Guillaume Lettre

Summary

Publications

  1. pmc The search for genetic modifiers of disease severity in the β-hemoglobinopathies
    Guillaume Lettre
    Montreal Heart Institute and Université Montréal, Montreal, Quebec H1T 1C8, Canada
    Cold Spring Harb Perspect Med 2:. 2012
  2. doi request reprint Using height association studies to gain insights into human idiopathic short and syndromic stature phenotypes
    Guillaume Lettre
    Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, H1T 1C8, Canada
    Pediatr Nephrol 28:557-62. 2013
  3. doi request reprint Genetic regulation of adult stature
    Guillaume Lettre
    Montreal Heart Institute Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Curr Opin Pediatr 21:515-22. 2009
  4. doi request reprint Recent progress in the study of the genetics of height
    Guillaume Lettre
    Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, Canada
    Hum Genet 129:465-72. 2011
  5. pmc Optimus Primer: A PCR enrichment primer design program for next-generation sequencing of human exonic regions
    Andrew Mk Brown
    Universite de Montreal, Montreal, Quebec, Canada
    BMC Res Notes 3:185. 2010
  6. doi request reprint Pooled DNA resequencing of 68 myocardial infarction candidate genes in French canadians
    Melissa Beaudoin
    Montreal Heart Institute, 5000 rue Belanger, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 5:547-54. 2012
  7. pmc Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry
    Amidou N'Diaye
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1002298. 2011
  8. pmc Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
    Melissa Beaudoin
    Montreal Heart Institute, Research Center, Montreal, Quebec, Canada
    PLoS Genet 9:e1003723. 2013
  9. pmc Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1001300. 2011
  10. doi request reprint Nonsense mutations in BAG3 are associated with early-onset dilated cardiomyopathy in French Canadians
    Nathalie Chami
    Centre de Recherche, Montreal Heart Institute, Montreal, Quebec, Canada Départment de médecine, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 30:1655-61. 2014

Detail Information

Publications19

  1. pmc The search for genetic modifiers of disease severity in the β-hemoglobinopathies
    Guillaume Lettre
    Montreal Heart Institute and Université Montréal, Montreal, Quebec H1T 1C8, Canada
    Cold Spring Harb Perspect Med 2:. 2012
    ....
  2. doi request reprint Using height association studies to gain insights into human idiopathic short and syndromic stature phenotypes
    Guillaume Lettre
    Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, H1T 1C8, Canada
    Pediatr Nephrol 28:557-62. 2013
    ....
  3. doi request reprint Genetic regulation of adult stature
    Guillaume Lettre
    Montreal Heart Institute Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Curr Opin Pediatr 21:515-22. 2009
    ..The identification of genes that regulate human height would greatly enhance our understanding of human growth and height-associated human syndromes...
  4. doi request reprint Recent progress in the study of the genetics of height
    Guillaume Lettre
    Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, Canada
    Hum Genet 129:465-72. 2011
    ..In this review, I highlight the progress made in the last 2 years in understanding how genetic variation controls height variation in humans, including non-Caucasian populations and children...
  5. pmc Optimus Primer: A PCR enrichment primer design program for next-generation sequencing of human exonic regions
    Andrew Mk Brown
    Universite de Montreal, Montreal, Quebec, Canada
    BMC Res Notes 3:185. 2010
    ....
  6. doi request reprint Pooled DNA resequencing of 68 myocardial infarction candidate genes in French canadians
    Melissa Beaudoin
    Montreal Heart Institute, 5000 rue Belanger, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 5:547-54. 2012
    ..Except for a few examples (eg, PCSK9), the role of low-frequency genetic variation (minor allele frequency [MAF]) ≈0.1%-5% on MI/coronary artery disease predisposition has not been extensively investigated...
  7. pmc Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry
    Amidou N'Diaye
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1002298. 2011
    ..01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits...
  8. pmc Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
    Melissa Beaudoin
    Montreal Heart Institute, Research Center, Montreal, Quebec, Canada
    PLoS Genet 9:e1003723. 2013
    ..Rather, these are expected to help focus functional studies of the corresponding disease loci...
  9. pmc Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1001300. 2011
    ..Our project has developed resources and methods that address both admixture- and SNP-association to maximize power for genetic discovery in even larger African-American consortia...
  10. doi request reprint Nonsense mutations in BAG3 are associated with early-onset dilated cardiomyopathy in French Canadians
    Nathalie Chami
    Centre de Recherche, Montreal Heart Institute, Montreal, Quebec, Canada Départment de médecine, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 30:1655-61. 2014
    ..Next-generation DNA sequencing of large panels of candidate genes (ie, targeted sequencing) or of the whole exome can rapidly and economically identify pathogenic mutations in familial DCM...
  11. pmc Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients
    Geneviève Galarneau
    Montreal Heart Institute, Montreal, Quebec, Canada
    Blood 122:434-42. 2013
    ..Our results provide new leads to gaining a better understanding of clinical variability in SCD, a "simple" monogenic disease. ..
  12. pmc Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
    Zari Dastani
    Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada
    PLoS Genet 8:e1002607. 2012
    ..4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance...
  13. pmc Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation
    Geneviève Galarneau
    Montreal Heart Institute, Montreal, Quebec, Canada
    Nat Genet 42:1049-51. 2010
    ..6% to 49.5%. We also identified rare missense variants that causally implicate MYB in HbF production...
  14. pmc Lessons and Implications from Genome-Wide Association Studies (GWAS) Findings of Blood Cell Phenotypes
    Nathalie Chami
    Montreal Heart Institute, Faculte de Medecine, Universite de Montreal, 5000 Belanger Street, Montreal, QC H1T 1C8, Canada
    Genes (Basel) 5:51-64. 2014
    ..g., myeloproliferative neoplasms) human blood-related diseases. Finally, we argue that blood phenotypes are ideal to study the genetics of complex human traits because they are fully amenable to experimental testing. ..
  15. ncbi request reprint Whole-genome sequencing in French Canadians from Quebec
    Cecile Low-Kam
    Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada
    Hum Genet 135:1213-1221. 2016
    ..Our results illustrate the value of low-pass WGS to study the genetics of human diseases in the founder French-Canadian population...
  16. doi request reprint Small island, big genetic discoveries
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Quebec, Canada, and the Faculté de Médecine, Universite de Montreal, Montreal, Quebec, Canada
    Nat Genet 47:1224-5. 2015
    ..These reports highlight the usefulness of large-scale genotype imputation based on whole-genome sequencing, particularly in isolated populations, in studying the genetics of complex human phenotypes. ..
  17. pmc Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries
    Melissa Beaudoin
    From the Montreal Heart Institute, Montreal, Quebec, Canada M B, K S L, C L S A, Simon Langlois, J C T, G L Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA R M G, C A H, K M Harvard Stem Cell Institute R M G, C A H, K M, Cambridge, MA Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA R M G, K M Center of Human Genetic Research H H W, R D, S K, Cardiovascular Research Center H H W, R D, S K, Massachusetts General Hospital, Boston Department of Medicine, Harvard Medical School, Boston, MA H H W, R D, S K Program in Medical and Population Genetics, Broad Institute, Cambridge, MA H H W, Rabat
    Arterioscler Thromb Vasc Biol 35:1472-9. 2015
    ..How these PHACTR1 SNPs influence CAD/MI risk, and whether PHACTR1 itself is the causal gene at the locus, is currently unknown...
  18. pmc Strategies to fine-map genetic associations with lipid levels by combining epigenomic annotations and liver-specific transcription profiles
    Ken Sin Lo
    Montreal Heart Institute, Montreal, Quebec, Canada
    Genomics 104:105-12. 2014
    ..These methods can be used to generate testable hypotheses for many non-coding SNPs associated with complex diseases or traits. ..
  19. pmc Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans
    Ken Sin Lo
    Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada
    Hum Genet 129:307-17. 2011
    ..Our results show similarities but also differences in the genetic regulation of hematological traits in European- and African-derived populations, and highlight the role of natural selection in shaping these differences...