Hoguen Kim

Summary

Affiliation: Yonsei University College of Medicine
Country: Korea

Publications

  1. doi Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers
    Hyun Ju Kang
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Lab Invest 89:948-59. 2009
  2. doi MicroRNA expression profile of gastrointestinal stromal tumors is distinguished by 14q loss and anatomic site
    Hee Jung Choi
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Int J Cancer 126:1640-50. 2010
  3. doi Can a biomarker-based scoring system predict pathologic complete response after preoperative chemoradiotherapy for rectal cancer?
    Hyuk Hur
    1Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea 2Department of Radiation Oncology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea 3Department of Medical Oncology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea 4Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Dis Colon Rectum 57:592-601. 2014
  4. pmc Diagnostic significance of serum HMGB1 in colorectal carcinomas
    Hanna Lee
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    PLoS ONE 7:e34318. 2012
  5. pmc Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors
    Kwon Tae You
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    PLoS Biol 5:e109. 2007
  6. ncbi Pathological characteristics of gastrointestinal stromal tumours with PDGFRA mutations
    Ji Eun Kwon
    Department of Pathology, Yonsei University College of Medicine, Seodaemun gu, Seoul, Korea
    Pathology 41:544-54. 2009
  7. doi Identification and selective degradation of neopeptide-containing truncated mutant proteins in the tumors with high microsatellite instability
    Won Kyu Kim
    Department of Pathology and Brain Korea 21 Projects for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
    Clin Cancer Res 19:3369-82. 2013
  8. doi Differential expression of CD133 based on microsatellite instability status in human colorectal cancer
    Jae Jun Park
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Mol Carcinog 53:E1-10. 2014
  9. ncbi Proteomic analysis distinguishes basaloid carcinoma as a distinct subtype of nonsmall cell lung carcinoma
    Long Shan Li
    Department of Pathology, Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea
    Proteomics 4:3394-400. 2004
  10. ncbi Frequent inactivation of SPARC by promoter hypermethylation in colon cancers
    Eungi Yang
    Department of Pathology, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Cancer 121:567-75. 2007

Detail Information

Publications89

  1. doi Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers
    Hyun Ju Kang
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Lab Invest 89:948-59. 2009
    ..Our results suggest that phosphorylated HMGB1 is transported to the cytoplasm, is subsequently secreted from the cell, and has a role in tumor progression through the activation of genes related to cell migration...
  2. doi MicroRNA expression profile of gastrointestinal stromal tumors is distinguished by 14q loss and anatomic site
    Hee Jung Choi
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Int J Cancer 126:1640-50. 2010
    ..The microRNA expression patterns of GISTs are closely related to the status of 14q loss, anatomic site, and tumor risk. These findings suggest that microRNA expression patterns can differentiate several subsets of GISTs...
  3. doi Can a biomarker-based scoring system predict pathologic complete response after preoperative chemoradiotherapy for rectal cancer?
    Hyuk Hur
    1Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea 2Department of Radiation Oncology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea 3Department of Medical Oncology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea 4Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Dis Colon Rectum 57:592-601. 2014
    ..Numerous molecular markers have been investigated as potential predictors of tumor responses to preoperative chemoradiotherapy (preCRT) for rectal cancer...
  4. pmc Diagnostic significance of serum HMGB1 in colorectal carcinomas
    Hanna Lee
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    PLoS ONE 7:e34318. 2012
    ..Our findings indicate that serum HMGB1 levels are increased in a subset of colorectal carcinomas, suggesting their potential utility as a supportive diagnostic marker for colorectal carcinomas...
  5. pmc Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors
    Kwon Tae You
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    PLoS Biol 5:e109. 2007
    ..Our findings suggest a novel mechanism of gene expression regulation for PTC-containing mRNAs in which the deleterious transcripts are regulated either by NMD or translational repression...
  6. ncbi Pathological characteristics of gastrointestinal stromal tumours with PDGFRA mutations
    Ji Eun Kwon
    Department of Pathology, Yonsei University College of Medicine, Seodaemun gu, Seoul, Korea
    Pathology 41:544-54. 2009
    ..The aim of this study was to identify the characteristics of PDGFRA-mutated gastrointestinal stromal tumours (GISTs) in comparison with KIT-mutated GISTs...
  7. doi Identification and selective degradation of neopeptide-containing truncated mutant proteins in the tumors with high microsatellite instability
    Won Kyu Kim
    Department of Pathology and Brain Korea 21 Projects for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
    Clin Cancer Res 19:3369-82. 2013
    ..However, mRNAs containing PTCs located in the last exon are not subject to degradation by NMD (NMD-irrelevant). This study aimed to discover whether genes with frameshift mutations in the last exon generate truncated mutant proteins...
  8. doi Differential expression of CD133 based on microsatellite instability status in human colorectal cancer
    Jae Jun Park
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Mol Carcinog 53:E1-10. 2014
    ..In conclusion, high levels of CD133 expression were observed more frequently in MSS CRC than in MSI-H, suggesting that differential expression of colon CSC markers may be linked to tumor characteristics dependent on MSI status...
  9. ncbi Proteomic analysis distinguishes basaloid carcinoma as a distinct subtype of nonsmall cell lung carcinoma
    Long Shan Li
    Department of Pathology, Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea
    Proteomics 4:3394-400. 2004
    ..Our findings suggest that basaloid carcinoma is a unique subtype of nonsmall cell lung carcinoma...
  10. ncbi Frequent inactivation of SPARC by promoter hypermethylation in colon cancers
    Eungi Yang
    Department of Pathology, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Cancer 121:567-75. 2007
    ..79% vs. 75.83% 5-year survival rate, p = 0.0014). The results indicate that epigenetic gene silencing of SPARC is frequent in colon cancers, and that inactivation of SPARC is related to rapid progression of colon cancers...
  11. ncbi Correlation of KIT and platelet-derived growth factor receptor alpha mutations with gene activation and expression profiles in gastrointestinal stromal tumors
    Hyun Ju Kang
    Department of Pathology, 134 Sichon dong, Seodaemun gu, CPO Box 8044, Yonsei University College of Medicine, Seoul 120 752, Korea
    Oncogene 24:1066-74. 2005
    ..Our findings demonstrate that mutations of KIT and PDGFRA affect differential activation and expression of some genes, and can be used for the molecular classification of GISTs...
  12. doi Activating mutations within the EGFR kinase domain: a molecular predictor of disease-free survival in resected pulmonary adenocarcinoma
    Young Joo Lee
    Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, CPO Box 8044, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Republic of Korea
    J Cancer Res Clin Oncol 135:1647-54. 2009
    ....
  13. doi Differential gene expression profiles of metastases in paired primary and metastatic colorectal carcinomas
    Kwi Hye Koh
    Brain Korea 21 Projects for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Oncology 75:92-101. 2008
    ..A total of 36 microarray experiments were analyzed by unsupervised two-way hierarchical clustering and multi-dimensional scaling (MDS)...
  14. doi 18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer
    Hyuk Hur
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    J Surg Oncol 103:17-24. 2011
    ..This study aims to evaluate the efficacy of (18)F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer...
  15. doi Thymidylate synthase gene polymorphism affects the response to preoperative 5-fluorouracil chemoradiation therapy in patients with rectal cancer
    Hyuk Hur
    Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 81:669-76. 2011
    ..This study aims to correlate thymidylate synthase (TS) gene polymorphisms with the tumor response to preoperative 5-fluorouracil (5-FU)-based chemoradiation therapy (CRT) in patients with rectal cancer...
  16. doi Identification of frequently mutated genes with relevance to nonsense mediated mRNA decay in the high microsatellite instability cancers
    Nara Shin
    Brain Korea 21 Projects for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Int J Cancer 128:2872-80. 2011
    ..The identified mutations are expected to contribute to MSI-H tumorigenesis by causing an absence of gene expression or low gene dosage effects...
  17. doi The diagnostic role of endoscopic submucosal dissection for gastric lesions with indefinite pathology
    Hyuk Lee
    Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Scand J Gastroenterol 47:1101-7. 2012
    ..We aimed to elucidate the role of endoscopic submucosal dissection (ESD) in clarifying the final pathologic diagnosis...
  18. doi Additive lymph node dissection may be necessary in minute submucosal cancer of the stomach after endoscopic resection
    Jie Hyun Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Ann Surg Oncol 19:779-85. 2012
    ..This study was designed to investigate the incidence of lymph node metastasis (LNM) in SM1-EGC based on surgical specimens and to evaluate the factors that indicate additional treatment after ER...
  19. doi Gene expression changes in patient-matched gastric normal mucosa, adenomas, and carcinomas
    Hyunki Kim
    Department of Pathology, Yonsei University College of Medicine, 120 752, Seoul, Republic of Korea
    Exp Mol Pathol 90:201-9. 2011
    ..The progressive alteration in gene expression in the transition from normal mucosa to carcinoma suggests that these changes may play critical roles in gastric carcinogenesis...
  20. ncbi Markedly enhanced cytolysis by E1B-19kD-deleted oncolytic adenovirus in combination with cisplatin
    A Rum Yoon
    Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
    Hum Gene Ther 17:379-90. 2006
    ....
  21. doi Loss of E-cadherin and MUC2 expressions correlated with poor survival in patients with stages II and III colorectal carcinoma
    Haeyoun Kang
    Department of Pathology, CHA University College of Medicine, Seongnam, Korea
    Ann Surg Oncol 18:711-9. 2011
    ..When considered together with tumor stage, molecular markers will allow us further insight into individual tumor biologies and prognoses...
  22. doi Signet ring cell mixed histology may show more aggressive behavior than other histologies in early gastric cancer
    Cheal Wung Huh
    Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
    J Surg Oncol 107:124-9. 2013
    ..However, the clinical significance of SRC mixture has not been reported. Aim was to investigate clinicopathologic features of mixed-SRC histology in early gastric cancer (EGC)...
  23. doi Differential features of pancreatobiliary- and intestinal-type ampullary carcinomas at MR imaging
    Yong Eun Chung
    Department of Radiology, Institute of Gastroenterology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seodaemun Ku, Shinchon Dong 134, Seoul 120 752, South Korea
    Radiology 257:384-93. 2010
    ..To define the differential imaging features of pancreatobiliary- and intestinal-type ampullary carcinomas at magnetic resonance (MR) imaging and to correlate these features with pathologic findings...
  24. ncbi Enhanced antitumor effect of oncolytic adenovirus expressing interleukin-12 and B7-1 in an immunocompetent murine model
    Young Sook Lee
    Brain Korea 21 Project for Medical Science, Institute for Cancer Research, Yonsei Cancer Center, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Clin Cancer Res 12:5859-68. 2006
    ..We investigated whether an armed viral platform, where lytic property of a viral infection is coupled to viral-mediated delivery of therapeutic genes, could increase the therapeutic potential of a viral-based therapy...
  25. ncbi Clinicopathologic characteristics related to the high variability of coding mononucleotide repeat sequences in tumors with high-microsatellite instability
    Kyung Young Chung
    Department of Thoracic Surgery, Yonsei University College of Medicine, Seoul, Korea
    Oncol Rep 10:439-44. 2003
    ..01). These findings suggest that mutational rates of the target genes in MSI-H tumors are diverse, and higher mutational rates are related to the length of mononucleotide repeat sequences of the target genes and histologic type of tumors...
  26. doi Analysis of nuclear high mobility group box 1 (HMGB1)-binding proteins in colon cancer cells: clustering with proteins involved in secretion and extranuclear function
    Hanna Lee
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    J Proteome Res 9:4661-70. 2010
    ..Our findings suggest that cytoplasmic HMGB1 binds to a number of molecules related to cancer progression and the unconventional secretory pathway...
  27. pmc Chromosomal imbalances in the colorectal carcinomas with microsatellite instability
    Long Shan Li
    Department of Pathology, and Brain Korea 21 Projects for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Am J Pathol 163:1429-36. 2003
    ..01 and P = 0.02, respectively). Our findings indicate that unique CIs were present in a subset of MSI-H colorectal carcinomas and that these CIs are related to the mutation of several target genes, especially of hRAD50...
  28. doi Oncologic outcomes after radical surgery following preoperative chemoradiotherapy for locally advanced lower rectal cancer: abdominoperineal resection versus sphincter-preserving procedure
    Jin Soo Kim
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    Ann Surg Oncol 16:1266-73. 2009
    ..The aim of this study was to compare the outcomes between abdominoperineal resection (APR) and SPP after preoperative CRT in patients with locally advanced lower rectal cancer...
  29. doi The prognostic impact of the number of lymph nodes retrieved after neoadjuvant chemoradiotherapy with mesorectal excision for rectal cancer
    Young Wan Kim
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    J Surg Oncol 100:1-7. 2009
    ..We aimed to assess factors associated with the number of nodes retrieved and the impact of the number of lymph nodes in rectal cancer patients who underwent neoadjuvant chemoradiation with radical surgery...
  30. doi A new versatile peptide-based size exclusion chromatography platform for global profiling and quantitation of candidate biomarkers in hepatocellular carcinoma specimens
    Hyoung Joo Lee
    Department of Biochemistry, Yonsei Proteome Research Center and Biomedical Proteome Research Center, Yonsei University, Seoul, Korea
    Proteomics 11:1976-84. 2011
    ..Thus, our pep-SEC platform is an efficient and versatile pre-fractionation system for the large-scale profiling and quantitation of candidate biomarkers in complex disease proteomes...
  31. doi Lymphovascular invasion is an important predictor of lymph node metastasis in endoscopically resected early gastric cancers
    Hyunki Kim
    Department of Pathology, Yonsei University College of Medicine, 120 752 Seoul, Republic of Korea
    Oncol Rep 25:1589-95. 2011
    ..Among these factors, the presence of LVI was the most important risk factor for LN metastasis in endoscopically resected early gastric cancer...
  32. doi Poorly Differentiated Carcinoma Component in Submucosal Layer Should be Considered as an Additional Criterion for Curative Endoscopic Resection of Early Gastric Cancer
    Da Hyun Jung
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Ann Surg Oncol 22:S772-7. 2015
    ..Therefore, we investigated whether a minor poorly differentiated carcinoma (PDC) component in the submucosal (SM) layer affects LNM in differentiated EGC...
  33. doi Macrophage migration inhibitory factor may be used as an early diagnostic marker in colorectal carcinomas
    Hanna Lee
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Am J Clin Pathol 129:772-9. 2008
    ..3% vs 29.5%). However, the specificity was not as high as that of CEA (90.6% vs 100.0%). Our findings indicate that MIF may be used as a diagnostic marker in colorectal carcinomas...
  34. ncbi Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation
    Yon Rak Choi
    Department of Pathology, Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, 120 752 Seoul, Korea
    Cancer Res 63:2188-93. 2003
    ....
  35. ncbi Differentially expressed proteins in gastrointestinal stromal tumors with KIT and PDGFRA mutations
    Hyun Ju Kang
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Proteomics 6:1151-7. 2006
    ..Moreover, it may play a role in the development and progression of GIST according to activating mutation type, as these proteins have been shown to be involved in tumor metastasis, apoptosis and immune response...
  36. pmc Therapeutic and tumor-specific immunity induced by combination of dendritic cells and oncolytic adenovirus expressing IL-12 and 4-1BBL
    Jing Hua Huang
    Brain Korea 21 Project for Medical Sciences, Institute for Cancer Research, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
    Mol Ther 18:264-74. 2010
    ..Taken together, these data highlight the potential therapeutic benefit of combining IL-12- and 4-1BBL-coexpressing oncolytic Ad with DCs and warrants further evaluation in the clinic...
  37. ncbi Phase II study of erlotinib in advanced non-small-cell lung cancer after failure of gefitinib
    Byoung Chul Cho
    Yonsei Cancer Center, Seoul, Korea
    J Clin Oncol 25:2528-33. 2007
    ..This study was designed to evaluate the efficacy and toxicity of erlotinib in patients with advanced non-small-cell lung cancer (NSCLC) who experienced disease progression after treatment with gefitinib...
  38. ncbi Tudor domain-containing protein 4 as a potential cancer/testis antigen in liver cancer
    Heejei Yoon
    Department of Pathology and BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
    Tohoku J Exp Med 224:41-6. 2011
    ..In conclusion, TDRD4 mRNA is expressed in a subset of liver cancers, and TDRD4 is a candidate CT antigen for liver cancer...
  39. doi MicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation
    Won Kyu Kim
    Department of Pathology, Yonsei, University College of Medicine, Seoul 120752, Korea
    Clin Cancer Res 17:7584-94. 2011
    ..This study aimed to discover microRNAs (miRNA) that target KIT and reveal the relationship between the discovered miRNAs and KIT expression in GISTs...
  40. doi Human liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients
    Keun Na
    Yonsei Proteome Reasearch Center, Yonsei University, Seoul, Korea
    Int J Cancer 133:408-15. 2013
    ..It is now feasible to further validate this novel plasma-based biomarker in the large cohort we assembled...
  41. doi High mobility group box-1 is phosphorylated by protein kinase C zeta and secreted in colon cancer cells
    Hanna Lee
    Department of Pathology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemoon ku, Seoul, Republic of Korea
    Biochem Biophys Res Commun 424:321-6. 2012
    ..Our findings suggest that PKC-ΞΆ is involved in the phosphorylation of HMGB1, and the phosphorylation of specific serine residues in the nuclear localization signal regions is related to enhanced HMGB1 secretion in colon cancer cells...
  42. doi Clinical outcomes and factors related to resectability and curability of EMR for early colorectal cancer
    Jae Jun Park
    Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea
    Gastrointest Endosc 74:1337-46. 2011
    ..EMR has emerged as an alternative therapeutic option for selected cases of early colorectal cancer (ECC). However, the factors associated with resectability and curability of EMR for ECC remain unknown...
  43. doi The differential impact of microsatellite instability as a marker of prognosis and tumour response between colon cancer and rectal cancer
    Sung Pil Hong
    Division of Gastroenterology, Yonsei University College of Medicine, Seoul, Republic of Korea
    Eur J Cancer 48:1235-43. 2012
    ..We investigated the differential impact of MSI between colon and rectal cancers as a marker of prognosis and chemotherapeutic response...
  44. doi Endoscopic resection for undifferentiated early gastric cancer
    Jie Hyun Kim
    Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Gastrointest Endosc 69:e1-9. 2009
    ..The aim of this study was to evaluate the clinicopathologic outcomes of ER performed in undifferentiated EGC with special reference to histopathologic subtypes to examine the feasibility of ER in undifferentiated EGC...
  45. doi High microsatellite instability predicts good prognosis in intestinal-type gastric cancers
    Hyunki Kim
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 26:585-92. 2011
    ..A subset of gastric cancers showed high microsatellite instability (MSI-H). The reported clinicopathological features of MSI-H gastric cancers are heterogeneous, and specific factors associated with prognosis have not been identified...
  46. doi Effectiveness of radical surgery after incomplete endoscopic mucosal resection for early colorectal cancers: a clinical study investigating risk factors of residual cancer
    Jae Hak Kim
    Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Dig Dis Sci 53:2941-6. 2008
    ..However, microscopic lateral margin positivity without gross remnant tumor and deep submucosal invasion might not indicate residual cancer. This needs to be further validated by a large scale, prospective study with long-term follow-up...
  47. ncbi Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy
    Joo Hang Kim
    Brain Korea 21 Project for Medical Sciences, Institute for Cancer Research, Yonsei Cancer Center, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul, Korea
    J Natl Cancer Inst 98:1482-93. 2006
    ..We investigated whether the expression of the cell matrix-degradative protein relaxin by adenovirus could improve adenovirus distribution and penetration in tumors...
  48. pmc Intestinal endometriosis mimicking carcinoma of rectum and sigmoid colon: a report of five cases
    Jin Soo Kim
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    Yonsei Med J 50:732-5. 2009
    ..We suggest to consider also intestinal endometriosis in reproductive women presenting with gastrointestinal symptoms and an intestinal mass of unknown origin...
  49. ncbi Identical epidermal growth factor receptor mutations in adenocarcinomatous and squamous cell carcinomatous components of adenosquamous carcinoma of the lung
    Shin Myung Kang
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Cancer 109:581-7. 2007
    ..Attempts to investigate the EGFR mutation status in each component of adenosquamous carcinoma and to characterize the patients according to mutation status may help to understand the histogenesis of adenosquamous carcinoma...
  50. doi Is the recent WHO histological classification for gastric cancer helpful for application to endoscopic resection?
    Yong Hoon Kim
    Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam Gu, Seoul, 135 720, Korea
    Gastric Cancer 19:869-75. 2016
    ..Thus, we assessed whether the WHO classification is helpful when endoscopic resection is performed for treatment of UD-EGC...
  51. doi Clinicopathologic features of gastric carcinoma with lymphoid stroma in early gastric cancer
    Cheal Wung Huh
    Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    J Surg Oncol 114:769-772. 2016
    ..Gastric carcinoma with lymphoid stroma (GCLS) is a rare variant of gastric cancer. The aims of this study were to investigate the clinicopathologic features of GCLS in early gastric cancer (EGC)...
  52. ncbi Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival
    Hyunki Kim
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Proteomics 6:3466-76. 2006
    ..Our findings indicate that suppression of SELENBP1 is a frequent and late event in colorectal carcinogenesis, and may contribute to the rapid progression of colorectal carcinoma...
  53. doi Surveillance strategy for rectal neuroendocrine tumors according to recurrence risk stratification
    Dong Hyun Kim
    Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul, 120 752, South Korea
    Dig Dis Sci 59:850-6. 2014
    ..However, the recommendations for disease surveillance after tumor resection have not been well established. We evaluated the long-term outcomes of rectal NETs and surveillance strategies according to recurrence risk stratification...
  54. ncbi Nuclear expression of Yes-associated protein 1 correlates with poor prognosis in intestinal type gastric cancer
    Meiying Song
    Brain Korea 21 Projects for Medical Science, and Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea
    Anticancer Res 32:3827-34. 2012
    ..To investigate the prognostic value of YAP1 in gastric cancer (GC), we assessed its expression in tumors from patients...
  55. ncbi ADP-overexpressing adenovirus elicits enhanced cytopathic effect by induction of apoptosis
    Chae Ok Yun
    Brain Korea 21 Project for Medical Sciences, Institute for Cancer Research, Yonsei Cancer Center, Seoul, Korea
    Cancer Gene Ther 12:61-71. 2005
    ....
  56. doi Comprehensive genome-wide proteomic analysis of human placental tissue for the Chromosome-Centric Human Proteome Project
    Hyoung Joo Lee
    Yonsei Proteome Research Center and Department of Integrated Omics for Biomedical Science, World Class University Program, Yonsei University, Seoul, Korea
    J Proteome Res 12:2458-66. 2013
    ..As far as we know, this work produced the highest number of proteins identified in the placenta and will be useful for annotating and mapping all proteins encoded in the human genome...
  57. ncbi Gastrointestinal stromal tumor of the rectum: an analysis of seven cases
    Seung Hyuk Baik
    Department of Surgery, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun Ku, 120 752, Seoul, South Korea
    Surg Today 37:455-9. 2007
    ..Gastrointestinal stromal tumors (GISTs) rarely originate in the rectum. We investigated the clinicopathologic characteristics of rectal GISTs...
  58. doi Microsatellite instability in sporadic gastric cancer: its prognostic role and guidance for 5-FU based chemotherapy after R0 resection
    Ji Yeong An
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    Int J Cancer 131:505-11. 2012
    ..MSI status in gastric cancer is not itself a prognostic indicator. However, it appears to be a possible guidance for the use of 5-FU-based chemotherapy in stage II and III gastric cancers after R0 resection...
  59. ncbi Protein profiling of human plasma samples by two-dimensional electrophoresis
    Sang Yun Cho
    Department of Biochemistry, College of Sciences, Yonsei Biomedical Proteome Research Center, Seoul, Korea
    Methods Mol Biol 428:57-75. 2008
    ..Here, we describe a typical 2DE procedure for plasma proteome under either a healthy or a diseased state (e.g., liver cancer) in which pre-fractionation and depletion are integral steps in the search for disease biomarkers...
  60. ncbi Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells
    Jie Hyun Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Oncol Rep 23:1523-8. 2010
    ..pylori-infected compared to non-infected gastric cancer tissues. Conclusively, H. pylori activated the Shh signaling pathway in CagA-dependent manner partly through the NF-kappaB pathway in gastric cancer cells...
  61. pmc Oncologic outcomes after neoadjuvant chemoradiation followed by curative resection with tumor-specific mesorectal excision for fixed locally advanced rectal cancer: Impact of postirradiated pathologic downstaging on local recurrence and survival
    Nam Kyu Kim
    Colorectal Cancer Clinic, Severance Hospital, Yonsei University Medical Center, Yonsei University College of Medicine, Seoul, Korea
    Ann Surg 244:1024-30. 2006
    ....
  62. doi A Randomized Phase 2 Study of Neoadjuvant Chemoradiaton Therapy With 5-Fluorouracil/Leucovorin or Irinotecan/S-1 in Patients With Locally Advanced Rectal Cancer
    Minkyu Jung
    Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 93:1015-22. 2015
    ....
  63. ncbi Expression of Wnt target genes in solid pseudopapillary tumor of the pancreas: a pilot study
    Chang Moo Kang
    Department of Surgery, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Pancreas 38:e53-9. 2009
    ....
  64. ncbi Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability
    Hyunki Kim
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    J Pathol 200:23-31. 2003
    ..001). These findings indicate that hMLH1 is one of the frequent methylation targets in CIMP-H gastric carcinomas and that inactivation of hMLH1 through promoter hypermethylation results in tumours following the MSI pathway...
  65. ncbi Different gene expression profiles between microsatellite instability-high and microsatellite stable colorectal carcinomas
    Hyunki Kim
    Department of Pathology, Yonsei University College of Medicine, Seoul 120 752, Korea
    Oncogene 23:6218-25. 2004
    ..Our findings indicate that there are many different genetic and transcriptomic characteristics between MSI-H and MSS colorectal carcinomas, and some of these differently expressed genes can be used as diagnostic or prognostic markers...
  66. ncbi Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas
    Kwi H Koh
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Lab Invest 85:1130-8. 2005
    ..Our findings suggest that mutations of hRAD50 and hMRE11 genes in MMR-deficient tumors are related to the defects in NHEJ, and this may result in chromosomal changes during the progression of tumor...
  67. doi Molecular markers predict distant metastases after adjuvant chemoradiation for rectal cancer
    Jun Won Kim
    Department of Radiation Oncology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Int J Radiat Oncol Biol Phys 84:e577-84. 2012
    ..We explored the role of molecular markers for predicting the outcome of adjuvant chemoradiation for rectal cancer patients...
  68. doi Application of a peptide-based PF2D platform for quantitative proteomics in disease biomarker discovery
    Hyoung Joo Lee
    Department of Biochemistry, Yonsei Proteome Research Center and Biomedical Proteome Research Center, Yonsei University, Seoul, Korea
    Proteomics 8:3371-81. 2008
    ....
  69. doi Quantitative analysis of phosphopeptides in search of the disease biomarker from the hepatocellular carcinoma specimen
    Hyoung Joo Lee
    Department of Biochemistry, College of Life Sciences and Biotechnology, Yonsei Proteome Research Center and Biomedical Proteome Research Center, Yonsei University, Seoul, Korea
    Proteomics 9:3395-408. 2009
    ....
  70. doi Robotic versus laparoscopic low anterior resection of rectal cancer: short-term outcome of a prospective comparative study
    Seung Hyuk Baik
    Department of Surgery, Yonsei University College of Medicine, Shinchon dong, Seodaemun Ku, Seoul, Korea
    Ann Surg Oncol 16:1480-7. 2009
    ..The aim of this study is to compare the short-term results between robotic-assisted low anterior resection (R-LAR), using the da Vinci Surgical System, and standard laparoscopic low anterior resection (L-LAR) in rectal cancer patients...
  71. ncbi An integrated proteome database for two-dimensional electrophoresis data analysis and laboratory information management system
    Sang Yun Cho
    Yonsei Proteome Research Center, Department of Biochemistry and Bioproducts Research Center, Yonsei University, Seoul, Korea
    Proteomics 2:1104-13. 2002
    ..The information in YPRC-PDB is updated easily and it is available to authorized users on the World Wide Web (http://yprcpdb.proteomix.org/ approximately damduck/)...
  72. ncbi [Serial episodes of gastric and cecal perforation in a patient with Behcet's disease involving the whole gastrointestinal tract: a case report]
    Dong Yeob Shin
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Korean J Gastroenterol 53:106-10. 2009
    ..Here, we present a 55-year-old Korean man with intestinal BD and multiple ileal and colonic ulcerations complicated by perforation, gastric ulcer with bleeding followed by perforation, and esophageal ulcers with bleeding...
  73. pmc A case of more abundant and dysplastic adenomas in the interposed colon than in the native colon
    Hye Jin Hwang
    Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 48:1075-8. 2007
    ..Changing of location and functional demand of colonic segment, and the exposure to different intraluminal contents might have facilitated the adenoma- carcinoma transformation in the interposed colon...
  74. ncbi Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas
    Sung P Hong
    Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 120 752 Seoul, Korea
    Oncol Rep 21:19-24. 2009
    ..It is concluded that Cripto-1 overexpression is involved in the tumorigenesis of gastric- and pancreatobiliary-type IPMNs...
  75. doi Factors related to preoperative assessment of the circumferential resection margin and the extent of mesorectal invasion by magnetic resonance imaging in rectal cancer: a prospective comparison study
    Young Wan Kim
    Department of Surgery, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun Ku, Seoul, 120 752, Korea
    World J Surg 33:1952-60. 2009
    ....
  76. pmc Needle knife-assisted endoscopic polypectomy for a large inflammatory fibroid colon polyp by making its stalk into an omega shape using an endoloop
    Byung Chang Kim
    Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 49:680-6. 2008
    ....
  77. ncbi MicroRNA involvement in gastrointestinal stromal tumor tumorigenesis
    Won Kyu Kim
    Brain Korea 21 Projects for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Curr Pharm Des 19:1227-35. 2013
    ..This review summarizes the characteristics of GISTs, their molecular and clinical implications, the role of microRNAs in GIST tumorigenesis, and their possible therapeutic potential...
  78. pmc Clinical impact of tumor regression grade after preoperative chemoradiation for locally advanced rectal cancer: subset analyses in lymph node negative patients
    Byung Soh Min
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    J Korean Soc Coloproctology 27:31-40. 2011
    ..We investigated the prognostic significance of tumor regression grade (TRG) after preoperative chemoradiation therapy (preop-CRT) for locally advanced rectal cancer especially in the patients without lymph node metastasis...
  79. doi Atypical teratoid/rhabdoid tumor: analysis of cytomorphologic features in CSF, focused on the differential diagnosis from mimickers
    Junjeong Choi
    Department of Pathology, Yonsei University College of Medicine, Seongsanno 250 Seodaemun Ku, Seoul, 120 752, Republic of Korea
    Diagn Cytopathol 40:592-6. 2012
    ..The presence of these cells in CSF indicates disseminated diseases and aggressive therapeutic consideration for patient management is required...
  80. ncbi Coxsackie and adenovirus receptor binding ablation reduces adenovirus liver tropism and toxicity
    Chae Ok Yun
    Brain Korea 21 Project for Medical Science, Institute for Cancer Research, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, 120 752, Korea
    Hum Gene Ther 16:248-61. 2005
    ....
  81. ncbi Synaptic scaffolding molecule binds to and regulates vasoactive intestinal polypeptide type-1 receptor in epithelial cells
    Heon Yung Gee
    Department of Pharmacology and Brain Korea 21 Project for Medical Science, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Gastroenterology 137:607-17, 617.e1-4. 2009
    ..We analyzed the association between S-SCAM and VPAC1...
  82. doi Comparison of the clinicopathologic features between flat and polypoid adenoma
    Sang Kil Lee
    Departments of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Scand J Gastroenterol 43:1116-21. 2008
    ..The aim of this study was to compare the clinicopathologic characteristics, including degree of dysplasia and malignancy, between flat and polypoid adenomas 5 mm in size or larger...
  83. ncbi Prognostic significance of circumferential resection margin following total mesorectal excision and adjuvant chemoradiotherapy in patients with rectal cancer
    Seung Hyuk Baik
    Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea
    Ann Surg Oncol 14:462-9. 2007
    ..This study was designed to evaluate the prognostic value of circumferential resection margin (CRM) in rectal cancer patients who underwent curative resection with adjuvant chemoradiotherapy (CRT)...
  84. pmc Achalasia combined with esophageal cancer treated by concurrent chemoradiation therapy
    Jun Chul Park
    Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Gut Liver 3:329-33. 2009
    ..Although surveillance endoscopy in achalasia patients is still controversial, periodic screening for cancer development in long-standing achalasia patients might be advisable...
  85. ncbi Noninvasive molecular biomarkers for the detection of colorectal cancer
    Hye Jung Kim
    Life Sciences Division, Korea Institute of Science and Technology, Seoul, Korea
    BMB Rep 41:685-92. 2008
    ..Here, noninvasive molecular biomarkers that are currently used in clinical settings and have the potential for use as CRC biomarkers are discussed...
  86. ncbi Overview and introduction to clinical proteomics
    Young Ki Paik
    Department of Biochemistry, Yonsei Proteome Research Center and Biomedical Proteome Research Center, Seoul, Korea
    Methods Mol Biol 428:1-31. 2008
    ....
  87. ncbi [Clinical and pathological significance of the genetic analysis in colorectal carcinomas]
    Hoguen Kim
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Korean J Gastroenterol 43:275-82. 2004
    ..MSI-H has been reported as a marker for better prognosis. Individualizing chemoradiation by use of predictive markers for response or resistance to therapy is important in patients with advanced disease or candidacy for adjuvant therapy...
  88. ncbi Clinical, histological, and immunohistochemical features predicting 1p/19q loss of heterozygosity in oligodendroglial tumors
    Se Hoon Kim
    Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea
    Acta Neuropathol 110:27-38. 2005
    ..Therefore, applying these features in clinical practice, would be helpful in clarifying oligodendroglial tumor diagnosis...
  89. ncbi Gastric true leiomyoma: computed tomographic findings and pathological correlation
    Mi Jung Lee
    Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea
    J Comput Assist Tomogr 31:204-8. 2007
    ..This study describes the computed tomographic (CT) findings of true leiomyomas in the stomach...