Intae Lee

Summary

Publications

  1. ncbi request reprint Antitumor efficacy of the cytotoxic RNase, ranpirnase, on A549 human lung cancer xenografts of nude mice
    Intae Lee
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6069, USA
    Anticancer Res 27:299-307. 2007
  2. ncbi request reprint The therapeutic mechanisms of ranpirnase-induced enhancement of radiation response on A549 human lung cancer
    Intae Lee
    Department of Radiology, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6069, USA
    In Vivo 21:721-8. 2007
  3. ncbi request reprint Mechanisms of enhanced tumoricidal efficacy of multiple small dosages of ranpirnase, the novel cytotoxic ribonuclease, on lung cancer
    Intae Lee
    Department of Radiology, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104 6069, USA
    Cancer Chemother Pharmacol 62:337-46. 2008
  4. ncbi request reprint Ranpirnase (Onconase), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy
    Intae Lee
    University of Pennsylvania, Department of Radiology, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6069, USA
    Expert Opin Biol Ther 8:813-27. 2008
  5. ncbi request reprint Possible mechanisms of improved radiation response by cytotoxic RNase, Onconase, on A549 human lung cancer xenografts of nude mice
    Dae Hong Kim
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 599:53-9. 2007
  6. pmc A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung
    Intae Lee
    Institute for Environmental Medicine, University of Pennsylvania, 3620 Hamilton Walk, 1 John Morgan Building, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 345:284-96. 2013
  7. ncbi request reprint Effect of ONCONASE +/- tamoxifen on ASPC-1 human pancreatic tumors in nude mice
    Intae Lee
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 530:187-96. 2003
  8. ncbi request reprint Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores
    Sophia P Wu
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
    Bioconjug Chem 16:542-50. 2005

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Antitumor efficacy of the cytotoxic RNase, ranpirnase, on A549 human lung cancer xenografts of nude mice
    Intae Lee
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6069, USA
    Anticancer Res 27:299-307. 2007
    ..The cytotoxic RNase, ranpirnase (ONCONASE, ONC), may have promising therapeutic implication as an alternative for cisplatin for the treatment of lung cancer, due to inhibition of protein synthesis by t-RNA cleavage...
  2. ncbi request reprint The therapeutic mechanisms of ranpirnase-induced enhancement of radiation response on A549 human lung cancer
    Intae Lee
    Department of Radiology, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6069, USA
    In Vivo 21:721-8. 2007
    ..As translational implications, the non-invasive monitoring response to individual therapy with ONC was also investigated to determine the underlying therapeutic mechanisms...
  3. ncbi request reprint Mechanisms of enhanced tumoricidal efficacy of multiple small dosages of ranpirnase, the novel cytotoxic ribonuclease, on lung cancer
    Intae Lee
    Department of Radiology, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104 6069, USA
    Cancer Chemother Pharmacol 62:337-46. 2008
    ..The effect of multiple small dosages of the cytotoxic RNase, ranpirnase (ONCONASE, ONC), on lung cancer was studied. The possible mechanisms for the enhanced tumoricidal efficacy of multiple small dosages of ONC were also investigated...
  4. ncbi request reprint Ranpirnase (Onconase), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy
    Intae Lee
    University of Pennsylvania, Department of Radiology, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6069, USA
    Expert Opin Biol Ther 8:813-27. 2008
    ..Onconase (the smallest member of the RNase A superfamily) has moved into clinical testing in the US and Europe...
  5. ncbi request reprint Possible mechanisms of improved radiation response by cytotoxic RNase, Onconase, on A549 human lung cancer xenografts of nude mice
    Dae Hong Kim
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 599:53-9. 2007
    ..This investigation suggests important potential clinical uses of ONC for the treatment of NSCLC cancer patients...
  6. pmc A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung
    Intae Lee
    Institute for Environmental Medicine, University of Pennsylvania, 3620 Hamilton Walk, 1 John Morgan Building, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 345:284-96. 2013
    ..Thus, MJ33 could be useful as a therapeutic agent to prevent ROS-mediated tissue injury associated with lung inflammation or in harvested lungs prior to transplantation...
  7. ncbi request reprint Effect of ONCONASE +/- tamoxifen on ASPC-1 human pancreatic tumors in nude mice
    Intae Lee
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 530:187-96. 2003
    ..ONC alone effectively retarded the tumor growth, but TAMX alone did not. ONC + TAMX was synergistically effective in inhibiting tumor growth...
  8. ncbi request reprint Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores
    Sophia P Wu
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
    Bioconjug Chem 16:542-50. 2005
    ....