Matthijs Kox

Summary

Publications

  1. pmc Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases RCI, Geert Grooteplein 10, 6500, HB, Nijmegen, The Netherlands
    Arthritis Res Ther 17:150. 2015
  2. ncbi request reprint Sepsis-induced immunoparalysis: mechanisms, markers, and treatment options
    L Hamers
    Department of Intensive Care Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Minerva Anestesiol 81:426-39. 2015
  3. pmc Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans
    Matthijs Kox
    Intensive Care Medicine, Anesthesiology, Nijmegen Institute for Infection, Inflammation and Immunity, and
    Proc Natl Acad Sci U S A 111:7379-84. 2014
  4. doi request reprint The influence of concentration/meditation on autonomic nervous system activity and the innate immune response: a case study
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Psychosom Med 74:489-94. 2012
  5. doi request reprint Effects of the α7 nicotinic acetylcholine receptor agonist GTS-21 on the innate immune response in humans
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Internal Mail 685, Geert Grooteplein 10, 6500 HB, Nijmegen, The Netherlands
    Shock 36:5-11. 2011
  6. pmc IFN-γ-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1
    Stan de Kleijn
    Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 8:e72249. 2013
  7. doi request reprint Effects of the 34C>T Variant of the AMPD1 Gene on Immune Function, Multi-Organ Dysfunction, and Mortality in Sepsis Patients
    Bart P Ramakers
    Department of Pharmacology and Toxicology Intensive Care Medicine Internal Medicine Human Genetics Anesthesiology Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands 4th Department of Internal Medicine, University of Athens, Medical School, Athens Intensive Care Unit, G Gennimatas General Hospital, Thessaloniki 1st Department of Critical Care Medicine, University of Athens, Medical School Intensive Care Unit, Tzaneion General Hospital of Piraeus Department of Respiratory Medicine, Sismanogleion General Hospital Department of Therapeutics, Alexandra General Hospital 1st Department of Propedeutic Surgery, University of Athens, Medical School, Athens, Greece
    Shock 44:542-7. 2015
  8. doi request reprint How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo
    Bart P Ramakers
    Department of Pharmacology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Crit Care Med 40:2609-16. 2012
  9. doi request reprint Interplay between the acute inflammatory response and heart rate variability in healthy human volunteers
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Shock 36:115-20. 2011
  10. doi request reprint Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia
    Matthijs Kox
    Departments of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 39:1866-70. 2011

Collaborators

Detail Information

Publications45

  1. pmc Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases RCI, Geert Grooteplein 10, 6500, HB, Nijmegen, The Netherlands
    Arthritis Res Ther 17:150. 2015
    ..In the present study, we determined whether tVNS is a feasible and safe procedure and investigated its putative anti-inflammatory effects during experimental human endotoxemia...
  2. ncbi request reprint Sepsis-induced immunoparalysis: mechanisms, markers, and treatment options
    L Hamers
    Department of Intensive Care Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Minerva Anestesiol 81:426-39. 2015
    ..The challenging heterogeneity of septic patients in respect to immunomodulatory advances will be discussed, and recommendations for future research are provided. ..
  3. pmc Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans
    Matthijs Kox
    Intensive Care Medicine, Anesthesiology, Nijmegen Institute for Infection, Inflammation and Immunity, and
    Proc Natl Acad Sci U S A 111:7379-84. 2014
    ..These results could have important implications for the treatment of conditions associated with excessive or persistent inflammation, such as autoimmune diseases. ..
  4. doi request reprint The influence of concentration/meditation on autonomic nervous system activity and the innate immune response: a case study
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Psychosom Med 74:489-94. 2012
    ..The study participant holds several world records with regard to tolerating extreme cold and claims that he can influence his autonomic nervous system and thereby his innate immune response...
  5. doi request reprint Effects of the α7 nicotinic acetylcholine receptor agonist GTS-21 on the innate immune response in humans
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Internal Mail 685, Geert Grooteplein 10, 6500 HB, Nijmegen, The Netherlands
    Shock 36:5-11. 2011
    ....
  6. pmc IFN-γ-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1
    Stan de Kleijn
    Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 8:e72249. 2013
    ..Specific stimulation of neutrophils present at the inflammatory sites might therefore have a pivotal role in regulating lymphocyte-mediated inflammation and autoimmune disease. ..
  7. doi request reprint Effects of the 34C>T Variant of the AMPD1 Gene on Immune Function, Multi-Organ Dysfunction, and Mortality in Sepsis Patients
    Bart P Ramakers
    Department of Pharmacology and Toxicology Intensive Care Medicine Internal Medicine Human Genetics Anesthesiology Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands 4th Department of Internal Medicine, University of Athens, Medical School, Athens Intensive Care Unit, G Gennimatas General Hospital, Thessaloniki 1st Department of Critical Care Medicine, University of Athens, Medical School Intensive Care Unit, Tzaneion General Hospital of Piraeus Department of Respiratory Medicine, Sismanogleion General Hospital Department of Therapeutics, Alexandra General Hospital 1st Department of Propedeutic Surgery, University of Athens, Medical School, Athens, Greece
    Shock 44:542-7. 2015
    ..The common 34C>T loss-of-function variant of AMPD1 (rs17602729) is associated with increased adenosine formation, but effects on immune function and outcome in sepsis patients are unknown...
  8. doi request reprint How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo
    Bart P Ramakers
    Department of Pharmacology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Crit Care Med 40:2609-16. 2012
    ..We aimed to determine the changes in adenosine metabolism and signaling both in vivo during experimental human endotoxemia and in vitro...
  9. doi request reprint Interplay between the acute inflammatory response and heart rate variability in healthy human volunteers
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Shock 36:115-20. 2011
    ..Therefore, the magnitude of endotoxemia-related HRV changes does not reflect the extent of the inflammatory response...
  10. doi request reprint Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia
    Matthijs Kox
    Departments of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 39:1866-70. 2011
    ..The cytokines tumor necrosis factor-α, interleukin-6, interleukin-10, interleukin-1 receptor antagonist, and transforming growth factor-β were measured...
  11. doi request reprint Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients
    Kim Timmermans
    Department of Intensive Care Medicine, Radboud Institute for Molecular Life Sciences, Radboud Center for Infectious Diseases RCI, Radboud University Medical Center, Internal Mail 710, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Intensive Care Med 42:551-61. 2016
    ..We investigated DAMP release in trauma patients, starting in the prehospital phase, and assessed its relationship with immune suppression and nosocomial infections...
  12. doi request reprint Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study
    Jenneke Leentjens
    Radboud University Nijmegen Medical Centre, Department of Intensive Care Medicine, Geert Grooteplein zuid 10, Nijmegen, The Netherlands
    Am J Respir Crit Care Med 186:838-45. 2012
    ..Although IFN-γ and granulocyte-macrophage colony-stimulating factor (GM-CSF) restore immune competence of ex vivo stimulated leukocytes of patients with sepsis, effects on immunoparalysis in vivo are not known...
  13. doi request reprint The Involvement of Danger-Associated Molecular Patterns in the Development of Immunoparalysis in Cardiac Arrest Patients
    Kim Timmermans
    1Department of Intensive Care Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands 2Department of Anesthesiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands 3Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
    Crit Care Med 43:2332-8. 2015
    ..We investigated if immunoparalysis develops following cardiac arrest and whether the release of danger-associated molecular patterns could be involved...
  14. doi request reprint The effects of brain injury on heart rate variability and the innate immune response in critically ill patients
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    J Neurotrauma 29:747-55. 2012
    ..73, p=0.002). Our data suggest that brain injury, and especially conditions associated with increased ICP, is associated with vagus nerve-mediated immune suppression...
  15. pmc Blueprints of signaling interactions between pattern recognition receptors: implications for the design of vaccine adjuvants
    Kim Timmermans
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Vaccine Immunol 20:427-32. 2013
    ..These consistent signaling interactions between PRR combinations may represent promising targets for immunomodulation and vaccine adjuvant development...
  16. doi request reprint DANGER IN THE INTENSIVE CARE UNIT: DAMPS IN CRITICALLY ILL PATIENTS
    Kim Timmermans
    Department of Intensive Care Medicine Department of Anesthesiology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands
    Shock 45:108-16. 2016
    ..Furthermore, we discuss the role of DAMPs as markers or therapeutic targets in several conditions frequently encountered in critically ill patients, such as sepsis, trauma, ventilator-induced lung injury, and cardiac arrest...
  17. pmc IL-1β processing in mechanical ventilation-induced inflammation is dependent on neutrophil factors rather than caspase-1
    Kim Timmermans
    Department of Anaesthesiology, RUNMC, Nijmegen, 6500 HB, The Netherlands
    Intensive Care Med Exp 1:27. 2013
    ..Herein, we studied the roles of IL-1β, caspase-1 and neutrophil factors in the mechanical ventilation-induced inflammatory response in mice...
  18. pmc Effects of vagus nerve stimulation and vagotomy on systemic and pulmonary inflammation in a two-hit model in rats
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e34431. 2012
    ..These results questions the clinical applicability of stimulation of the cholinergic anti-inflammatory pathway in systemically inflamed patients admitted to the ICU where MV is initiated...
  19. doi request reprint Circulating iFABP Levels as a marker of intestinal damage in trauma patients
    Kim Timmermans
    Departments of Intensive Care Medicine, Anesthesiology, and Emergency Medicine, Helicopter Emergency Medical Services, and Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands
    Shock 43:117-20. 2015
    ..As intestinal injury is suggested to be related to late complications, such as multiorgan dysfunction syndrome or sepsis in trauma patients, strategies to prevent intestinal damage after trauma could be of benefit to these patients. ..
  20. doi request reprint Influence of different breathing patterns on heart rate variability indices and reproducibility during experimental endotoxaemia in human subjects
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Internal Mail 685, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands
    Clin Sci (Lond) 121:215-22. 2011
    ..Moreover, paced breathing did not result in a significant improvement in reproducibility. Therefore employing a paced breathing protocol is not required to obtain valid HRV data during endotoxaemia...
  21. pmc Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients
    Mark van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen, 6500HB, The Netherlands
    Crit Care 15:R297. 2011
    ..We examined plasma biomarkers in delirious and nondelirious patients and the role of these biomarkers on long-term cognitive function...
  22. pmc Transcriptome kinetics of circulating neutrophils during human experimental endotoxemia
    Stan de Kleijn
    Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e38255. 2012
    ..These changes in neutrophil transcriptome suggest a combination of early activation of circulating neutrophils by TNFα and G-CSF and a mobilization of young neutrophils from the bone marrow...
  23. doi request reprint Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change?
    Jenneke Leentjens
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Respir Crit Care Med 187:1287-93. 2013
    ..In addition, we present an appraisal of the recent advances in immunotherapy as an adjunctive treatment for sepsis...
  24. doi request reprint Mitochondrial DNA and TLR9 Signaling Is Not Involved in Mechanical Ventilation-Induced Inflammation
    Kim Timmermans
    From the Departments of Anesthesiology and Intensive Care Medicine, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands and Radboud Centre for Infectious Diseases RCI, Nijmegen, The Netherlands
    Anesth Analg 124:531-534. 2017
    ..Cytokine concentrations were similar between wild-type and TLR9/ mice. Mechanical ventilation does not result in the release of mtDNA, and TLR9 is not involved in mechanical ventilation-induced inflammation...
  25. ncbi request reprint Patterns in Bacterial- and Viral-Induced Immunosuppression and Secondary Infections in the ICU
    Rebecca M Koch
    Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, Nijmegen, The Netherlands Radboud university medical center, Radboud Institute for Molecular Life Sciences, Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Nijmegen, The Netherlands
    Shock 47:5-12. 2017
    ..Finally, future perspectives in the context of the development of diagnostic markers and possibilities for personalized therapy to improve the diagnosis and treatment of immunocompromised patients are discussed...
  26. pmc Immunologic Consequences of Hypoxia during Critical Illness
    Harmke D Kiers
    From the Departments of Intensive Care Medicine H D K, J G v d H, P P, M K and Anesthesiology H D K, G J S, M K, and the Radboud Centre for Infectious Diseases H D K, J G v d H, P P, M K, Radboud University Medical Center, Nijmegen, The Netherlands and Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado H K E
    Anesthesiology 125:237-49. 2016
    ....
  27. pmc The effects of orally administered Beta-glucan on innate immune responses in humans, a randomized open-label intervention pilot-study
    Jenneke Leentjens
    Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands Radboud Institute for Infectious Diseases, Nijmegen, The Netherlands
    PLoS ONE 9:e108794. 2014
    ..Oral β-glucan is inexpensive and well-tolerated, and therefore may represent a promising immunostimulatory compound for human use...
  28. pmc Short-term hyperoxia does not exert immunologic effects during experimental murine and human endotoxemia
    Dorien Kiers
    Department of Intensive Care Medicine, Radboud University Medical Center, Geert Grooteplein zuid 10, Nijmegen, 6500 HB, Netherlands
    Sci Rep 5:17441. 2015
    ..Our results indicate that hyperoxia does not exert direct anti-inflammatory effects and temper expectations of using it as an immunomodulatory treatment strategy. ..
  29. doi request reprint Inflammation-induced increases in plasma endocan levels are associated with endothelial dysfunction in humans in vivo
    Laura A E Cox
    Departments of Anesthesiology, Pain and Palliative Medicine, and Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    Shock 43:322-6. 2015
    ..Therefore, this study suggests that endocan could be a novel marker of endothelial dysfunction in inflammatory conditions. ..
  30. doi request reprint Soluble urokinase-type plasminogen activator levels are related to plasma cytokine levels but have low predictive value for mortality in trauma patients
    Kim Timmermans
    Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Department of Anaesthesiology, Radboud University Medical Center, Nijmegen, The Netherlands Electronic address
    J Crit Care 30:476-80. 2015
    ..The kinetics of suPAR and its correlation with the immune response and outcome in trauma patients are unknown...
  31. pmc Systemic inflammation decreases pain threshold in humans in vivo
    Moniek de Goeij
    Department of Anesthesiology, Pain and Palliative Medicine RUNMC, Nijmegen, The Netherlands
    PLoS ONE 8:e84159. 2013
    ..Changes in pain threshold during systemic inflammation evoked by human endotoxemia, were evaluated with three quantitative sensory testing methods...
  32. doi request reprint Plasma Nuclear and Mitochondrial DNA Levels, and Markers of Inflammation, Shock, and Organ Damage in Patients with Septic Shock
    Kim Timmermans
    Department of Intensive Care Medicine Department of Anesthesiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Radboud Centre for Infectious Diseases, Nijmegen, The Netherlands
    Shock 45:607-12. 2016
    ....
  33. doi request reprint Effects of serostatus and gender on the HRV-16-induced local immune response
    Rebecca M Koch
    Radboud University Medical Center, 6500 HB, Radboud Institute for Molecular Life Sciences, Department of Intensive Care Medicine, 6500 HB, Nijmegen, The Netherlands Electronic address
    Vaccine 34:4087-91. 2016
    ..These results have important implications for the design of future experimental cold studies: seronegative subjects, from both sexes can be included. ..
  34. doi request reprint Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis
    Shih Chin Cheng
    Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands
    Nat Immunol 17:406-13. 2016
    ..Finally, the immunometabolic defects in humans were partially restored by therapy with recombinant interferon-γ, which suggested that metabolic processes might represent a therapeutic target in sepsis. ..
  35. doi request reprint EFFECTS OF EXPERIMENTAL HUMAN ENDOTOXEMIA ON DIAPHRAGM FUNCTION
    Jonne Doorduin
    Departments of Critical Care Medicine Pulmonary Diseases, Radboud University Medical Center, Nijmegen, The Netherlands
    Shock 44:316-22. 2015
    ..However, the effects of in vivo endotoxin administration on diaphragm function in humans have not been studied. Our aim was to evaluate diaphragm function in a model of systemic inflammation in healthy subjects...
  36. pmc Gamma-irradiated bacille Calmette-Guérin vaccination does not modulate the innate immune response during experimental human endotoxemia in adult males
    Linda A C Hamers
    Department of Intensive Care Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases RCI, P O Box 9101, 6500 HB Nijmegen, Netherlands Department of Internal Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases RCI, P O Box 9101, 6500 HB Nijmegen, Netherlands
    J Immunol Res 2015:261864. 2015
    ..In conclusion, gamma-irradiated BCG is unlikely to represent an effective treatment option to restore immunocompetence in patients with sepsis-induced immunoparalysis. This trial is registered with NCT02085590...
  37. doi request reprint Body mass index is not associated with cytokine induction during experimental human endotoxemia
    Lucas T van Eijk
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Innate Immun 20:61-7. 2014
    ..No relationship between BMI and the cytokine response was found in healthy volunteers subjected to experimental endotoxemia. These data question the relationship between BMI and cytokine responses in critical illness. ..
  38. doi request reprint Potentially Inadvertent Immunomodulation: Norepinephrine Use in Sepsis
    Roeland F Stolk
    1 Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    Am J Respir Crit Care Med 194:550-8. 2016
    ..However, also for these agents, in vivo immunologic data in humans are largely lacking. As such, human studies on the immunomodulatory properties of norepinephrine and viable alternatives are highly warranted. ..
  39. doi request reprint "Less is more" in critically ill patients: not too intensive
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    JAMA Intern Med 173:1369-72. 2013
    ....
  40. doi request reprint GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biochem Pharmacol 78:863-72. 2009
    ..GTS-21 may be promising from a therapeutic perspective because of its suitability for human use...
  41. doi request reprint Mechanical ventilation of mice under general anesthesia during experimental procedures
    Ilona van den Brink
    Department of Anesthesiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Lab Anim (NY) 42:253-7. 2013
    ..Hemodynamic and pulmonary parameters remained within the normal ranges. The authors believe that this ventilation technique can be of great value for experimental procedures in mice that require general anesthesia...
  42. pmc Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans
    Lucas T van Eijk
    Department of Intensive Care Medicine, and Radboud Institute for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands
    Blood 124:2643-6. 2014
    ..This trial was registered at www.clinicaltrial.gov as #NCT01522794. ..
  43. pmc Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series
    Corine E Delsing
    Department of Internal Medicine, Division of Experimental Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    BMC Infect Dis 14:166. 2014
    ....
  44. doi request reprint Randomized controlled trial of daily interruption of sedatives in critically ill children
    Carin W M Verlaat
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Paediatr Anaesth 24:151-6. 2014
    ..To study the feasibility of daily interruption of sedatives in critically ill children...
  45. doi request reprint Modulation of the Innate Immune Response through the Vagus Nerve
    Matthijs Kox
    Department of Intensive Care Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases RCI, Nijmegen, The Netherlands
    Nephron 131:79-84. 2015
    ..We discuss the difficulties and drawbacks associated with investigating this pathway in humans, and finally, we provide future perspectives. ..