Mitchell K P Lai

Summary

Publications

  1. doi request reprint Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology
    Mitchell K P Lai
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore
    J Neural Transm (Vienna) 115:1165-72. 2008
  2. doi request reprint Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease
    Mitchell K P Lai
    Memory, Aging and Cognition Centre, National University Health System, Kent Ridge, Singapore
    Psychopharmacology (Berl) 213:431-9. 2011
  3. doi request reprint Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia
    Mitchell K P Lai
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    Neuroreport 21:1111-5. 2010
  4. pmc Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease
    Shirley W Y Tsang
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Singapore
    Neurobiol Aging 29:1524-32. 2008
  5. ncbi request reprint Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia
    Jasinda H Lee
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    J Parkinsons Dis 6:733-739. 2016
  6. doi request reprint Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias
    Yuan Sheng
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    J Neurol Sci 315:110-4. 2012
  7. pmc Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias
    Huayang Xing
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09 01, Centre for Translational Medicine MD6, 14 Medical Drive, Kent Ridge, 117599, Singapore
    Mol Brain 9:84. 2016
  8. doi request reprint Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease
    Nur Ezan Mohamed
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    J Alzheimers Dis 44:431-7. 2015
  9. doi request reprint Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden
    Michelle G K Tan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Department of Clinical Research, Singapore General Hospital, Singapore
    Neurochem Int 64:29-36. 2014
  10. ncbi request reprint Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease
    Shirley W Y Tsang
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Singapore
    Neurobiol Aging 28:1381-7. 2007

Collaborators

Detail Information

Publications24

  1. doi request reprint Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology
    Mitchell K P Lai
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore
    J Neural Transm (Vienna) 115:1165-72. 2008
    ....
  2. doi request reprint Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease
    Mitchell K P Lai
    Memory, Aging and Cognition Centre, National University Health System, Kent Ridge, Singapore
    Psychopharmacology (Berl) 213:431-9. 2011
    ..However, it is unclear whether such deficits play a role in non-cognitive, neuropsychiatric behaviors that occur frequently in AD and cause significant caregiver distress...
  3. doi request reprint Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia
    Mitchell K P Lai
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    Neuroreport 21:1111-5. 2010
    ..This study suggests a pathogenic link between neurofibrillary tangle load and aggressive behaviours in the hippocampus of dementia patients...
  4. pmc Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease
    Shirley W Y Tsang
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Singapore
    Neurobiol Aging 29:1524-32. 2008
    ..We propose that NR2A and GlyRS should be further assessed as novel targets of behavioral pharmacotherapy in AD...
  5. ncbi request reprint Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia
    Jasinda H Lee
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    J Parkinsons Dis 6:733-739. 2016
    ..While the loss of M1-G-protein coupling has been associated with β-amyloid (Aβ) burden in AD, the status of M1 coupling to G-proteins in Parkinson's disease-related or mixed dementias is unclear...
  6. doi request reprint Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias
    Yuan Sheng
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    J Neurol Sci 315:110-4. 2012
    ..In this study, we measured cortical H(3) receptors in patients with subcortical ischemic vascular dementia (SIVD) and mixed SIVD/AD (MIX)...
  7. pmc Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias
    Huayang Xing
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09 01, Centre for Translational Medicine MD6, 14 Medical Drive, Kent Ridge, 117599, Singapore
    Mol Brain 9:84. 2016
    ..However, antecedent signaling events as well as the nature of pCRMP2 association with Aβ and other neuropathologic markers require further study. ..
  8. doi request reprint Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease
    Nur Ezan Mohamed
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    J Alzheimers Dis 44:431-7. 2015
    ..However, it is unclear whether subcortical ischemic vascular dementia (SIVD) and mixed SIVD/AD (MixD) manifest similar changes in the glutamatergic system...
  9. doi request reprint Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden
    Michelle G K Tan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Department of Clinical Research, Singapore General Hospital, Singapore
    Neurochem Int 64:29-36. 2014
    ..Furthermore, RPH3A expression is selectively downregulated in cultured neurons treated with Aβ25-35 peptides. Our data suggest that presynaptic SNARE dysfunction forms part of the synaptopathology of AD. ..
  10. ncbi request reprint Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease
    Shirley W Y Tsang
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Singapore
    Neurobiol Aging 28:1381-7. 2007
    ....
  11. doi request reprint Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease
    Nur Ezan Mohamed
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    Neurochem Int 58:820-5. 2011
    ..Our study suggests that GluR2 up-regulation may be an adaptive process in SIVD, and that this process is repressed in the presence of concomitant AD in mixed dementia...
  12. doi request reprint Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex
    Jasinda H Lee
    Memory, Aging and Cognition Centre, National University Health System, Singapore
    Neurochem Int 57:985-9. 2010
    ..Our study suggests that CB1 receptors are intact in AD and may play a role in preserving cognitive function. Therefore, CB1 receptors should be further assessed as a potential therapeutic target in AD...
  13. ncbi request reprint Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease
    Mitchell K P Lai
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurobiol Dis 22:555-61. 2006
    ..This study suggests that APOE epsilon4 selectively affects presynaptic cholinergic function which may contribute to the clinical and neuropathological features of AD...
  14. doi request reprint An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease
    Chingli Lee
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    J Neurochem 136:637-50. 2016
    ..In primary mixed cultures, treatment with amyloid peptides specifically up-regulated FynT in activated astrocytes. This study points to altered alternative splicing as a potential pathogenic mechanism in AD...
  15. ncbi request reprint Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load
    Joyce R Chong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    J Alzheimers Dis . 2016
    ..In contrast, the status of TGFβ2, which has been shown to mediate amyloid-β (Aβ)-mediated neuronal death, are unclear both in AD and in Lewy body dementias (LBD) with differential neuritic plaque and neurofibrillary tangle burden...
  16. doi request reprint Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients
    Jasinda H Lee
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09 01, Centre for Translational Medicine MD6, 14 Medical Drive, Kent Ridge, 117599, Singapore
    Psychopharmacology (Berl) 233:591-8. 2016
    ..However, the identification of these receptors in human cortex and their status in Alzheimer's disease (AD), which is characterized by both cognitive impairments and neuropsychiatric behaviours, have not been reported...
  17. pmc Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK
    Siew Ying Wong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09 01, Centre for Translational Medicine MD6, 14 Medical Drive, Kent Ridge, 117599, Singapore
    J Neuroinflammation 13:251. 2016
    ..Here, we aimed to investigate the mechanisms underlying andrographolide's effect on the expression of anti-inflammatory and antioxidant heme oxygenase-1 (HO-1) in primary astrocytes...
  18. pmc Andrographolide attenuates LPS-stimulated up-regulation of C-C and C-X-C motif chemokines in rodent cortex and primary astrocytes
    Siew Ying Wong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 16 Medical Drive, Kent Ridge, 117600, Singapore
    J Neuroinflammation 13:34. 2016
    ..In this study, we aimed to assess andrographolide's potential utility as an anti-neuroinflammatory therapeutic...
  19. ncbi request reprint Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease
    Mitchell K P Lai
    Department of Clinical Research, Singapore General Hospital, Singapore
    Brain Res 974:82-7. 2003
    ..Our data indicate further study of 5-HT(1A) receptors as a pharmacological target for the treatment of behavioral symptoms in AD...
  20. doi request reprint Decreased immunoreactivities of neocortical AMPA receptor subunits correlate with motor disability in Lewy body dementias
    Nur Ezan Mohamed
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore, 117597, Singapore
    J Neural Transm (Vienna) 121:71-8. 2014
    ..Our study suggests that GluA2/3/4 losses may be a neurochemical marker of motor disability in Lewy body dementias. ..
  21. doi request reprint Biological Effects of Naturally Occurring Sphingolipids, Uncommon Variants, and Their Analogs
    Mitchell K P Lai
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    Neuromolecular Med 18:396-414. 2016
    ..This manuscript provides an overview of SP metabolism and signaling, their perturbations in neurological diseases, as well as potential impacts of modulating this system in the brain. ..
  22. pmc Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease
    Xavier Gallart-Palau
    Division of Chemical Biology and Biotechnology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore
    Mol Brain 9:27. 2016
    ..In this study, we used unbiased, discovery-driven quantitative proteomics to assess the molecular basis of gender influences on risk of Alzheimer's disease with cerebrovascular disease (AD + CVD)...
  23. doi request reprint Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions
    Ying Yang
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    Neurochem Int 94:90-7. 2016
    ..Our study suggests a mechanism for hypoperfusion-associated WML involving HIF-1α-SphK2-S1P-mediated disruption of OPC differentiation, and proposes the SphK signaling pathway as a potential therapeutic target for white matter disease...
  24. doi request reprint Andrographolide attenuates interleukin-1β-stimulated upregulation of chemokine CCL5 and glial fibrillary acidic protein in astrocytes
    Siew Ying Wong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Neuroreport 25:881-6. 2014
    ..These data suggest that andrographolide should be evaluated further as a therapeutic for central nervous system diseases characterized by astrocyte-mediated neuroinflammatory processes. ..