- Clustering of HCV coinfections on HIV phylogeny indicates domestic and sexual transmission of HCV
Roger D Kouyos
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland, Institute of Medical Virology, University of Zurich, Zurich, Switzerland, Laboratory of Virology, University Hospital Geneva, Geneva, Switzerland, Division of Immunology and Allergy, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland, Department Biomedicine, University of Basel, Basel, Switzerland, Division of Infectious Diseases, Geneva University Hospital, Geneva, Division of Immunology, University Hospital Lausanne, Lausanne, Switzerland, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Division of Infectious Diseases, Cantonal Hospital St Gallen, St Gallen, Switzerland and Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland
Int J Epidemiol 43:887-96. 2014
..HCV coinfection remains a major cause of morbidity and mortality among HIV-infected individuals and its incidence has increased dramatically in HIV-infected men who have sex with men(MSM)...
- On the role of resonance in drug failure under HIV treatment interruption
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germany
Theor Biol Med Model 10:44. 2013
..In the present study we used a mathematical model to analyse the parameters affecting the output of drug treatment interruption and the premises of the resonance hypothesis...
- Hospital-community interactions foster coexistence between methicillin-resistant strains of Staphylococcus aureus
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
PLoS Pathog 9:e1003134. 2013
..Thus, our results indicate that the large heterogeneities existing in human populations make coexistence between hospital- and community-associated strains of MRSA a likely outcome...
- Estimating the basic reproductive number from viral sequence data
Institute of Integrative Biology, Eidgenossische Technische Hochschule ETH Zurich, Zurich, Switzerland
Mol Biol Evol 29:347-57. 2012
..We apply the method to genetic data of the HIV-1 epidemic in Switzerland...
- Assessing the Paradox Between Transmitted and Acquired HIV Type 1 Drug Resistance Mutations in the Swiss HIV Cohort Study From 1998 to 2012
Wan Lin Yang
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
J Infect Dis 212:28-38. 2015
..Although the prevalence of drug resistance in patients who are not responding to treatment has declined in developed countries, the prevalence of TDR mutations has not. Mechanisms causing this paradox are poorly explored...
- High hepatic and extrahepatic mortality and low treatment uptake in HCV-coinfected persons in the Swiss HIV cohort study between 2001 and 2013
Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich, University of Zurich, Switzerland Electronic address
J Hepatol 63:573-80. 2015
- Reasons for late presentation to HIV care in Switzerland
Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland
J Int AIDS Soc 18:20317. 2015
..Late presentation to HIV care leads to increased morbidity and mortality. We explored risk factors and reasons for late HIV testing and presentation to care in the nationally representative Swiss HIV Cohort Study (SHCS)...
- The impact of vaccination on the breadth and magnitude of the antibody response to influenza A viruses in HIV-infected individuals
aInstitute of Medical Virology, University of Zurich, Zurich, Switzerland bDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich cPhD Program in Microbiology and Immunology, Life Science Zurich Graduate School, Zurich, Switzerland
AIDS 29:1803-10. 2015
..Also, there is no information about the breadth of the antibody response in HIV-infected individuals...
- A novel Acute Retroviral Syndrome Severity Score predicts the key surrogate markers for HIV-1 disease progression
Dominique L Braun
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
PLoS ONE 9:e114111. 2014
..A risk-based scoring system associated with surrogate markers of HIV-1 disease progression could be helpful to stratify patients with PHI at highest risk for HIV-1 disease progression...
- Inferring epidemic contact structure from phylogenetic trees
Gabriel E Leventhal
Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland
PLoS Comput Biol 8:e1002413. 2012
..Using a phylogeny from the Swiss HIV epidemic, we show that this epidemic has a significantly more unbalanced tree than would be expected from random mixing...
- Modeling the effect of HIV coinfection on clearance and sustained virologic response during treatment for hepatitis C virus
Department of Ecology and Evolutionary Biology, Princeton University, 106A Guyot Hall, Princeton, NJ 08544, USA Electronic address
Epidemics 12:1-10. 2015
..Understanding the within-host dynamics of these coinfecting pathogens is crucial, particularly in light of new, direct-acting antiviral agents (DAAs) for HCV treatment that are becoming available...
- Loss to follow-up of HIV-infected women after delivery: The Swiss HIV Cohort Study and the Swiss Mother and Child HIV Cohort Study
Department of Infectious Diseases, University Hospital Bern, Bern, Switzerland
J Int AIDS Soc 17:19535. 2014
..After delivery, however, childcare and competing commitments might lead to disengagement from HIV care. The aim of this study was to quantify loss to follow-up (LTFU) from HIV care after delivery and to identify risk factors for LTFU...
- Cycling empirical antibiotic therapy in hospitals: meta-analysis and models
Pia Abel Zur Wiesch
Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland Division of Global Health Equity, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Pathog 10:e1004225. 2014
..Our results suggest that "adjustable cycling" suppresses multiple resistance and warrants further investigations that allow comparing various diseases and hospital settings. ..
- Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1
Institute of Biogeochemistry and Pollutant Dynamics, ETH Zurich, Zurich, Switzerland
PLoS Genet 10:e1004439. 2014
..The estimated epistasis in the adapting populations is significantly negative. Our results highlight the importance of recombination in the evolution of HIV-I. ..