Song Li

Summary

Publications

  1. ncbi Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms
    Song Li
    Laboratory for Brain and Mind, Institute of Neuroinformatics, Dalian University of Technology, Dalian, 116023, China
    Life Sci 80:1373-81. 2007
  2. ncbi Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress
    Li Song
    Department of Pharmacology, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    Pharmacol Biochem Behav 83:186-93. 2006
  3. doi Chronic mild stress impairs cognition in mice: from brain homeostasis to behavior
    Song Li
    Laboratory for Brain and Mind, Institute of Neuroinformatics, Dalian University of Technology, Dalian, 116024, China
    Life Sci 82:934-42. 2008
  4. doi Possible involvement of NO/NOS signaling in hippocampal amyloid-beta production induced by transient focal cerebral ischemia in aged rats
    Song Li
    Institute of Neuroinformatics, Dalian University of Technology, 116024 Dalian, China
    Neurosci Lett 470:106-10. 2010
  5. pmc Rapid cytotoxicity of antimicrobial peptide tempoprin-1CEa in breast cancer cells through membrane destruction and intracellular calcium mechanism
    Che Wang
    Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, China
    PLoS ONE 8:e60462. 2013
  6. ncbi Antidepressant-like effects of piperine and its derivative, antiepilepsirine
    Song Li
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Asian Nat Prod Res 9:421-30. 2007
  7. pmc Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein
    Chengyong Dong
    Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiiated Hospital of Dalian Medical University, Dalian, Liaoning, China
    Oncotarget 7:8850-65. 2016
  8. doi Differential impairment of spatial and nonspatial cognition in a mouse model of brain aging
    Wei Wang
    Laboratory of Brain and Mind, Institute of Neuroinformatics, Dalian University of Technology, 116024, Dalian, China
    Life Sci 85:127-35. 2009
  9. doi Double-Edged Roles of Nitric Oxide Signaling on APP Processing and Amyloid-β Production In Vitro: Preliminary Evidence from Sodium Nitroprusside
    Zheng Xu Cai
    Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China
    Neurotox Res 29:21-34. 2016
  10. doi [Mutation spectrum of phenylalanine hydroxylase gene in patients with phenylketonuria in Tianjin and surrounding areas of Northern China]
    Li Song
    Pediatric Research Institute, Tianjin Children s Hospital, Tianjin, 300074 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:7-12. 2010

Collaborators

Detail Information

Publications64

  1. ncbi Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms
    Song Li
    Laboratory for Brain and Mind, Institute of Neuroinformatics, Dalian University of Technology, Dalian, 116023, China
    Life Sci 80:1373-81. 2007
    ....
  2. ncbi Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress
    Li Song
    Department of Pharmacology, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    Pharmacol Biochem Behav 83:186-93. 2006
    ....
  3. doi Chronic mild stress impairs cognition in mice: from brain homeostasis to behavior
    Song Li
    Laboratory for Brain and Mind, Institute of Neuroinformatics, Dalian University of Technology, Dalian, 116024, China
    Life Sci 82:934-42. 2008
    ....
  4. doi Possible involvement of NO/NOS signaling in hippocampal amyloid-beta production induced by transient focal cerebral ischemia in aged rats
    Song Li
    Institute of Neuroinformatics, Dalian University of Technology, 116024 Dalian, China
    Neurosci Lett 470:106-10. 2010
    ..The present data may be important in understanding, at least in part, the pathological role of NO/NOS system involved in hippocampal A beta production and neuronal damage induced by transient cerebral ischemia...
  5. pmc Rapid cytotoxicity of antimicrobial peptide tempoprin-1CEa in breast cancer cells through membrane destruction and intracellular calcium mechanism
    Che Wang
    Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, China
    PLoS ONE 8:e60462. 2013
    ..In summary, the present study indicates that temporin-1CEa triggers rapid cell death in breast cancer cells. This rapid cytotoxic activity might be mediated by both membrane destruction and intracellular calcium mechanism...
  6. ncbi Antidepressant-like effects of piperine and its derivative, antiepilepsirine
    Song Li
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Asian Nat Prod Res 9:421-30. 2007
    ....
  7. pmc Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein
    Chengyong Dong
    Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiiated Hospital of Dalian Medical University, Dalian, Liaoning, China
    Oncotarget 7:8850-65. 2016
    ..These results suggest that targeting NgBR in combination with chemotherapeutic drugs, such as 5-FU, could improve the efficacy of current anticancer treatments. ..
  8. doi Differential impairment of spatial and nonspatial cognition in a mouse model of brain aging
    Wei Wang
    Laboratory of Brain and Mind, Institute of Neuroinformatics, Dalian University of Technology, 116024, Dalian, China
    Life Sci 85:127-35. 2009
    ..However, the different influences of D-Gal on spatial and nonspatial cognition are as yet unclear...
  9. doi Double-Edged Roles of Nitric Oxide Signaling on APP Processing and Amyloid-β Production In Vitro: Preliminary Evidence from Sodium Nitroprusside
    Zheng Xu Cai
    Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China
    Neurotox Res 29:21-34. 2016
    ..This preliminary study may provide further evidence to clarify the molecular roles of NO and NO-related signaling in AD and supply potential molecular targets for AD treatment. ..
  10. doi [Mutation spectrum of phenylalanine hydroxylase gene in patients with phenylketonuria in Tianjin and surrounding areas of Northern China]
    Li Song
    Pediatric Research Institute, Tianjin Children s Hospital, Tianjin, 300074 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:7-12. 2010
    ....
  11. pmc Growing Teratoma Syndrome Secondary to Ovarian Giant Immature Teratoma in an Adolescent Girl: A Case Report and Literature Review
    Song Li
    From the Department of General Surgery SL, ZL, CD, FL, QL, DS, ZG, LW, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China and Dalian Medical University SL, ZL, CD, FL, Dalian, Liaoning Province, China
    Medicine (Baltimore) 95:e2647. 2016
    ..3-month (range 1-216 months, n = 48) median follow-up. Moreover, regular follow-ups with imaging and serum tumor markers are important and must not be neglected...
  12. doi Effects of acute restraint stress on different components of memory as assessed by object-recognition and object-location tasks in mice
    Song Li
    Institute of Neuroinformatics, Dalian University of Technology, 116024 Dalian, China
    Behav Brain Res 227:199-207. 2012
    ....
  13. ncbi Therapies for Parkinson's diseases: alternatives to current pharmacological interventions
    Song Li
    Center for Translational Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China
    J Neural Transm (Vienna) 123:1279-1299. 2016
    ....
  14. doi Nanomaterial-modulated autophagy: underlying mechanisms and functional consequences
    Wei Zheng
    Center for Translational Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China
    Nanomedicine (Lond) 11:1417-30. 2016
    ..The present review highlights the impacts of various NMs on autophagy and their functional consequences. The possible underlying mechanisms for NM-modulated autophagy are also discussed. ..
  15. doi Design and synthesis of piperidine derivatives as novel human heat shock protein 70 inhibitors for the treatment of drug-resistant tumors
    Yanqun Zeng
    Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China Laboratory of Computer Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Rd, Beijing, 100850, China
    Eur J Med Chem 97:19-31. 2015
    ..46 μM. The LD50 was 869.0 mgkg(-1). These data suggest that HSP70-36 may be a potential candidate compound for tumour treatment. ..
  16. doi Free radical scavenging activity and neuroprotective potentials of D138, one Cu(II)/Zn(II) Schiff-base complex derived from N,N'-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine
    Che Wang
    Department of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, 116029, China
    Neurochem Res 39:1834-44. 2014
    ....
  17. doi Novel substituted heteroaromatic piperazine and piperidine derivatives as inhibitors of human enterovirus 71 and coxsackievirus a16
    Xian Zhang
    Key Laboratory of Structure Based Drug Design and Discovery of the Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, Liangning, China
    Molecules 18:5059-71. 2013
    ..The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity...
  18. doi Antitumor effects and cell selectivity of temporin-1CEa, an antimicrobial peptide from the skin secretions of the Chinese brown frog (Rana chensinensis)
    Che Wang
    Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, Liaoning 116029, China
    Biochimie 94:434-41. 2012
    ..In summary, temporin-1CEa, an amphiphilic α-helical cationic peptide, may represent a novel anticancer agent for breast cancer therapy, considering its cancer cell selectivity and relatively lower cytotoxicity to normal cells...
  19. ncbi Morphological and Crystalline Transitions in Monohydrous and Anhydrous Aripiprazole for a Long-Acting Injectable Suspension
    Xinyi Tan
    Department of Pharmaceutics, Shenyang Pharmaceutical University, Wen Hua Road No 103, Shenyang, China
    AAPS PharmSciTech . 2016
    ..In the case of APZ powders, we wished to obtain more information to guide in the industrial production and experimental design of suspensions in the future...
  20. pmc Nurr1-Based Therapies for Parkinson's Disease
    Jie Dong
    The Center for Translational Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China
    CNS Neurosci Ther 22:351-9. 2016
    ..This review highlights the recent progress in preclinical studies of Nurr1-based therapies and discusses the outlook of this emerging therapy as a promising new generation of PD medication. ..
  21. pmc Comparison of Methods for the Reconstruction of the Hepatic Artery in Mouse Orthotopic Liver Transplantation
    Ning Pan
    Department of Anesthesiology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
    PLoS ONE 10:e0133030. 2015
    ..The available methods of sutured anastomosis for reconstruction of the hepatic artery are complicated, resulting in a high incidence of complications and failure. Therefore, we developed and evaluated a new model of AOLT in mice...
  22. doi Asymmetric Synthesis and Absolute Configuration Assignment of a New Type of Bedaquiline Analogue
    Chang Jiang Qiao
    School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
    Molecules 20:22272-85. 2015
    ....
  23. doi Synthesis of potent inhibitors of β-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents
    Yan Liu
    School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
    Molecules 17:4770-81. 2012
    ..5 µg/mL).These compounds may prove useful in the discovery and development of new anti-tuberculosis drugs...
  24. doi Development of a UPLC-ESI-MS/MS method for the determination of larotaxel in beagle dog plasma: application to the pharmacokinetic study
    Zhenzhen Liu
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China
    Anal Bioanal Chem 403:323-30. 2012
    ..4, 0.8, and 1.6 mg/kg. The area under the concentration-time curve and the peak concentration of larotaxel seemed to increase with increasing dose proportionally, suggesting linear pharmacokinetics...
  25. pmc EEG dynamics reflects the partial and holistic effects in mental imagery generation
    Jian Li
    Institute of Neuroinformatics, Dalian University of Technology, Dalian, China
    J Zhejiang Univ Sci B 11:944-51. 2010
    ..The generation of partial mental imagery is not a subprocess of holistic imagery, but it is relevant to holistic imagery and requires correct modification from the holistic information...
  26. doi Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2
    Lingchen Guo
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
    Chem Biol Interact 181:138-43. 2009
    ..Panaxydol also increased the protein levels of p21, pRb and the hypophosphorylated pRb in a dose-dependent manner. These findings suggest that panaxydol is of value for further exploration as a potential anti-cancer agent...
  27. doi Marchantin C, a macrocyclic bisbibenzyl, induces apoptosis of human glioma A172 cells
    Yan Qiu Shi
    Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 Wen Hua Xi Road, Jinan, Shandong 250012, China
    Cancer Lett 262:173-82. 2008
    ....
  28. ncbi Antitumor activities of a novel indolin-2-ketone compound, Z24: more potent inhibition on bFGF-induced angiogenesis and bcl-2 over-expressing cancer cells
    Li Li Wang
    Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing, 100850, PR China
    Eur J Pharmacol 502:1-10. 2004
    ..The higher selectivity of Z24 on Bcl-2 protein and on bFGF other than VEGF signaling path may contribute to its efficiency against tumor and tumor-associated angiogenesis...
  29. ncbi A glycosylated nitric oxide donor, beta-Gal-NONOate, and its site-specific antitumor activity
    Chang Chen
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, China
    Arch Pharm (Weinheim) 339:366-71. 2006
    ....
  30. pmc PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells
    Ming Zhi Zhang
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 101:2311-6. 2004
    ..Reduced PKHD1 levels in pck rat kidneys and its colocalization with polycystins may underlie the pathogenic basis for cystogenesis in polycystic kidney diseases...
  31. doi Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis
    Jie Zhou
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastroenterology 134:556-67. 2008
    ..The goal of this study is to investigate further the role of Cd36 in hepatic steatosis...
  32. doi Reversal effect of a macrocyclic bisbibenzyl plagiochin E on multidrug resistance in adriamycin-resistant K562/A02 cells
    Yan Qiu Shi
    School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
    Eur J Pharmacol 584:66-71. 2008
    ....
  33. ncbi FK506-binding protein ligands: structure-based design, synthesis, and neurotrophic/neuroprotective properties of substituted 5,5-dimethyl-2-(4-thiazolidine)carboxylates
    Liqin Zhao
    Laboratory of Computer Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China
    J Med Chem 49:4059-71. 2006
    ..This study further suggests the clinical potential of novel FKBP ligands as a new therapeutic approach in the treatment of neurodegenerative disorders, such as Parkinson's disease...
  34. ncbi Fabrication and application of single nucleotide polymorphisms library on magnetic nanoparticles using adaptor PCR
    Hongna Liu
    Hunan Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou 412008, China
    J Nanosci Nanotechnol 8:405-9. 2008
    ..0, whereas heterozygous genotypes had ratios near to 1.0. Without any complex multiplex PCR procedure, it is a simple, efficient and reliable method for the multiplex SNPs detection using limited amount of DNA samples from individuals...
  35. ncbi Targeted delivery of antisense oligodeoxynucleotides to folate receptor-overexpressing tumor cells
    Lijuan Yang
    Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 639 Salk Hall, Pittsburgh, PA 15213, USA
    J Control Release 95:321-31. 2004
    ..Intracellular delivery of EGFR antisense ODN also sensitized KB cells to doxorubicin (DOX) treatment. Thus targeted delivery of ODN via this novel lipid vector may have potential in treating tumors that overexpress FR...
  36. ncbi J2 prolongs the corneal allograft survival through inhibition of the CD4+ T cell-mediated response in vivo
    He Xiao
    Department of Molecular Immunology, Institute of Basic Medical Sciences, 100850, Beijing, China
    Transpl Immunol 18:130-7. 2007
    ..All these results suggest that J2 is a potential lead for the development of new immunosuppressive agents to prevent the corneal allograft rejection...
  37. ncbi Doxorubicin and selenium cooperatively induce fas signaling in the absence of Fas/Fas ligand interaction
    Song Li
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 27:3075-82. 2007
    ..Mitochondrial activation of caspase-9 is in part responsible for the synergy. The present study aimed at examining the death receptor pathway in activating caspase-8 by the two-drug combination...
  38. ncbi Angiogenesis inhibitor Z24 induces endothelial cell apoptosis and suppresses tumor growth and metastasis
    Haiyan Lu
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People s Republic of China
    J Pharmacol Sci 97:533-40. 2005
    ..6%, P<0.0001) and decreased lung weights (38.5%, P<0.01) compared to the vehicle group. All these findings support that Z24 is a promising angiogenesis inhibitor for limiting tumor growth and metastasis...
  39. ncbi Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice
    Simrat P S Saini
    Center for Pharmacogenetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 41:497-505. 2005
    ..PXR is a potential therapeutic target for clinical treatment of jaundice. (HEPATOLOGY 2005;41:497-505.)...
  40. ncbi Biomimetic collagen scaffolds for human bone cell growth and differentiation
    Xuebin B Yang
    University Orthopaedics, University of Southampton, Southampton S016 6YD, UK
    Tissue Eng 10:1148-59. 2004
    ....
  41. ncbi Dynamic infrared imaging for the detection of malignancy
    Terry M Button
    Department of Radiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Phys Med Biol 49:3105-16. 2004
    ..It is shown that dynamic infrared images formed at the vasomotor and cardiogenic frequencies of the normal and malignant breast have image pattern differences, which may allow for breast cancer detection...
  42. ncbi Proteomic profiling of bone marrow mesenchymal stem cells upon transforming growth factor beta1 stimulation
    Daojing Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 279:43725-34. 2004
    ..This study demonstrates that proteomic tools are valuable in studying stem cell differentiation and elucidating the underlying molecular mechanisms...
  43. ncbi Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Pathol 32:64-72. 2004
    ..This implies that arsenic liver toxicity involves disturbances of some cancer-related molecules...
  44. ncbi Inhibition of LPS- and CpG DNA-induced TNF-alpha response by oxidized phospholipids
    Zheng Ma
    Center for Pharmacogenetics, Univ of Pittsburgh School of Pharmacy, 639 Salk Hall, Pittsburgh, PA 15213, USA
    Am J Physiol Lung Cell Mol Physiol 286:L808-16. 2004
    ..Further studies on the mechanisms of action may lead to development of a new type of anti-inflammatory drug for treatment of acute inflammatory diseases such as sepsis...
  45. ncbi The long, but not the short, presequence of human coproporphyrinogen oxidase is essential for its import and sorting to mitochondria
    Shinji Susa
    The Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Tohoku J Exp Med 200:39-45. 2003
    ..This correction revealed that mouse pCPO has also a longer presequence, which are very similar to the long presequence of human. These results indicate that the long, but not short, presequence is the real one...
  46. ncbi Evaluation of the effect of protamine on human prostate carcinoma PC-3m using contrast enhanced Doppler ultrasound
    Jie Tang
    Department of Ultrasound, Chinese People s Liberation Army General Hospital, Beijing, Peole s Republic of China
    J Urol 170:611-4. 2003
    ..We evaluated the ability of contrast enhanced Doppler ultrasound (CEDU) to demonstrate changes in tumor vascularity during angiogenesis inhibitive therapy in PC-3m human prostate carcinoma...
  47. ncbi Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, 305 8506, Tsukuba, Ibaraki, Japan
    Arch Toxicol 77:305-12. 2003
    ....
  48. ncbi In vitro lipofection with novel series of symmetric 1,3-dialkoylamidopropane-based cationic surfactants containing single primary and tertiary amine polar head groups
    Mohammad Sheikh
    Division of Pharmaceutics, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, 75 DeKalb Avenue, Brooklyn, NY 11201, USA
    Chem Phys Lipids 124:49-61. 2003
    ....
  49. ncbi Lipid-mediated delivery of peptide nucleic acids to pulmonary endothelium
    Xing Yuan
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 639 Salk Hall, Pittsburgh, PA 15213, USA
    Biochem Biophys Res Commun 302:6-11. 2003
    ..Thus delivery of PNA to pulmonary endothelium may prove to be a therapeutically useful for the treatment of pulmonary vascular diseases...
  50. ncbi [Targeted AGEes and AGEs cross-link in drug discovery: preventing and reversing arterial sclerosis in aging and diabetes]
    Wu Zhong
    Beijing Institute of Pharmnacology and Toxicology, Beijing 100850, China
    Yao Xue Xue Bao 40:91-6. 2005
  51. ncbi In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells
    Hans Minderman
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer Ther 4:885-900. 2005
    ..To study irinotecan (CPT-11)-induced changes in expression profiles of genes associated with cell cycle control and apoptosis in myeloid leukemia cells in vitro and in vivo...
  52. ncbi Chemical and physical regulation of stem cells and progenitor cells: potential for cardiovascular tissue engineering
    Ngan F Huang
    Joint Graduate Group in Bioengineering, University of California San Francisco and University of California Berkeley, Berkeley, California, USA
    Tissue Eng 13:1809-23. 2007
    ....
  53. ncbi Regulation of endothelial cell function by GRGDSP peptide grafted on interpenetrating polymers
    Shyam Patel
    Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA
    J Biomed Mater Res A 83:423-33. 2007
    ..This study provides a rational base for surface engineering of cardiovascular implants...
  54. ncbi cDNA microarray analysis of the expression profiles of Trichophyton rubrum in response to novel synthetic fatty acid synthase inhibitor PHS11A
    Wenliang Zhang
    College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Fungal Genet Biol 44:1252-61. 2007
    ..PHS11A also affected transcription of some genes involved in lipid metabolism, cAMP and MAPK pathways, and multidrug resistance. Quantitative real-time PCR was performed for selected genes to verify the microarray results...
  55. ncbi PCR amplification on magnetic nanoparticles: application for high-throughput single nucleotide polymorphism genotyping
    Hongna Liu
    Key Laboratory of Green Packaging and Application of Biological Nanotechnology of Hunan Province, Hunan University of Technology, Zhuzhou, China
    Biotechnol J 2:508-11. 2007
    ..0. Without any purification and concentration of PCR products, this new MNP-PCR based genotyping assay potentially provides a rapid, labor-saving method for genotyping of a large number of individuals...
  56. pmc Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid
    Haitao Zhang
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer 107:2942-8. 2006
    ..The present study was designed to investigate whether a combination of alphaTS and MSA would produce an additive or a greater than additive effect in suppressing AR level, AR transactivation, and prostate-specific antigen (PSA)...
  57. pmc Anisotropic mechanosensing by mesenchymal stem cells
    Kyle Kurpinski
    Department of Bioengineering and Center for Tissue Engineering, UC Berkeley and UC San Francisco Joint Graduate Program in Bioengineering, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:16095-100. 2006
    ..The differential cellular responses to the anisotropic mechanical environment have important implications in cardiovascular development, tissue remodeling, and tissue engineering...
  58. ncbi [A study of genetic diversity in lactate dehydrogenase of Streptococcus mutans from clinical isolates]
    De qin Yang
    Department of Operative Dentistry and Endodontics, West China Stomatology Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:781-4. 2006
    ..mutans isolates may be determined by genetic heterogeneity from virulent factors. The relationship between LDH activity or genetic diversity and cariogenicity of S. mutans (serotype c) isolates was studied in this research...
  59. ncbi The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder
    Song Li
    Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Pharmacol Biochem Behav 85:324-31. 2006
    ..These behavioral deficits can be ameliorated by repeated administration of valproate or diazepam at some special dose ranges...
  60. ncbi Potent inhibition of the CD4-dependent T cell response by J2, a novel nonpeptide organic ligand of CD4 D1
    He Xiao
    Department of Molecular Immunology, Institute of Basic Medical Sciences, Taiping Road 27, 100850 Beijing, China
    Mol Immunol 44:784-95. 2007
    ..All the results demonstrated the therapeutic potential of this compound as a novel immunosuppressive agent...
  61. ncbi Modeling and synthesis of non-cyclic derivatives of GPI-1046 as potential FKBP ligands with neurotrophic properties
    Liqin Zhao
    Laboratory of Computer Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, China
    Bioorg Med Chem Lett 16:4385-90. 2006
    ..However, in the absence of exogenously added NGF, all test compounds, including GPI-1046, failed to afford any positive effect on DRGs. This study suggests the intriguing potential of these compounds for further investigation...
  62. ncbi Myotube assembly on nanofibrous and micropatterned polymers
    Ngan F Huang
    Joint Graduate Program in Bioengineering, University of California San Francisco University of California Berkeley, 94720 1762, USA
    Nano Lett 6:537-42. 2006
    ..This bottom-up approach from nanoscale to tissue level demonstrates the potential of nanofibrous polymers for engineering the assembly of cell and tissue structure...
  63. ncbi Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis
    Yunfei Zhou
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 66:404-11. 2006
    ..In summary, our study indicates that targeting both EGFR and ErbB2 simultaneously could enhance therapy over that of single agents directed at EGFR or ErbB2 in cancers that can be identified as being primarily heterodimer-dependent...
  64. ncbi Correlation between prostate cancer grade and vascularity on color doppler imaging: preliminary findings
    Jie Tang
    Department of Ultrasound, Chinese People s Liberation Army General Hospital, 28 Fu Xing Road, Beijing 100853, People s Republic of China
    J Clin Ultrasound 31:61-8. 2003
    ..We examined the relationship between the amount of prostate cancer-associated vascularity as seen on color Doppler imaging and the tumor grade...