Wei Li

Summary

Publications

  1. ncbi request reprint Estimation of the optimal electrophoretic temperature of DNA single-strand conformation polymorphism by DNA base composition
    Wei Li
    Laboratory of Pediatrics, Medical Scientific Research Center, Guangxi Medical University, China
    Electrophoresis 24:2283-9. 2003
  2. ncbi request reprint Detection of known thalassemia point mutations by snapback single-strand conformation polymorphism: the feasibility analysis
    Wei Li
    Medical Science Research Center, Guangxi Medical University, and Department of Anal and Colorectal Surgery, The First Affiliated Hospital of Guangxi Medical University, PR China
    Clin Biochem 39:833-42. 2006
  3. ncbi request reprint Creation of DNA overhangs by using modified DNA overhang cloning method
    Wei Li
    Laboratory of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People s Republic of China
    Appl Microbiol Biotechnol 75:703-9. 2007
  4. ncbi request reprint p53 Gene mutations in sporadic colorectal carcinoma in Guangxi region
    Feng Gao
    Department of Anal and Colorectal Surgery, The First Affiliated Hospital, Guangxi Medical University, Guangxi, PR China
    Cancer Invest 24:689-95. 2006
  5. pmc Detection of ligation products of DNA linkers with 5'-OH ends by denaturing PAGE silver stain
    Feng Gao
    Department of Anal and Colorectal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
    PLoS ONE 7:e39251. 2012
  6. doi request reprint Poorly differentiated gastroenteropancreatic neuroendocrine carcinoma associated with X-linked hyperimmunoglobulin M syndrome
    Reenu K Malhotra
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Medical School, 6431 Fannin St, MSB 2 278, Houston, TX 77030, USA
    Arch Pathol Lab Med 132:847-50. 2008
  7. ncbi request reprint Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms
    Song Li
    Laboratory for Brain and Mind, Institute of Neuroinformatics, Dalian University of Technology, Dalian, 116023, China
    Life Sci 80:1373-81. 2007
  8. ncbi request reprint Photodegradation mechanism of two dyes: the influence of adsorption behavior on the novel TiO2 particles
    Wei Li
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    J Environ Sci (China) 16:328-31. 2004
  9. ncbi request reprint Reconstruction of ancient genome and gene order from complete microbial genome sequences
    Yuhong Wang
    Department of Molecular Biology, Jilin University, Changchun 130023, PR China
    J Theor Biol 239:494-8. 2006
  10. ncbi request reprint In vitro and in vivo biocompatibility of graded hydroxyapatite-zirconia composite bioceramic
    Renfu Quan
    Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University, Jiefang Road 88, Hangzhou 310009, China
    J Mater Sci Mater Med 19:183-7. 2008

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Estimation of the optimal electrophoretic temperature of DNA single-strand conformation polymorphism by DNA base composition
    Wei Li
    Laboratory of Pediatrics, Medical Scientific Research Center, Guangxi Medical University, China
    Electrophoresis 24:2283-9. 2003
    ..T(s) could be estimated by the formula T(s) = [80 x C/(A+1)]/[2.71 + [C/(A+1)]]. T(s) could be increased dramatically by the complementary sequences in both 5'-and 3'-ends of a DNA single-strand...
  2. ncbi request reprint Detection of known thalassemia point mutations by snapback single-strand conformation polymorphism: the feasibility analysis
    Wei Li
    Medical Science Research Center, Guangxi Medical University, and Department of Anal and Colorectal Surgery, The First Affiliated Hospital of Guangxi Medical University, PR China
    Clin Biochem 39:833-42. 2006
    ..To explore if snapback single-strand conformation polymorphism (snapback SSCP) can be applied to the detection of known thalassemia point mutations...
  3. ncbi request reprint Creation of DNA overhangs by using modified DNA overhang cloning method
    Wei Li
    Laboratory of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People s Republic of China
    Appl Microbiol Biotechnol 75:703-9. 2007
    ..The creation of DNA overhangs by using complementary DNA oligonucleotides, T4 ligase, and RNase H is simpler and cheaper than that by using reverse transcriptase and RNase H...
  4. ncbi request reprint p53 Gene mutations in sporadic colorectal carcinoma in Guangxi region
    Feng Gao
    Department of Anal and Colorectal Surgery, The First Affiliated Hospital, Guangxi Medical University, Guangxi, PR China
    Cancer Invest 24:689-95. 2006
    ..67 percent) in < 60 year old patients (P < 0.05). The frequency (47.83 percent) of p53 gene mutations in rectal carcinoma was higher than that (16 percent) in colonic carcinoma (P < 0.025)...
  5. pmc Detection of ligation products of DNA linkers with 5'-OH ends by denaturing PAGE silver stain
    Feng Gao
    Department of Anal and Colorectal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
    PLoS ONE 7:e39251. 2012
    ..Our findings may probably indicate that some DNA nicks with 5'-OH ends can be joined by commercial T4 or E. coli DNA ligase even in the absence of PNK...
  6. doi request reprint Poorly differentiated gastroenteropancreatic neuroendocrine carcinoma associated with X-linked hyperimmunoglobulin M syndrome
    Reenu K Malhotra
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Medical School, 6431 Fannin St, MSB 2 278, Houston, TX 77030, USA
    Arch Pathol Lab Med 132:847-50. 2008
    ..A review of the literature of gastroenteropancreatic neuroendocrine tumors is presented with the discussion of a possible relationship of these tumors with immunodeficiency...
  7. ncbi request reprint Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms
    Song Li
    Laboratory for Brain and Mind, Institute of Neuroinformatics, Dalian University of Technology, Dalian, 116023, China
    Life Sci 80:1373-81. 2007
    ....
  8. ncbi request reprint Photodegradation mechanism of two dyes: the influence of adsorption behavior on the novel TiO2 particles
    Wei Li
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    J Environ Sci (China) 16:328-31. 2004
    ..The different effect of SO4(2-), HCO3- on the adsorption and photodegradation of two dyes confirmed these results...
  9. ncbi request reprint Reconstruction of ancient genome and gene order from complete microbial genome sequences
    Yuhong Wang
    Department of Molecular Biology, Jilin University, Changchun 130023, PR China
    J Theor Biol 239:494-8. 2006
    ..This method provides a new computational tool for studying microbial genome structure and evolution...
  10. ncbi request reprint In vitro and in vivo biocompatibility of graded hydroxyapatite-zirconia composite bioceramic
    Renfu Quan
    Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University, Jiefang Road 88, Hangzhou 310009, China
    J Mater Sci Mater Med 19:183-7. 2008
    ..It was found that the graded HA-ZrO(2) composite bioceramics exhibited superior osteoinductive ability, which may be a promising bioceramics implant...
  11. ncbi request reprint [Effects of edaravone, minocycline and ONO-1078 on oxygen/glucose deprivation-induced electrophysiological alteration in rat hippocampal slices]
    Wei Li
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China
    Yao Xue Xue Bao 39:81-4. 2004
    ....
  12. ncbi request reprint [Dry eye relevant to ocular surgery]
    Zu guo Liu
    Eye Institute and Affiliated Xiamen Eye Center, Xiamen University, Xiamen 361005, China
    Zhonghua Yan Ke Za Zhi 45:483-5. 2009
    ..More studies regarding the mechanism, prevention and treatment are required to increase our knowledge of surgery-associated dry eye...
  13. ncbi request reprint Effects of berberine on expression of LOX-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL
    Siming Guan
    Department of Geriatrics, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
    Am J Chin Med 38:1161-9. 2010
    ..Berberine can inhibit the expression of LOX-1 and promote the expression of SR-BI in macrophage-derived foam cells. Therefore, berberine could be used to treat atherosclerotic diseases...
  14. pmc Silver and Cyanine Staining of Oligonucleotides in Polyacrylamide Gel
    Weizhong Tang
    Department of Colorectal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi 530021, China
    PLoS ONE 10:e0144422. 2015
    ..The sensitivity of cyanine staining of ≤ 11-nt long oligonucleotides could be enhanced about 250-fold by fixing the gels with methanol fixing solution. ..
  15. doi request reprint A high throughput method for rapid screening of chitosanase-producing fungal strain under acidic conditions
    Su Ding
    College of Life Science and Technology, Guangxi University, Nanning, 530004, Guangxi, China
    World J Microbiol Biotechnol 32:174. 2016
    ..87 U/mL (increased by 369.2 % as compared to that of its parental strain).Taking together, the method is easy, efficient and particularly suited to rapid screen acidophilic fungal strains with high chitosanase-production. ..
  16. doi request reprint Purification and characterization of an intracellular α-glucosidase with high transglycosylation activity from A. niger M-1
    Yun Kai Zhang
    College of Life Science and Technology, Guangxi University, Nanning, Guangxi, P R China
    Prep Biochem Biotechnol 41:201-17. 2011
    ..21% to 15.80% using the purified enzyme in the solution of 25% maltose and 3% glucose. This intracellular α-glucosidase has potential applications in the synthesis of sugar derivatives and the investigation of associated mechanisms...
  17. pmc Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos
    Wei Li
    Interdisciplinary Graduate Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Dev Biol 304:338-54. 2007
    ....
  18. ncbi request reprint Isolation and expression analysis of testicular type Sox9b in allotetraploid fish
    Jifang Liu
    Key Laboratory of Protein Chemistry and Fish Developmental Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, People s Republic of China
    Mar Biotechnol (NY) 9:329-34. 2007
    ..In addition, the diverse tissue-specific expression profiles of Sox9b provided significant molecular evidence for the lineage-specific subfunction partitioning of Sox9 genes...
  19. ncbi request reprint [Preparation of graded zirconia-hydroxyapatite composite bioceramic and its immunocompatibility in vitro]
    Renfu Quan
    Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University, Hangzhou 310009, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 23:1056-61. 2006
    ..01). The numbers of PBMCs activated by the graded composite material group were less than that of the simply composite material group and the technique of graded composite will be helpful to improve its immunocompatibility...
  20. pmc Human amniotic epithelial cells as novel feeder layers for promoting ex vivo expansion of limbal epithelial progenitor cells
    Ying Ting Chen
    TissueTech Inc, and Ocular Surface Center, Miami, FL 33173, USA
    Stem Cells 25:1995-2005. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  21. ncbi request reprint [Biological properties study and animal experiment of polylactide/polytrimethylene carbonate blends membrane]
    Xiaoqiang Yang
    Research Institute of Daily Chemistry of China, Taiyuan 030024, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 23:578-82. 2006
    ..In the experimental application of this member to preventing adhesion after rabbit intestine operation, the membrane demonstrated good effect. In conclusion, PLA/PTMC blends membrane is a material with good biocompatibility...
  22. ncbi request reprint Induction of tobacco genes in response to oligochitosan
    Fuyun Zhang
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China
    Mol Biol Rep 34:35-40. 2007
    ..The results suggest that the usefulness of mRNA differential display technique for the detection of plant metabolic pathways affected by oligochitosan...
  23. ncbi request reprint Translational regulation of rat multidrug resistance-associated protein 2 expression is mediated by upstream open reading frames in the 5' untranslated region
    Yuanyuan Zhang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 0305, USA
    Mol Pharmacol 71:377-83. 2007
    ..We conclude that among the uORFs in the Mrp2 5'UTR, the uORF starting at nucleotide -109 probably plays an important role in the regulation of Mrp2 protein expression...
  24. ncbi request reprint Preparation of graded zirconia hydroxyapatite composite bioceramic and its immunocompatibility in vitro
    Renfu Quan
    Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University, 310009 Hangzhou, China
    J Biomater Appl 22:123-44. 2007
    ..The PBMCs activated by graded ZrO(2)-HA composite bioceramic is noticeably smaller than that by simplex ZrO(2)-HA composite bioceramic; these results, however can only be seen under the amplified effect of PHA-stimulation...
  25. doi request reprint False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathology
    Rooshdiya Z Karim
    Department of Anatomical Pathology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Ann Surg 247:1003-10. 2008
    ..To investigate a cohort of melanoma patients with false negative (FN) sentinel node (SN) biopsies (SNBs) to identify the reasons for the FN result...
  26. doi request reprint Detection of drug resistance-associated genes of multidrug-resistant Acinetobacter baumannii
    Xiao Lin Yin
    Department of Microbiology and Immunology of Hebei Medical University, Shijiazhuang City, Hebei Province, People s Republic of China
    Microb Drug Resist 14:145-50. 2008
    ..The positive rate of qacEDelta1-sul1 and intl1 were 80.6% and 58.1%, respectively. Six different PFGE clones were found, of which two dominated. The findings show that clinical isolates of MDRAB harbor various kinds of resistance genes...
  27. pmc The R protein of SARS-CoV: analyses of structure and function based on four complete genome sequences of isolates BJ01-BJ04
    Zuyuan Xu
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China
    Genomics Proteomics Bioinformatics 1:155-65. 2003
    ..Findings suggest that it is possible to obtain information about the phylogeny of SARS-CoV, as well as potential tools for drug design, genotyping and diagnostics of SARS...
  28. pmc Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets
    David S Johnson
    Department of Genetics, Stanford University Medical Center, Stanford, California 94305, USA
    Genome Res 18:393-403. 2008
    ..The spike-in DNA samples and the data presented here provide a stable benchmark against which future ChIP platforms, protocol improvements, and analysis methods can be evaluated...
  29. ncbi request reprint EXAFS studies on adsorption irreversibility of Zn(II) on TiO2: temperature dependence
    Wei Li
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    J Colloid Interface Sci 319:385-91. 2008
    ..g., soils or natural waters) zinc and other similar heavy metals are likely more mobile at higher temperatures...
  30. pmc Alu elements mediate MYB gene tandem duplication in human T-ALL
    Jennifer O'Neil
    Department of Pediatric Oncology, Belfer Foundation Institute for Innovative Cancer Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 204:3059-66. 2007
    ..We conclude that Alu-mediated MYB tandem duplication occurs at low frequency during normal thymocyte development and is clonally selected during the molecular pathogenesis of human T-ALL...
  31. ncbi request reprint Antidepressant-like effects of piperine and its derivative, antiepilepsirine
    Song Li
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Asian Nat Prod Res 9:421-30. 2007
    ....
  32. ncbi request reprint Effects of the Chinese traditional prescription Xiaoyaosan decoction on chronic immobilization stress-induced changes in behavior and brain BDNF, TrkB, and NT-3 in rats
    Jia Xu Chen
    School of Pre clinical Medicine, Beijing University of Traditional Chinese Medicine, No 11 Beisanhuan Donglu, Chaoyang District, Beijing, P R China
    Cell Mol Neurobiol 28:745-55. 2008
    ..The behavioral effects of the XYS were correlated to the biochemical actions. These results suggest that the XYS decoction produces an antidepressant-like effect, which appears to be involved by BDNF in the brain...
  33. ncbi request reprint Carboxymethyl chitosan-coated capillary and its application in CE of proteins
    Xiaofang Fu
    Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, PR China
    Electrophoresis 28:1958-63. 2007
    ..Finally, the volatile BGE HAc-NH4Ac was utilized to separate rhEPO for its further application with CE-MS, achieving a satisfactory result...
  34. ncbi request reprint Bacillus qingdaonensis sp. nov., a moderately haloalkaliphilic bacterium isolated from a crude sea-salt sample collected near Qingdao in eastern China
    Qian fu Wang
    Institute of Cell Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, People s Republic of China
    Int J Syst Evol Microbiol 57:1143-7. 2007
    ..4 %. On the basis of phenotypic and molecular properties, strain CM1(T) represents a novel Bacillus species, for which the name Bacillus qingdaonensis sp. nov. is proposed. The type strain is CM1(T) (=CGMCC 1.6134(T)=JCM 14087(T))...
  35. ncbi request reprint Development of an improved preparation and an enzyme-linked immunosorbent assay for anti-neuroexcitation peptide (ANEP)
    Mingxin Ma
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China
    J Biochem Biophys Methods 70:635-40. 2007
    ..It was confirmed that the antibody reacted with recombinant ANEP by both Western blotting and ELISA results. Using purified antibody, the immunoassay method was developed...
  36. ncbi request reprint [Cloning and sequencing of the junction fragment of dystrophin gene with exons 3 to 5 deletion]
    Min Zhong
    Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:757-9. 2006
    ..To study the mechanisms of dystrophin gene deletion by cloning and sequencing the junction fragment of dystrophin gene with exons 3 to 5 deletion...
  37. ncbi request reprint A draft sequence of the rice genome (Oryza sativa L. ssp. indica)
    Jun Yu
    Beijing Genomics Institute Center of Genomics and Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China
    Science 296:79-92. 2002
    ..4% of predicted rice genes had a homolog in A. thaliana. The large proportion of rice genes with no recognizable homologs is due to a gradient in the GC content of rice coding sequences...
  38. ncbi request reprint Comparative analysis of the pig BAC sequence involved in the regulation of myostatin gene
    Zhengquan Yu
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, China
    Sci China C Life Sci 48:168-80. 2005
    ..Many putative transcription factors play an important role in the muscle development, and the complex interaction between myostatin and these factors may be required for proper muscle development...
  39. pmc Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencing
    Rasmus Wernersson
    Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark
    BMC Genomics 6:70. 2005
    ..Comparative whole genome analysis of Mammalia can benefit from the addition of more species. The pig is an obvious choice due to its economic and medical importance as well as its evolutionary position in the artiodactyls...
  40. ncbi request reprint Nigramides A-S, dimeric amide alkaloids from the roots of Piper nigrum
    Kun Wei
    Faculty of Pharmaceutical Sciences, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
    J Org Chem 70:1164-76. 2005
    ..On the basis of this biosynthetic hypothesis, the first study of the thermal and Lewis acid mediated Diels-Alder reactions of piperine in different organic solvents and under solventless conditions is also described...
  41. ncbi request reprint Enhanced expression of natural resistance-associated macrophage protein 1 in atherosclerotic lesions may be associated with oxidized lipid-induced apoptosis
    Wei Li
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1030:202-7. 2004
    ..This finding reveals a novel function of Nramp1 in atherogenesis...
  42. pmc Changes of mRNA expression of enkephalin and prodynorphin in hippocampus of rats with chronic immobilization stress
    Jia Xu Chen
    School of Basic Medical Science, Beijing University of Traditional Chinese Medicine, Beijing 100029, China
    World J Gastroenterol 10:2547-9. 2004
    ..To observe the changes of enkephalin mRNA and prodynorphin mRNA in hippocampus of rats induced by chronic immobilization stress...
  43. ncbi request reprint [Variations of the zinc finger protein 161 gene in Chinese with or without high myopia]
    Guo Bing Wang
    Ocular Genetics and Molecular Biology, National Ophthalmological Labs and Zhongshan Ophthalmic Center, Zhongshan University, Guangzhou 510060, China
    Yi Chuan 26:155-9. 2004
    ..Ala56Ala is a non-sense mutation identified in 5 of the 204 patients and 3 of 116 controls. No evidence shows that these variations are responsible for high myopia...
  44. pmc Evolution and variation of the SARS-CoV genome
    Jianfei Hu
    College of Life Sciences, Peking University, Beijing 100871, China
    Genomics Proteomics Bioinformatics 1:216-25. 2003
    ..Our manual analysis of the BLASTN results demonstrates that the HE (hemagglutinin-esterase) gene exists in the SARS-CoV, and many mutations made it unfamiliar to us...
  45. ncbi request reprint Rapid determination of aristolochic acid I and II in Aristolochia plants from different regions by beta-cyclodextrin-modified capillary zone electrophoresis
    Wei Li
    The Key Lab of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China
    J Chromatogr A 1049:211-7. 2004
    ..The result indicated high variability in the contents of aristolochic acids due to different species and regions. The comparison of CZE method with high performance liquid chromatography (HPLC) was also discussed...
  46. pmc The structure analysis and antigenicity study of the N protein of SARS-CoV
    Jingqiang Wang
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China
    Genomics Proteomics Bioinformatics 1:145-54. 2003
    ..Compared with other viral structural proteins, the low variation rate of the N protein with regards to its size suggests its importance to the survival of the virus...
  47. ncbi request reprint Complete nucleotide sequence and organization of the naphthalene catabolic plasmid pND6-1 from Pseudomonas sp. strain ND6
    Wei Li
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China
    Gene 336:231-40. 2004
    ..Results of this study indicated that globally distributed naphthalene catabolic genes are highly conserved among different bacterial species...
  48. pmc The structural characterization and antigenicity of the S protein of SARS-CoV
    Jingxiang Li
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China
    Genomics Proteomics Bioinformatics 1:108-17. 2003
    ..Phylogenetic analysis reveals several conserved regions that might be potent drug targets...
  49. pmc A complete sequence of the T. tengcongensis genome
    Qiyu Bao
    Beijing Genomics Institute Genomics and Bioinformatics Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences CAS, Beijing 100101, China
    Genome Res 12:689-700. 2002
    ..It is concluded that thermophiles are a biologically and phylogenetically divergent group of prokaryotes that have converged to sustain extreme environmental conditions over evolutionary timescale...
  50. ncbi request reprint Real-time monitoring of DNA polymerase activity using molecular beacon
    Changbei Ma
    State Key Laboratory of Chemo Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Engineering Research Center for Bio Nanotechnology of Hunan Province, Hunan University, Changsha, People s Republic of China
    Anal Biochem 353:141-3. 2006
  51. ncbi request reprint Structural polymorphism of telomeric DNA regulated by pH and divalent cation
    Daisuke Miyoshi
    Department of Chemistry, Faculty of Science and Engineering, Konan University, Higashinada ku, Kobe, Japan
    Nucleosides Nucleotides Nucleic Acids 22:203-21. 2003
    ....
  52. ncbi request reprint Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1
    Daniel Kirchhofer
    Department of Physiology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 278:36341-9. 2003
    ..Therefore, previously demonstrated roles of HAI-1 in various physiological and pathological processes likely involve both HAI-1B and HAI-1...
  53. ncbi request reprint A normal mucin-binding lectin from the sponge Craniella australiensis
    Chuannan Xiong
    Dalian Institute of Chemical Physics, Chinese Academy of Science, Liaoning Dalian 116023, PR China
    Comp Biochem Physiol C Toxicol Pharmacol 143:9-16. 2006
    ..The lectin reaction is independent of the presence of divalent cations Ca2+ and Mg2+. The sequence of N-terminal residues of CAL was determined as TSSCQSIVVE. The lectin showed a potent mitogenic response towards BALB/c splenocytes...
  54. pmc The role of microRNA genes in papillary thyroid carcinoma
    Huiling He
    Human Cancer Genetics Program, Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 102:19075-80. 2005
    ..We conclude that up-regulation of several miRs and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation...
  55. pmc Beneficial effects of exercise and its molecular mechanisms on depression in rats
    Hang Zheng
    West China Medical Center, Sichuan University, Chengdu, Sichuan 610041, PR China
    Behav Brain Res 168:47-55. 2006
    ....
  56. ncbi request reprint [The SNPs analysis of encoding sequence of interacting factor gene in Chinese population]
    Jiang Li
    Ophthalmology Center Sun Yat sen University of Medical Sciences, Guangzhou, Guangdong, 510060 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:454-6. 2003
    ..To screen the variations of TG interacting factor(TGIF) gene in encoding sequence in Chinese high myopia patients and normal controls and to analyze the SNPs of TGIF gene encoding sequence in Chinese population...
  57. ncbi request reprint Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin
    Bin Fan
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 280:34513-20. 2005
    ..The identification of HAI-1B as a potential physiological regulator of prostasin function, as described herein, may further the investigation of the role of prostasin in normal physiology and cancer...
  58. pmc Detection of gyrA and parC mutations associated with ciprofloxacin resistance in Neisseria gonorrhoeae by use of oligonucleotide biochip technology
    Wenming Zhou
    Institute of Dermatology, Anhui Medical University, Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, People s Republic of China
    J Clin Microbiol 42:5819-24. 2004
    ..In conclusion, the oligonucleotide biochip technology has potential utility for the rapid and reliable identification of point mutations in the drug resistance genes of N. gonorrhoeae...
  59. ncbi request reprint Direct synaptic connections between rods and OFF cone bipolar cells in the rabbit retina
    Wei Li
    Department of Ophthalmology and Visual Science, University of Texas Medical School at Houston, Texas 77030, USA
    J Comp Neurol 474:1-12. 2004
    ..In summary, we report anatomical evidence for direct connections between rods and OFF cone bipolar cells in a nonrodent mammal. Our data suggest that this alternative rod pathway may be a common feature of the mammalian retina...
  60. pmc The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle trafficking
    Qing Zhang
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Hum Mol Genet 11:697-706. 2002
    ..Therefore, the mu gene is a member of the novel gene set that has evolved in higher eukaryotes to regulate the synthesis/function of highly specialized subcellular organelles such as melanosomes and platelet dense granules...
  61. ncbi request reprint Use of polylactic acid/polytrimethylene carbonate blends membrane to prevent postoperative adhesions
    Yuyue Qin
    College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, People s Republic of China
    J Biomed Mater Res B Appl Biomater 79:312-9. 2006
    ..01), but the treatment group was better than the control group (p < 0.05). The in-vivo studies confirmed that PLA/PTMC blends membrane could prevent postoperative adhesions...
  62. ncbi request reprint Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein
    Wei Li
    Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 281:15916-22. 2006
    ..Here we report the expression and preliminary characterization of recombinant full-length wild-type human htt. Our results support a model of htt composed entirely of HEAT repeats that stack to form an elongated superhelix...
  63. ncbi request reprint Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model
    Winston S N Shim
    Research and Development Unit, National Heart Center, 17 Third Hospital Avenue, Singapore 168752, Singapore
    J Biomed Sci 13:579-91. 2006
    ..These data demonstrate that gene transfer of ANG-1 and VEGF enhances angiogenesis, but ANG-1 promotes sustained improvement of ventricular perfusion that expedites recovery of ischemic myocardium via arteriogenesis...
  64. ncbi request reprint Streptomyces jietaisiensis sp. nov., isolated from soil in northern China
    Liang He
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    Int J Syst Evol Microbiol 55:1939-44. 2005
    ..It is proposed, therefore, that this organism be classified as a novel species of the genus Streptomyces, for which the name Streptomyces jietaisiensis sp. nov. is proposed. The type strain is FXJ46(T) (=AS 4.1859(T)=JCM 12279(T))...
  65. pmc Intrastromal invasion by limbal epithelial cells is mediated by epithelial-mesenchymal transition activated by air exposure
    Tetsuya Kawakita
    TissueTech, Inc, Ocular Surface Center, 7000 SW 97 Ave, Suite 213, Miami, FL 33173, USA
    Am J Pathol 167:381-93. 2005
    ....
  66. ncbi request reprint Classification of Streptomyces griseus (Krainsky 1914) Waksman and Henrici 1948 and related species and the transfer of 'Microstreptospora cinerea' to the genus Streptomyces as Streptomyces yanii sp. nov
    Zhiheng Liu
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    Int J Syst Evol Microbiol 55:1605-10. 2005
    ..It is proposed that S. caviscabies and S. setonii should be considered as later heterotypic synonyms of S. griseus and that S. argenteolus AS 4.1693(T) should also be assigned to this taxon...
  67. ncbi request reprint [PCR site-directed mutagenesis of long QT syndrome KCNQ1 gene in vitro]
    Wei Li
    Institute of Cardiology, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430 022, China
    Yi Chuan 26:589-93. 2004
    ..Under the fluorescence microscope, the green fluorescence was spread in the transfected HEK293 cell, meaning the pIRES(2)-EGFP-KCNQ1 containing the mutation site was expressed correctly...
  68. pmc A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
    Qianben Wang
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 27:380-92. 2007
    ..These collaborating factors, together with AR, form a regulatory hierarchy that governs androgen-dependent gene expression and prostate cancer growth and offer potential new opportunities for therapeutic intervention...
  69. ncbi request reprint Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells
    Jie Ouyang
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, FL 33136, USA, and Department of Ophthalmology, Veterans General Hospital, Taichung, Taiwan
    Invest Ophthalmol Vis Sci 47:2397-407. 2006
    ..Pax6 continues to be expressed in the ocular surface epithelia of the postnatal eye. The goal of this study was to investigate a possible role for Pax6 in controlling dynamics of the ocular surface epithelia...