, 261 Wen Hwa 1st Road, Kwei Shan, Tao Yuan 333, Taiwan, ROC
    J Ethnopharmacol 158:310-6. 2014
    ..In this study, we evaluated the anti-inflammatory effects of casticin and its underlying molecular mechanism in lipopolysaccharide (LPS)-stimulated macrophages...
  9. doi Anti-inflammatory activity and percutaneous absorption of quercetin and its polymethoxylated compound and glycosides: the relationships to chemical structures
    Chwan Fwu Lin
    Department of Cosmetic Science, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan
    Eur J Pharm Sci 47:857-64. 2012
    ..Rutin provoked some skin redness and inflammation after a 5-day administration in nude mouse. QM caused no irritation, suggesting that it is a superior candidate for topical delivery...
  10. doi Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation
    Zih Ying Li
    Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan
    Am J Chin Med 44:165-76. 2016
    ..These results suggest that SG might increase the effect of apoptosis on HL-60 cells through caspase-3 activation, mitochondrial-mediated pathways, and the MAPK pathway. ..
  11. ncbi Evaluation of Anti-Inflammatory Effects of Helminthostachys zeylanica Extracts via Inhibiting Bradykinin-Induced MMP-9 Expression in Brain Astrocytes
    Hsi Lung Hsieh
    Department of Nursing, Division of Basic Medical Sciences, and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Gui Shan, Tao Yuan, Taiwan
    Mol Neurobiol 53:5995-6005. 2016
    ..g., ERK1/2 and p38 MAPK) by BK. These data indicated that the H. zeylanica extracts may be has anti-inflammatory activity by reducing BK-induced ROS-dependent MMP-9 expression via these related pathways in brain astrocytes...
  12. pmc Inhibition of endosomal fusion activity of influenza virus by Rheum tanguticum (da-huang)
    Ta Jen Lin
    Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, 259 Wen Hwa First Road, Kweishan, Taoyuan 333, Taiwan, R O C
    Sci Rep 6:27768. 2016
    ..Rex has the capacity to inhibit influenza viruses by blocking viral endocytosis. Thus, rhubarb might provide an alternative therapeutic approach when resistant viruses become more prevalent. ..
  13. pmc Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium
    Chun Yu Chen
    Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Sci Rep 5:18204. 2015
    ..The anti-inflammatory effects of PFE on activated human neutrophils were mediated through two independent signaling pathways involving SFKs (Src and Lyn) and mobilization of intracellular Ca(2+). ..
  14. doi Quantiosomes as a multimodal nanocarrier for integrating bioimaging and Carboplatin delivery
    Chwan Fwu Lin
    Department of Cosmetic Science, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan
    Pharm Res 31:2664-76. 2014
    ..Here we report the development of quantiosomes, niosomes formed from Span 60, cholesterol, and quantum dots (QDs), for achieving sensitive bioimaging and anticancer drug delivery...
  15. doi Anti-inflammatory effect of sophoraflavanone G isolated from Sophora flavescens in lipopolysaccharide-stimulated mouse macrophages
    Zih Yi Wun
    Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, 261 Wen Hwa 1st Road, Kwei Shan, Tao Yuan 333, Taiwan, ROC
    Food Chem Toxicol 62:255-61. 2013
    ..These results suggest that SG has an anti-inflammatory effect, inhibiting pro-inflammatory cytokines and mediators production via interruption of the NF-κB and MAPK signaling pathways...