Benoit Le Goff

Summary

Publications

  1. ncbi request reprint Ultrasound assessment of the posterior sacroiliac ligaments
    Benoit Le Goff
    Hotel Dieu, Nantes University Hospital, Nantes, France
    Clin Exp Rheumatol 29:1014-7. 2011
  2. ncbi request reprint Pharmacodynamics of bisphosphonates in arthritis
    Benoit Le Goff
    INSERM UMR S957, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
    Expert Rev Clin Pharmacol 4:633-41. 2011
  3. doi request reprint Role for interleukin-6 in structural joint damage and systemic bone loss in rheumatoid arthritis
    Benoit Le Goff
    Service de Rhumatologie, Hotel Dieu, 1, Place Alexis Ricordeau, 44093 Nantes Cedex 1, France
    Joint Bone Spine 77:201-5. 2010
  4. ncbi request reprint A comparison between bisphosphonates and other treatments for osteoporosis
    B Le Goff
    INSERM U957, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Nantes, France
    Curr Pharm Des 16:3037-44. 2010
  5. pmc A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis
    Benoit Le Goff
    INSERM UMR S 957, 1 rue Gaston Veil, 44035, Nantes Cedex 1, France
    Arthritis Res Ther 11:R185. 2009
  6. doi request reprint Six-month response to anti-TNF drugs in axial spondylarthropathy according to the fulfillment or not of New-York criteria for ankylosing spondylitis or French recommendations for anti-TNF use. A "real life" retrospective study on 175 patients
    Stephanie Gerard
    Rheumatology Unit, Nantes University Hospital CHU Nantes, Place Alexis Ricordeau, 44093, Nantes Cedex 01, France
    Joint Bone Spine 75:680-7. 2008
  7. doi request reprint Feasibility and safety of ultrasound-guided caudal epidural glucocorticoid injections
    Anne Blanchais
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, Nantes Cedex 1, France
    Joint Bone Spine 77:440-4. 2010
  8. doi request reprint Randomised study versus control group of customised therapeutic education for patients in follow-up for rheumatoid arthritis
    Marianne Pot-Vaucel
    Nantes University Hospital, 1, Place Alexis Ricordeau, 44093 Nantes Cedex, France
    Joint Bone Spine 83:199-206. 2016
  9. doi request reprint Osteoclasts in RA: diverse origins and functions
    Benoit Le Goff
    Service de Rhumatologie, Hotel Dieu, 1, Place Alexis Ricordeau, 44093 Nantes Cedex 1, France LUNAM Université, 44000 Nantes, France INSERM, UMR957, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, 44035 Nantes, France Université de NANTES, Nantes Atlantique Universites, 44035 Nantes, France Electronic address
    Joint Bone Spine 80:586-91. 2013
  10. doi request reprint Bone Morphogenetic Protein 2 and Transforming Growth Factor β1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts
    Marguerite Chemel
    French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Universite de Nantes, Nantes, France Musculoskeletal Department, Nantes University Hospital, Nantes, France
    Am J Pathol 187:156-162. 2017

Collaborators

  • Yves Maugars
  • Jean Marie Berthelot
  • Dominique Heymann
  • Frederic Blanchard
  • Catherine Ansquer
  • Pierre Youinou
  • Christelle Darrieutort-Laffite
  • Pascale Guillot
  • Joëlle Glemarec
  • Anne Blanchais
  • Geraldine Bart
  • Marianne Pot-Vaucel
  • Marguerite Chemel
  • Aurélie Najm
  • Lucie Planche
  • Régis Brion
  • Olivier Hamel
  • Mélanie Penhoat
  • Oriane Mérot
  • Vincent André
  • Stephanie Gerard
  • Marie Françoise Heymann
  • Audrey Lamora
  • Bénédicte Brulin
  • Celine Charrier
  • Franck Verrecchia
  • Aude Isabelle Segaliny
  • Elise Soltner-Neel
  • David Boutoille
  • Hubert Desal
  • Marie Pierre Aubert
  • Herve Redon
  • Françoise Bodere
  • Peggy Augereau
  • Marie Astrid Boutet
  • Mathias Chatelais
  • Alain Saraux
  • Christophe Leux
  • Anne Maëlle Fontenoy
  • Jacques Paineau
  • Severine Battaglia
  • Anne Riet

Detail Information

Publications35

  1. ncbi request reprint Ultrasound assessment of the posterior sacroiliac ligaments
    Benoit Le Goff
    Hotel Dieu, Nantes University Hospital, Nantes, France
    Clin Exp Rheumatol 29:1014-7. 2011
    ..They are recognised as a potential source of aspecific low back pain or peripartum pelvic pain. The aim of this study was to assess the characteristics of these ligaments using high resolution ultrasonography (HRUS)...
  2. ncbi request reprint Pharmacodynamics of bisphosphonates in arthritis
    Benoit Le Goff
    INSERM UMR S957, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
    Expert Rev Clin Pharmacol 4:633-41. 2011
    ..If their indication in the prevention of glucocorticoid-induced osteoporosis is clear, any beneficial effects on bone erosions are still controversial but interesting preliminary results warrant further investigations...
  3. doi request reprint Role for interleukin-6 in structural joint damage and systemic bone loss in rheumatoid arthritis
    Benoit Le Goff
    Service de Rhumatologie, Hotel Dieu, 1, Place Alexis Ricordeau, 44093 Nantes Cedex 1, France
    Joint Bone Spine 77:201-5. 2010
    ..Thus, in patients with RA, blocking IL-6 may be effective both in diminishing the inflammatory manifestations and in preventing the bone complications of the disease...
  4. ncbi request reprint A comparison between bisphosphonates and other treatments for osteoporosis
    B Le Goff
    INSERM U957, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Nantes, France
    Curr Pharm Des 16:3037-44. 2010
    ..This review gives an overview of the recent data on the efficacity and tolerance of bisphosphonates in the different forms of osteoporosis and compares them to the other treatments currently available...
  5. pmc A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis
    Benoit Le Goff
    INSERM UMR S 957, 1 rue Gaston Veil, 44035, Nantes Cedex 1, France
    Arthritis Res Ther 11:R185. 2009
    ..We hypothesized that MTX and ZA could have an additive effect to prevent both bone erosion and systemic bone loss...
  6. doi request reprint Six-month response to anti-TNF drugs in axial spondylarthropathy according to the fulfillment or not of New-York criteria for ankylosing spondylitis or French recommendations for anti-TNF use. A "real life" retrospective study on 175 patients
    Stephanie Gerard
    Rheumatology Unit, Nantes University Hospital CHU Nantes, Place Alexis Ricordeau, 44093, Nantes Cedex 01, France
    Joint Bone Spine 75:680-7. 2008
    ....
  7. doi request reprint Feasibility and safety of ultrasound-guided caudal epidural glucocorticoid injections
    Anne Blanchais
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, Nantes Cedex 1, France
    Joint Bone Spine 77:440-4. 2010
    ..To assess the feasibility and safety of caudal epidural glucocorticoid injections performed with ultrasound guidance...
  8. doi request reprint Randomised study versus control group of customised therapeutic education for patients in follow-up for rheumatoid arthritis
    Marianne Pot-Vaucel
    Nantes University Hospital, 1, Place Alexis Ricordeau, 44093 Nantes Cedex, France
    Joint Bone Spine 83:199-206. 2016
    ..We have evaluated customized objectives, predefined during a therapeutic education session for rheumatoid arthritis (RA)...
  9. doi request reprint Osteoclasts in RA: diverse origins and functions
    Benoit Le Goff
    Service de Rhumatologie, Hotel Dieu, 1, Place Alexis Ricordeau, 44093 Nantes Cedex 1, France LUNAM Université, 44000 Nantes, France INSERM, UMR957, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, 44035 Nantes, France Université de NANTES, Nantes Atlantique Universites, 44035 Nantes, France Electronic address
    Joint Bone Spine 80:586-91. 2013
    ..Research into these interactions may identify new targets for treatments against the bone abnormalities associated with chronic inflammatory disease. ..
  10. doi request reprint Bone Morphogenetic Protein 2 and Transforming Growth Factor β1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts
    Marguerite Chemel
    French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Universite de Nantes, Nantes, France Musculoskeletal Department, Nantes University Hospital, Nantes, France
    Am J Pathol 187:156-162. 2017
    ..This work identifies TGF-β1 and BMP-2 as potent inhibitors of IL-34 expression in RA synovial fibroblasts. These cytokines, as upstream inhibitors of IL-34, may thus contribute to antagonize inflammation and bone erosions in RA...
  11. pmc Is There an Association Between Magnetic Resonance Imaging and Neurological Signs in Patients With Vertebral Osteomyelitis?: A Retrospective Observational Study on 121 Patients
    Geraldine Bart
    From the Rheumatology Unit, Hotel Dieu, Nantes University Hospital, Nantes, France GB, YM, BLG Radiology Department, IRIS, Nantes, France HR Infectious Diseases Unit, Hotel Dieu, Nantes University Hospital, Nantes, France DB Neurosurgery Unit, Hotel Dieu, Nantes University Hospital, Nantes, France OH and Biometrics and Biostatistic Platform, Hotel Dieu, Nantes University Hospital, Nantes, France LP
    Medicine (Baltimore) 95:e2373. 2016
    ..Cervical involvement, vertebral destruction, angular kyphosis, dural compression, effacement of subarachnoid space and compressive myelopathy on MRI were risk factors associated with neurological complications. ..
  12. doi request reprint Outcome and safety of TNFα antagonist therapy in 475 consecutive outpatients (with rheumatoid arthritis or spondyloarthropathies) treated by a single physician according to their eligibility for clinical trials
    Jean Marie Berthelot
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, 44093 Nantes Cedex 01, France
    Joint Bone Spine 77:564-9. 2010
    ....
  13. doi request reprint Weekly home self-assessment of RAPID-4/3 scores in rheumatoid arthritis: a 6-month study in 26 patients
    Anne Blanchais
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, 44093 Nantes Cedex 01, France
    Joint Bone Spine 77:582-7. 2010
    ....
  14. doi request reprint Information on glucocorticoid therapy in the main studies of biological agents
    Vincent André
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Joint Bone Spine 78:478-83. 2011
    ..To evaluate reported information on prednisone therapy in the main studies of biological agents used to treat rheumatoid arthritis (RA)...
  15. pmc Cystic angiomatosis, a heterogeneous condition: Four new cases and a literature review
    Aurélie Najm
    Rheumatology Department, Pôle Hospitalo Universitaire 4, Hopital Hotel Dieu, Centre Hospitalo Universitaire de Nantes, Nantes Cedex 1, France
    Medicine (Baltimore) 95:e5213. 2016
    ..These 2 conditions also differ in terms of their location, visceral involvement, and response to treatment...
  16. doi request reprint Sodium (18)F-sodium fluoride PET failed to predict responses to TNFα antagonist therapy in 31 patients with possible spondyloarthritis not meeting ASAS criteria
    Christelle Darrieutort-Laffite
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, 1, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Joint Bone Spine 82:411-6. 2015
    ..To determine whether (18)F-NaF positron-emission tomography (PET) contributes to the diagnosis of spondyloarthritis and whether observed uptakes predict the response to TNFα antagonist therapy...
  17. doi request reprint Usefulness of a pre-procedure ultrasound scanning of the lumbar spine before epidural injection in patients with a presumed difficult puncture: A randomized controlled trial
    Christelle Darrieutort-Laffite
    Rheumatology Unit, Hotel Dieu, 1, Place Alexis Ricordeau, 44093 Nantes Cedex 1, France Electronic address
    Joint Bone Spine 82:356-61. 2015
    ..The purpose of the study was to determine if the selection of the optimum puncture level by US may facilitate epidural steroid injection in case of presumed difficult puncture (BMI>30 kg/m(2), age>60 years or lumbar scoliosis)...
  18. pmc IL-1β and TNFα promote monocyte viability through the induction of GM-CSF expression by rheumatoid arthritis synovial fibroblasts
    Christelle Darrieutort-Laffite
    INSERM, UMR 957, 44035 Nantes, France Rheumatology Unit, Nantes University Hospital, 44093 Nantes, France Université de NANTES, Nantes Atlantique Universites, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculte de Medecine, 44035 Nantes, France
    Mediators Inflamm 2014:241840. 2014
    ..SF could be a source of cytokines and growth factors driving macrophages survival and activation. Here, we studied the effect of SF on monocyte viability and phenotype...
  19. doi request reprint Pathogenesis of hyperostosis: a key role for mesenchymatous cells?
    Jean Marie Berthelot
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, 44093, Nantes Cedex 01, France Electronic address
    Joint Bone Spine 80:592-6. 2013
    ..These cells normally exert immunosuppressive effects, which may be subverted in spondyloarthritis, notably by a T-cell population that homes specifically to the entheses. ..
  20. doi request reprint Side effects of corticosteroid injections: what's new?
    Jean Marie Berthelot
    Department of Rheumatology, Hotel Dieu, Place Alexis Ricordeau, Nantes University Hospital Center, 44093 Nantes, France
    Joint Bone Spine 80:363-7. 2013
    ..Dexamethasone-based preparations seem to contain no particles or crystals, and have not induced any neurological accidents in various animal models, even after direct administration into vertebral or carotid arteries...
  21. doi request reprint Assessment of calcific tendonitis of rotator cuff by ultrasonography: comparison between symptomatic and asymptomatic shoulders
    Benoit Le Goff
    Rheumatology Unit, Hotel Dieu, Nantes University Hospital, Nantes, France
    Joint Bone Spine 77:258-63. 2010
    ..We looked for differences on ultrasound (US) and power Doppler findings between symptomatic and asymptomatic cases of shoulder calcific tendonitis...
  22. doi request reprint Thymic Hassall's corpuscles, regulatory T-cells, and rheumatoid arthritis
    Jean Marie Berthelot
    Rheumatology Unit, Nantes University Hospital, Nantes, France
    Semin Arthritis Rheum 39:347-55. 2010
    ..To review evidence for the involvement of thymic Hassall's corpuscles (HC) in the pathogenesis of rheumatoid arthritis (RA)...
  23. doi request reprint Ultrasonography for diagnosing atypical gout. Two case reports
    Benoit Le Goff
    CHU de Nantes, Service de Rhumatologie, 1 Place Alexis Ricordeau, 44093 Nantes Cedex 1, France
    Joint Bone Spine 75:610-2. 2008
    ..In addition, ultrasonography was useful for guided aspiration of joint fluid or other material containing monosodium urate crystals. Thus, ultrasonography may contribute to improve the diagnosis and treatment of gout...
  24. doi request reprint Detection of a lumbar foraminal venous varix by Color Doppler Ultrasound
    Christelle Darrieutort-Laffite
    Rheumatology Unit, Nantes University Hospital, Hotel Dieu, 1, Place Alexis Ricordeau, 44093 Nantes Cedex 1, France Electronic address
    Joint Bone Spine 83:451-2. 2016
    ..We showed for the first time that Color Doppler Ultrasound can detect venous malformation of the spine. This imaging modality could help us in the diagnosis of atypical lesions of the spine to confirm their vascular origin. ..
  25. doi request reprint NETosis: At the crossroads of rheumatoid arthritis, lupus, and vasculitis
    Jean Marie Berthelot
    Rheumatology Unit, Nantes University Hospital, CHU Nantes, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France Electronic address
    Joint Bone Spine . 2016
    ..Inhibiting NETois may not be sufficient to improve autoimmune disorders whereas such latent infections remain uncontrolled...
  26. doi request reprint Strong opioids for noncancer pain due to musculoskeletal diseases: Not more effective than acetaminophen or NSAIDs
    Jean Marie Berthelot
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France Electronic address
    Joint Bone Spine 82:397-401. 2015
    ..Healthcare providers often overestimate the efficacy of step III analgesics, despite pain score decreases of only 0.8 to 1.2 points. ..
  27. doi request reprint Essential role for CD103+ cells in the pathogenesis of spondyloarthritides
    Jean Marie Berthelot
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, 44093 Nantes Cedex 01, France Electronic address
    Joint Bone Spine 82:8-12. 2015
    ..The sensitivity of these diseases to retinoids further supports a pathogenic role for transient CD103+ cell failure. ..
  28. doi request reprint High pain catastrophizing scores in one-fourth of patients on biotherapy for spondylarthritis or rheumatoid arthritis
    Mélanie Penhoat
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, 44093 Nantes Cedex 01, France
    Joint Bone Spine 81:235-9. 2014
    ..To measure catastrophizing scores in patients on biotherapy for spondyloarthritis (SpA) or rheumatoid arthritis (RA)...
  29. doi request reprint Ultrasonography of the lumbar spine: sonoanatomy and practical applications
    Christelle Darrieutort-Laffite
    Service de Rhumatologie, Hotel Dieu, 1, Place Alexis Ricordeau, 44093 Nantes Cedex, France
    Joint Bone Spine 81:130-6. 2014
    ....
  30. doi request reprint Three-dimensional versus two-dimensional ultrasonographic assessment of peripheral enthesitis in spondylarthritis
    Oriane Mérot
    Rheumatology Unit, Hotel Dieu, Nantes University Hospital, 1 Place Alexis Ricordeau, 44095, Nantes, France
    Clin Rheumatol 33:131-5. 2014
    ..001). 3D US showed good intra- and interobserver reliability in the assessment of enthesitis in SpA and shortened the needed time for scanning. It can be performed by a nonexperienced examiner without loss of reliability. ..
  31. doi request reprint Evidence supporting a role for dormant bacteria in the pathogenesis of spondylarthritis
    Jean Marie Berthelot
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Joint Bone Spine 80:135-40. 2013
    ..TNFα antagonists rarely reactivate dormant bacteria, with the exception of Mycobacterium tuberculosis, which, together with metastatic cells, is the most extensively studied latency model to date...
  32. doi request reprint Regulatory B cells play a key role in immune system balance
    Jean Marie Berthelot
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Joint Bone Spine 80:18-22. 2013
    ..Research into the interactions between the gut microbiota and Bregs holds considerable promise...
  33. doi request reprint High intraindividual week-to-week variability in BASDAI and BASFI values: are several evaluations needed before starting or stopping TNFalpha antagonist therapy for spondyloarthropathies?
    Jean Marie Berthelot
    Hôtel Dieu Teaching Hospital, Nantes, France
    Joint Bone Spine 75:167-71. 2008
    ..To evaluate intraindividual variability of the BASDAI, BASFI, and HAQ in patients with spondyloarthropathies...
  34. doi request reprint Rheumatoid arthritis and periodontal disease
    Jean Marie Berthelot
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Joint Bone Spine 77:537-41. 2010
    ..g., scaling, root planing and, if needed, dental surgery), particularly as periodontitis is also associated with an increased risk of premature atheroma...
  35. doi request reprint OPG, RANK and RANK ligand expression in thyroid lesions
    Marie Françoise Heymann
    INSERM, ERI 7, Nantes, F 44035, France
    Regul Pept 148:46-53. 2008
    ..Thus OPG/RANK/RANKL molecular triad might play a role during pathogenesis of follicular and parafollicular tumors...