Moses Laman

Summary

Publications

  1. doi request reprint Ultrasonographic assessment of splenic volume at presentation and after anti-malarial therapy in children with malarial anaemia
    Moses Laman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle, 6959, WA, Australia
    Malar J 14:219. 2015
  2. pmc Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea
    Moses Laman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    BMC Infect Dis 14:630. 2014
  3. pmc Artemether-lumefantrine versus artemisinin-naphthoquine in Papua New Guinean children with uncomplicated malaria: a six months post-treatment follow-up study
    Moses Laman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle, 6959, WA, Australia
    Malar J 14:121. 2015
  4. pmc Ethical challenges in integrating patient-care with clinical research in a resource-limited setting: perspectives from Papua New Guinea
    Moses Laman
    Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea
    BMC Med Ethics 14:29. 2013
  5. pmc Rapid antigen detection tests for malaria diagnosis in severely ill Papua New Guinean children: a comparative study using Bayesian latent class models
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    PLoS ONE 7:e48701. 2012
  6. pmc Predictors of acute bacterial meningitis in children from a malaria-endemic area of Papua New Guinea
    Moses Laman
    Papua New Guinea Institute of Medical Research, Madang and Goroka, Papua New Guinea
    Am J Trop Med Hyg 86:240-5. 2012
  7. pmc Severe anemia in Papua New Guinean children from a malaria-endemic area: a case-control etiologic study
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    PLoS Negl Trop Dis 6:e1972. 2012
  8. doi request reprint Gametocyte Clearance Kinetics Determined by Quantitative Magnetic Fractionation in Melanesian Children with Uncomplicated Malaria Treated with Artemisinin Combination Therapy
    Stephan Karl
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia Infection and Immunity Division, Walter and Eliza Hall Institute, Parkville, Victoria, Australia Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia
    Antimicrob Agents Chemother 59:4489-96. 2015
  9. pmc A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum/Plasmodium vivax infections
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle 6959, Western Australia, Australia
    Malar J 11:107. 2012
  10. pmc Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial
    Moses Laman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea
    PLoS Med 11:e1001773. 2014

Collaborators

Detail Information

Publications29

  1. doi request reprint Ultrasonographic assessment of splenic volume at presentation and after anti-malarial therapy in children with malarial anaemia
    Moses Laman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle, 6959, WA, Australia
    Malar J 14:219. 2015
    ..Few cross-sectional and no longitudinal studies have assessed the relationship between splenic volume measured ultrasonographically and haemoglobin concentrations in children with malaria...
  2. pmc Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea
    Moses Laman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    BMC Infect Dis 14:630. 2014
    ....
  3. pmc Artemether-lumefantrine versus artemisinin-naphthoquine in Papua New Guinean children with uncomplicated malaria: a six months post-treatment follow-up study
    Moses Laman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle, 6959, WA, Australia
    Malar J 14:121. 2015
    ....
  4. pmc Ethical challenges in integrating patient-care with clinical research in a resource-limited setting: perspectives from Papua New Guinea
    Moses Laman
    Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea
    BMC Med Ethics 14:29. 2013
    ..In this article, we discuss the ethical implications of such approach with perspectives from Papua New Guinea...
  5. pmc Rapid antigen detection tests for malaria diagnosis in severely ill Papua New Guinean children: a comparative study using Bayesian latent class models
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    PLoS ONE 7:e48701. 2012
    ..vivax...
  6. pmc Predictors of acute bacterial meningitis in children from a malaria-endemic area of Papua New Guinea
    Moses Laman
    Papua New Guinea Institute of Medical Research, Madang and Goroka, Papua New Guinea
    Am J Trop Med Hyg 86:240-5. 2012
    ..04). In young children, a bulging fontanel added to the model (P < 0.001). Simple clinical features predict ABM in children in Papua New Guinea but malaria microscopy augments diagnostic precision...
  7. pmc Severe anemia in Papua New Guinean children from a malaria-endemic area: a case-control etiologic study
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    PLoS Negl Trop Dis 6:e1972. 2012
    ..There are few detailed etiologic studies of severe anemia in children from malaria-endemic areas and none in those countries with holoendemic transmission of multiple Plasmodium species...
  8. doi request reprint Gametocyte Clearance Kinetics Determined by Quantitative Magnetic Fractionation in Melanesian Children with Uncomplicated Malaria Treated with Artemisinin Combination Therapy
    Stephan Karl
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia Infection and Immunity Division, Walter and Eliza Hall Institute, Parkville, Victoria, Australia Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia
    Antimicrob Agents Chemother 59:4489-96. 2015
    ..falciparum transmission by 4 days relative to artemether-lumefantrine, but the longer elimination half-life of naphthoquine than of lumefantrine suppresses P. vivax recurrence and consequent gametocytemia. ..
  9. pmc A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum/Plasmodium vivax infections
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle 6959, Western Australia, Australia
    Malar J 11:107. 2012
    ..No P. vivax DNA was detected. These findings do not support the hypothesis that P. vivax sequestration occurs in human brain...
  10. pmc Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial
    Moses Laman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea
    PLoS Med 11:e1001773. 2014
    ..In this study, the efficacy, tolerability, and safety of these ACTs were assessed in PNG children aged 0.5-5 y...
  11. pmc Subacute sclerosing panencephalitis in papua new guinean children: the cost of continuing inadequate measles vaccine coverage
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    PLoS Negl Trop Dis 5:e932. 2011
    ..We report a series of 22 SSPE cases presenting between November 2007 and July 2009 in Madang Province, PNG, including localized clusters with the highest ever reported annual incidence...
  12. pmc Comparison of an assumed versus measured leucocyte count in parasite density calculations in Papua New Guinean children with uncomplicated malaria
    Moses Laman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle 6959, Western Australia, Australia
    Malar J 13:145. 2014
    ....
  13. doi request reprint γδ T cells and CD14+ monocytes are predominant cellular sources of cytokines and chemokines associated with severe malaria
    Danielle I Stanisic
    Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Victoria, Australia Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    J Infect Dis 210:295-305. 2014
    ..Severe malaria (SM) is associated with high levels of cytokines such as tumor necrosis factor (TNF), interleukin 1 (IL-1), and interleukin 6 (IL-6). The role of chemokines is less clear, as is their cellular source...
  14. pmc Features and prognosis of severe malaria caused by Plasmodium falciparum, Plasmodium vivax and mixed Plasmodium species in Papua New Guinean children
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    PLoS ONE 6:e29203. 2011
    ..The features and prognosis of mixed Plasmodium species infections are poorly characterized. Detailed prospective studies that include accurate malaria diagnosis and detection of co-morbidities are lacking...
  15. pmc Meningeal inflammation increases artemether concentrations in cerebrospinal fluid in Papua New Guinean children treated with intramuscular artemether
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Antimicrob Agents Chemother 55:5027-33. 2011
    ..These data suggest that pharmacovigilance should be heightened when intramuscular artemether is given to severely ill children with evidence of meningeal inflammation...
  16. pmc Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea
    Tamarah Koleala
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    Malar J 14:37. 2015
    ....
  17. doi request reprint Accuracy of initial clinical diagnosis of acute bacterial meningitis in children from a malaria-endemic area of Papua New Guinea
    Jimmy Aipit
    Modilon General Hospital, Paediatrics Unit, Madang, Papua New Guinea
    Trans R Soc Trop Med Hyg 108:444-8. 2014
    ..The diagnosis of acute bacterial meningitis (ABM) is challenging in resource-limited settings where cerebral malaria and viral encephalitis are also common...
  18. pmc Prevalence and implications of cerebrospinal fluid leukocytosis in Papua New Guinean children hospitalized with severe malaria
    Moses Laman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Freemantle, Western Australia, Australia Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    Am J Trop Med Hyg 89:866-8. 2013
    ..vivax infections, and it is generally mild. Its presence in a blood slide-positive child should prompt consideration of alternative diagnoses and empiric antibiotic therapy...
  19. pmc Reduced risk of Plasmodium vivax malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control study
    Anna Rosanas-Urgell
    PNG Institute of Medical Research, Madang, Papua New Guinea
    PLoS Med 9:e1001305. 2012
    ..vivax infection and disease...
  20. doi request reprint Plasma Plasmodium falciparum histidine-rich protein-2 concentrations do not reflect severity of malaria in Papua new guinean children
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Western Australia
    Clin Infect Dis 52:440-6. 2011
    ..However, where transmission is more intense, plasma PfHRP-2 might not reliably predict complications and mortality...
  21. doi request reprint Accuracy of cerebrospinal leucocyte count, protein and culture for the diagnosis of acute bacterial meningitis: a comparative study using Bayesian latent class analysis
    Laurens Manning
    School of Medicine and Pharmacology, Fremantle Hospital, University of Western Australia, Fremantle, WA, Australia
    Trop Med Int Health 19:1520-4. 2014
    ..To examine the utility of laboratory methods other than bacterial culture in diagnosing acute bacterial meningitis (ABM)...
  22. doi request reprint Lumbar puncture in children from an area of malaria endemicity who present with a febrile seizure
    Moses Laman
    Papua New Guinea Institute of Medical Research, Modilon General Hospital, Madang, Papua New Guinea
    Clin Infect Dis 51:534-40. 2010
    ..Our primary hypothesis was that children who present with a single seizure but with no clinical signs of meningism or coma do not require LP as part of initial diagnostic assessment...
  23. pmc Reference intervals for common laboratory tests in Melanesian children
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Am J Trop Med Hyg 85:50-4. 2011
    ..This has implications for clinical care and safety monitoring in pharmaceutical intervention trials and vaccine studies...
  24. pmc Increasing chloramphenicol resistance in Streptococcus pneumoniae isolates from Papua New Guinean children with acute bacterial meningitis
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Antimicrob Agents Chemother 55:4454-6. 2011
    ..All isolates were ceftriaxone sensitive. These data support ceftriaxone rather than conventional chloramphenicol for all PNG children with suspected ABM...
  25. ncbi request reprint Isolation of Vibrio cholerae and other enteric microbiota from patients with suspected cholera during the 2009 outbreak in Madang Province, Papua New Guinea
    Monalisa P Kas
    Papua New Guinea Institute of Medical Research, Goroka and Madang, Papua New Guinea
    P N G Med J 56:110-5. 2013
    ....
  26. pmc Clinical features and outcome in children with severe Plasmodium falciparum malaria: a meta-analysis
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    PLoS ONE 9:e86737. 2014
    ..Although global malaria mortality is declining, estimates may not reflect better inpatient management of severe malaria (SM) where reported case fatality rates (CFRs) vary from 1-25%...
  27. pmc Comparison of three methods for detection of gametocytes in Melanesian children treated for uncomplicated malaria
    Stephan Karl
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Malar J 13:319. 2014
    ....
  28. pmc A case of ultrasound-guided prenatal diagnosis of prune belly syndrome in Papua New Guinea--implications for management
    Maria Ome
    Papua New Guinea Institute of Medical Research, Vector Borne Disease Unit, Madang, Papua New Guinea
    BMC Pediatr 13:70. 2013
    ..We report a case of prune belly syndrome from Papua New Guinea, which was suspected on pregnancy ultrasound scan and confirmed upon delivery...