Miguel R Abboud

Summary

Affiliation: American University of Beirut
Country: Lebanon

Publications

  1. doi request reprint Sickle cell disease at the dawn of the molecular era
    Miguel R Abboud
    Children s Cancer Centre of Lebanon, American University of Beirut Medical Centre, Beirut, Lebanon
    Hemoglobin 33:S93-S106. 2009
  2. ncbi request reprint Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study
    Miguel R Abboud
    Department of Pediatrics, Medical University of South Carolina, Charleston, USA
    Blood 103:2822-6. 2004
  3. pmc Discontinuing prophylactic transfusions increases the risk of silent brain infarction in children with sickle cell disease: data from STOP II
    Miguel R Abboud
    American University of Beirut Medical Center, Beirut, Lebanon
    Blood 118:894-8. 2011
  4. ncbi request reprint Prevention and management of strokes in patients with sickle cell disease
    Miguel R Abboud
    Children s Cancer Center of Lebanon, American University of Beirut Medical Center, P O Box 11 0236 Riad El Solh, Beirut 1107 2020, Lebanon
    Curr Hematol Rep 5:15-22. 2006
  5. doi request reprint Implementation of an intensive risk-stratified treatment protocol for children and adolescents with acute lymphoblastic leukemia in Lebanon
    Samar Muwakkit
    Department of Pediatrics and Adolescent Medicine, Children s Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    Am J Hematol 87:678-83. 2012
  6. doi request reprint Pulmonary hypertension in children and young adults with sickle cell disease: evidence for familial clustering
    Hanane A Dahoui
    Children s Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    Pediatr Blood Cancer 54:398-402. 2010
  7. ncbi request reprint Radiographic predictors of neurocognitive functioning in pediatric Sickle Cell disease
    Mary C Kral
    Department of Pediatrics, Medical University of South Carolina, Charleston, 29425, USA
    J Child Neurol 21:37-44. 2006
  8. ncbi request reprint Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma
    Karim Z Masrouha
    Department of Surgery, American University of Beirut Medical Center, PO Box 11 0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
    Skeletal Radiol 41:1453-61. 2012
  9. doi request reprint Effect of chronic transfusion therapy on progression of neurovascular pathology in pediatric patients with sickle cell anemia
    Sarah Bishop
    Department of Pediatrics, Medical University of South Carolina, Charleston, USA
    Blood Cells Mol Dis 47:125-8. 2011
  10. doi request reprint Severe cerebral vaso-occlusive disease in macrophage activation syndrome
    Mohamad K El-Bitar
    Division of Pediatric Neurology and Pediatric Epilepsy Program, Department of Pediatrics, American University of Beirut Medical Center, 2020l Beirut, Lebanon
    Pediatr Neurol 42:283-6. 2010

Collaborators

Detail Information

Publications38

  1. doi request reprint Sickle cell disease at the dawn of the molecular era
    Miguel R Abboud
    Children s Cancer Centre of Lebanon, American University of Beirut Medical Centre, Beirut, Lebanon
    Hemoglobin 33:S93-S106. 2009
    ..Our current understanding of the dysregulated vascular biology pathways in SCD provides a basis for new clinical trials investigating promising targeted therapeutics...
  2. ncbi request reprint Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study
    Miguel R Abboud
    Department of Pediatrics, Medical University of South Carolina, Charleston, USA
    Blood 103:2822-6. 2004
    ..Furthermore, patients with abnormal MRA findings and higher TCD velocities are at higher risk for stroke, and their cerebral TAMVs are unlikely to decrease without transfusion...
  3. pmc Discontinuing prophylactic transfusions increases the risk of silent brain infarction in children with sickle cell disease: data from STOP II
    Miguel R Abboud
    American University of Beirut Medical Center, Beirut, Lebanon
    Blood 118:894-8. 2011
    ..Together with data from STOP, these findings demonstrate that transfusions prevent the development of silent infarcts in patients with SCD and abnormal TCD but normal MRA...
  4. ncbi request reprint Prevention and management of strokes in patients with sickle cell disease
    Miguel R Abboud
    Children s Cancer Center of Lebanon, American University of Beirut Medical Center, P O Box 11 0236 Riad El Solh, Beirut 1107 2020, Lebanon
    Curr Hematol Rep 5:15-22. 2006
    ..Moreover, the development of alternatives to chronic transfusions, such as hydroxyurea and other pharmacologic therapies, may also improve the outlook for patients at high risk for stroke...
  5. doi request reprint Implementation of an intensive risk-stratified treatment protocol for children and adolescents with acute lymphoblastic leukemia in Lebanon
    Samar Muwakkit
    Department of Pediatrics and Adolescent Medicine, Children s Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    Am J Hematol 87:678-83. 2012
    ..Children treated on this protocol experienced significant toxicity necessitating expert supportive care, but benefited from improved cure rates and prolonged survival...
  6. doi request reprint Pulmonary hypertension in children and young adults with sickle cell disease: evidence for familial clustering
    Hanane A Dahoui
    Children s Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    Pediatr Blood Cancer 54:398-402. 2010
    ..Our objective was to determine the prevalence of PHTN and identify factors associated with PHTN among children and young adults with SCD in Lebanon...
  7. ncbi request reprint Radiographic predictors of neurocognitive functioning in pediatric Sickle Cell disease
    Mary C Kral
    Department of Pediatrics, Medical University of South Carolina, Charleston, 29425, USA
    J Child Neurol 21:37-44. 2006
    ..We found an association between low hemoglobin and neurocognitive impairment. We also found that abnormalities on transcranial Doppler ultrasonography can herald subtle neurocognitive deficits. (J Child Neurol 2006;21:37-44)...
  8. ncbi request reprint Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma
    Karim Z Masrouha
    Department of Surgery, American University of Beirut Medical Center, PO Box 11 0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon
    Skeletal Radiol 41:1453-61. 2012
    ....
  9. doi request reprint Effect of chronic transfusion therapy on progression of neurovascular pathology in pediatric patients with sickle cell anemia
    Sarah Bishop
    Department of Pediatrics, Medical University of South Carolina, Charleston, USA
    Blood Cells Mol Dis 47:125-8. 2011
    ..Chronic blood transfusion (CBT) is currently the standard of care for primary and secondary stroke prevention in children with sickle cell anemia (SCA). However, the effect of CBT on cerebrovascular pathology is not well known...
  10. doi request reprint Severe cerebral vaso-occlusive disease in macrophage activation syndrome
    Mohamad K El-Bitar
    Division of Pediatric Neurology and Pediatric Epilepsy Program, Department of Pediatrics, American University of Beirut Medical Center, 2020l Beirut, Lebanon
    Pediatr Neurol 42:283-6. 2010
    ..To our knowledge, this description is the first of these findings in association with macrophage activation syndrome...
  11. doi request reprint Venous sinus thrombosis leading to stroke in a patient with sickle cell disease on hydroxyurea and high hemoglobin levels: treatment with thrombolysis
    Charif A Sidani
    Department of Radiology, American University of Beirut Medical Center, Beirut, Lebanon
    Am J Hematol 83:818-20. 2008
    ..One year later he developed symptomatic avascular necrosis of the right hip. High hemoglobin levels resulting from hydroxyurea therapy may have contributed to development of complications in this patient...
  12. doi request reprint NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon
    Nathalie K Zgheib
    Department of Pharmacology and Toxicology, American University of Beirut, Faculty of Medicine, Beirut, Lebanon
    Pediatr Blood Cancer 64:146-150. 2017
    ..415C>T low-function variant that is associated with decreased thiopurine metabolism and leukopenia in childhood acute lymphoblastic leukemia (ALL) and other diseases...
  13. doi request reprint Thrombosis in children with acute lymphoblastic leukemia treated at a tertiary care center in Lebanon: revisiting the role of predictive models
    Carol Al-Aridi
    Department of Pediatrics, Children s Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    Pediatr Hematol Oncol 28:676-81. 2011
    ..The authors also examine necessary modifications in a recently published model before it could predict VTE in their patients...
  14. doi request reprint Safety and efficacy of high dose intravenous desferrioxamine for reduction of iron overload in sickle cell disease
    Ram Kalpatthi
    Division of Pediatric Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina, USA
    Pediatr Blood Cancer 55:1338-42. 2010
    ..Intravenous (IV) infusions of high dose DFO have been utilized in non-compliant patients with heavy iron overload in small case series...
  15. ncbi request reprint Transcranial Doppler ultrasonography and neurocognitive functioning in children with sickle cell disease
    Mary C Kral
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pediatrics 112:324-31. 2003
    ..We examined the relationship between cerebral blood flow velocity, measured by transcranial Doppler (TCD) ultrasonography, and neurocognitive functioning...
  16. doi request reprint Iron deficiency in young Lebanese children: association with elevated blood lead levels
    Samar Muwakkit
    Department of Pediatrics, Division of Hematology Oncology, American University of Beirut Medical Center, Beirut, Lebanon
    J Pediatr Hematol Oncol 30:382-6. 2008
    ..To measure the prevalence of transferrin saturation (TS) <12%, and iron-deficiency anemia (IDA) in Lebanese children, and their association with dietary habits, sociodemographic characteristics, and blood lead levels...
  17. doi request reprint Limb salvage surgery for children and adolescents with malignant bone tumors in a developing country
    Rachid Haidar
    Children s Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    Pediatr Blood Cancer 51:787-91. 2008
    ..To describe the 5-year experience of a multidisciplinary limb salvage program for children and adolescents with malignant bone tumors in Lebanon...
  18. doi request reprint Effect of Malnutrition at Diagnosis on Clinical Outcomes of Children With Acute Lymphoblastic Leukemia
    Nadine Yazbeck
    Department of Pediatrics and Adolescent Medicine, Children s Cancer Institute of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    J Pediatr Hematol Oncol 38:107-10. 2016
    ....
  19. doi request reprint Alpha thalassemia allelic frequency in Lebanon
    Chantal Farra
    Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Pediatr Blood Cancer 62:120-2. 2015
    ..It is well established that Mediterranean and Arab countries are high risk areas for thalassemia in general, and for alpha thalassemia in particular. Reports of alpha thalassemia gene mutations from the Lebanese population are limited...
  20. doi request reprint Pulmonary complications of sickle cell disease
    Ruby A Khoury
    Children s Cancer Centre of Lebanon, Department of Paediatrics and Adolescent Medicine, American University of Beirut, Medical Centre, Beirut, Lebanon
    Hemoglobin 35:625-35. 2011
    ..Asthma is also commonly seen in patients with sickle cell disease and is associated with a more complicated course. Chronic lung disease develops in a significant proportion of patients with sickle cell disease...
  21. ncbi request reprint Moyamoya syndrome in childhood sickle cell disease: a predictive factor for recurrent cerebrovascular events
    Scott R Dobson
    Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA
    Blood 99:3144-50. 2002
    ....
  22. doi request reprint Familial infantile pyknocytosis in association with pulmonary hypertension
    Hanane A Dahoui
    Children s Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    Pediatr Blood Cancer 51:290-2. 2008
    ..He died at 39 days from sepsis. The findings support a possible autosomal recessive inheritance. We hypothesize that pulmonary hypertension may be secondary to or aggravated by neonatal hemolysis...
  23. doi request reprint Renal venous thrombosis in a newborn with prothrombotic risk factors
    Samar A Muwakkit
    Division of Hematology Oncology, American University of Beirut Medical Center, Beirut, Lebanon
    Blood Coagul Fibrinolysis 20:458-60. 2009
    ..This case and other studies clearly demonstrate that neonatal RVT should be evaluated for thrombophilia conditions...
  24. doi request reprint Seven-year experience of using Repiphysis expandable prosthesis in children with bone tumors
    Said Saghieh
    Children s Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    Pediatr Blood Cancer 55:457-63. 2010
    ..Results of the use of the non-invasive expandable endoprosthetic device Repiphysis in limb salvage surgery for skeletally immature children with bone cancer have been promising...
  25. doi request reprint Bereaved parental evaluation of the quality of a palliative care program in Lebanon
    Rima Saad
    Children s Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    Pediatr Blood Cancer 57:310-6. 2011
    ..This study aimed at evaluating the quality of care provided to children with cancer at the Children's Cancer Center of Lebanon (CCCL) during their last month of life as perceived by the bereaved parents...
  26. doi request reprint Morvan syndrome following B-cell lymphoma
    Mohamad K El-Bitar
    Division of Pediatric Neurology Pediatric Epilepsy Program, Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon
    J Child Neurol 25:1038-41. 2010
    ..He achieved complete remission following 7 consecutive, monthly intravenous immunoglobulin injections. The present case is described in the context of the available literature...
  27. ncbi request reprint Primary malignant peripheral nerve sheath tumor of the lung in a young child without neurofibromatosis type 1
    Samar A Muwakkit
    Children s Cancer Center of Lebanon, American University of Beirut, Beirut, Lebanon, and Department of Hematology and Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Pediatr Blood Cancer 47:636-8. 2006
    ..MPNST of the lung has similar clinical and radiologic characteristics as pleuropulmonary blastoma. We suggest to include MPNST of the lung in the differential diagnosis of intrapulmonary masses in children...
  28. doi request reprint Acute lymphoblastic leukemia in low and middle-income countries: disease characteristics and treatment results
    Miguel R Abboud
    Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Curr Opin Oncol 26:650-5. 2014
    ..We will review the current state of the treatment of acute lymphoblastic leukemia in low-income and medium-income countries...
  29. doi request reprint Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia
    Nathalie K Zgheib
    aDepartment of Pharmacology and Toxicology, American University of Beirut bDepartment of Pediatrics and Adolescent Medicine, Children s Cancer Center of Lebanon cDepartment of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Pharmacogenet Genomics 24:387-96. 2014
    ....
  30. ncbi request reprint Renal kallikrein: a risk marker for nephropathy in children with sickle cell disease
    Shayla Bergmann
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pediatr Hematol Oncol 28:147-53. 2006
    ..The mechanisms or factors that promote SCN are not fully elucidated. In the present study, the role of renal kallikrein as a risk marker for promoting SCN was explored in a cross-sectional study...
  31. doi request reprint Cerebral infarction in children with sickle cell disease: a concise overview
    Khaled M Musallam
    Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Hemoglobin 35:618-24. 2011
    ..In this article we overview the current knowledge of cerebral infarction in this patient population and discuss recent updates on the role of preventive intervention...
  32. doi request reprint Stem-cell transplantation in children and adults with sickle cell disease: an update
    Ruby Khoury
    Children s Cancer Center of Lebanon, Department of Pediatrics and Adolescent Medicine, American University of Beirut, Medical Center, Beirut, Lebanon
    Expert Rev Hematol 4:343-51. 2011
    ..The main limitation of HSCT in both adults and children with SCD remains the lack of availability of fully matched HLA sibling donors for patients meeting transplant criteria...
  33. ncbi request reprint Spontaneous splenic rupture in a patient with factor XIII deficiency and a novel mutation
    Hassan Khalife
    Children s Cancer Center of Lebanon and Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon
    Pediatr Blood Cancer 50:113-4. 2008
    ..The child had severe deficiency with two episodes of intracerebral hemorrhage. He also developed spontaneous splenic rupture, an unusual complication of this disorder...
  34. ncbi request reprint Clinical presentation and treatment outcome of children with Burkitt lymphoma in Lebanon: a single institution's experience
    Samar A Muwakkit
    Children s Cancer Center of Lebanon, American University of Beirut, Lebanon
    J Pediatr Hematol Oncol 26:749-53. 2004
    ..If confirmed in a larger series of patients, this study could have a major impact on the treatment of Burkitt lymphoma in Lebanon and other countries with limited resources...
  35. ncbi request reprint Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP study
    Robert J Adams
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Blood 103:3689-94. 2004
    ..Substantial differences in the probability of conversion to abnormal TCD were observed, with younger children and those with higher velocity more likely to have an abnormal TCD with rescreening...
  36. ncbi request reprint Sickle cell anaemia: epidemiology and cost of illness
    Paul J Nietert
    Center for Health Care Research and Department of Medicine, Medical University of South Carolina, 29425, USA corrected
    Pharmacoeconomics 20:357-66. 2002
    ..As new diagnostic methods and treatment options become available, balancing costs associated with SCA and quality of healthcare will continue to present challenges to many healthcare providers and insurers...
  37. ncbi request reprint Liver biopsy results in patients with sickle cell disease on chronic transfusions: poor correlation with ferritin levels
    Lina B Karam
    Department of Pediatric Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Pediatr Blood Cancer 50:62-5. 2008
    ..The aim of this study was to determine whether serum ferritin levels correlated with liver iron content in sickle cell patients on chronic transfusion...
  38. doi request reprint Chemical and functional analysis of generic hydroxyurea formulations
    Virginia L Harrod
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Hematol Oncol 25:423-9. 2008
    ..Generic hydroxyurea formulations represent a potent yet inexpensive therapeutic option for children with SCA worldwide...