Lei Li

Summary

Publications

  1. doi request reprint Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma
    Lei Li
    Institute of Urology, The 1st Affiliated Hospital, Xi an Jiaotong University, 277, YanTa Western Road, Xi an, Shaanxi 710061, China
    Cancer Lett 272:61-9. 2008
  2. doi request reprint Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway
    Linlin Zhang
    Department of Urology, The First Affiliated Hospital of Xi an Jiaotong University, China
    Cancer Lett 323:48-57. 2012
  3. pmc Twisted epithelial-to-mesenchymal transition promotes progression of surviving bladder cancer T24 cells with hTERT-dysfunction
    Yan Xue
    Department of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an, Shaanxi, China
    PLoS ONE 6:e27748. 2011
  4. pmc Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression
    Kai jie Wu
    Department of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an 710061, China
    Acta Pharmacol Sin 30:1162-8. 2009
  5. pmc PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl-2 pathway
    Dong Zhang
    Department of Urology, The First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an, Shaanxi, PR China
    Cancer Res 71:2193-202. 2011
  6. doi request reprint Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties
    Linlin Zhang
    Department of Urology, The First Affiliated Hospital of Xi an Jiaotong University, Xi an 710061, China
    J Cancer Res Clin Oncol 138:675-86. 2012
  7. pmc Increased PrLZ-mediated androgen receptor transactivation promotes prostate cancer growth at castration-resistant stage
    Lei Li
    Sex Hormone Research Center, Department of Urology, The First Affiliated Hospital, Xi an Jiaotong University, Xi an 710061, China
    Carcinogenesis 34:257-67. 2013
  8. ncbi request reprint [Impact of PrLZ overexpression on invasion of prostate cancer LNCaP cells in vitro]
    Dong Zhang
    Department of Urology, The First Affiliated Hospital, Xi an Jiaotong University, Xi an, Shaanxi, China
    Ai Zheng 28:483-6. 2009
  9. doi request reprint PrLZ expression is associated with the progression of prostate cancer LNCaP cells
    Lei Li
    Department of Urology, The First Affiliated Hospital of Xi an Jiaotong University, Urology Institute of Xi an Jiaotong University, Xi an, Shaanxi, China
    Mol Carcinog 48:432-40. 2009
  10. doi request reprint FGF2-mediated reciprocal tumor cell-endothelial cell interplay contributes to the growth of chemoresistant cells: a potential mechanism for superficial bladder cancer recurrence
    Yule Chen
    Department of Urology, First Affiliated Hospital of Xi an Jiaotong University, 277 Yanta West Road, Xi an, 710061, China
    Tumour Biol 37:4313-21. 2016

Collaborators

Detail Information

Publications38

  1. doi request reprint Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma
    Lei Li
    Institute of Urology, The 1st Affiliated Hospital, Xi an Jiaotong University, 277, YanTa Western Road, Xi an, Shaanxi 710061, China
    Cancer Lett 272:61-9. 2008
    ..Our results suggested silibinin might be as one of the candidate chemopreventive agents for renal cell carcinoma therapy...
  2. doi request reprint Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway
    Linlin Zhang
    Department of Urology, The First Affiliated Hospital of Xi an Jiaotong University, China
    Cancer Lett 323:48-57. 2012
    ..Therefore, our findings demonstrated that genistein may be a dietary phytochemical with potential to target prostate CSCs...
  3. pmc Twisted epithelial-to-mesenchymal transition promotes progression of surviving bladder cancer T24 cells with hTERT-dysfunction
    Yan Xue
    Department of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an, Shaanxi, China
    PLoS ONE 6:e27748. 2011
    ..However, it has not been elucidated the characteristics of telomere maintenance and progression ability after long-term culture in bladder cancer T24 cells with hTERT dysfunction...
  4. pmc Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression
    Kai jie Wu
    Department of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an 710061, China
    Acta Pharmacol Sin 30:1162-8. 2009
    ..This study was designed to evaluate this efficacy and possible mechanisms using a novel highly bone metastatic ARCaP(M) cell model...
  5. pmc PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl-2 pathway
    Dong Zhang
    Department of Urology, The First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an, Shaanxi, PR China
    Cancer Res 71:2193-202. 2011
    ....
  6. doi request reprint Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties
    Linlin Zhang
    Department of Urology, The First Affiliated Hospital of Xi an Jiaotong University, Xi an 710061, China
    J Cancer Res Clin Oncol 138:675-86. 2012
    ..We aim to investigate the potential role of cancer stem cells (CSCs) in PCa progression...
  7. pmc Increased PrLZ-mediated androgen receptor transactivation promotes prostate cancer growth at castration-resistant stage
    Lei Li
    Sex Hormone Research Center, Department of Urology, The First Affiliated Hospital, Xi an Jiaotong University, Xi an 710061, China
    Carcinogenesis 34:257-67. 2013
    ....
  8. ncbi request reprint [Impact of PrLZ overexpression on invasion of prostate cancer LNCaP cells in vitro]
    Dong Zhang
    Department of Urology, The First Affiliated Hospital, Xi an Jiaotong University, Xi an, Shaanxi, China
    Ai Zheng 28:483-6. 2009
    ..We previously found that PrLZ overexpression can enhance the survival of prostate cancer LNCaP cells in vitro. This study was to investigate the impact of PrLZ on the invasion of LNCaP cells and its possible mechanism...
  9. doi request reprint PrLZ expression is associated with the progression of prostate cancer LNCaP cells
    Lei Li
    Department of Urology, The First Affiliated Hospital of Xi an Jiaotong University, Urology Institute of Xi an Jiaotong University, Xi an, Shaanxi, China
    Mol Carcinog 48:432-40. 2009
    ....
  10. doi request reprint FGF2-mediated reciprocal tumor cell-endothelial cell interplay contributes to the growth of chemoresistant cells: a potential mechanism for superficial bladder cancer recurrence
    Yule Chen
    Department of Urology, First Affiliated Hospital of Xi an Jiaotong University, 277 Yanta West Road, Xi an, 710061, China
    Tumour Biol 37:4313-21. 2016
    ..Thus, targeting chemotherapy-induced FGF2 upregulation may provide a promising approach to manage the recurrence of superficial bladder cancer. ..
  11. pmc Infiltrating mast cells enhance prostate cancer invasion via altering LncRNA-HOTAIR/PRC2-androgen receptor (AR)-MMP9 signals and increased stem/progenitor cell population
    Lei Li
    Department of Urology, Sex Hormone Research Center, The First Affiliated Hospital, Xi an Jiaotong University, Xi an, China
    Oncotarget 6:14179-90. 2015
    ..Targeting these newly identified inflammatory mast cells-AR signals may help us to better suppress PCa metastasis at the castration resistant stage. ..
  12. doi request reprint Overexpression of FABP7 promotes cell growth and predicts poor prognosis of clear cell renal cell carcinoma
    Jiancheng Zhou
    Department of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an, China
    Urol Oncol 33:113.e9-17. 2015
    ..The aim of the present study was to determine the differential expression of genes between normal kidney and clear cell RCC (ccRCC) samples and investigate the biological function of the most frequently altered gene in RCC cells...
  13. ncbi request reprint [Type IV collagenase expression in human prostate carcinoma cell lines with different metastasis potentials]
    Lin Lin Zhang
    Department of Urology, First Affiliated Hospital of Xi an Jiaotong University Medical School, Xi an, Shaanxi 710061, China
    Zhonghua Nan Ke Xue 12:913-6. 2006
    ..To investigate the correlation between type IV collagenase expression and metastatic potential of human prostate carcinoma cells...
  14. doi request reprint Metformin sensitizes prostate cancer cells to radiation through EGFR/p-DNA-PKCS in vitro and in vivo
    Tingting Zhang
    a Department of Urology, The Second Hospital of Xi an Jiaotong University, Xi an, Shaanxi, China
    Radiat Res 181:641-9. 2014
    ..Our results indicate that metformin enhances prostate cancer cell radiosensitivity in vitro and in vivo. Exposure to metformin before radiation therapy could be a beneficial option for the treatment of prostate cancer. ..
  15. ncbi request reprint Overexpression of coxsackie and adenovirus receptor inhibit growth of human bladder cancer cell in vitro and in vivo
    Lin Lin Zhang
    Institute of Urology, First Hospital of Xi an Jiaotong University, Xi an 710061, China
    Acta Pharmacol Sin 28:895-900. 2007
    ..To study the effect of the overexpression of coxsackie and the adenovirus receptor (CAR) on the growth of the human bladder cancer cell in vitro and in vivo...
  16. ncbi request reprint Comparison of seven screening methods in the diagnosis of bladder cancer
    Yi Sun
    Institute of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an 710061, China
    Chin Med J (Engl) 119:1763-71. 2006
    ..And at the same time we evaluated the clinical value of these seven detecting methods in the diagnosis of bladder cancer...
  17. pmc Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-β1/Smad/MMP9 signals
    Hongjun Xie
    Sex Hormone Research Center, Department of Urology, The First Affiliated Hospital, Xi an Jiaotong University, Xi an, China
    Oncotarget 6:12326-39. 2015
    ..Targeting this newly identified signaling may help us to better inhibit PCa metastasis. ..
  18. doi request reprint Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis
    Qiang Dang
    Department of Urology, the First Affiliated Hospital of the Medical College of Xi an Jiaotong University, Xi an, PR, China
    Mol Carcinog 54:831-40. 2015
    ..All these findings suggest kaempferol might be an effective and novel chemotherapeutic drug to apply for the future therapeutic agent to combat bladder cancer...
  19. doi request reprint Novel green-light KTP laser en bloc enucleation for nonmuscle-invasive bladder cancer: technique and initial clinical experience
    Dalin He
    1 Department of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an, P R China
    J Endourol 28:975-9. 2014
    ..Recently, lasers have been explored as treatment tools for bladder tumors. Here, we report a novel tumor en bloc enucleation using a front-firing green-light potassium-titanyl-phosphate laser and its initial clinical application...
  20. doi request reprint Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling
    Wenbin Song
    Department of Urology, the First Affiliated Hospital of the Medical College of Xi an Jiaotong University, Xi an, Shaanxi 710061, P R China
    Oncol Rep 31:1350-6. 2014
    ..Collectively, our results suggest that kaempferol may serve as a candidate for chemo-preventive or chemotherapeutic agents for RCC...
  21. ncbi request reprint Concomitant activation of the JAK/STAT3 and ERK1/2 signaling is involved in leptin-mediated proliferation of renal cell carcinoma Caki-2 cells
    Lei Li
    Institute of Urology, The 1st Affiliated Hospital, Xi an Jiaotong University, Xi an, Shaanxi, China
    Cancer Biol Ther 7:1787-92. 2008
    ....
  22. ncbi request reprint [The molecular mechanism of PML in inducing apoptosis of bladder cancer cell line]
    Lei Li
    Institute of Urology, No 1 Hospital, Xi an Jiaotong University, Shanxi 710061, China
    Zhonghua Yi Xue Za Zhi 85:1766-9. 2005
    ..Study the affection of inducing expression of PML in the apoptosis and the molecular mechanism of bladder cancer...
  23. ncbi request reprint Overexpression of PML induced apoptosis in bladder cancer cell by caspase dependent pathway
    Lei Li
    Institute of Urology, No 1 Hospital, Xi an Jiaotong University, Shaanxi 710061, China
    Cancer Lett 236:259-68. 2006
    ..Our results demonstrate a novel mechanism of PML-induced apoptosis by down-regulation of Survivin and activation of Caspase dependent pathway...
  24. pmc Insulin-like growth factor binding protein-3 mediates interleukin-24-induced apoptosis through inhibition of the mTOR pathway in prostate cancer
    Yuefeng Du
    Department of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an, Shaanxi, P R China
    Oncol Rep 34:2273-81. 2015
    ..We then showed that the combination of IL-24 and IGFBP-3 significantly suppressed PC tumor growth in vivo. We propose that the IGFBP-3 and IL-24 non-toxic mTOR inhibitors can be used as an adjuvant in the treatment of PC. ..
  25. ncbi request reprint A simple prognostic model involving prostate-specific antigen, alkaline phosphatase and albumin for predicting the time required to progress to castration-resistant prostate cancer in patients who received androgen deprivation therapy
    Wei Lv
    Department of Urology, The First Affiliated Hospital, Xi an Jiaotong University, Xi an, 710061, China
    Int Urol Nephrol . 2016
    ....
  26. pmc Androgen receptor (AR) signaling promotes RCC progression via increased endothelial cell proliferation and recruitment by modulating AKT → NF-κB → CXCL5 signaling
    Zhenfeng Guan
    Department of Urology, The First Affiliated Hospital, Xi an Jiaotong University, Xi an 710061, China
    Sci Rep 6:37085. 2016
    ..Targeting this newly identified AR-induced AKT → NF-κB → CXCL5 pathway may facilitate the development of new therapies for slowing RCC progression...
  27. doi request reprint ASC-J9 suppresses renal cell carcinoma progression by targeting an androgen receptor-dependent HIF2α/VEGF signaling pathway
    Dalin He
    Sex Hormone Research Center, Department of Urology, The First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    Cancer Res 74:4420-30. 2014
    ..Taken together, our results revealed a novel role for AR in RCC initiation and progression with implications for novel therapeutic strategies...
  28. ncbi request reprint Over-expression of hypoxia-inducible factor-1alpha increases the invasive potency of LNCaP cells in vitro
    Yong Luo
    Department of Urology, First Hospital of Xi an Jiaotong University, Xi an Jiaotong University, Ministry of Education, Xi an, People s Republic of China
    BJU Int 98:1315-9. 2006
    ....
  29. doi request reprint Priapism as the initial manifestation of a penile and lower limb cutaneous metastasis of prostate adenocarcinoma with low serum PSA level
    Dalin He
    Department of Urology, the First Affiliated Hospital of the Medical College of Xi an Jiaotong University, Xi an, China
    J Androl 33:1160-4. 2012
    ..This is the first known case of metastatic prostate cancer found in both penis and skin with a low serum prostate-specific antigen level. Priapism presented as the initial clinical manifestation of metastatic prostate cancer...
  30. ncbi request reprint [Construction of lentivirus vector of interference of EGFL7 gene and its inhibitive role on the invasion of laryngeal cancer cell]
    Xiaoxia Wang
    Department of Otolaryngology, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, 710061, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 25:1135-8, 1141. 2011
    ..To construct a lentivirus vector of RNA interference (RNAi) of EGFL7 gene and observe its inhibitive role on the invasion of laryngeal cancer cell...
  31. pmc Infiltrating macrophages increase RCC epithelial mesenchymal transition (EMT) and stem cell-like populations via AKT and mTOR signaling
    Zhao Yang
    Sex Hormone Research Center, Department of Urology, The First Affiliated Hospital, Xi an Jiaotong University, Xi an 710061, China
    Oncotarget 7:44478-44491. 2016
    ..Targeting this newly identified signaling may help us to better inhibit RCC metastasis...
  32. pmc Tetrandrine suppresses proliferation, induces apoptosis, and inhibits migration and invasion in human prostate cancer cells
    Wei Liu
    Department of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University Oncology Research Lab, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of the People s Republic of China, Xi an, 710061, China
    Asian J Androl 17:850-3. 2015
    ..The accumulating evidence suggests that TET could be a potential therapeutic candidate against prostate cancer in a clinical setting. ..
  33. doi request reprint Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma
    Zhenkun Ma
    Department of Urology, The First Affiliated Hospital of Xi an Jiaotong University, Xi an, Shaanxi 710061, P R China
    Oncol Rep 34:2461-8. 2015
    ..These findings also indicate that GLI1 is a novel regulator for the potential therapeutic application of silibinin against RCC. ..
  34. pmc Infiltrating mast cells increase prostate cancer chemotherapy and radiotherapy resistances via modulation of p38/p53/p21 and ATM signals
    Hongjun Xie
    Chawnshang Chang Sex Hormone Research Center, Department of Urology, The First Affiliated Hospital, Xi an Jiaotong University, Xi an 710061, China
    Oncotarget 7:1341-53. 2016
    ..Targeting this newly identified signaling may help us better suppress PCa chemotherapy and radiotherapy resistance. ..
  35. doi request reprint Silibinin inhibits β-catenin/ZEB1 signaling and suppresses bladder cancer metastasis via dual-blocking epithelial-mesenchymal transition and stemness
    Kaijie Wu
    Department of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an 710061, China
    Cell Signal 25:2625-33. 2013
    ..Overall, this study reveals a novel mechanism for silibinin targeting bladder cancer metastasis, in which inactivation of β-catenin/ZEB1 signaling by silibinin leads to dual-block of EMT and stemness. ..
  36. pmc Structural insights into Paf1 complex assembly and histone binding
    Xinlei Chu
    State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, Tianjin 300071, China, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and Synergetic Innovation Center of Chemical Science and Engineering, 94 Weijin Road, Tianjin 300071, China
    Nucleic Acids Res 41:10619-29. 2013
    ..Our results shed light on the PAF1C assembly process and substrate recognition during various PAF1C-coordinated histone modifications. ..
  37. ncbi request reprint [Expression of high mobility group protein A in male mouse testicular cell lines]
    Zheng bing Ma
    Department of Obstetrics and Gynecology, Tangdu Hospital, The Fourth Military Medical University, Xi an, Shaanxi 710038, China
    Zhonghua Nan Ke Xue 15:534-7. 2009
    ....
  38. doi request reprint KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8
    Yuan Yuan Su
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, and Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, and National Center of Nanoscience and Technology, Beijing, China
    J Neurosci 33:17884-96. 2013
    ..8. Therefore, our results reveal that KIF5B is required for the forward transport and axonal function of Nav1.8, suggesting a mechanism for axonal accumulation of Nav1.8 in inflammatory pain. ..