Bruce L Levine

Summary

Publications

  1. ncbi request reprint Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection
    Bruce L Levine
    Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, USA
    Nat Med 8:47-53. 2002
  2. pmc A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients
    Jianqing J Yu
    Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Virology 379:78-86. 2008
  3. pmc Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5
    Dawn A Maier
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Hum Gene Ther 24:245-58. 2013
  4. pmc Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate
    Cheryl L L Chiang
    Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, 19104, USA
    J Transl Med 9:198. 2011
  5. doi request reprint Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission
    Christina S Chu
    Department of Obstetrics and Gynecology and Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Immunol Immunother 61:629-41. 2012
  6. pmc Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    David L Porter
    Abramson Cancer Center, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 365:725-33. 2011
  7. pmc Adoptive immunotherapy: good habits instilled at youth have long-term benefits
    Chrystal M Paulos
    Abramson Family Cancer Research Institute, University of Pennsylvania, BRB II III, Room 554, 421 Curie Boulevard, Philadelphia, PA, 19104 6160, USA
    Immunol Res 42:182-96. 2008
  8. pmc T cells expressing chimeric antigen receptors can cause anaphylaxis in humans
    Marcela V Maus
    Abramson Cancer Center MVM, ARH, GLB, SMA, BLL, YZ, MK, CHJ, the Department of Medicine MVM, ARH, GLB, SMA and the Department of Pathology and Laboratory Medicine BLL, XL, YZ, CHJ and MK, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104
    Cancer Immunol Res 1:26-31. 2013
  9. doi request reprint Pilot study of prophylactic ex vivo costimulated donor leukocyte infusion after reduced-intensity conditioned allogeneic stem cell transplantation
    Anita J Kumar
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
    Biol Blood Marrow Transplant 19:1094-101. 2013
  10. pmc Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes
    Qunrui Ye
    Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Transl Med 9:131. 2011

Detail Information

Publications51

  1. ncbi request reprint Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection
    Bruce L Levine
    Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, USA
    Nat Med 8:47-53. 2002
    ....
  2. pmc A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients
    Jianqing J Yu
    Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Virology 379:78-86. 2008
    ..When we applied our integration assay to patient PBMCs, we found that the use of HAART is associated with reduced levels of integrated DNA...
  3. pmc Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5
    Dawn A Maier
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Hum Gene Ther 24:245-58. 2013
    ..Based on these findings, we initiated a clinical trial testing the safety and feasibility of CCR5 gene-edited CD4+ T-cell transfer in study subjects with HIV-1 infection...
  4. pmc Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate
    Cheryl L L Chiang
    Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, 19104, USA
    J Transl Med 9:198. 2011
    ..Due to the wide range of methods for generating DCs, there is no common protocol or defined set of criteria to validate the immunogenicity and function of DC vaccines...
  5. doi request reprint Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission
    Christina S Chu
    Department of Obstetrics and Gynecology and Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Immunol Immunother 61:629-41. 2012
    ..In spite of increased rates of complete response to initial chemotherapy, most patients with advanced ovarian cancer relapse and succumb to progressive disease. Immunotherapy may have potential for consolidation therapy...
  6. pmc Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    David L Porter
    Abramson Cancer Center, and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 365:725-33. 2011
    ..Remission was ongoing 10 months after treatment. Hypogammaglobulinemia was an expected chronic toxic effect...
  7. pmc Adoptive immunotherapy: good habits instilled at youth have long-term benefits
    Chrystal M Paulos
    Abramson Family Cancer Research Institute, University of Pennsylvania, BRB II III, Room 554, 421 Curie Boulevard, Philadelphia, PA, 19104 6160, USA
    Immunol Res 42:182-96. 2008
    ..We also describe how aAPCs can be used to broaden ACT to treat patients with a wide variety of cancers, chronic infectious diseases, and autoimmune manifestations...
  8. pmc T cells expressing chimeric antigen receptors can cause anaphylaxis in humans
    Marcela V Maus
    Abramson Cancer Center MVM, ARH, GLB, SMA, BLL, YZ, MK, CHJ, the Department of Medicine MVM, ARH, GLB, SMA and the Department of Pathology and Laboratory Medicine BLL, XL, YZ, CHJ and MK, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104
    Cancer Immunol Res 1:26-31. 2013
    ..These results indicate that the potential immunogenicity of CARs derived from murine antibodies may be a safety issue for mRNA CARs, especially when administered using an intermittent dosing schedule...
  9. doi request reprint Pilot study of prophylactic ex vivo costimulated donor leukocyte infusion after reduced-intensity conditioned allogeneic stem cell transplantation
    Anita J Kumar
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
    Biol Blood Marrow Transplant 19:1094-101. 2013
    ..Relapse remains the major cause of treatment failure after RIC HSCT even with rapid withdrawal of immune suppression and the use of prophylactic aDLI, and better strategies to prevent relapse are needed...
  10. pmc Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes
    Qunrui Ye
    Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Transl Med 9:131. 2011
    ..Development of a standardized platform for the rapid expansion of tumor-infiltrating lymphocytes (TILs) with anti-tumor function from patients with limited TIL numbers or tumor tissues challenges their clinical application...
  11. pmc Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies
    Gregory L Beatty
    Abramson Cancer Center University of Pennsylvania, Philadelphia, PA Division of Hematology Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    Cancer Immunol Res 2:112-20. 2014
    ..Thus, these findings support the development of mRNA CAR-based strategies for carcinoma and other solid tumors. ..
  12. pmc HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ
    Anupama Sharma
    Rena Rowan Breast Center, PENN Medicine, Philadelphia, Pennsylvania, USA
    Cancer 118:4354-62. 2012
    ..A vaccine targeting HER-2/neu expression in DCIS may initiate immunity against invasive cancer...
  13. pmc T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    Michael Kalos
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sci Transl Med 3:95ra73. 2011
    ....
  14. doi request reprint Efficient clinical-scale enrichment of lymphocytes for use in adoptive immunotherapy using a modified counterflow centrifugal elutriation program
    Daniel J Powell
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cytotherapy 11:923-35. 2009
    ....
  15. pmc Engineered T cells for cancer therapy
    Carl H June
    Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, 8th Floor, Philadelphia, PA, 19104 5156, USA
    Cancer Immunol Immunother 63:969-75. 2014
    ....
  16. pmc A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside
    Cheryl Lai Lai Chiang
    Ovarian Cancer Research Center, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 19:4801-15. 2013
    ..Hypochlorous acid (HOCl) oxidation is a new method for inducing primary necrosis and enhancing the immunogenicity of tumor cells...
  17. pmc Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV
    Pablo Tebas
    Department of Medicine and Center for AIDS Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Blood 121:1524-33. 2013
    ..We conclude that gene-modified T cells have the potential to decrease the fitness of HIV-1 and conditionally replicative lentiviral vectors have a promising safety profile in T cells...
  18. pmc Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    Stephan A Grupp
    Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    N Engl J Med 368:1509-18. 2013
    ..The emergence of tumor cells that no longer express the target indicates a need to target other molecules in addition to CD19 in some patients with ALL...
  19. pmc Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells
    John Scholler
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104 6076, USA
    Sci Transl Med 4:132ra53. 2012
    ..Engineered T cells are a promising form of synthetic biology for long-term delivery of protein-based therapeutics. These results provide a framework to guide the therapy of a wide spectrum of human diseases...
  20. pmc CD28 costimulation is essential for human T regulatory expansion and function
    Tatiana N Golovina
    Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 181:2855-68. 2008
    ....
  21. doi request reprint Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment
    Elizabeth O Hexner
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
    Am J Hematol 91:453-60. 2016
    ..Taken together, these preliminary data suggest rapid engraftment in recipients of a single UCBT combined with relatively low doses of activated T cells, though potentially complicated by severe GVHD...
  22. doi request reprint T cells expressing chimeric antigen receptors can cause anaphylaxis in humans
    Marcela V Maus
    Authors Affiliations Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
    Cancer Immunol Res 1:26-31. 2013
    ..These results indicate that the potential immunogenicity of CARs derived from murine antibodies may be a safety issue for mRNA CARs, especially when administered using an intermittent dosing schedule...
  23. ncbi request reprint T lymphocyte engineering ex vivo for cancer and infectious disease
    Bruce L Levine
    The University of Pennsylvania School of Medicine, Hospital of University of Pennsylvania, Department of Pathology and Laboratory Medicine, M6 40 Maloney, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Expert Opin Biol Ther 8:475-89. 2008
    ....
  24. pmc Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial
    Edward A Stadtmauer
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
    Blood 117:63-71. 2011
    ..The provision of a primed autologous T-cell product significantly improved subsequent influenza vaccine responses. This trial was registered at www.clinicaltrials.gov as #NCT00499577...
  25. doi request reprint Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
    David L Porter
    Division of Hematology Oncology, Department of Medicine, and Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Sci Transl Med 7:303ra139. 2015
    ..Minimal residual disease was not detectable in patients who achieved CR, suggesting that disease eradication may be possible in some patients with advanced CLL. ..
  26. pmc Combination immunotherapy after ASCT for multiple myeloma using MAGE-A3/Poly-ICLC immunizations followed by adoptive transfer of vaccine-primed and costimulated autologous T cells
    Aaron P Rapoport
    Authors Affiliations University of Maryland Marlene and Stewart Greenebaum Cancer Center Center for Vaccine Development and Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland Oncovir Inc, Washington, District of Columbia Department of Pathology, University of Pennsylvania and Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
    Clin Cancer Res 20:1355-65. 2014
    ....
  27. pmc Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor
    Yangbing Zhao
    Abramson Family Cancer Research Institute and Department of Pathology and Laboratory Medicine and Thoracic Oncology Research Laboratory and Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Cancer Res 70:9053-61. 2010
    ..This approach may increase the therapeutic index of T cells engineered to express powerful activation domains without the associated safety concerns of integrating viral vectors...
  28. pmc Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells
    Gary P Wang
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
    Mol Ther 17:844-50. 2009
    ....
  29. ncbi request reprint A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation
    David L Porter
    Stem Cell Transplant Program, Division of Hematology Oncology, 16 Penn Tower, 3400 Spruce St, Philadelphia, PA 19104, USA
    Blood 107:1325-31. 2006
    ..Adoptive transfer of costimulated activated allogeneic T cells is feasible, does not result in excessive GVHD, and may contribute to durable remissions in diseases where conventional DLI has been disappointing...
  30. doi request reprint Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia
    David T Teachey
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
    Cancer Discov 6:664-79. 2016
    ..These comprehensive profiling data provide novel insights into CRS biology and, importantly, represent the first data that can accurately predict which patients have a high probability of becoming critically ill...
  31. ncbi request reprint Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation
    Elizabeth O Hexner
    Division of Hematology Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Blood Marrow Transplant 13:1135-44. 2007
    ..CD3/CD28 costimulation of UCB T cells represents a potential strategy for enhancing the engraftment of UCB...
  32. ncbi request reprint Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion
    Brian J Czerniecki
    Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Res 67:1842-52. 2007
    ..DC1 vaccination strategies may therefore have potential for both the prevention and the treatment of early breast cancer...
  33. ncbi request reprint Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation
    Ginna G Laport
    Translational Research Program, Abramsonm Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Blood 102:2004-13. 2003
    ....
  34. pmc Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection
    Hirotoshi Ebinuma
    Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Virol 82:5043-53. 2008
    ..Detection of FoxP3 expression in non-HCV-specific CD4 T cells suggests that immune regulation through antigen-specific Treg induction extends beyond HCV...
  35. doi request reprint Engineered T cells: the promise and challenges of cancer immunotherapy
    Andrew D Fesnak
    Department of Pathology and Laboratory Medicine and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 5156, USA
    Nat Rev Cancer 16:566-81. 2016
    ..In this Review we describe some of the most recent and promising advances in engineered T cell therapy with a particular emphasis on what the next generation of T cell therapy is likely to entail. ..
  36. pmc T cell engineering as therapy for cancer and HIV: our synthetic future
    Carl H June
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104 5156, USA Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104 5156, USA Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 5156, USA
    Philos Trans R Soc Lond B Biol Sci 370:20140374. 2015
    ..Many questions remain in the field of engineered T cells, but the encouraging response rates pave a wide road for future investigation into fields as diverse as cancer and chronic infections. ..
  37. doi request reprint Innovation and opportunity for chimeric antigen receptor targeted T cells
    J Joseph Melenhorst
    Department of Pathology and Laboratory Medicine, Clinical Cell and Vaccine Production Facility, University of Pennsylvania, Philadelphia, PA 19143 5156, USA
    Cytotherapy 15:1046-53. 2013
    ..Current challenges include managing a potent therapy that is a dividing, rather than a static drug, safeguarding against potential toxicity, and further development to enable access to a greater number of patients. ..
  38. doi request reprint Convergence of gene and cell therapy
    Alexey Bersenev
    Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Regen Med 7:50-6. 2012
    ..Some notable recent clinical developments in cellular engineering by gene transfer offer lessons on how the field has emerged, and hint at additional future clinical applications...
  39. pmc Gene transfer in humans using a conditionally replicating lentiviral vector
    Bruce L Levine
    Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:17372-7. 2006
    ..There is no evidence for insertional mutagenesis after 21-36 months of observation. Immune function improved in four subjects. Lentiviral vectors appear promising for gene transfer to humans...
  40. ncbi request reprint TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients
    Katia Schlienger
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 9:1517-27. 2003
    ..We also sought to measure preexisting antitumor immunity in patients with advanced ovarian cancer...
  41. ncbi request reprint Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells
    Mary A Marovich
    Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
    J Infect Dis 186:1242-52. 2002
    ..These data support an ongoing HIV vaccine trial comparing conventional vaccine delivery routes with ex vivo vaccine-loaded autologous DCs for immunogenicity in HIV-1-uninfected volunteers...
  42. pmc Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies
    Xin Huang
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Ther 16:580-9. 2008
    ..Taken together, these data indicate that T cells from PB and UCB can be stably modified using a non-viral DNA transfer system, and that such modified T cells may be useful in the treatment of refractory leukemia and lymphoma...
  43. ncbi request reprint In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures
    Wayne R Godfrey
    University of Minnesota Cancer Center, MMC no 806, 420 Delaware St, SE, Minneapolis, MN 55455, USA
    Blood 104:453-61. 2004
    ..This approach will enable more detailed biologic studies of Treg cells and facilitate the evaluation of cultured Treg cells as a novel form of immunosuppressive therapy...
  44. ncbi request reprint Immune reconstitution following autologous transfers of CD3/CD28 stimulated CD4(+) T cells to HIV-infected persons
    Wendy B Bernstein
    Division of Retrovirology, Walter Reed Army Institute of Research, Rockville MD 20850, USA
    Clin Immunol 111:262-74. 2004
    ..These data provide further evidence that adoptive transfer of activated autologous CD4(+) T cells can augment the immune system...
  45. ncbi request reprint Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load
    Laurent M Humeau
    VIRxSYS Corporation, Gaithersburg, MD 20877, USA
    Mol Ther 9:902-13. 2004
    ....
  46. ncbi request reprint L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection
    Patricia A Taylor
    University of Minnesota Cancer Center and Department of Pediatrics, Division of BMT, Minneapolis, MN 55455, USA
    Blood 104:3804-12. 2004
    ..These data indicate that Treg cellular therapy warrants clinical consideration for the inhibition of GVHD and the promotion of alloengraftment...
  47. pmc CD28-mediated regulation of multiple myeloma cell proliferation and survival
    Nizar J Bahlis
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL, USA
    Blood 109:5002-10. 2007
    ..These data also point to CD28 as a potential therapeutic target in the treatment of MM...
  48. pmc Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system
    Xin Huang
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 107:483-91. 2006
    ..This study is the first report demonstrating that the SB transposon system can mediate stable gene transfer in human primary PBLs, which may be advantageous for T-cell-based gene therapies...
  49. ncbi request reprint Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer
    Aaron P Rapoport
    University of Maryland Greenebaum Cancer Center and Center for Vaccine Development, 22 South Greene Street Baltimore, Maryland 21201, USA
    Nat Med 11:1230-7. 2005
    ..05). In the setting of lymphopenia, combined vaccine therapy and adoptive T-cell transfer fosters the development of enhanced memory T-cell responses...
  50. ncbi request reprint Phase I clinical trial of costimulated, IL-4 polarized donor CD4+ T cells as augmentation of allogeneic hematopoietic cell transplantation
    Daniel H Fowler
    Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Blood Marrow Transplant 12:1150-60. 2006
    ..Allograft augmentation with costimulated, IL-4-polarized donor CD4(+) T cells resulted in activated Th1, Th2, and inflammatory cytokine pathways without an apparent increase in GVHD...
  51. ncbi request reprint Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function
    Wayne R Godfrey
    Department of Pediatrics, University of Minnesota Cancer Center, Division of Hematology, Oncology, and Transplantation, Minneapolis, USA
    Blood 105:750-8. 2005
    ..Banked cord blood specimens may serve as a readily available source of Treg cells for immunotherapy...