Julia Ley-Zaporozhan

Summary

Publications

  1. doi request reprint MR for the evaluation of obstructive pulmonary disease
    Julia Ley-Zaporozhan
    Department of Pediatric Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Magn Reson Imaging Clin N Am 16:291-308, ix. 2008
  2. doi request reprint Low dose multi-detector CT of the chest (iLEAD Study): visual ranking of different simulated mAs levels
    Julia Ley-Zaporozhan
    Department of Diagnostic and Interventional Radiology, Ruprecht Karls University, Heidelberg, Germany
    Eur J Radiol 73:428-33. 2010
  3. doi request reprint Visualization of morphological parenchymal changes in emphysema: comparison of different MRI sequences to 3D-HRCT
    Julia Ley-Zaporozhan
    Department of Pediatric Radiology, Ruprecht Karls University, Heidelberg, Germany
    Eur J Radiol 73:43-9. 2010
  4. doi request reprint Quantification of lung volume at different tidal volumes and positive end-expiratory pressures in a porcine model by using retrospective respiratory gated 4D-computed tomography
    Julia Ley-Zaporozhan
    Department of Radiology E010, German Cancer Research Center, Heidelberg, Germany
    Invest Radiol 43:461-9. 2008
  5. doi request reprint Imaging of airways: chronic obstructive pulmonary disease
    Julia Ley-Zaporozhan
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Radiol Clin North Am 47:331-42. 2009
  6. doi request reprint Four-dimensional visualization of thoracic blood flow by magnetic resonance imaging in a patient following correction of transposition of the great arteries (d-TGA) and uncorrected aortic coarctation
    J Ley-Zaporozhan
    German Cancer Research Center DKFZ Heidelberg, Radiology E010, Heidelberg, Germany
    Acta Radiol 50:909-13. 2009
  7. doi request reprint Repeatability and reproducibility of quantitative whole-lung perfusion magnetic resonance imaging
    Julia Ley-Zaporozhan
    Department of Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany
    J Thorac Imaging 26:230-9. 2011
  8. doi request reprint Imaging phenotypes of chronic obstructive pulmonary disease
    Julia Ley-Zaporozhan
    Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany
    J Magn Reson Imaging 32:1340-52. 2010
  9. doi request reprint [Increased transparency in thin-slice computed tomography of lung parenchyma]
    J Ley-Zaporozhan
    Division of Cardiothoracic Imaging, Department of Medical Imaging, University of Toronto, NCSB IC560, 585 University Avenue, M5G2N2, Toronto, ON, Kanada
    Radiologe 51:881-94; quiz 895. 2011
  10. ncbi request reprint Quantitative 3D pulmonary MR-perfusion in patients with pulmonary arterial hypertension: correlation with invasive pressure measurements
    Sebastian Ley
    Department of Pediatric Radiology, Children s Hospital University Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Eur J Radiol 61:251-5. 2007

Detail Information

Publications36

  1. doi request reprint MR for the evaluation of obstructive pulmonary disease
    Julia Ley-Zaporozhan
    Department of Pediatric Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Magn Reson Imaging Clin N Am 16:291-308, ix. 2008
    ..MR techniques designed for obstructive lung disease have the capability of directly imaging the anatomic and pathophysiologic derangements and may prove useful for monitoring response to therapy...
  2. doi request reprint Low dose multi-detector CT of the chest (iLEAD Study): visual ranking of different simulated mAs levels
    Julia Ley-Zaporozhan
    Department of Diagnostic and Interventional Radiology, Ruprecht Karls University, Heidelberg, Germany
    Eur J Radiol 73:428-33. 2010
    ..The aim of our study was to determine the accuracy of visual perception of differences in image quality and noise at low dose chest CT...
  3. doi request reprint Visualization of morphological parenchymal changes in emphysema: comparison of different MRI sequences to 3D-HRCT
    Julia Ley-Zaporozhan
    Department of Pediatric Radiology, Ruprecht Karls University, Heidelberg, Germany
    Eur J Radiol 73:43-9. 2010
    ..However, the capability of MRI to visualize morphological parenchymal alterations in emphysema is undetermined. Thus, the aim of the study was to compare different MRI sequences with CT...
  4. doi request reprint Quantification of lung volume at different tidal volumes and positive end-expiratory pressures in a porcine model by using retrospective respiratory gated 4D-computed tomography
    Julia Ley-Zaporozhan
    Department of Radiology E010, German Cancer Research Center, Heidelberg, Germany
    Invest Radiol 43:461-9. 2008
    ..For this purpose, the influence of different tidal volumes and positive end-expiratory pressure (PEEP) on quantitative assessment of lung volumes (LVs) and lung compartments was analyzed...
  5. doi request reprint Imaging of airways: chronic obstructive pulmonary disease
    Julia Ley-Zaporozhan
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Radiol Clin North Am 47:331-42. 2009
    ..MR imaging is well suited for gaining functional information on perfusion and ventilation in COPD, while direct visualization and measurement of peripheral airways is not possible up to now...
  6. doi request reprint Four-dimensional visualization of thoracic blood flow by magnetic resonance imaging in a patient following correction of transposition of the great arteries (d-TGA) and uncorrected aortic coarctation
    J Ley-Zaporozhan
    German Cancer Research Center DKFZ Heidelberg, Radiology E010, Heidelberg, Germany
    Acta Radiol 50:909-13. 2009
    ..Additionally, increased flow to the supraaortic vessels was found due to aortic coarctation...
  7. doi request reprint Repeatability and reproducibility of quantitative whole-lung perfusion magnetic resonance imaging
    Julia Ley-Zaporozhan
    Department of Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany
    J Thorac Imaging 26:230-9. 2011
    ..Our aim was to assess the intraobserver and interobserver repeatability and reproducibility of perfusion MRI to prove the concept that perfusion is suitable for therapy monitoring...
  8. doi request reprint Imaging phenotypes of chronic obstructive pulmonary disease
    Julia Ley-Zaporozhan
    Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany
    J Magn Reson Imaging 32:1340-52. 2010
    ..The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype-driven characterization, and dedicated therapy monitoring of the disease...
  9. doi request reprint [Increased transparency in thin-slice computed tomography of lung parenchyma]
    J Ley-Zaporozhan
    Division of Cardiothoracic Imaging, Department of Medical Imaging, University of Toronto, NCSB IC560, 585 University Avenue, M5G2N2, Toronto, ON, Kanada
    Radiologe 51:881-94; quiz 895. 2011
    ....
  10. ncbi request reprint Quantitative 3D pulmonary MR-perfusion in patients with pulmonary arterial hypertension: correlation with invasive pressure measurements
    Sebastian Ley
    Department of Pediatric Radiology, Children s Hospital University Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Eur J Radiol 61:251-5. 2007
    ..Furthermore, quantitative perfusion data were correlated with invasive pressure measurements...
  11. ncbi request reprint Investigation of retrospective respiratory gating techniques for acquisition of thin-slice 4D-Multidetector-computed Tomorgraphy (MDCT) of the lung: Feasibility study in a large animal model
    Sebastian Ley
    Department of Radiology E010, German Cancer Research Center DKFZ, Heidelberg, Germany
    Exp Lung Res 32:395-412. 2006
    ..Both gating devices allowed for reliable 4D-MDCT image acquisition. No differences were found for calculated LV and MLD, whereas the respiratory cycle was more precisely detected using the laser based gating device...
  12. doi request reprint Assessment of thoracic aortic dimensions in an experimental setting: comparison of different unenhanced magnetic resonance angiography techniques with electrocardiogram-gated computed tomography angiography for possible application in the pediatric popula
    Julia Ley-Zaporozhan
    Department of Radiology E010, German Cancer Research Center, Heidelberg, Germany
    Invest Radiol 43:179-86. 2008
    ..To compare different unenhanced magnetic resonance angiography (MRA) techniques for quantitative evaluation of vessel lumen in an experimental setting in young pigs whose dimensions allow for a comparison with a pediatric population...
  13. doi request reprint Magnetic resonance imaging to assess the effect of exercise training on pulmonary perfusion and blood flow in patients with pulmonary hypertension
    Sebastian Ley
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Eur Radiol 23:324-31. 2013
    ..To evaluate whether careful exercise training improves pulmonary perfusion and blood flow in patients with pulmonary hypertension (PH), as assessed by magnetic resonance imaging (MR)...
  14. doi request reprint Validation of magnetic resonance phase-contrast flow measurements in the main pulmonary artery and aorta using perivascular ultrasound in a large animal model
    Sebastian Ley
    Department of Pediatric Radiology, Children s Hospital University Heidelberg, Germany
    Invest Radiol 43:421-6. 2008
    ....
  15. ncbi request reprint Impact of oxygen inhalation on the pulmonary circulation: assessment by magnetic resonance (MR)-perfusion and MR-flow measurements
    Sebastian Ley
    Department of Pediatric Radiology, Children s Hospital University Heidelberg, Heidelberg, Germany
    Invest Radiol 42:283-90. 2007
    ..However, the effect of hyperoxia on the pulmonary circulation is not yet fully understood. In this study the impact of hyperoxia on the pulmonary circulation was evaluated...
  16. ncbi request reprint MR flow measurements for assessment of the pulmonary, systemic and bronchosystemic circulation: impact of different ECG gating methods and breathing schema
    Sebastian Ley
    Department of Pediatric Radiology, Children s Hospital University Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Eur J Radiol 61:124-9. 2007
    ..The goal was to evaluate the impact of the gating method and the breathing schema on the pulmonary, systemic and bronchosystemic circulation...
  17. ncbi request reprint Value of MR phase-contrast flow measurements for functional assessment of pulmonary arterial hypertension
    Sebastian Ley
    Department of Radiology E010, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur Radiol 17:1892-7. 2007
    ..MRI is a feasible technique for the differentiation between PAH and volunteers. Further studies have to be conducted for the absolute calculation of pressure estimates...
  18. ncbi request reprint Evaluation of aortic regurgitation in congenital heart disease: value of MR imaging in comparison to echocardiography
    Sebastian Ley
    Department of Radiology E010, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 280, Heidelberg, Germany
    Pediatr Radiol 37:426-36. 2007
    ..Assessment is based on clinical and echocardiographic (ECHO) findings such as the configuration of the valve and the regurgitation fraction (RF)...
  19. doi request reprint In vivo Gd-DTPA concentration for MR lung perfusion measurements: assessment with computed tomography in a porcine model
    Michael Puderbach
    Department of Radiology, German Cancer Research Center, Heidelberg, Germany
    Eur Radiol 18:2102-7. 2008
    ..The CA dose for quantification of lung perfusion with time-resolved MR studies must be chosen carefully since even with low doses (0.05 mmol/kg) the CAC may exceed the range of linearity in the AIF...
  20. doi request reprint Diagnostic performance of state-of-the-art imaging techniques for morphological assessment of vascular abnormalities in patients with chronic thromboembolic pulmonary hypertension (CTEPH)
    Sebastian Ley
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Eur Radiol 22:607-16. 2012
    ..To determine the most comprehensive imaging technique for the assessment of pulmonary arteries in patients with chronic thromboembolic pulmonary hypertension (CTEPH)...
  21. ncbi request reprint Morphological and functional imaging in COPD with CT and MRI: present and future
    Julia Ley-Zaporozhan
    Department of Radiology E010, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur Radiol 18:510-21. 2008
    ..The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype-driven characterization and dedicated therapy monitoring of COPD as presented in this review...
  22. doi request reprint Noninvasive 4D pressure difference mapping derived from 4D flow MRI in patients with repaired aortic coarctation: comparison with young healthy volunteers
    Fabian Rengier
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Int J Cardiovasc Imaging 31:823-30. 2015
    ..001). Noninvasive 4D pressure difference mapping derived from 4D flow MRI enables detection of altered intraluminal aortic pressures and showed significant spatial and temporal changes in patients with repaired aortic coarctation. ..
  23. pmc Functional lung MRI in chronic obstructive pulmonary disease: comparison of t1 mapping, oxygen-enhanced t1 mapping and dynamic contrast enhanced perfusion
    Bertram J Jobst
    Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany Translational Lung Research Center Heidelberg TLRC, Member of the German Lung Research Center DZL, Heidelberg, Germany Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University of Heidelberg, Heidelberg, Germany
    PLoS ONE 10:e0121520. 2015
    ..The aim of this study was to evaluate the potential value of lung Magnetic resonance imaging (MRI) with native and oxygen-enhanced T1 mapping for the assessment of COPD patients in comparison with contrast enhanced perfusion MRI...
  24. ncbi request reprint Visualization of coronary arteries in patients after childhood Kawasaki syndrome: value of multidetector CT and MR imaging in comparison to conventional coronary catheterization
    Raoul Arnold
    Department of Paediatric Cardiology, University Hospital, Heidelberg, Germany
    Pediatr Radiol 37:998-1006. 2007
    ..At present, conventional coronary catheterization (CCC) and angiography is still regarded as the gold standard. Less-invasive methods such as multidetector CT angiography (MDCT-A) and MRI have been used sporadically...
  25. doi request reprint High-resolution phase-contrast MRI of aortic and pulmonary blood flow during rest and physical exercise using a MRI compatible bicycle ergometer
    Tim Frederik Weber
    Department of Diagnostic and Interventional Radiology, University Medical Center Heidelberg, INF 110, 69120 Heidelberg, Germany
    Eur J Radiol 80:103-8. 2011
    ..To establish high-resolution phase-contrast magnetic resonance imaging (PC-MRI) using a MRI compatible bicycle ergometer to quantify aortic and pulmonary blood flow during resting conditions and exercise...
  26. ncbi request reprint Proton MRI in COPD
    Julia Ley-Zaporozhan
    Department of Radiology, E 010, German Cancer Research Center, Heidelberg, Germany
    COPD 4:55-65. 2007
  27. doi request reprint Assessment of the relationship between morphological emphysema phenotype and corresponding pulmonary perfusion pattern on a segmental level
    Mark Bryant
    Department of Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany
    Eur Radiol 25:72-80. 2015
    ..Distinct morphological emphysema phenotypes were assessed by CT to show characteristic perfusion defect patterns...
  28. doi request reprint Computed tomographic imaging of the airways in COPD and asthma
    Hans Ulrich Kauczor
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany
    J Thorac Imaging 26:290-300. 2011
    ..This review will provide an overview of CT for the diagnosis of chronic obstructive pulmonary disease and asthma, its role in phenotyping these diseases, and the measurement of disease severity and functional compromise...
  29. doi request reprint Whole-body MRI in the pediatric patient
    Sebastian Ley
    Department of Diagnostic and Interventional Radiology, Section of Pediatric Radiology, Ruprecht Karls University Heidelberg, Germany
    Eur J Radiol 70:442-51. 2009
    ..e. fever of unknown origin, osteonecrosis) staging and for disease severity assessment of syndromes affecting the whole body. These applications will be reviewed and imaging protocols will be presented...
  30. doi request reprint Imaging of pulmonary pathologies: focus on magnetic resonance imaging
    Hans Ulrich Kauczor
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Proc Am Thorac Soc 6:458-63. 2009
    ..Under investigation is the application of MRI for chronic obstructive pulmonary disease as well as asthma. In this regard the additional benefit from MRI using hyperpolarized gases has to be determined...
  31. pmc Pulmonary perfusion imaging using MRI: clinical application
    Sebastian Ley
    Division of Cardiothoracic Imaging, Department of Medical Imaging, Toronto General Hospital, University of Toronto and University Health Network, Toronto General Hospital, 585 University Avenue, Toronto, Ontario, M5G 2N2, Canada
    Insights Imaging 3:61-71. 2012
    ..Lung perfusion is one of the key components of oxygenation. It is hampered in pulmonary arterial diseases and secondary due to parenchymal diseases...
  32. doi request reprint Long-term outcome after external tracheal stabilization due to congenital tracheal instability
    Sebastian Ley
    Diagnostic and Interventional Radiology, Section of Pediatric Radiology, University Children s Hospital, Im Neuenheimer Feld 430, Heidelberg, Germany
    Ann Thorac Surg 89:918-25. 2010
    ..This study presents the long-term follow-up (1992 through 2008) of patients who received surgical treatment with external tracheal stabilization in our institution...
  33. ncbi request reprint Assessment of the relationship between lung parenchymal destruction and impaired pulmonary perfusion on a lobar level in patients with emphysema
    Julia Ley-Zaporozhan
    Department of Radiology, Johannes Gutenberg University, Mainz, Germany
    Eur J Radiol 63:76-83. 2007
    ..To assess the relationship between lung parenchymal destruction and impaired pulmonary perfusion on a lobar level using CT and MRI in patients with emphysema...
  34. ncbi request reprint Quantitative analysis of emphysema in 3D using MDCT: influence of different reconstruction algorithms
    Julia Ley-Zaporozhan
    Department of Radiology, Johannes Gutenberg University Hospital, Langenbeckstr 1, 55131 Mainz, Germany
    Eur J Radiol 65:228-34. 2008
    ..The aim of the study was to compare the influence of different reconstruction algorithms on quantitative emphysema analysis in patients with severe emphysema...
  35. ncbi request reprint Accuracy of automated volumetry of pulmonary nodules across different multislice CT scanners
    Marco Das
    Department of Diagnostic Radiology, RWTH Aachen University, Pauwelsstrasse 30, 52072 Aachen, Germany
    Eur Radiol 17:1979-84. 2007
    ..Nodule volumetry is accurate with a reasonable volume error in data from different scanner vendors. This may have an important impact for intraindividual follow-up studies...
  36. doi request reprint Concepts for visualization of multidirectional phase-contrast MRI of the heart and large thoracic vessels
    Roland Unterhinninghofen
    Institute of Computer Science and Engineering, University of Karlsruhe, Haid und Neu Str 7, 76131, Karlsruhe, Germany
    Acad Radiol 15:361-9. 2008
    ..The objective of this work is to present a new versatile software tool and to demonstrate its practical value for the examination of multidirectional blood flow...