Yoshimi Kuroiwa

Summary

Publications

  1. doi request reprint Antigen-specific human polyclonal antibodies from hyperimmunized cattle
    Yoshimi Kuroiwa
    Hematech, Inc, 4401 S Technology Dr, Sioux Falls, South Dakota 57106, USA
    Nat Biotechnol 27:173-81. 2009
  2. pmc Assessment of genome integrity with array CGH in cattle transgenic cell lines produced by homologous recombination and somatic cell cloning
    George E Liu
    Hematech Inc, Sioux Falls, SD, 57106, USA
    Genome Integr 2:6. 2011
  3. pmc Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle
    Hiroaki Matsushita
    SAB Biotherapeutics, Inc, Sioux Falls, South Dakota, United States of America Hematech, Inc, Sioux Falls, South Dakota, United States of America
    PLoS ONE 10:e0130699. 2015
  4. pmc Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production
    Hiroaki Matsushita
    Sanford Applied Biosciences L L C, Sioux Falls, South Dakota, United States of America Hematech, Inc, Sioux Falls, South Dakota, United States of America
    PLoS ONE 9:e90383. 2014
  5. pmc Physiological level production of antigen-specific human immunoglobulin in cloned transchromosomic cattle
    Akiko Sano
    Kyowa Hakko Kirin, CO, Ltd, Chiyoda ku, Tokyo, Japan Hematech, Inc, Sioux Falls, South Dakota, United States of America
    PLoS ONE 8:e78119. 2013

Collaborators

Detail Information

Publications5

  1. doi request reprint Antigen-specific human polyclonal antibodies from hyperimmunized cattle
    Yoshimi Kuroiwa
    Hematech, Inc, 4401 S Technology Dr, Sioux Falls, South Dakota 57106, USA
    Nat Biotechnol 27:173-81. 2009
    ..Purified, fully human and chimeric hIgGs were highly active in an in vitro toxin neutralization assay and protective in an in vivo mouse challenge assay...
  2. pmc Assessment of genome integrity with array CGH in cattle transgenic cell lines produced by homologous recombination and somatic cell cloning
    George E Liu
    Hematech Inc, Sioux Falls, SD, 57106, USA
    Genome Integr 2:6. 2011
    ..abstract:..
  3. pmc Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle
    Hiroaki Matsushita
    SAB Biotherapeutics, Inc, Sioux Falls, South Dakota, United States of America Hematech, Inc, Sioux Falls, South Dakota, United States of America
    PLoS ONE 10:e0130699. 2015
    ..The high production levels of fully hIgG with hIgG1 subclass dominancy in a large farm animal species achieved here is an important milestone towards broad therapeutic applications of hpAbs. ..
  4. pmc Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production
    Hiroaki Matsushita
    Sanford Applied Biosciences L L C, Sioux Falls, South Dakota, United States of America Hematech, Inc, Sioux Falls, South Dakota, United States of America
    PLoS ONE 9:e90383. 2014
    ..We further demonstrate that bIGL cluster deletion greatly improves fully hIgGs production in the sera of TKO Tc cattle, with 51.3% fully hIgGs (hIgG/hIgκ plus hIgG/hIgλ). ..
  5. pmc Physiological level production of antigen-specific human immunoglobulin in cloned transchromosomic cattle
    Akiko Sano
    Kyowa Hakko Kirin, CO, Ltd, Chiyoda ku, Tokyo, Japan Hematech, Inc, Sioux Falls, South Dakota, United States of America
    PLoS ONE 8:e78119. 2013
    ..We further demonstrate that, upon immunization by tumor immunogens, high titer tumor immunogen-specific human IgG (hIgG) can be produced from such Tc cattle. ..