Stephen B Kritchevsky

Summary

Publications

  1. pmc 25-Hydroxyvitamin D, parathyroid hormone, and mortality in black and white older adults: the health ABC study
    Stephen B Kritchevsky
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1207, USA
    J Clin Endocrinol Metab 97:4156-65. 2012
  2. pmc Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function
    Brian J Reardon
    Division of Nutritional Sciences, Cornell University, 209 Savage Hall, Ithaca, NY 14853, USA
    BMC Med Genet 14:122. 2013
  3. pmc Chronic inflammation is associated with low physical function in older adults across multiple comorbidities
    Tina E Brinkley
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 64:455-61. 2009
  4. doi request reprint Age-related changes of hyoid bone position in healthy older adults with aspiration
    Xin Feng
    Department of Otolaryngology, Wake Forest School of Medicine, Winston Salem, North Carolina, U S A
    Laryngoscope 124:E231-6. 2014
  5. pmc Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults
    Anthony P Marsh
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109 7868, USA
    J Gerontol A Biol Sci Med Sci 68:828-36. 2013
  6. pmc Low 25-hydroxyvitamin D predicts the onset of mobility limitation and disability in community-dwelling older adults: the Health ABC Study
    Denise K Houston
    Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1207, USA
    J Gerontol A Biol Sci Med Sci 68:181-7. 2013
  7. pmc Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults
    John R Stehle
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1212-8. 2012
  8. pmc Factors influencing bolus dwell times in healthy older adults assessed endoscopically
    Susan G Butler
    Department of Otolaryngology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Laryngoscope 121:2526-34. 2011
  9. pmc Correlates and prevalence of insufficient 25-hydroxyvitamin D status in black and white older adults: the health, aging and body composition study
    M Kyla Shea
    Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    J Am Geriatr Soc 59:1165-74. 2011
  10. pmc Relationship between 25-hydroxyvitamin D and cognitive function in older adults: the Health, Aging and Body Composition Study
    Valerie K Wilson
    Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina
    J Am Geriatr Soc 62:636-41. 2014

Collaborators

Detail Information

Publications61

  1. pmc 25-Hydroxyvitamin D, parathyroid hormone, and mortality in black and white older adults: the health ABC study
    Stephen B Kritchevsky
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1207, USA
    J Clin Endocrinol Metab 97:4156-65. 2012
    ..Whether the relationship is similar in Blacks and to what extent differences in 25(OH)D explain racial disparities in mortality is unclear...
  2. pmc Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function
    Brian J Reardon
    Division of Nutritional Sciences, Cornell University, 209 Savage Hall, Ithaca, NY 14853, USA
    BMC Med Genet 14:122. 2013
    ..This study explores mechanisms for an effect of vitamin D in lung through an in vivo gene expression study, an expression quantitative trait loci (eQTL) analysis in lung tissue, and a population-based cohort study of sequence variants...
  3. pmc Chronic inflammation is associated with low physical function in older adults across multiple comorbidities
    Tina E Brinkley
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 64:455-61. 2009
    ....
  4. doi request reprint Age-related changes of hyoid bone position in healthy older adults with aspiration
    Xin Feng
    Department of Otolaryngology, Wake Forest School of Medicine, Winston Salem, North Carolina, U S A
    Laryngoscope 124:E231-6. 2014
    ..We hypothesized that altered position of the hyoid bone associated with aging may negatively affect airway protection during swallowing (i.e., aspiration) in older adults...
  5. pmc Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults
    Anthony P Marsh
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109 7868, USA
    J Gerontol A Biol Sci Med Sci 68:828-36. 2013
    ..Demonstrating that muscle strength and power are not adversely affected during "intentional" weight loss in older adults is important given the wide-ranging negative health effects of excess adiposity...
  6. pmc Low 25-hydroxyvitamin D predicts the onset of mobility limitation and disability in community-dwelling older adults: the Health ABC Study
    Denise K Houston
    Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1207, USA
    J Gerontol A Biol Sci Med Sci 68:181-7. 2013
    ....
  7. pmc Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults
    John R Stehle
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1212-8. 2012
    ..We hypothesized that markers of MT, soluble CD14 (sCD14) and lipopolysaccharide (LPS) binding protein (LBP), may be a source of chronic inflammation in older persons and be associated with poorer physical function...
  8. pmc Factors influencing bolus dwell times in healthy older adults assessed endoscopically
    Susan G Butler
    Department of Otolaryngology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Laryngoscope 121:2526-34. 2011
    ..Because it has been previously reported that some healthy older adults aspirate, we also sought to determine if bolus dwell time varied as a function of aspiration status...
  9. pmc Correlates and prevalence of insufficient 25-hydroxyvitamin D status in black and white older adults: the health, aging and body composition study
    M Kyla Shea
    Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    J Am Geriatr Soc 59:1165-74. 2011
    ..To determine the prevalence and correlates of vitamin D insufficiency in black and white older adults...
  10. pmc Relationship between 25-hydroxyvitamin D and cognitive function in older adults: the Health, Aging and Body Composition Study
    Valerie K Wilson
    Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina
    J Am Geriatr Soc 62:636-41. 2014
    ..To examine the relationship between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance over time in older adults in the Health, Aging and Body Composition (Health ABC) Study...
  11. pmc Associations of BMI and adipose tissue area and density with incident mobility limitation and poor performance in older adults
    Rachel A Murphy
    Laboratory of Epidemiology, and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD RAM, IR, and TBH the Sections on Comparative Medicine Pathology, Radiology TCR, and Gerontology and Geriatrics SBK, Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC the Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA HNA the Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA ABN the Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN SS the Center for Aging and Population Health, Department of Medicine, University of Pittsburgh, Pittsburgh, PA BHG and the Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, Baltimore, MD EMS
    Am J Clin Nutr 99:1059-65. 2014
    ..Obesity is a risk factor for disability, but risk of specific adipose depots is not completely understood...
  12. pmc 25-hydroxyvitamin D status and change in physical performance and strength in older adults: the Health, Aging, and Body Composition Study
    Denise K Houston
    Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1207, USA
    Am J Epidemiol 176:1025-34. 2012
    ..Older adults with low 25(OH)D concentrations had poorer physical performance over 4 years of follow-up, but low 25(OH)D concentrations were not associated with a faster rate of decline in physical performance or strength...
  13. pmc Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia
    Heidi D Klepin
    Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC 27157, USA
    Blood 121:4287-94. 2013
    ..GA methods, with a focus on cognitive and PF, improve risk stratification and may inform interventions to improve outcomes for older AML patients...
  14. pmc Fat mass loss predicts gain in physical function with intentional weight loss in older adults
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 68:80-6. 2013
    ..The purpose of this study is to determine the independent associations between changes in fat and lean mass and changes in physical function in older, overweight, and obese adults undergoing intentional WL...
  15. pmc The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial
    M Kyla Shea
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 94:839-46. 2011
    ....
  16. pmc The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jingzhong Ding
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 90:499-504. 2009
    ..Cross-sectional studies suggest that pericardial fat is positively associated with coronary artery disease independent of total body fat...
  17. pmc Serum 25-hydroxyvitamin D and physical function in older adults: the Cardiovascular Health Study All Stars
    Denise K Houston
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Am Geriatr Soc 59:1793-801. 2011
    ..To examine the association between 25-hydroxyvitamin D (25(OH)D) and physical function in adults of advanced age...
  18. pmc Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach
    Tina E Brinkley
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1099-106. 2012
    ..We used factor analysis to identify inflammatory factor(s) and examine their associations with adiposity in older adults at risk for disability...
  19. pmc Overweight and obesity over the adult life course and incident mobility limitation in older adults: the health, aging and body composition study
    Denise K Houston
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1207, USA
    Am J Epidemiol 169:927-36. 2009
    ..0001) on risk of mobility limitation for the cumulative effect of obesity in men and overweight and/or obesity in women. Onset of overweight and obesity in earlier life contributes to an increased risk of mobility limitation in old age...
  20. pmc Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis
    M Kyla Shea
    Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Am J Clin Nutr 98:197-208. 2013
    ..Animal studies have shown that vitamin K treatment reduced vascular calcification, but human data are limited...
  21. pmc Association between inflammatory components and physical function in the health, aging, and body composition study: a principal component analysis approach
    Fang Chi Hsu
    Department of Biostatistical Sciences, Wake Forest University School of Medicine, 100 North Main Street, Suite 2323, Winston Salem, NC 27101, USA
    J Gerontol A Biol Sci Med Sci 64:581-9. 2009
    ..This study uses principal component analysis to identify inflammatory "component(s)" and evaluates associations between the identified component(s) and measures of physical function...
  22. pmc Association between non-subcutaneous adiposity and calcified coronary plaque: a substudy of the Multi-Ethnic Study of Atherosclerosis
    Jingzhong Ding
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Clin Nutr 88:645-50. 2008
    ..Excessive non-subcutaneous fat deposition may impair the functions of surrounding tissues and organs through the release of inflammatory cytokines and free fatty acids...
  23. pmc Change in 25-hydroxyvitamin D and physical performance in older adults
    Denise K Houston
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1207, USA
    J Gerontol A Biol Sci Med Sci 66:430-6. 2011
    ....
  24. pmc The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss
    M Kyla Shea
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 19:1636-46. 2011
    ..Additional studies are needed to clarify the observed gender differences and evaluate how these changes in body composition influence functional status...
  25. pmc The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study
    M Kyla Shea
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 65:519-25. 2010
    ..Data from the Arthritis, Diet, and Activity Promotion Trial (ADAPT) were used to determine whether randomization to a weight reduction program was associated with total mortality in overweight/obese older adults...
  26. pmc The relationship of aspiration status with tongue and handgrip strength in healthy older adults
    Susan G Butler
    Department of Otolaryngology, Claude D Pepper Older Americans Independence Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 66:452-8. 2011
    ..Furthermore, as muscle weakness may reflect a global effect of aging, we further investigated whether tongue strength is correlated with handgrip strength...
  27. pmc Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study
    Kristen M Beavers
    Department of Internal Medicine, National Institute on Aging, Baltimore, MD, USA
    Am J Clin Nutr 97:552-60. 2013
    ..In older adults, every 0.1-m/s slower gait speed is associated with a 12% higher mortality. However, little research has identified risk factors for gait-speed decline...
  28. pmc The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 68:617-23. 2013
    ..Metabolic syndrome (MetS) and functional limitation have been linked, but whether and how specific components of MetS and associated factors, such as inflammation, drive this relationship is unknown...
  29. pmc Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys
    Seung Jun Choi
    Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 68:258-67. 2013
    ..Our results support a detrimental effect of aging on the intrinsic force and power generation of myofilament lattice and physical performance in vervet monkeys...
  30. pmc Lean mass loss is associated with low protein intake during dietary-induced weight loss in postmenopausal women
    Melanie J Bopp
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, General Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Diet Assoc 108:1216-20. 2008
    ..Therefore, inadequate protein intake during caloric restriction may be associated with adverse body-composition changes in postmenopausal women...
  31. ncbi request reprint Effects of liquid type, delivery method, and bolus volume on penetration-aspiration scores in healthy older adults during flexible endoscopic evaluation of swallowing
    Susan G Butler
    Department of Otolaryngology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Otol Rhinol Laryngol 120:288-95. 2011
    ..The type of liquid (eg, water or milk) that should be used during flexible endoscopic evaluation of swallowing (FEES) has received little investigation. Aspiration may vary as a function of the thin liquid type used during FEES...
  32. pmc Long-term physical activity and inflammatory biomarkers in older adults
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Med Sci Sports Exerc 42:2189-96. 2010
    ..The purpose of this study was to determine the effects of a 12-month physical activity (PA) intervention on inflammatory biomarkers in elderly men and women...
  33. pmc Exercise training and plasma C-reactive protein and interleukin-6 in elderly people
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 56:2045-52. 2008
    ..To determine the effects of a long-term exercise intervention on two prominent biomarkers of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)) in elderly men and women...
  34. pmc Aging-related geniohyoid muscle atrophy is related to aspiration status in healthy older adults
    Xin Feng
    Department of Otolaryngology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 68:853-60. 2013
    ..This study aimed to explore whether aging and aspiration in older adults were related to GH muscle atrophy and fatty infiltration...
  35. pmc The feasibility of inpatient geriatric assessment for older adults receiving induction chemotherapy for acute myelogenous leukemia
    Heidi D Klepin
    Comprehensive Cancer Center, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 59:1837-46. 2011
    ..To test the feasibility and utility of a bedside geriatric assessment (GA) to detect impairment in multiple geriatric domains in older adults initiating chemotherapy for acute myelogenous leukemia (AML)...
  36. pmc Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease
    Jingzhong Ding
    Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC
    Diabetes 64:3464-74. 2015
    ..Taken together with several lines of previous experimental evidence, these data suggest that alterations of the cholesterol metabolism gene network represent a molecular link between obesity/inflammation and T2D/CAC. ..
  37. pmc Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure
    Chirapa Puntawangkoon
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Cardiovasc Magn Reson 11:48. 2009
    ..We hypothesized that reduced lower extremity blood flow (LBF) due to reduced forward cardiac output would contribute to submaximal exercise intolerance in older HF patients...
  38. pmc Tongue adiposity and strength in healthy older adults
    Susan G Butler
    Wake Forest University School of Medicine, Department of Otolaryngology, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Laryngoscope 122:1600-4. 2012
    ....
  39. pmc Serum parathyroid hormone levels predict falls in older adults with diabetes mellitus
    Denise K Houston
    Sticht Center on Aging, Wake Forest University, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 56:2027-32. 2008
    ..To examine the association between serum parathyroid hormone (PTH) levels and incident falls in older adults with diabetes mellitus...
  40. pmc Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials
    Stephen B Kritchevsky
    Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States of America
    PLoS ONE 10:e0121993. 2015
    ..The purpose of this meta-analysis of randomized controlled trials (RCTs) of weight loss was to clarify the effects of intentional weight loss on mortality...
  41. pmc Circulating phylloquinone concentrations of adults in the United States differ according to race and ethnicity
    M Kyla Shea
    Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC, USA
    J Nutr 142:1060-6. 2012
    ..S. adults, especially among those of Chinese American descent, which merits consideration in the design and interpretation of future population-based and clinical studies of vitamin K and related diseases...
  42. pmc Lower extremity muscle function after strength or power training in older adults
    Anthony P Marsh
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109 7868, USA
    J Aging Phys Act 17:416-43. 2009
    ..In older adults with compromised function, PT leads to similar increases in strength and larger increases in power than ST...
  43. pmc Factors influencing aspiration during swallowing in healthy older adults
    Susan G Butler
    Department of Otolaryngology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Laryngoscope 120:2147-52. 2010
    ..Although flexible endoscopic evaluation of swallowing (FEES) is an established diagnostic tool, little data exist on the effects of varying liquid types on the swallowing outcomes in healthy older adults...
  44. pmc Association between vitamin D status and physical performance: the InCHIANTI study
    Denise K Houston
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 62:440-6. 2007
    ..Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined the association between vitamin D status and physical performance...
  45. pmc A long-term intensive lifestyle intervention and physical function: the look AHEAD Movement and Memory Study
    Denise K Houston
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 23:77-84. 2015
    ..To assess the long-term effects of an intensive lifestyle intervention on physical function using a randomized post-test design in the Look AHEAD trial...
  46. pmc Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study
    Tina E Brinkley
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Hypertension 53:846-52. 2009
    ..These data suggest that ox-LDL may be related to the pathogenesis of arterial stiffness...
  47. pmc The association of pericardial fat with calcified coronary plaque
    Jingzhong Ding
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 16:1914-9. 2008
    ..Pericardial fat has a higher secretion of inflammatory cytokines than subcutaneous fat. Cytokines released from pericardial fat around coronary arteries may act locally on the adjacent cells...
  48. pmc Delivery of a Vitamin D Intervention in Homebound Older Adults Using a Meals-on-Wheels Program: A Pilot Study
    Denise K Houston
    Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, North Carolina
    J Am Geriatr Soc 63:1861-7. 2015
    ..To assess the feasibility of a vitamin D intervention delivered through a Meals-on-Wheels (MOW) program to improve 25-hydroxyvitamin D (25(OH)D) concentrations and reduce falls in homebound older adults...
  49. pmc Effects of aging and levodopa on the laryngeal adductor reflex in rats
    Xin Feng
    Department of Otolaryngology, Wake Forest School of Medicine, Winston Salem, NC 27157, United States
    Exp Gerontol 47:900-7. 2012
    ..In conclusion, increases in laryngeal muscle activity levels and reflex amplitudes accompanied age reductions in dopaminergic neurons but were not reversed with levodopa administration...
  50. pmc Aging and physical mobility in group-housed Old World monkeys
    Carol A Shively
    Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Age (Dordr) 34:1123-31. 2012
    ..Thus, walking speed may be a useful indicator of decline in physical mobility in nonhuman primate models of aging...
  51. pmc Association of Serum Erythropoietin With Cardiovascular Events, Kidney Function Decline, and Mortality: The Health Aging and Body Composition Study
    Pranav S Garimella
    From the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA P S G, M J S Kidney Research Institute R K and Department of Anesthesiology and Pain Medicine K V P, University of Washington, Seattle Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC S B K Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT C R P Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego J H I Renal Section, VA Pittsburgh Healthcare System L F F and Department of Epidemiology, Graduate School of Public Health A B N, University of Pittsburgh, PA Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco M G S Department of General Internal Medicine, San Francisco VA Medical Center, CA M G S and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA T B H
    Circ Heart Fail 9:e002124. 2016
    ..No large studies of which we are aware have evaluated the association of endogenous erythropoietin levels with clinical outcomes in the community-living older adults...
  52. doi request reprint Self-reported Mobility in Older Patients Predicts Early Postoperative Outcomes after Elective Noncardiac Surgery
    Sunghye Kim
    From the Department of Internal Medicine, Section of General Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina S K Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, North Carolina A P M, X I L, S B K, W J R, L G Department of Health and Exercise Science, Wake Forest University, Winston Salem, North Carolina A P M, W J R Department of Anesthesiology, Wake Forest School of Medicine, Winston Salem, North Carolina L R, C R, L G Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina X I L Department of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina S B K Department of Internal Medicine, Section of Molecular Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina L G and Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston Salem, North Carolina L G
    Anesthesiology 124:815-25. 2016
    ..The aim of this study was to evaluate whether self-reported mobility is predictive of postoperative outcomes in older patients undergoing elective noncardiac surgery...
  53. pmc Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults
    Daniel J Tyrrell
    Sticht Center on Aging and Department of Internal Medicine, Section on Gerontology and Geriatrics, Wake Forest School of Medicine, Winston Salem, North Carolina
    J Gerontol A Biol Sci Med Sci 70:1394-9. 2015
    ..Here, we examined the relationship between gait speed and skeletal muscle mitochondrial bioenergetics, and further evaluated whether blood-based bioenergetic profiling might have similar associations with gait speed...
  54. pmc Transcriptomic profiles of aging in purified human immune cells
    Lindsay M Reynolds
    Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina, 27157, USA
    BMC Genomics 16:333. 2015
    ..Previous transcriptomic studies have identified many genes with age-associated expression levels; however, small samples sizes and mixed cell types often make these results difficult to interpret...
  55. pmc Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1014-21. 2012
    ..In conclusion, a low-fat diet may preserve tissue HSP70 and health with aging, whereas high-fat diets, insulin resistance, and genetic factors may be more important than age for determining HSP70 levels...
  56. doi request reprint The influence of extracellular matrix derived from skeletal muscle tissue on the proliferation and differentiation of myogenic progenitor cells ex vivo
    Matthew M Stern
    J Paul Sticht Center on Aging and Rehabilitation, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 30:2393-9. 2009
    ..Furthermore, the model system demonstrated here can be applied to the study of interactions between the ECM of a particular tissue and a cell population of interest...
  57. pmc Graph theory analysis of functional brain networks and mobility disability in older adults
    Christina E Hugenschmidt
    Sticht Center on Aging and Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina
    J Gerontol A Biol Sci Med Sci 69:1399-406. 2014
    ..Changes in function may be evident earlier than changes in structure and may be more directly related to mobility. Therefore, we assessed whether functional brain networks varied with mobility function in older adults...
  58. pmc Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study
    Kaycee M Sink
    Sticht Center on Aging, Wake Forest University, Winston Salem, North Carolina 27157, USA
    Arch Intern Med 169:1195-202. 2009
    ..Hypertension (HTN) is a risk factor for dementia, and animal studies suggest that centrally active angiotensin-converting enzyme (ACE) inhibitors (those that cross the blood-brain barrier) may protect against dementia beyond HTN control...
  59. pmc Changes in cognitive function in a randomized trial of physical activity: results of the lifestyle interventions and independence for elders pilot study
    Jeff D Williamson
    Roena Kulynych Center for Memory and Cognition Research, Department of Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27151, USA
    J Gerontol A Biol Sci Med Sci 64:688-94. 2009
    ....
  60. ncbi request reprint Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study
    Denise K Houston
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157 1207, USA
    Am J Clin Nutr 87:150-5. 2008
    ..Dietary surveys suggest that many older, community-dwelling adults consume insufficient dietary protein, which may contribute to the age-related loss of lean mass (LM)...
  61. pmc Circulating uncarboxylated matrix gla protein is associated with vitamin K nutritional status, but not coronary artery calcium, in older adults
    M Kyla Shea
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 141:1529-34. 2011
    ..Plasma ucMGP did not reflect CAC in healthy older adults...