Janusz Limon

Summary

Publications

  1. ncbi Dwarfism in art
    Janusz Limon
    Department of Biology and Genetics Medical University, Debinki 1 Street, 80 211 Gdansk, Poland, tel 48 58 349 15 31, E mail
    Dev Period Med 19:403-6. 2015
  2. pmc Angiotensin converting enzyme gene polymorphism is associated with severity of coronary artery disease in men with high total cholesterol levels
    Joanna Borzyszkowska
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1, 80 211 Gdansk, Poland
    J Appl Genet 53:175-82. 2012
  3. pmc Limited significance of family history for presence of BRCA1 gene mutation in Polish breast and ovarian cancer cases
    Izabela Brozek
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1, 80 211, Gdansk, Poland
    Fam Cancer 11:351-4. 2012
  4. pmc Prevalence of the most frequent BRCA1 mutations in Polish population
    Izabela Brozek
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1, Gdansk, Poland
    J Appl Genet 52:325-30. 2011
  5. pmc Spectrum of NIPBL gene mutations in Polish patients with Cornelia de Lange syndrome
    Alina Kuźniacka
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1 str, 80211, Gdansk, Poland
    J Appl Genet 54:27-33. 2013
  6. pmc High Resolution Melting analysis as a rapid and efficient method of screening for small mutations in the STK11 gene in patients with Peutz-Jeghers syndrome
    Pawel Borun
    Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, Poznan, 60 479, Poland
    BMC Med Genet 14:58. 2013
  7. pmc The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study
    Piotr Rutkowski
    Department of Soft Tissue Bone Sarcoma and Melanoma, Maria Sklodowska Curie Memorial Cancer Center, Warsaw, Poland
    BMC Cancer 12:107. 2012
  8. ncbi BRCA1 and BRCA2 point mutations and large rearrangements in breast and ovarian cancer families in Northern Poland
    Magdalena Ratajska
    Department of Biology and Genetics, Medical University of Gdansk, 80 210 Gdansk, Debinki 1, 80 210, Poland
    Oncol Rep 19:263-8. 2008
  9. ncbi Left ventricular size, mass and function in relation to angiotensin-converting enzyme gene and angiotensin-II type 1 receptor gene polymorphisms in patients with coronary artery disease
    Marcin Gruchala
    First Department of Cardiology Medical University of Gdansk, Gdansk, Poland
    Clin Chem Lab Med 41:522-8. 2003
  10. ncbi High frequency of BRCA1/2 germline mutations in consecutive ovarian cancer patients in Poland
    Izabela Brozek
    Department of Biology and Genetics, Medical University of Gdansk, Poland
    Gynecol Oncol 108:433-7. 2008

Detail Information

Publications45

  1. ncbi Dwarfism in art
    Janusz Limon
    Department of Biology and Genetics Medical University, Debinki 1 Street, 80 211 Gdansk, Poland, tel 48 58 349 15 31, E mail
    Dev Period Med 19:403-6. 2015
    ..The aim of the present article is to show how dwarfs were portrayed in a variety of art forms at different moments in the history of our world. ..
  2. pmc Angiotensin converting enzyme gene polymorphism is associated with severity of coronary artery disease in men with high total cholesterol levels
    Joanna Borzyszkowska
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1, 80 211 Gdansk, Poland
    J Appl Genet 53:175-82. 2012
    ..These results suggest that men who carry ACE c.2306-117_404 DD genotype and have high total cholesterol, high LDL cholesterol and low HDL cholesterol levels may be predisposed to the development of more severe CAD...
  3. pmc Limited significance of family history for presence of BRCA1 gene mutation in Polish breast and ovarian cancer cases
    Izabela Brozek
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1, 80 211, Gdansk, Poland
    Fam Cancer 11:351-4. 2012
    ..The high frequency of mutations detected in breast cancer patients lacking obvious family history shows that breast cancer patients should be qualified for genetic testing on the basis of wide clinical and pathological criteria...
  4. pmc Prevalence of the most frequent BRCA1 mutations in Polish population
    Izabela Brozek
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1, Gdansk, Poland
    J Appl Genet 52:325-30. 2011
    ..Carriage of one of these mutations is connected with a very high relative risk of breast cancer...
  5. pmc Spectrum of NIPBL gene mutations in Polish patients with Cornelia de Lange syndrome
    Alina Kuźniacka
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1 str, 80211, Gdansk, Poland
    J Appl Genet 54:27-33. 2013
    ..The review of the types of mutations found so far in Polish patients, their frequency and correlation with the severity of the observed phenotype shows that Polish CdLS cases do not significantly differ from other populations...
  6. pmc High Resolution Melting analysis as a rapid and efficient method of screening for small mutations in the STK11 gene in patients with Peutz-Jeghers syndrome
    Pawel Borun
    Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, Poznan, 60 479, Poland
    BMC Med Genet 14:58. 2013
    ..Depending on the studied population, its incidence has been estimated to range from 1:200 000 even up to 1:50 000 births. Being an autosomal disease, PJS is caused in most cases by mutations in the STK11 gene...
  7. pmc The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study
    Piotr Rutkowski
    Department of Soft Tissue Bone Sarcoma and Melanoma, Maria Sklodowska Curie Memorial Cancer Center, Warsaw, Poland
    BMC Cancer 12:107. 2012
    ..The aim of the study was to analyze the outcomes and factors predicting results of SU therapy in inoperable/metastatic CD117(+) GIST patients after IM failure...
  8. ncbi BRCA1 and BRCA2 point mutations and large rearrangements in breast and ovarian cancer families in Northern Poland
    Magdalena Ratajska
    Department of Biology and Genetics, Medical University of Gdansk, 80 210 Gdansk, Debinki 1, 80 210, Poland
    Oncol Rep 19:263-8. 2008
    ..However, families with strong breast/ovarian cancer history who are negative for these common mutations should be offered a complete BRCA gene screening, including MLPA analysis...
  9. ncbi Left ventricular size, mass and function in relation to angiotensin-converting enzyme gene and angiotensin-II type 1 receptor gene polymorphisms in patients with coronary artery disease
    Marcin Gruchala
    First Department of Cardiology Medical University of Gdansk, Gdansk, Poland
    Clin Chem Lab Med 41:522-8. 2003
    ..However, it indicates that the influence of polymorphisms may be present in specific patient populations...
  10. ncbi High frequency of BRCA1/2 germline mutations in consecutive ovarian cancer patients in Poland
    Izabela Brozek
    Department of Biology and Genetics, Medical University of Gdansk, Poland
    Gynecol Oncol 108:433-7. 2008
    ..We estimated the prevalence of BRCA1/2 germline mutations in consecutive ovarian cancers and correlated the mutation status with clinicopathological features...
  11. doi Cancer predisposing BARD1 mutations in breast-ovarian cancer families
    Magdalena Ratajska
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1, 80 211 Gdansk, Poland
    Breast Cancer Res Treat 131:89-97. 2012
    ..Our findings suggest that BARD1 mutations may be regarded as cancer risk alleles and warrant further investigation to determine their actual contribution to non-BRCA1/2 breast and ovarian cancer families...
  12. ncbi Association between the Pl(A) platelet glycoprotein GPIIIa polymorphism and extent of coronary artery disease
    Marcin Gruchała
    First Department of Cardiology, Medical University of Gdansk, Poland
    Int J Cardiol 88:229-37. 2003
    ..The aim of the current investigation was to investigate the association between Pl(A) GPIIIa polymorphism and the extent of angiographically confirmed CAD in patients from the north region of Poland...
  13. ncbi Increased risk of non-small cell lung cancer and frequency of somatic TP53 gene mutations in Pro72 carriers of TP53 Arg72Pro polymorphism
    Amelia Szymanowska
    Department of Allergology, Medical University of Gdansk, Gdansk, Poland
    Lung Cancer 52:9-14. 2006
    ..Additionally, the correlation between Pro72 and somatic TP53 mutations suggests that Pro72 allele carriers may be predisposed to tumour development along a p53 associated form of NSCLC, a finding that warrants further investigations...
  14. ncbi EGFR, PIK3CA and PTEN gene status and their protein product expression in neuroblastic tumours
    Ewa Izycka-Swieszewska
    Department of Pathomorphology, Medical University of Gdansk, 7 Debinki St, Gdansk, Poland
    Folia Neuropathol 48:238-45. 2010
    ..Both newly detected mutations in exon 5 of PIK3CA occurred in very low risk neuroblastic tumours in infants. EGFR, PI3Kp110 and PTEN expression is a common feature of NB...
  15. ncbi Germline NBS1 mutations in families with aggregation of Breast and/or ovarian cancer from north-east Poland
    Celina Kanka
    Department of Biology and Genetics, Medical University of Gdansk, Gdansk, Poland
    Anticancer Res 27:3015-8. 2007
    ..The carrier frequency of the 657del5 and I171V NBS1 gene mutations among Polish patients with familial breast and/or ovarian cancer was compared with that of randomly selected newborns...
  16. pmc Mutational analysis in podocin-associated hereditary nephrotic syndrome in Polish patients: founder effect in the Kashubian population
    Beata S Lipska
    Department of Biology and Genetics, Medical University of Gdansk, Debinki str 1, 80211, Gdansk, Poland
    J Appl Genet 54:327-33. 2013
    ..1032delT deletion...
  17. ncbi BRCA1 and BRCA2 mutation analysis in breast-ovarian cancer families from northeastern Poland
    Magdalena Perkowska
    Department of Biology and Genetics, Medical University of Gdansk, Poland
    Hum Mutat 21:553-4. 2003
    ..This warrants further careful BRCA mutation screening in order to optimise genetic counselling and disease prevention in affected families...
  18. doi Cornelia de Lange syndrome case due to genomic rearrangements including NIPBL
    Magdalena Ratajska
    Department of Biology and Genetics, Medical University of Gdansk, Poland
    Eur J Med Genet 53:378-82. 2010
    ..In a single patient, we identified a large deletion encompassing exons 35 to 47 of the NIPBL gene. Our finding was validated by aCGH and further characterized by long-range PCR and DNA sequencing of the breakpoint junction...
  19. pmc HER2 Amplification Has no Prognostic Value in Sporadic and Hereditary Ovarian Tumours
    Izabela Brozek
    Department of Biology and Genetics, Medical University of Gdansk
    Hered Cancer Clin Pract 4:39-42. 2006
    ..There is no significant difference in the clinical outcome of patients with HER2 amplified and non-amplified tumours (p = 0.3). Our results suggest a different biological role of HER2 amplification in ovarian and breast cancer...
  20. doi Novel, activating KIT-N822I mutation in familial cutaneous mastocytosis
    Bartosz Wasag
    Department of Biology and Genetics, Medical University of Gdansk, Gdansk, Poland
    Exp Hematol 39:859-65.e2. 2011
    ..In the children, tryptase measurement and skin histopathological examination were performed...
  21. ncbi Cytogenetic analysis and clinical significance of chromosome 7 aberrations in acute leukaemia
    Izabela Brozek
    Department of Biology and Genetics, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    J Appl Genet 44:401-12. 2003
    ..The complete remission (CR) rate was significantly lower in this group in comparison to the group of AML patients with a normal karyotype (p = 0.01) in bone marrow cells...
  22. doi Periventricular heterotopia in a boy with interstitial deletion of chromosome 4p
    Katarzyna Gawlik-Kuklinska
    Department of Biology and Genetics, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Eur J Med Genet 51:165-71. 2008
    ..Additionally, our patient developed a seizure disorder due to abnormal neuronal migration, i.e., periventricular heterotopia...
  23. doi Expression and significance of HER family receptors in neuroblastic tumors
    Ewa Izycka-Swieszewska
    Department of Pathomorphology, Medical University of Gdansk, ul Debinki 7, 80 211 Gdansk, Poland
    Clin Exp Metastasis 28:271-82. 2011
    ..Our study showed that the role of HER family members in NT biology is interrelated and complex but their expression level may present a novel prognostic factor for NT patients outcome...
  24. pmc c.1810C>T polymorphism of NTRK1 gene is associated with reduced survival in neuroblastoma patients
    Beata S Lipska
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1, 80 211 Gdansk, Poland
    BMC Cancer 9:436. 2009
    ..Therefore, the entire coding sequence of NTRK1 gene has been analysed in order to identify mutations and/or polymorphisms which may alter TrkA receptor expression...
  25. ncbi A girl with duplication 9q34 syndrome
    Katarzyna Gawlik-Kuklinska
    Department of Biology and Genetics, Medical University, Gdansk, Poland
    Am J Med Genet A 143:2019-23. 2007
    ..Due to late presentation and diagnosis, our patient was not evaluated and characterized until adolescence, when particular attention was paid to the development of secondary sexual characteristics, secondary amenorrhea and obesity...
  26. ncbi Prevalence and clinical correlations of BRCA1/BRCA2 unclassified variant carriers among unselected primary ovarian cancer cases - preliminary report
    Ewa J Majdak
    Department of Gynecology, Medical University of Gdansk, ul Kliniczna 1A, Gdnask, Poland
    Eur J Cancer 41:143-50. 2005
    ..Except for infertility and hyperthyroidism, unclassified variant-linked ovarian tumours share features with sporadic tumours rather than with BRCA1 pathogenic mutations...
  27. ncbi Association of the ScaI atrial natriuretic peptide gene polymorphism with nonfatal myocardial infarction and extent of coronary artery disease
    Marcin Gruchala
    First Department of Cardiology, Medical University of Gdansk, Gdansk, Poland
    Am Heart J 145:125-31. 2003
    ..According to our knowledge, this study is the first to look for the potential association of the ScaI ANP gene polymorphism with the history of nonfatal myocardial infarction and the extent of coronary artery disease (CAD)...
  28. ncbi Primary leiomyosarcoma of the mesentery in two sisters: clinical and molecular characteristics
    Magdalena Koczkowska
    Department of Biology and Genetics, Medical University of Gdansk, Poland
    Pol J Pathol 64:59-63. 2013
    ..2-13.1 with the minimal overlapping region of 9.2 Mb. Our study provides further evidence for the significant role of the genes located in this region in the early stage of carcinogenesis...
  29. doi JAK2 and MPL gene mutations in V617F-negative myeloproliferative neoplasms
    Anna Siemiatkowska
    Department of Biology and Genetics, Medical University of Gdansk, Debinki 1, 80 210 Gdansk, Poland
    Leuk Res 34:387-9. 2010
    ..Our results confirm that routine JAK2 analysis should include exon 12 mutations in polycythemia vera patients. MPL gene mutations seem to be associated with thrombocytosis, regardless of the type of myeloproliferative neoplasm...
  30. pmc Cornelia de Lange syndrome with NIPBL mutation and mosaic Turner syndrome in the same individual
    Jolanta Wierzba
    Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, Poland
    BMC Med Genet 13:43. 2012
    ..Turner syndrome (TS) results from the partial or complete absence of one of the X chromosomes, usually associated with congenital lymphedema, short stature, and gonadal dysgenesis...
  31. ncbi Loss of genetic material within 1p and 19q chromosomal arms in low grade gliomas of central nervous system
    Daniel Recławowicz
    Neurosurgery Department, Medical University of Gdansk, Gdansk, Poland
    Folia Neuropathol 51:26-32. 2013
    ..Its incidence depends on the type of diagnosed glioma. Deletions also have prognostic significance in the test group what constitutes the basis for inclusion of determining deletion 1p/19q into diagnostic and treatment algorithm in LGGs...
  32. doi A case of mast cell leukaemia with exon 9 KIT mutation and good response to imatinib
    Andrzej Mital
    Department of Hematology and Transplantology, Medical University of Gdansk, Poland
    Eur J Haematol 86:531-5. 2011
    ..Mast cell leukaemia (MCL), the aggressive form of this disease, requires cytoreductive therapy, such as cladribine, interferon-alpha-2b and, most recently, tyrosine kinase inhibitors - dasatinib or imatinib...
  33. doi The angiotensinogen AGT p.M235T gene polymorphism may be responsible for the development of severe anaphylactic reactions to insect venom allergens
    Marek Niedoszytko
    Department of Allergology, Medical University of Gdansk, Poland
    Int Arch Allergy Immunol 153:166-72. 2010
    ..M235T and angiotensin-converting enzyme ACE I/D, I/I, D/D gene polymorphisms in patients with IVA and to relate the presence of these gene variants to the course of IVA and the safety of treatment...
  34. ncbi Cytogenetic and molecular findings in 75 clear cell renal cell carcinomas
    Iwona Kardas
    Department of Biology and Genetics, Medical University of Gdansk, 1 Debinki St, 80 211 Gdansk, Poland
    Oncol Rep 13:949-56. 2005
    ..Together with our case, all but 1 RCC with t(X;1)(p11.2;p34) had morphology with a clear cell component, which contrasts these RCCs from tumors harboring t(X;1)(p11.2;q21) that largely had papillary morphology...
  35. ncbi A unique occurrence of a cerebral atypical teratoid/rhabdoid tumor in an infant and a spinal canal primitive neuroectodermal tumor in her father
    Ewa Izycka-Swieszewska
    Department of Pathology, Medical University of Gdansk, Poland
    J Neurooncol 61:219-25. 2003
    ..Thus, our findings emphasize the genetic differences between the two specimens and suggest that the occurrence of these two aggressive tumors of CNS in one family could be coincidental...
  36. doi Regeneration of comparative genomic hybridization oligonucleotide microarrays with dimethylurea
    Anna Ronowicz
    Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, 80 416 Gdansk, Poland
    Anal Biochem 426:91-3. 2012
    ..We also demonstrated that regenerated arrays can detect smaller alterations (16-200kbp), such as common copy number variants, as well as complex aberration profiles in tumor DNA...
  37. pmc beta-2-adrenergic receptor gene polymorphism confers susceptibility to Graves disease
    Krystian Jazdzewski
    Departmrnt of Hypertension and Diabetology, Medical University of Gdansk, Debinki 1, 80 211 Gdansk, Poland
    Int J Mol Med 19:181-6. 2007
    ..00073, pcorr=0.0044). In conclusion, Gln27 carriers (79CC or 79GC genotypes) have increased risk of Graves disease. Our results suggest that ADRB2 plays a role in susceptibility to Graves disease in humans...
  38. ncbi Karyotypic characterization of 64 nonmalignant thyroid goiters
    Mariola Iliszko
    Department of Biology and Genetics, Medical University, Debinki str 1, 80 211 Gdansk, Poland
    Cancer Genet Cytogenet 161:178-80. 2005
    ..Deletion of 18p11 was found in four cases, and in three of them as the sole change. Selection and clonal evolution of aneuploid cells present in nonmalignant goiters could underlie progression into adenoma formation...
  39. ncbi Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster
    Dorota Zurawa-Janicka
    Department of Biochemistry, University of Gdansk, Gdansk, Poland
    Acta Biochim Pol 55:9-19. 2008
    ..A full-length cDNA sequence of the hamster HtrA1 gene was obtained. It codes for a 50 kDa protein which has 98 and 96% identity with mouse and human counterparts, respectively...
  40. doi Management of familial hypercholesterolemia in children and adolescents. Position paper of the Polish Lipid Expert Forum
    Małgorzata Myśliwiec
    Faculty and Clinic of Pediatrics, Diabetes and Endocrinology, Medical University of Gdansk, Gdansk, Poland
    J Clin Lipidol 8:173-80. 2014
    ..These recommendations present the current epidemiological status, guidelines for diagnosing FH in Polish children and adolescents, and effective treatment options. ..
  41. doi Management of familial heterozygous hypercholesterolemia: Position Paper of the Polish Lipid Expert Forum
    Andrzej Rynkiewicz
    1st Department of Cardiology, Medical University of Gdansk, Debinki 7, 80 211 Gdansk, Poland
    J Clin Lipidol 7:217-21. 2013
    ..The aim of the position paper was to present the importance and scale of this problem in Poland, which has not been raised enough so far, as well as the recommendations of diagnosis, treatment and prevention methods...
  42. ncbi Partial trisomy of distal 5q and partial monosomy of Xp as a result of mating between two translocation carriers: a female with a balanced translocation t(X;5)(p11;q31) and a male with a der(13;14)(q10;q10)--a case report and a family study
    Barbara Wysocka
    Department of Biology and Genetics, Medical University of Gdansk, Poland
    Ann Genet 45:143-6. 2002
    ..The parents' karyotypes are 46,X,t(X;5)(p11.1;q31) and 45,XY,der(13;14)(q10;q10), respectively...
  43. ncbi Loss of heterozygosity at chromosomes 3p and 17p in primary non-small cell lung cancer
    Magdalena Chmara
    Department of Biology and Genetics, Medical University of Gdansk, Gdansk, Poland
    Anticancer Res 24:4259-63. 2004
    ..Loss of heterozygosity (LOH) of selected regions at chromosomes 3p and 17p in non-small cell lung cancer (NSCLC) and the association of these abnormalities with major clinical parameters and prognosis were studied...
  44. ncbi Loss of heterozygosity in 73 human thyroid tumors
    Agnieszka Wozniak
    Department of Biology and Genetics, Medical University of Gdansk, Gdansk, Poland
    Neuro Endocrinol Lett 26:521-5. 2005
    ..For PTC, tumors negative for RET/PTC rearrangements were preferred...
  45. doi Routine brush cytology and fluorescence in situ hybridization for assessment of pancreatobiliary strictures
    Marian Smoczynski
    Department of Gastroenterology and Hepatology, Medical University of Gdansk, Gdansk, Poland
    Gastrointest Endosc 75:65-73. 2012
    ..Fluorescence in situ hybridization (FISH) can be used to detect chromosomal aneuploidy in biliary brushing specimens, and, according to some reports, it may improve the sensitivity of routine cytology...