Philippe Legrand

Summary

Publications

  1. doi request reprint The consumption of food products from linseed-fed animals maintains erythrocyte omega-3 fatty acids in obese humans
    Philippe Legrand
    Biochimie Nutrition Humaine Agrocampus INRA, Rennes, France
    Lipids 45:11-9. 2010
  2. pmc The complex and important cellular and metabolic functions of saturated fatty acids
    Philippe Legrand
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Rennes, INRA USC 2012, 65 rue de Saint Brieuc, CS 84215, Rennes Cedex, France
    Lipids 45:941-6. 2010
  3. ncbi request reprint Conversion of hexadecanoic acid to hexadecenoic acid by rat Delta 6-desaturase
    Herve Guillou
    Laboratoire de Biochimie, INRA ENSA, Rennes, France
    J Lipid Res 44:450-4. 2003
  4. doi request reprint Myristic acid increases dihydroceramide Δ4-desaturase 1 (DES1) activity in cultured rat hepatocytes
    Hélène Ezanno
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Ouest, INRA USC 2012, 65 rue de Saint Brieuc, CS 84215, 35042, Rennes Cedex, France
    Lipids 47:117-28. 2012
  5. pmc Trans-vaccenate is Δ13-desaturated by FADS3 in rodents
    Vincent Rioux
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Ouest Institut National de la Recherche Agronomique INRA USC2012, Rennes, France
    J Lipid Res 54:3438-52. 2013
  6. ncbi request reprint Myristic acid increases delta6-desaturase activity in cultured rat hepatocytes
    Sophie Jan
    Laboratoire de Biochimie, INRA ENSA, 65 rue de Saint Brieuc, CS84215, 35042 Rennes, France
    Reprod Nutr Dev 44:131-40. 2004
  7. ncbi request reprint Myristic acid increases the activity of dihydroceramide Delta4-desaturase 1 through its N-terminal myristoylation
    Erwan Beauchamp
    Laboratoire de Biochimie, INRA Agrocampus Rennes, 65 rue de Saint Brieuc, CS 84215, 35042 Rennes Cedex, France
    Biochimie 89:1553-61. 2007
  8. ncbi request reprint Distinct roles of endoplasmic reticulum cytochrome b5 and fused cytochrome b5-like domain for rat Delta6-desaturase activity
    Herve Guillou
    Laboratoire de Biochimie, Institut National de la Recherche Agronomique Ecole Nationale Supérieure Agronomique, Rennes, France
    J Lipid Res 45:32-40. 2004
  9. doi request reprint N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria: partial involvement in the apoptotic effect of myristic acid
    Erwan Beauchamp
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Ouest INRA USC 2012, Rennes, France
    Biochimie 91:1411-9. 2009
  10. ncbi request reprint Dietary myristic acid at physiologically relevant levels increases the tissue content of C20:5 n-3 and C20:3 n-6 in the rat
    Vincent Rioux
    Laboratoire de Biochimie, INRA Agrocampus, 65 rue de Saint Brieuc, 35042 Rennes, France
    Reprod Nutr Dev 45:599-612. 2005

Collaborators

  • Vincent Rioux
  • Frederique Pedrono
  • Maryline Kouba
  • Laurence Bernard
  • Odile Sergent
  • J Mourot
  • Philippe Guesnet
  • B Schmitt
  • Erwan Beauchamp
  • Daniel Catheline
  • Benjamin Choque
  • Fanny Lemarié
  • Herve Guillou
  • Sophie Jan
  • Sabine D'andréa
  • Dominique Lagadic-Gossmann
  • Justine Marchix
  • Hélène Blanchard
  • Hélène Ezanno
  • Fatiha Aliche-Djoudi
  • Jérôme Le Bloc'h
  • Monique Bouriel
  • Bernadette Delplanque
  • Alain Fautrel
  • Stéphanie Dayot
  • Cécile Duby
  • Jean Noël Thibault
  • Nathalie Boulier-Monthéan
  • Martine Chevanne
  • Normand Podechard
  • Philippe Nourissat
  • Marie Thérèse Dimanche-Boitrel
  • Gaëlle Marteil
  • Xavier Tekpli
  • Diana Goenaga
  • Stéphanie Dalaine
  • Romain Barnouin
  • Stéphanie Daval

Detail Information

Publications26

  1. doi request reprint The consumption of food products from linseed-fed animals maintains erythrocyte omega-3 fatty acids in obese humans
    Philippe Legrand
    Biochimie Nutrition Humaine Agrocampus INRA, Rennes, France
    Lipids 45:11-9. 2010
    ....
  2. pmc The complex and important cellular and metabolic functions of saturated fatty acids
    Philippe Legrand
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Rennes, INRA USC 2012, 65 rue de Saint Brieuc, CS 84215, Rennes Cedex, France
    Lipids 45:941-6. 2010
    ..The variety of their functions demonstrates that SFA should no longer be considered as a single group...
  3. ncbi request reprint Conversion of hexadecanoic acid to hexadecenoic acid by rat Delta 6-desaturase
    Herve Guillou
    Laboratoire de Biochimie, INRA ENSA, Rennes, France
    J Lipid Res 44:450-4. 2003
    ..Evidence is therefore presented that the rat Delta 6-desaturase, which acts on the 18- and 24-carbon fatty acids of the n-6 and n-3 series, is also able to catalyze palmitic acid Delta 6 -desaturation...
  4. doi request reprint Myristic acid increases dihydroceramide Δ4-desaturase 1 (DES1) activity in cultured rat hepatocytes
    Hélène Ezanno
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Ouest, INRA USC 2012, 65 rue de Saint Brieuc, CS 84215, 35042, Rennes Cedex, France
    Lipids 47:117-28. 2012
    ..Finally, the myristic acid-associated increase in DES1 activity slightly enhanced the number of apoptotic cells...
  5. pmc Trans-vaccenate is Δ13-desaturated by FADS3 in rodents
    Vincent Rioux
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Ouest Institut National de la Recherche Agronomique INRA USC2012, Rennes, France
    J Lipid Res 54:3438-52. 2013
    ..In rat hepatocytes, knockdown of FADS3 expression specifically reduces trans-vaccenate Δ13-desaturation. Evidence is presented that FADS3 is the first "methyl-end" fatty acid desaturase functionally characterized in mammals. ..
  6. ncbi request reprint Myristic acid increases delta6-desaturase activity in cultured rat hepatocytes
    Sophie Jan
    Laboratoire de Biochimie, INRA ENSA, 65 rue de Saint Brieuc, CS84215, 35042 Rennes, France
    Reprod Nutr Dev 44:131-40. 2004
    ..e. oleic acid (C18:1n-9), linoleic acid (C18:2n-6) and alpha-linoleic acid (C18:3n-3) was dose-dependent in the range 0.1-0.5 mmol x L(-1) myristic acid concentration...
  7. ncbi request reprint Myristic acid increases the activity of dihydroceramide Delta4-desaturase 1 through its N-terminal myristoylation
    Erwan Beauchamp
    Laboratoire de Biochimie, INRA Agrocampus Rennes, 65 rue de Saint Brieuc, CS 84215, 35042 Rennes Cedex, France
    Biochimie 89:1553-61. 2007
    ..This N-terminal modification has a great impact on dihydroceramide Delta4-desaturase activity. These results suggest therefore that myristic acid may play an important role in the biosynthesis of ceramide and in sphingolipid metabolism...
  8. ncbi request reprint Distinct roles of endoplasmic reticulum cytochrome b5 and fused cytochrome b5-like domain for rat Delta6-desaturase activity
    Herve Guillou
    Laboratoire de Biochimie, Institut National de la Recherche Agronomique Ecole Nationale Supérieure Agronomique, Rennes, France
    J Lipid Res 45:32-40. 2004
    ..These data suggest distinct and essential roles for both the desaturase cytochrome b5-like domain and free endoplasmic reticulum cytochrome b5 for Delta6-desaturase activity...
  9. doi request reprint N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria: partial involvement in the apoptotic effect of myristic acid
    Erwan Beauchamp
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Ouest INRA USC 2012, Rennes, France
    Biochimie 91:1411-9. 2009
    ....
  10. ncbi request reprint Dietary myristic acid at physiologically relevant levels increases the tissue content of C20:5 n-3 and C20:3 n-6 in the rat
    Vincent Rioux
    Laboratoire de Biochimie, INRA Agrocampus, 65 rue de Saint Brieuc, 35042 Rennes, France
    Reprod Nutr Dev 45:599-612. 2005
    ..This result suggests that dietary myristic acid may participate in the regulation of highly unsaturated fatty acid biosynthesis and metabolism...
  11. ncbi request reprint Although it is rapidly metabolized in cultured rat hepatocytes, lauric acid is used for protein acylation
    Vincent Rioux
    Laboratoire de Biochimie, INRA ENSA, 65 rue de Saint Brieuc, CS84215, 35042 Rennes, France
    Reprod Nutr Dev 43:419-30. 2003
    ..Therefore, these results show for the first time that, although it is rapidly metabolized in hepatocytes, exogenous lauric acid is a substrate for the acylation of liver proteins...
  12. doi request reprint Short chain saturated fatty acids decrease circulating cholesterol and increase tissue PUFA content in the rat
    Philippe Legrand
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Ouest, INRA USC 2012, 65 rue de Saint Brieuc, CS 84215, 35042, Rennes Cedex, France
    Lipids 45:975-86. 2010
    ..This study supports the hypothesis that in diets with identical well-balanced LNA/ALA ratios, short chain SFA may decrease circulating cholesterol and increase tissue polyunsaturated fatty acid content in the rat...
  13. pmc The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues
    Frederique Pedrono
    Laboratoire de Biochimie et Nutrition Humaine, USC INRA 2012, Agrocampus Ouest, Rennes, France
    J Lipid Res 51:472-9. 2010
    ..To conclude, we showed in this study that FADS3 does exist under multiple protein isoforms depending on the mammalian tissues. These results will help further investigations to determine the physiological function of FADS3...
  14. doi request reprint Regulation of mammalian desaturases by myristic acid: N-terminal myristoylation and other modulations
    Vincent Rioux
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Ouest, INRA USC 2012, Rennes, France
    Biochim Biophys Acta 1811:1-8. 2011
    ..This article discusses several topics, such as the myristoylation of the dihydroceramide Δ4-desaturase, the myristoylation of the NADH-cytochrome b5 reductase which is part of the whole desaturase complex, and other putative mechanisms...
  15. doi request reprint [New regulatory and signal functions for myristic acid]
    Erwan Beauchamp
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Rennes INRA USC 2012, 65, rue de Saint Brieuc, 35042 Rennes Cedex, France
    Med Sci (Paris) 25:57-63. 2009
    ..Modulations of the cellular concentration of this fatty acid and its associated myristoylation function might be used as regulators of these metabolic pathways...
  16. doi request reprint The 51 kDa FADS3 is secreted in the ECM of hepatocytes and blood in rat
    Hélène Blanchard
    Laboratoire de Biochimie et Nutrition Humaine, INRA USC 2012, Agrocampus Ouest, F 35042, Rennes, France
    J Cell Biochem 115:199-207. 2014
    ....
  17. ncbi request reprint Saturated fatty acids: simple molecular structures with complex cellular functions
    Vincent Rioux
    Biochemistry and Human Nutrition Laboratory, Agrocampus Rennes, INRA USC 2012, Rennes, France
    Curr Opin Clin Nutr Metab Care 10:752-8. 2007
    ..Elucidated biochemical mechanisms like protein acylation (N-myristoylation, S-palmitoylation) and putative physiological roles are described...
  18. pmc Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat
    Fanny Lemarié
    Laboratory of Biochemistry and Human Nutrition, Agrocampus Ouest INRA USC 1378, Rennes, France
    PLoS ONE 10:e0133600. 2015
    ..However, these modifications were not associated with increased body weight or food consumption...
  19. doi request reprint Revisiting the metabolism and physiological functions of caprylic acid (C8:0) with special focus on ghrelin octanoylation
    Fanny Lemarié
    Laboratoire de Biochimie Nutrition Humaine, Agrocampus Ouest, INRA USC 1378, Rennes, France
    Biochimie 120:40-8. 2016
    ..The subsequent aim of this review is to demonstrate the relevance of carrying out further studies to better understand the physiological functions of this particular fatty acid. ..
  20. doi request reprint Physical and chemical modulation of lipid rafts by a dietary n-3 polyunsaturated fatty acid increases ethanol-induced oxidative stress
    Fatiha Aliche-Djoudi
    EA 4427 SeRAIC IRSET, IFR 140, UFR des Sciences Pharmaceutiques et Biologiques, Universite de Rennes 1, Rennes Cedex, France
    Free Radic Biol Med 51:2018-30. 2011
    ..To conclude, the ability of EPA to modify lipid raft physical and chemical properties plays a key role in the enhancement, by this dietary n-3 PUFA, of ethanol-induced oxidative stress...
  21. doi request reprint Excessive dietary linoleic acid induces proinflammatory markers in rats
    Justine Marchix
    Laboratoire de Biochimie et Nutrition Humaine, INRA USC 2012, Agrocampus Ouest, Rennes, France
    J Nutr Biochem 26:1434-41. 2015
    ..The present study provides further support for the proinflammatory properties of LA and suggests an LA-derivatives pathway involved in the inflammatory process. ..
  22. doi request reprint Dietary linoleic acid requirements in the presence of α-linolenic acid are lower than the historical 2 % of energy intake value, study in rats
    Benjamin Choque
    Laboratoire de Biochimie et Nutrition Humaine, INRA USC 2012, Agrocampus Ouest, 65 rue de Saint Brieuc, 35042Rennes Cedex, France
    Br J Nutr 113:1056-68. 2015
    ..These data suggest that the requirements in humans should be revisited, considering the presence of ALA to set up the recommendation for LA. ..
  23. doi request reprint Linoleic acid: between doubts and certainties
    Benjamin Choque
    Laboratoire de Biochimie et Nutrition Humaine, INRA USC 2012, Agrocampus Ouest, 65 rue de Saint Brieuc, 35042 Rennes Cedex, France
    Biochimie 96:14-21. 2014
    ....
  24. ncbi request reprint Lauric acid is desaturated to 12:1n-3 by hepatocytes and rat liver homogenates
    Philippe Legrand
    Laboratoire de Biochimie INRA ENSA, Rennes, France
    Lipids 37:569-72. 2002
    ..This result suggests that lauric acid desaturation could be the first step in the biosynthesis of alpha-linolenic acid in animal cells...
  25. ncbi request reprint Natural alkylglycerols restrain growth and metastasis of grafted tumors in mice
    Frederique Pedrono
    Laboratoire de Pharmacologie Moleculaire, Faculte de Pharmacie, Rennes, France
    Nutr Cancer 48:64-9. 2004
    ..These findings suggest that the antitumor activity of SLO is likely mediated by the presence of alkylglycerols...
  26. pmc The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis
    Sabine D'andréa
    Laboratoire de Biochimie, INRA ENSA, 65 rue de Saint Brieuc, CS84215, 35042 Rennes Cedex, France
    Biochem J 364:49-55. 2002
    ..A similar mechanism in the n-6 series is strongly suggested...