Keunhee Oh

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. doi request reprint Invariant NKT cells regulate experimental autoimmune uveitis through inhibition of Th17 differentiation
    Keunhee Oh
    Laboratory of Immunology, Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea
    Eur J Immunol 41:392-402. 2011
  2. doi request reprint CP-690550, a Janus kinase inhibitor, suppresses CD4+ T-cell-mediated acute graft-versus-host disease by inhibiting the interferon-γ pathway
    Hyung Bae Park
    Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea
    Transplantation 90:825-35. 2010
  3. doi request reprint Transglutaminase 2 exacerbates experimental autoimmune encephalomyelitis through positive regulation of encephalitogenic T cell differentiation and inflammation
    Keunhee Oh
    Laboratory of Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak ro Jongno gu, Seoul, Republic of Korea
    Clin Immunol 145:122-32. 2012
  4. pmc Airway epithelial cells initiate the allergen response through transglutaminase 2 by inducing IL-33 expression and a subsequent Th2 response
    Keunhee Oh
    Department of Biomedical Sciences, Laboratory of Immunology and Cancer Biology, Seoul, Korea
    Respir Res 14:35. 2013
  5. pmc Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens
    Hee Gyung Kang
    Kidney Research Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Immunology 129:567-77. 2010
  6. doi request reprint Both CD45RA+ and CD45RO+ human CD4+ T cells drive direct xenogeneic T-cell responses against porcine aortic endothelial cells
    Chi Hwa Kim
    Laboratory of Immunology, Department of Anatomy, College of Medicine, Seoul National University, Seoul, Korea
    Xenotransplantation 17:224-32. 2010
  7. pmc Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice
    Keunhee Oh
    Laboratory of Immunology, Department of Biomedical Sciences Transplantation Research Institute, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Exp Med 208:1707-19. 2011
  8. doi request reprint The effect of alloferon on the enhancement of NK cell cytotoxicity against cancer via the up-regulation of perforin/granzyme B secretion
    Seyeon Bae
    Department of Anatomy, Seoul National University College of Medicine, Seoul, Republic of Korea
    Immunobiology 218:1026-33. 2013
  9. doi request reprint Prognostic and functional importance of the engraftment-associated genes in the patient-derived xenograft models of triple-negative breast cancers
    Hyeong Gon Moon
    Department of Surgery, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, 110 744, Seoul, Korea
    Breast Cancer Res Treat 154:13-22. 2015
  10. pmc Intratumoral administration of secondary lymphoid chemokine and unmethylated cytosine-phosphorothioate-guanine oligodeoxynucleotide synergistically inhibits tumor growth in vivo
    So Mi Oh
    Laboratory of Immunology, Transplantation Research Institute, Seoul, Korea
    J Korean Med Sci 26:1270-6. 2011

Collaborators

Detail Information

Publications20

  1. doi request reprint Invariant NKT cells regulate experimental autoimmune uveitis through inhibition of Th17 differentiation
    Keunhee Oh
    Laboratory of Immunology, Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea
    Eur J Immunol 41:392-402. 2011
    ..Our results indicate that invariant NKT cells inhibited autoimmune uveitis predominantly through the cytokine-independent inhibition of Th17 differentiation...
  2. doi request reprint CP-690550, a Janus kinase inhibitor, suppresses CD4+ T-cell-mediated acute graft-versus-host disease by inhibiting the interferon-γ pathway
    Hyung Bae Park
    Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea
    Transplantation 90:825-35. 2010
    ..Here, we evaluated the protective effect of CP-690550, a newly developed Janus kinase inhibitor, in an acute GVHD model...
  3. doi request reprint Transglutaminase 2 exacerbates experimental autoimmune encephalomyelitis through positive regulation of encephalitogenic T cell differentiation and inflammation
    Keunhee Oh
    Laboratory of Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak ro Jongno gu, Seoul, Republic of Korea
    Clin Immunol 145:122-32. 2012
    ..This study is the first to report a pathogenic role for TG2 in the EAE progress and suggests that therapeutic targeting of TG2 may be effective against multiple sclerosis...
  4. pmc Airway epithelial cells initiate the allergen response through transglutaminase 2 by inducing IL-33 expression and a subsequent Th2 response
    Keunhee Oh
    Department of Biomedical Sciences, Laboratory of Immunology and Cancer Biology, Seoul, Korea
    Respir Res 14:35. 2013
    ..In this study, we evaluated the role of TG2 in the pathogenesis of allergic asthma, particularly whether TG2 affects initial activation signaling leading to Th2 differentiation against antigens...
  5. pmc Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens
    Hee Gyung Kang
    Kidney Research Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Immunology 129:567-77. 2010
    ..Consequently, FIDC-induced T-cell hyporesponsiveness could reflect anergy rather than specific deletion. Our findings suggest that FIDCs of donor strain could be used to induce long-term graft survival...
  6. doi request reprint Both CD45RA+ and CD45RO+ human CD4+ T cells drive direct xenogeneic T-cell responses against porcine aortic endothelial cells
    Chi Hwa Kim
    Laboratory of Immunology, Department of Anatomy, College of Medicine, Seoul National University, Seoul, Korea
    Xenotransplantation 17:224-32. 2010
    ..Here, we sought to determine whether human peripheral blood memory/activated phenotype T cells are directly responsive to porcine endothelial cells...
  7. pmc Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice
    Keunhee Oh
    Laboratory of Immunology, Department of Biomedical Sciences Transplantation Research Institute, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Exp Med 208:1707-19. 2011
    ..Therefore, TG2 represents an interesting potential target for therapeutic intervention...
  8. doi request reprint The effect of alloferon on the enhancement of NK cell cytotoxicity against cancer via the up-regulation of perforin/granzyme B secretion
    Seyeon Bae
    Department of Anatomy, Seoul National University College of Medicine, Seoul, Republic of Korea
    Immunobiology 218:1026-33. 2013
    ..All taken together, these results suggest that alloferon has anti-tumor effects through up-regulation of NK-activating receptor 2B4 and the enhancement of granule exocytosis from NK cells...
  9. doi request reprint Prognostic and functional importance of the engraftment-associated genes in the patient-derived xenograft models of triple-negative breast cancers
    Hyeong Gon Moon
    Department of Surgery, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, 110 744, Seoul, Korea
    Breast Cancer Res Treat 154:13-22. 2015
    ..Our results show that the PDX engraftment may reflect the aggressive phenotype in breast cancer. Genes associated with the PDX engraftment may provide a novel prognostic biomarker and therapeutic targets in TNBC. ..
  10. pmc Intratumoral administration of secondary lymphoid chemokine and unmethylated cytosine-phosphorothioate-guanine oligodeoxynucleotide synergistically inhibits tumor growth in vivo
    So Mi Oh
    Laboratory of Immunology, Transplantation Research Institute, Seoul, Korea
    J Korean Med Sci 26:1270-6. 2011
    ..These results suggest that the combined use of chemokines and adjuvant molecules may be a possible strategy in clinical tumor immunotherapy...
  11. pmc Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help
    Juhyun Kim
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110 799, Korea
    Nat Commun 6:7994. 2015
    ..These results suggest that the memory programme is CD8(+) T-cell-intrinsic, and provide insight into the role of CD4 help in CD8(+) T-cell responses. ..
  12. pmc Murine Sca1(+)Lin(-) bone marrow contains an endodermal precursor population that differentiates into hepatocytes
    Keunhee Oh
    Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea
    Exp Mol Med 47:e187. 2015
    ..The presence of equivalent endodermal precursor populations in human bone marrow would facilitate the development of these cells into an effective treatment modality for chronic liver diseases. ..
  13. pmc Anti-asthmatic activities of an ethanol extract of Aster yomena in an ovalbumin-induced murine asthma model
    Ji Hyun Sim
    1 Department of Anatomy and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
    J Med Food 17:606-11. 2014
    ..yomena extract. These findings suggest that A. yomena could be a promising natural agent for treating bronchial asthma in humans...
  14. pmc Transglutaminase 2 facilitates the distant hematogenous metastasis of breast cancer by modulating interleukin-6 in cancer cells
    Keunhee Oh
    Laboratory of Immunology, Interdisciplinary Program of Tumor Biology, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, Korea
    Breast Cancer Res 13:R96. 2011
    ....
  15. pmc Maturation-resistant dendritic cells ameliorate experimental autoimmune uveoretinitis
    Keunhee Oh
    Laboratory of Immunology, Transplantation Research Institute, Seoul National University College of Medicine, Seoul 110 799, Korea
    Immune Netw 11:399-405. 2011
    ..Recently our group reported that donor strain-derived immature DC pretreatment successfully controlled the adverse immune response during allogeneic transplantation...
  16. ncbi request reprint Porcine PD-L1: cloning, characterization, and implications during xenotransplantation
    Dae Hyun Jeon
    Laboratory of Molecular Genetics and Stem Cell Differentiation, Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea
    Xenotransplantation 14:236-42. 2007
    ..Endogenous negative regulatory signals like the programmed death 1 (PD-1)-programmed death ligand 1 (PD-L1) system are candidate targets for the control of cell-mediated xenogeneic immune response...
  17. ncbi request reprint Direct regulatory role of NKT cells in allogeneic graft survival is dependent on the quantitative strength of antigenicity
    Keunhee Oh
    Laboratory of Immunology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Immunol 174:2030-6. 2005
    ..Taken together, we concluded that CD1d-dependent NKT cells may directly affect the outcome of allogeneic skin graft through an IL-10-dependent regulatory mechanism...
  18. doi request reprint Cytogenetic heterogeneity and their serial dynamic changes during acquisition of cytogenetic aberrations in cultured mesenchymal stem cells
    Jung Ah Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Mutat Res 777:60-8. 2015
    ..In particular, we believe it is critical to test for chromosomal aberrations using both G-banding and FISH to ensure the safety of human stem cells that are manufactured in vitro for clinical applications. ..
  19. doi request reprint A receptor-independent, cell-based JAK activation assay for screening for JAK3-specific inhibitors
    Keunhee Oh
    Laboratory of Immunology, Department of Anatomy, Seoul National University College of Medicine, Republic of Korea
    J Immunol Methods 354:45-52. 2010
    ..Thus, we generated a receptor-independent, cell-based selective screening system for specific JAK3 inhibitors, which is easily convertible to a high-throughput screening platform...