Izabela Laczmanska

Summary

Publications

  1. pmc Customized Array Comparative Genomic Hybridization Analysis of 25 Phosphatase-encoding Genes in Colorectal Cancer Tissues
    Izabela Laczmanska
    Genetics Department, Wroclaw Medical University, Wroclaw, Poland
    Cancer Genomics Proteomics 14:69-74. 2017
  2. ncbi request reprint Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer
    Izabela Laczmanska
    Genetics Department, Medical University, Wroclaw, Poland
    Acta Biochim Pol 58:467-70. 2011
  3. doi request reprint Assessment of chromosomal imbalances in CIMP-high and CIMP-low/CIMP-0 colorectal cancers
    Joanna Kozlowska
    Department of Genetics, Wroclaw Medical University, ul Marcinkowskiego 1, 50 368 Wroclaw, Poland
    Tumour Biol 33:1015-9. 2012
  4. doi request reprint Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer
    Izabela Laczmanska
    Department of Genetics, Wroclaw Medical University, Wroclaw, Poland
    J Hum Genet 58:11-5. 2013
  5. doi request reprint The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual's susceptibility to sporadic colorectal cancer
    Justyna Gil
    Department of Genetics, Medical University of Wroclaw, Marcinkowskiego 1, 50 368, Wroclaw, Poland
    Mol Biol Rep 39:527-34. 2012
  6. pmc Vitamin D receptor gene polymorphisms in relation to the risk of colorectal cancer in the Polish population
    Izabela Laczmanska
    Genetics Department, Wroclaw Medical University, Wroclaw, Poland
    Tumour Biol 35:12397-401. 2014
  7. doi request reprint Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype
    Pawel Karpinski
    Department of Genetics, Wroclaw Medical University, ul Marcinkowskiego 1, Wroclaw, Poland
    Cancer Epidemiol 34:338-44. 2010
  8. doi request reprint Copy number alterations of chromosomal regions enclosing protein tyrosine phosphatase receptor-like genes in colorectal cancer
    Izabela Laczmanska
    Genetics Department, Wroclaw Medical University, Wroclaw, Poland Electronic address
    Pathol Res Pract 210:893-6. 2014
  9. doi request reprint Polymorphisms in nucleotide excision repair genes and basal cell carcinoma of the skin
    Karolina A Pesz
    Department of Genetics, Wroclaw Medical University, Wroclaw, Poland Department of Dermatology, Venerology and Allergology, Wroclaw Medical University, Wroclaw, Poland
    Int J Dermatol 53:1474-7. 2014
  10. ncbi request reprint High PTPRQ Expression and Its Relationship to Expression of PTPRZ1 and the Presence of KRAS Mutations in Colorectal Cancer Tissues
    Izabela Laczmanska
    Genetics Department, Wroclaw Medical University, Wroclaw, Poland
    Anticancer Res 36:677-81. 2016

Collaborators

Detail Information

Publications13

  1. pmc Customized Array Comparative Genomic Hybridization Analysis of 25 Phosphatase-encoding Genes in Colorectal Cancer Tissues
    Izabela Laczmanska
    Genetics Department, Wroclaw Medical University, Wroclaw, Poland
    Cancer Genomics Proteomics 14:69-74. 2017
    ..However, little is known about small intragenic gains and losses that may lead to either changes in expression or enzyme activity and even loss of protein function...
  2. ncbi request reprint Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer
    Izabela Laczmanska
    Genetics Department, Medical University, Wroclaw, Poland
    Acta Biochim Pol 58:467-70. 2011
    ....
  3. doi request reprint Assessment of chromosomal imbalances in CIMP-high and CIMP-low/CIMP-0 colorectal cancers
    Joanna Kozlowska
    Department of Genetics, Wroclaw Medical University, ul Marcinkowskiego 1, 50 368 Wroclaw, Poland
    Tumour Biol 33:1015-9. 2012
    ....
  4. doi request reprint Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer
    Izabela Laczmanska
    Department of Genetics, Wroclaw Medical University, Wroclaw, Poland
    J Hum Genet 58:11-5. 2013
    ..The results of our study show a statistically significant difference between promoter methylation in cancerous and healthy tissue. This result supports the hypothesis that the PTPR family has an important role in the etiology of CRC...
  5. doi request reprint The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual's susceptibility to sporadic colorectal cancer
    Justyna Gil
    Department of Genetics, Medical University of Wroclaw, Marcinkowskiego 1, 50 368, Wroclaw, Poland
    Mol Biol Rep 39:527-34. 2012
    ..1) The XPC C/A (i11) genotype is associated with an increased risk of sporadic colorectal cancer. (2) The NER pathway has been highlighted in our study, as a most important in modulation of individual susceptibility to sCRC...
  6. pmc Vitamin D receptor gene polymorphisms in relation to the risk of colorectal cancer in the Polish population
    Izabela Laczmanska
    Genetics Department, Wroclaw Medical University, Wroclaw, Poland
    Tumour Biol 35:12397-401. 2014
    ..Both of these loci are associated with cancer. We do not observe any such association for the FokI polymorphism. In conclusion, a small modification in VDR expression may play a role in such a multipathway process as tumorigenesis. ..
  7. doi request reprint Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype
    Pawel Karpinski
    Department of Genetics, Wroclaw Medical University, ul Marcinkowskiego 1, Wroclaw, Poland
    Cancer Epidemiol 34:338-44. 2010
    ..The aim of the present study was to evaluate whether polymorphisms in the genes encoding methyl-group metabolism pathway predispose to CIMP+ and/or CIMP- CRC...
  8. doi request reprint Copy number alterations of chromosomal regions enclosing protein tyrosine phosphatase receptor-like genes in colorectal cancer
    Izabela Laczmanska
    Genetics Department, Wroclaw Medical University, Wroclaw, Poland Electronic address
    Pathol Res Pract 210:893-6. 2014
    ..Our study also revealed that gains on chromosome 20q12 and losses on chromosome 18p11.2 are connected with the absence of the BRAF mutation and the conventional adenocarcinoma pathway. ..
  9. doi request reprint Polymorphisms in nucleotide excision repair genes and basal cell carcinoma of the skin
    Karolina A Pesz
    Department of Genetics, Wroclaw Medical University, Wroclaw, Poland Department of Dermatology, Venerology and Allergology, Wroclaw Medical University, Wroclaw, Poland
    Int J Dermatol 53:1474-7. 2014
    ..The aim of this study was to find associations between SNPs in selected NER genes and sporadic BCC development...
  10. ncbi request reprint High PTPRQ Expression and Its Relationship to Expression of PTPRZ1 and the Presence of KRAS Mutations in Colorectal Cancer Tissues
    Izabela Laczmanska
    Genetics Department, Wroclaw Medical University, Wroclaw, Poland
    Anticancer Res 36:677-81. 2016
    ..Protein tyrosine phosphatase receptor-like type Q (PTPRQ) and protein tyrosine phosphatase receptor-like type Z polypeptide 1 (PTPRZ1) have both been shown to be important in development of many cancer types including CRC...
  11. doi request reprint Hexasomy 13q31.3q34 due to two marker chromosomes with inverted duplication in a fetus with increased nuchal translucency
    Agnieszka Stembalska
    Department of Genetics, Wroclaw Medical University, Poland
    Birth Defects Res A Clin Mol Teratol 103:255-9. 2015
    ..Their examination has to be complemented by additional analyses like fluorescent in situ hybridization or array comparative genomic hybridization...
  12. ncbi request reprint Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations
    Izabela Laczmanska
    Department of Genetics, Wroclaw Medical University, Marcinkowskiego 1, Wroclaw, Poland
    Environ Mol Mutagen 48:666-71. 2007
    ..Our study indicated that, of the polymorphisms studied, only XPC (exon 15 and intron 11) is associated with BLM-induced CAs, suggesting a role of the NER pathway in the repair of BLM-induced chromosomal aberrations...
  13. ncbi request reprint Exonic deletions in the NF1 gene in patients with neurofibromatosis type I from the lower Silesian region of Poland
    Izabela Laczmanska
    Department of Genetics, Wroclaw Medical University, Poland
    Adv Clin Exp Med 23:517-21. 2014
    ....