Małgorzata Lenartowicz

Summary

Publications

  1. ncbi request reprint [Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases]
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, 6 R Ingardena St, 30 060 Cracow, Poland
    Postepy Biochem 56:317-27. 2010
  2. pmc Prenatal treatment of mosaic mice (Atp7a mo-ms) mouse model for Menkes disease, with copper combined by dimethyldithiocarbamate (DMDTC)
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Krakow, Poland
    PLoS ONE 7:e40400. 2012
  3. doi request reprint Mutation in the CPC motif-containing 6th transmembrane domain affects intracellular localization, trafficking and copper transport efficiency of ATP7A protein in mosaic mutant mice--an animal model of Menkes disease
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Ingardena 6, Gronostajowa 9, 30 387 Krakow, Poland
    Metallomics 4:197-204. 2012
  4. doi request reprint Alterations in the expression of the Atp7a gene in the early postnatal development of the mosaic mutant mice (Atp7a mo-ms) - An animal model for Menkes disease
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Gene Expr Patterns 11:41-7. 2011
  5. doi request reprint Developmental changes in the expression of the Atp7a gene in the liver of mice during the postnatal period
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Krakow, Poland
    J Exp Zool A Ecol Genet Physiol 313:209-17. 2010
  6. doi request reprint Effects of copper supplementation on the structure and content of elements in kidneys of mosaic mutant mice
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Biol Trace Elem Res 136:204-20. 2010
  7. doi request reprint Copper metabolism disorders affect testes structure and gamete quality in male mice
    Małgorzata Kowal
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Ingardena 6, Krakow, Poland
    Syst Biol Reprod Med 56:431-44. 2010
  8. ncbi request reprint Alternative splicing in the Atp7a gene in the Cu deficient mosaic mutation in mice
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, R Ingardena 6, 30 060 Krakow, Poland
    Folia Biol (Krakow) 52:219-23. 2004
  9. pmc Haemolysis and perturbations in the systemic iron metabolism of suckling, copper-deficient mosaic mutant mice - an animal model of Menkes disease
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Krakow, Poland
    PLoS ONE 9:e107641. 2014
  10. doi request reprint Increased prostaglandin E₂-EP2 signalling in cumulus cells of female mice sired by males with the Y-chromosome long-arm deletion
    Katarzyna Kotarska
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30 387 Krakow, Poland
    Reprod Fertil Dev 25:900-6. 2013

Detail Information

Publications12

  1. ncbi request reprint [Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases]
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, 6 R Ingardena St, 30 060 Cracow, Poland
    Postepy Biochem 56:317-27. 2010
    ..Disturbances of ATP7A and ATP7B function caused by mutations lead to severe metabolic diseases Menkes and Wilson diseases, respectively...
  2. pmc Prenatal treatment of mosaic mice (Atp7a mo-ms) mouse model for Menkes disease, with copper combined by dimethyldithiocarbamate (DMDTC)
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Krakow, Poland
    PLoS ONE 7:e40400. 2012
    ....
  3. doi request reprint Mutation in the CPC motif-containing 6th transmembrane domain affects intracellular localization, trafficking and copper transport efficiency of ATP7A protein in mosaic mutant mice--an animal model of Menkes disease
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Ingardena 6, Gronostajowa 9, 30 387 Krakow, Poland
    Metallomics 4:197-204. 2012
    ..Mouse models of Menkes disease belong to the mottled mutant group. The mosaic mutant represents another interesting animal model for Menkes disease that will be of value in research on copper metabolism and transport in mammals...
  4. doi request reprint Alterations in the expression of the Atp7a gene in the early postnatal development of the mosaic mutant mice (Atp7a mo-ms) - An animal model for Menkes disease
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Gene Expr Patterns 11:41-7. 2011
    ..We speculate that disturbance in the expression of the Atp7a gene and, consequently, change in the copper concentration of the organs, may contribute to the early fatal outcome of mosaic males...
  5. doi request reprint Developmental changes in the expression of the Atp7a gene in the liver of mice during the postnatal period
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Krakow, Poland
    J Exp Zool A Ecol Genet Physiol 313:209-17. 2010
    ..The expression of Atp7a gene and ATP7A protein was also confirmed in primary hepatocytes from adult mouse. Demonstration of the hepatic Atp7a gene expression may shed light on new aspects of copper metabolism in the liver in mammals...
  6. doi request reprint Effects of copper supplementation on the structure and content of elements in kidneys of mosaic mutant mice
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Biol Trace Elem Res 136:204-20. 2010
    ..We suggest that copper excess may impair the activity of Na(+)/K(+) ATP-ase in renal tubules of ms/- males. The content of Mg, P, and Cl in kidneys in mutants was also changed after copper administration...
  7. doi request reprint Copper metabolism disorders affect testes structure and gamete quality in male mice
    Małgorzata Kowal
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Ingardena 6, Krakow, Poland
    Syst Biol Reprod Med 56:431-44. 2010
    ..Additionally, in mutants, copulatory plugs and fertile copulation outcome were decreased after copper treatment...
  8. ncbi request reprint Alternative splicing in the Atp7a gene in the Cu deficient mosaic mutation in mice
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, R Ingardena 6, 30 060 Krakow, Poland
    Folia Biol (Krakow) 52:219-23. 2004
    ..However, such a strong linkage between this polymorphism and the mosaic phenotype (lasting for 96 outbred generations), suggests that the mutation is in the Atp7a gene...
  9. pmc Haemolysis and perturbations in the systemic iron metabolism of suckling, copper-deficient mosaic mutant mice - an animal model of Menkes disease
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Krakow, Poland
    PLoS ONE 9:e107641. 2014
    ..These findings indicate that haemolysis is an additional pathogenic factor in a mouse model of Menkes diseases and provides evidence of a new indirect connection between copper deficiency and iron metabolism. ..
  10. doi request reprint Increased prostaglandin E₂-EP2 signalling in cumulus cells of female mice sired by males with the Y-chromosome long-arm deletion
    Katarzyna Kotarska
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30 387 Krakow, Poland
    Reprod Fertil Dev 25:900-6. 2013
    ..BR and B10.BR(Y(del)) female mice. It supports the hypothesis that genes of the Y-chromosome long arm may be involved in establishment of epigenetic marks in X-bearing spermatozoa...
  11. ncbi request reprint Testicular morphology and expression of aromatase in testes of mice with the mosaic mutation (Atp7a mo-ms)
    Małgorzata Kotula-Balak
    Department of Endocrinology and Tissue Culture, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Theriogenology 67:423-34. 2007
    ..The higher level of endogenous estrogens can additionally enhance morphological alterations within the testes. It seems also likely that excess estrogens may affect the survival rate of the mosaic males...
  12. doi request reprint Changes in germ cells population and in vitro oocyte maturation in female mice with imperforated vagina
    Małgorzata Lenartowicz
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Krakow, Poland
    J Exp Zool A Ecol Genet Physiol 309:269-77. 2008
    ..Our data show that females with an imperforated vagina can be a useful model for studying the mechanism of genetic control of the development of the urogenital tract in mammals...