Jaewon Ko

Summary

Affiliation: Yonsei University
Country: Korea

Publications

  1. pmc The leucine-rich repeat superfamily of synaptic adhesion molecules: LRRTMs and Slitrks
    Jaewon Ko
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Mol Cells 34:335-40. 2012
  2. pmc Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 194:323-34. 2011
  3. pmc The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo
    Gilberto J Soler-Llavina
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5453, USA
    Proc Natl Acad Sci U S A 108:16502-9. 2011
  4. pmc LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Neuron 64:791-8. 2009
  5. pmc Neurexins physically and functionally interact with GABA(A) receptors
    Chen Zhang
    Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Neuron 66:403-16. 2010
  6. pmc An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus
    Mark R Etherton
    Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, CA, USA
    EMBO J 30:2908-19. 2011
  7. pmc MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development
    Kangduk Lee
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Proc Natl Acad Sci U S A 110:336-41. 2013
  8. doi request reprint LAR-RPTPs: synaptic adhesion molecules that shape synapse development
    Ji Won Um
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Trends Cell Biol 23:465-75. 2013
  9. pmc High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex
    Antony A Boucard
    Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 287:9399-413. 2012
  10. pmc PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission
    Ji Seung Ko
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Proc Natl Acad Sci U S A 112:1874-9. 2015

Collaborators

  • Thomas C Sudhof
  • Hyun Kim
  • Pavel Uvarov
  • Yong Chul Bae
  • Matti S Airaksinen
  • Eunjoon Kim
  • Joris De Wit
  • H Shawn Je
  • Manu Sharma
  • Antony A Boucard
  • Ji Won Um
  • Dongmin Lee
  • Gayoung Choii
  • Kangduk Lee
  • Katsuhiko Tabuchi
  • Gilberto J Soler-Llavina
  • Mark R Etherton
  • Chen Zhang
  • Sangmin Jeon
  • Seung Hee Lee
  • Daun Jeong
  • Hyeyeon Kang
  • Yi Sul Cho
  • Dongseok Park
  • Tae Yong Choi
  • Se Young Choi
  • Minhye Kim
  • Won Do Heo
  • Yeonsoo Choi
  • Gopal Pramanik
  • Cha Yeon Kim
  • Seong Gyu Lee
  • Min Young Song
  • Kee Hun Kim
  • Soo Jin Kim
  • Beom Seok Park
  • Doyoun Kim
  • Kang Sik Park
  • Jie Oh Lee
  • Jungyong Nam
  • Hyun Woo Lee
  • Yoonji Kim
  • Yuan Qiang
  • Sung Jin Lee
  • Robert C Malenka
  • Marc V Fuccillo
  • Axel T Brunger
  • Deniz Atasoy
  • Demet Arac
  • ALFRED J ROBISON
  • Marc V Fucillo
  • Xiaofei Yang

Detail Information

Publications14

  1. pmc The leucine-rich repeat superfamily of synaptic adhesion molecules: LRRTMs and Slitrks
    Jaewon Ko
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Mol Cells 34:335-40. 2012
    ..Their basic biochemical properties, proposed functions at synapses, physiological significances, and open questions are summarized...
  2. pmc Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 194:323-34. 2011
    ....
  3. pmc The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo
    Gilberto J Soler-Llavina
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5453, USA
    Proc Natl Acad Sci U S A 108:16502-9. 2011
    ..These results show that neurexin ligands in vivo form a dynamic synaptic cell adhesion network, with compensation between NLs and LRRTMs during early synapse development and functional divergence upon synapse maturation...
  4. pmc LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Neuron 64:791-8. 2009
    ..Thus, our data suggest that two unrelated postsynaptic cell-adhesion molecules, LRRTMs and neuroligins, unexpectedly bind to neurexins as the same presynaptic receptor, but that their binding is subject to distinct regulatory mechanisms...
  5. pmc Neurexins physically and functionally interact with GABA(A) receptors
    Chen Zhang
    Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Neuron 66:403-16. 2010
    ..Our findings suggest that besides their other well-documented interactions, presynaptic neurexins directly act on postsynaptic GABA(A) receptors, which may contribute to regulate the excitatory/inhibitory balance in brain...
  6. pmc An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus
    Mark R Etherton
    Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, CA, USA
    EMBO J 30:2908-19. 2011
    ..Our results suggest that the cytoplasmic tail of neuroligin-3 has a central role in synaptic transmission by modulating the recruitment of AMPA receptors to postsynaptic sites at excitatory synapses...
  7. pmc MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development
    Kangduk Lee
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Proc Natl Acad Sci U S A 110:336-41. 2013
    ..Taken together, our data suggest that MDGAs inhibit the activity of neuroligin-2 in controlling the function of inhibitory synapses and that MDGAs do so by binding to neuroligin-2...
  8. doi request reprint LAR-RPTPs: synaptic adhesion molecules that shape synapse development
    Ji Won Um
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Trends Cell Biol 23:465-75. 2013
    ..This review highlights the emerging role of LAR-RPTPs as synapse organizers in orchestrating synapse development. ..
  9. pmc High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex
    Antony A Boucard
    Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 287:9399-413. 2012
    ....
  10. pmc PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission
    Ji Seung Ko
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Proc Natl Acad Sci U S A 112:1874-9. 2015
    ..Our results collectively suggest that presynaptic PTPσ, together with GPC-4, acts in a HS-dependent manner to maintain excitatory synapse development and function...
  11. pmc Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins
    Ji Won Um
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Cell Rep 6:1096-109. 2014
    ..However, CST-3 does not directly bind to Nrxs. Viewed together, these data suggest that the three CSTs redundantly regulate inhibitory synapse formation, inhibitory synapse function, and neuron development in concert with Nrxs. ..
  12. pmc Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94304 5543, USA
    EMBO J 28:3244-55. 2009
    ..Thus, neuroligin-1 performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities...
  13. doi request reprint LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding
    Ji Won Um
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea Department of Physiology and BK21 PLUS Project to Medical Sciences, Yonsei University College of Medicine, Seoul 120 751, Korea
    Cell Rep 14:808-22. 2016
    ..Collectively, our data highlight alternative splicing and differential presynaptic ligand utilization in the regulation of LRRTMs, revealing key regulatory mechanisms for excitatory synapse development. ..
  14. doi request reprint Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion
    Ji Won Um
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Nat Commun 5:5423. 2014
    ..Thus, we propose a model in which Slitrks mediate synaptogenic functions through direct binding to LAR-RPTPs and the subsequent lateral assembly of LAR-RPTPs/Slitrks complexes. ..